| BML Capital Management, LLC | US$5343.8万 | 34.31% |
| Deep Track Capital, LP | US$3504.4万 | 0.57% |
| BlackRock, Inc. | US$2777.6万 | 0.00% |
| RA CAPITAL MANAGEMENT, L.P. | US$2551.5万 | 0.27% |
| Vivo Capital, LLC | US$2500.0万 | 2.08% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$1937.8万 | 0.00% |
| Frazier Life Sciences Management, L.P. | US$1847.0万 | 0.48% |
| Rock Springs Capital Management LP | US$1677.2万 | 0.99% |
| Decheng Capital LLC | US$1515.7万 | 2.29% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$1451.6万 | 0.02% |
| Balyasny Asset Management L.P. | US$1260.5万 | 0.02% |
| CITADEL ADVISORS LLC | US$1056.8万 | 0.00% |
| MORGAN STANLEY | US$1029.9万 | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | US$909.2万 | 0.00% |
| STATE STREET CORP | US$753.3万 | 0.00% |
| Kalehua Capital Management LLC | US$687.1万 | 4.86% |
| BRAIDWELL LP | US$637.2万 | 0.21% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$621.0万 | 0.00% |
| Palo Alto Investors LP | US$605.0万 | 0.93% |
| ACADIAN ASSET MANAGEMENT LLC | US$577.0万 | 0.01% |
| Woodline Partners LP | US$557.1万 | 0.02% |
| Connor, Clark & Lunn Investment Management Ltd. | US$531.9万 | 0.01% |
| DEUTSCHE BANK AG\ | US$374.2万 | 0.00% |
| Aldebaran Capital, LLC | US$355.2万 | 2.72% |
| D. E. Shaw & Co., Inc. | US$337.8万 | 0.00% |
| MILLENNIUM MANAGEMENT LLC | US$283.5万 | 0.00% |
| NORTHERN TRUST CORP | US$273.1万 | 0.00% |
| Three Bridge Wealth Advisors, LLC | US$268.1万 | 0.74% |
| MARSHALL WACE, LLP | US$267.4万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$235.8万 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$225.2万 | 0.00% |
| GOLDMAN SACHS GROUP INC | US$220.8万 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | US$191.4万 | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | US$188.5万 | 0.00% |
| PANAGORA ASSET MANAGEMENT INC | US$188.4万 | 0.01% |
| Logos Global Management LP | US$187.5万 | 0.09% |
| Monashee Investment Management LLC | US$187.5万 | 1.02% |
| JPMORGAN CHASE & CO | US$169.8万 | 0.00% |
| Aisling Capital Management LP | US$162.9万 | 0.34% |
| Bollard Group LLC | US$161.9万 | 0.05% |
| TWO SIGMA INVESTMENTS, LP | US$148.4万 | 0.00% |
| MPM BIOIMPACT LLC | US$147.0万 | 0.11% |
| SUPERSTRING CAPITAL MANAGEMENT LP | US$137.4万 | 0.98% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | US$123.8万 | 0.02% |
| Russell Investments Group, Ltd. | US$115.6万 | 0.00% |
| HighTower Advisors, LLC | US$114.7万 | 0.00% |
| RAYMOND JAMES FINANCIAL INC | US$99.9万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$97.9万 | 0.00% |
| WELLINGTON MANAGEMENT GROUP LLP | US$96.4万 | 0.00% |
| SEI INVESTMENTS CO | US$81.4万 | 0.00% |
| Invesco Ltd. | US$80.6万 | 0.00% |
| MACKENZIE FINANCIAL CORP | US$80.0万 | 0.00% |
| Bank of New York Mellon Corp | US$77.6万 | 0.00% |
| UBS Group AG | US$77.6万 | 0.00% |
| Verdad Advisers, LP | US$73.9万 | 0.83% |
| Qube Research & Technologies Ltd | US$72.9万 | 0.00% |
| Informed Momentum Co LLC | US$66.9万 | 0.08% |
| Assenagon Asset Management S.A. | US$66.5万 | 0.00% |
| FMR LLC | US$66.1万 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$58.8万 | 0.00% |
| Creative Planning | US$57.0万 | 0.00% |
| ADAR1 Capital Management, LLC | US$49.7万 | 0.03% |
| AMERICAN CENTURY COMPANIES INC | US$44.5万 | 0.00% |
| Nuveen, LLC | US$44.3万 | 0.00% |
| ALPS ADVISORS INC | US$36.8万 | 0.00% |
| XTX Topco Ltd | US$36.7万 | 0.01% |
| JANE STREET GROUP, LLC | US$34.6万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$29.8万 | 0.00% |
| RHUMBLINE ADVISERS | US$28.3万 | 0.00% |
| Quadrature Capital Ltd | US$27.2万 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$27.2万 | 0.00% |
| Vanguard Global Advisers, LLC | US$25.8万 | 0.00% |
| CenterBook Partners LP | US$25.0万 | 0.01% |
| MetLife Investment Management, LLC | US$16.5万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$16.3万 | 0.00% |
| Cambridge Investment Research Advisors, Inc. | US$15.7万 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | US$14.9万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$13.6万 | 0.00% |
| EntryPoint Capital, LLC | US$12.4万 | 0.04% |
| Diversified Trust Co | US$11.0万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$10.2万 | 0.00% |
| SG Americas Securities, LLC | US$10.0万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$9.5万 | 0.00% |
| Vontobel Holding Ltd. | US$9.4万 | 0.00% |
| TWO SIGMA SECURITIES, LLC | US$8.4万 | 0.01% |
| NEUBERGER BERMAN GROUP LLC | US$8.3万 | 0.00% |
| BARCLAYS PLC | US$8.1万 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$8.0万 | 0.01% |
| Police & Firemen's Retirement System of New Jersey | US$7.4万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$7.2万 | 0.00% |
| ProShare Advisors LLC | US$7.0万 | 0.00% |
| Engineers Gate Manager LP | US$6.9万 | 0.00% |
| CRA Financial Services, LLC | US$6.7万 | 0.01% |
| Vanguard Personalized Indexing Management, LLC | US$6.6万 | 0.00% |
| CIBC Asset Management Inc | US$6.5万 | 0.00% |
| ExodusPoint Capital Management, LP | US$6.3万 | 0.00% |
| Hudson Bay Capital Management LP | US$6.3万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | US$6.1万 | 0.00% |
| STRS OHIO | US$6.0万 | 0.00% |
| PRUDENTIAL FINANCIAL INC | US$5.0万 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | US$4.6万 | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | US$4.4万 | 0.00% |
| SIMPLEX TRADING, LLC | US$4.2万 | 0.00% |
| Jefferies Financial Group Inc. | US$4.1万 | 0.00% |
| MERCER GLOBAL ADVISORS INC /ADV | US$4.0万 | 0.00% |
| M&T Bank Corp | US$3.8万 | 0.00% |
| Ameritas Investment Partners, Inc. | US$3.5万 | 0.00% |
| Legal & General Group Plc | US$3.1万 | 0.00% |
| CITIGROUP INC | US$2.9万 | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | US$2.4万 | 0.00% |
| Rockefeller Capital Management L.P. | US$2.3万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$1.9万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$1.9万 | 0.00% |
| Tower Research Capital LLC (TRC) | US$1.5万 | 0.00% |
| MBM WEALTH CONSULTANTS, LLC | US$1.2万 | 0.00% |
| Sterling Capital Management LLC | US$1.1万 | 0.00% |
| GF FUND MANAGEMENT CO. LTD. | US$9071.0 | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | US$7763.0 | 0.00% |
| CWM, LLC | US$5093.0 | 0.00% |
| GAMMA Investing LLC | US$3825.0 | 0.00% |
| Capital Advisors, Ltd. LLC | US$2000.0 | 0.00% |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | US$1875.0 | 0.00% |
| EverSource Wealth Advisors, LLC | US$1789.0 | 0.00% |
| Farther Finance Advisors, LLC | US$1437.0 | 0.00% |
| Parallel Advisors, LLC | US$1339.0 | 0.00% |
| Smartleaf Asset Management LLC | US$1312.0 | 0.00% |
| NISA INVESTMENT ADVISORS, LLC | US$1193.0 | 0.00% |
| Cornerstone Financial Management LLC | US$1013.0 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | US$804.2 | 0.00% |
| Truvestments Capital LLC | US$563.0 | 0.00% |
| SBI Securities Co., Ltd. | US$251.0 | 0.00% |
| Allworth Financial LP | US$184.0 | 0.00% |
| Root Financial Partners, LLC | US$101.0 | 0.00% |
| ROTHSCHILD INVESTMENT LLC | US$34.0 | 0.00% |
| Essential Partners LLC | US$19.0 | 0.00% |
| MAI Capital Management | US$4.0 | 0.00% |
| ROYAL BANK OF CANADA | US$0.0 | 0.00% |