| BlackRock, Inc. | US$10.0亿 | 0.02% |
| BAKER BROS. ADVISORS LP | US$3.5亿 | 2.03% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$3.4亿 | 0.02% |
| STATE STREET CORP | US$3.3亿 | 0.01% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$2.6亿 | 0.01% |
| RENAISSANCE TECHNOLOGIES LLC | US$2.2亿 | 0.34% |
| AMERICAN CENTURY COMPANIES INC | US$2.1亿 | 0.11% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$1.6亿 | 0.02% |
| DIMENSIONAL FUND ADVISORS LP | US$1.6亿 | 0.03% |
| Commodore Capital LP | US$1.5亿 | 8.59% |
| GEODE CAPITAL MANAGEMENT, LLC | US$1.5亿 | 0.01% |
| Deep Track Capital, LP | US$1.3亿 | 2.07% |
| JPMORGAN CHASE & CO | US$1.2亿 | 0.01% |
| WELLINGTON MANAGEMENT GROUP LLP | US$1.1亿 | 0.02% |
| FIRST TRUST ADVISORS LP | US$1.0亿 | 0.08% |
| PRIMECAP MANAGEMENT CO/CA/ | US$8981.4万 | 0.07% |
| Nuveen, LLC | US$8700.6万 | 0.02% |
| CITADEL ADVISORS LLC | US$8243.4万 | 0.01% |
| Holocene Advisors, LP | US$8194.1万 | 0.20% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$7909.2万 | 0.01% |
| BVF INC/IL | US$7072.0万 | 2.25% |
| Soleus Capital Management, L.P. | US$6969.0万 | 2.82% |
| GOLDMAN SACHS GROUP INC | US$6655.4万 | 0.01% |
| LOOMIS SAYLES & CO L P | US$6310.3万 | 0.08% |
| MORGAN STANLEY | US$6138.8万 | 0.00% |
| NORTHERN TRUST CORP | US$6000.9万 | 0.01% |
| RTW INVESTMENTS, LP | US$5913.5万 | 0.59% |
| Affinity Asset Advisors, LLC | US$4773.6万 | 2.47% |
| FMR LLC | US$4680.8万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$4281.6万 | 0.00% |
| Avoro Capital Advisors LLC | US$4243.2万 | 0.42% |
| VANGUARD FIDUCIARY TRUST CO | US$3993.0万 | 0.01% |
| Artisan Partners Limited Partnership | US$3931.1万 | 0.06% |
| Bank of New York Mellon Corp | US$3664.9万 | 0.01% |
| MARSHALL WACE, LLP | US$3533.6万 | 0.04% |
| PRINCIPAL FINANCIAL GROUP INC | US$3387.5万 | 0.02% |
| PANAGORA ASSET MANAGEMENT INC | US$3298.9万 | 0.12% |
| T. Rowe Price Investment Management, Inc. | US$3162.2万 | 0.02% |
| Pictet Asset Management Holding SA | US$3016.7万 | 0.03% |
| Driehaus Capital Management LLC | US$2800.4万 | 0.21% |
| TWO SIGMA INVESTMENTS, LP | US$2760.5万 | 0.02% |
| AMERIPRISE FINANCIAL INC | US$2620.7万 | 0.01% |
| D. E. Shaw & Co., Inc. | US$2511.6万 | 0.02% |
| Frazier Life Sciences Management, L.P. | US$2477.5万 | 0.64% |
| Pacer Advisors, Inc. | US$2434.8万 | 0.07% |
| Public Sector Pension Investment Board | US$2395.3万 | 0.07% |
| Man Group plc | US$2210.2万 | 0.04% |
| Bain Capital Life Sciences Investors, LLC | US$2157.0万 | 1.95% |
| Balyasny Asset Management L.P. | US$2074.8万 | 0.03% |
| SEGALL BRYANT & HAMILL, LLC | US$2071.3万 | 0.30% |
| Woodline Partners LP | US$1975.1万 | 0.07% |
| Invesco Ltd. | US$1853.8万 | 0.00% |
| Prosight Management, LP | US$1816.2万 | 2.98% |
| UBS Group AG | US$1750.4万 | 0.00% |
| SILVERARC CAPITAL MANAGEMENT, LLC | US$1627.7万 | 1.66% |
| RHUMBLINE ADVISERS | US$1589.5万 | 0.01% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$1579.2万 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$1425.5万 | 0.00% |
| Fisher Asset Management, LLC | US$1380.7万 | 0.00% |
| RICE HALL JAMES & ASSOCIATES, LLC | US$1380.3万 | 0.77% |
| AQR CAPITAL MANAGEMENT LLC | US$1357.7万 | 0.01% |
| Legal & General Group Plc | US$1346.2万 | 0.00% |
| GLENMEDE TRUST CO NA | US$1336.9万 | 0.07% |
| Logos Global Management LP | US$1237.6万 | 0.62% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | US$1202.2万 | 0.02% |
| California Public Employees Retirement System | US$1160.5万 | 0.01% |
| Spruce Street Capital LP | US$1124.4万 | 2.70% |
| Swiss National Bank | US$1097.2万 | 0.01% |
| VICTORY CAPITAL MANAGEMENT INC | US$1092.4万 | 0.01% |
| ROYAL BANK OF CANADA | US$1076.1万 | 0.00% |
| RAYMOND JAMES FINANCIAL INC | US$998.3万 | 0.00% |
| Squarepoint Ops LLC | US$981.7万 | 0.01% |
| GENDELL JEFFREY L | US$932.1万 | 0.13% |
| C WorldWide Group Holding A/S | US$884.0万 | 0.19% |
| MACKENZIE FINANCIAL CORP | US$881.1万 | 0.01% |
| PEREGRINE CAPITAL MANAGEMENT LLC | US$862.8万 | 0.32% |
| CAPITAL FUND MANAGEMENT S.A. | US$859.4万 | 0.04% |
| Palo Alto Investors LP | US$857.7万 | 1.31% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$847.5万 | 0.01% |
| Eagle Health Investments LP | US$843.9万 | 1.48% |
| Senator Investment Group LP | US$831.7万 | 0.38% |
| Atle Fund Management AB | US$823.6万 | 2.66% |
| ACADIAN ASSET MANAGEMENT LLC | US$805.5万 | 0.01% |
| Robeco Institutional Asset Management B.V. | US$779.8万 | 0.01% |
| Engineers Gate Manager LP | US$737.2万 | 0.09% |
| ALLIANCEBERNSTEIN L.P. | US$730.1万 | 0.00% |
| ExodusPoint Capital Management, LP | US$722.5万 | 0.06% |
| NEUBERGER BERMAN GROUP LLC | US$697.4万 | 0.01% |
| MARTINGALE ASSET MANAGEMENT L P | US$688.7万 | 0.17% |
| Rock Springs Capital Management LP | US$650.6万 | 0.38% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$649.9万 | 0.01% |
| FRANKLIN RESOURCES INC | US$645.4万 | 0.00% |
| SG Americas Securities, LLC | US$632.9万 | 0.01% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$631.0万 | 0.01% |
| BARCLAYS PLC | US$618.7万 | 0.00% |
| Hudson Bay Capital Management LP | US$613.9万 | 0.02% |
| Rafferty Asset Management, LLC | US$574.3万 | 0.02% |
| Tetragon Partners GP Ltd | US$565.0万 | 1.10% |
| MOORE CAPITAL MANAGEMENT, LP | US$560.5万 | 0.11% |
| BESSEMER GROUP INC | US$560.1万 | 0.01% |
| SummitTX Capital, L.P. | US$552.5万 | 0.17% |
| JANUS HENDERSON GROUP PLC | US$544.7万 | 0.00% |
| SEI INVESTMENTS CO | US$543.9万 | 0.01% |
| WEDGE CAPITAL MANAGEMENT L L P/NC | US$534.8万 | 0.10% |
| DEUTSCHE BANK AG\ | US$529.5万 | 0.00% |
| DAFNA Capital Management LLC | US$493.2万 | 1.12% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$492.7万 | 0.01% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$486.6万 | 0.01% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$482.3万 | 0.00% |
| ALPS ADVISORS INC | US$479.7万 | 0.02% |
| Rhenman & Partners Asset Management AB | US$471.2万 | 0.58% |
| PRUDENTIAL FINANCIAL INC | US$466.3万 | 0.01% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$457.7万 | 0.01% |
| Assenagon Asset Management S.A. | US$431.8万 | 0.01% |
| Knott David M Jr | US$424.3万 | 2.53% |
| WELLS FARGO & COMPANY/MN | US$417.0万 | 0.00% |
| Thrivent Financial for Lutherans | US$389.7万 | 0.01% |
| Krensavage Asset Management, LLC | US$381.3万 | 1.49% |
| Russell Investments Group, Ltd. | US$347.5万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | US$329.3万 | 0.00% |
| Illinois Municipal Retirement Fund | US$321.7万 | 0.04% |
| State of Alaska, Department of Revenue | US$320.1万 | 0.03% |
| MetLife Investment Management, LLC | US$314.2万 | 0.02% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$303.8万 | 0.00% |
| Exome Asset Management LLC | US$297.4万 | 1.54% |
| Vident Advisory, LLC | US$297.3万 | 0.03% |
| Bridgewater Associates, LP | US$296.3万 | 0.01% |
| KLP KAPITALFORVALTNING AS | US$290.3万 | 0.01% |
| Pathstone Holdings, LLC | US$289.9万 | 0.01% |
| HRT FINANCIAL LP | US$289.9万 | 0.01% |
| Vanguard Global Advisers, LLC | US$288.7万 | 0.00% |
| STEMPOINT CAPITAL LP | US$284.6万 | 0.54% |
| Allianz Asset Management GmbH | US$284.2万 | 0.00% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | US$275.6万 | 0.02% |
| PROFUND ADVISORS LLC | US$275.0万 | 0.10% |
| Focus Partners Wealth | US$272.5万 | 0.00% |
| Creative Planning | US$265.3万 | 0.00% |
| NATIXIS ADVISORS, LLC | US$264.7万 | 0.00% |
| Louisiana State Employees Retirement System | US$258.8万 | 0.05% |
| HighVista Strategies LLC | US$258.8万 | 0.71% |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | US$257.0万 | 0.03% |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | US$253.8万 | 0.01% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$252.5万 | 0.00% |
| State of Tennessee, Department of Treasury | US$236.7万 | 0.01% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$236.3万 | 0.01% |
| Federation des caisses Desjardins du Quebec | US$233.9万 | 0.01% |
| Amundi | US$228.8万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$215.6万 | 0.02% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$203.4万 | 0.00% |
| ROYCE & ASSOCIATES LP | US$196.9万 | 0.02% |