| FMR LLC | US$3.7億 | 0.02% |
| T. Rowe Price Investment Management, Inc. | US$3.6億 | 0.25% |
| BlackRock, Inc. | US$1.8億 | 0.00% |
| Redmile Group, LLC | US$1.2億 | 8.05% |
| STATE STREET CORP | US$1.2億 | 0.00% |
| PRIMECAP MANAGEMENT CO/CA/ | US$1.0億 | 0.08% |
| WELLINGTON MANAGEMENT GROUP LLP | US$1.0億 | 0.02% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$9687.7萬 | 0.00% |
| Driehaus Capital Management LLC | US$8966.5萬 | 0.66% |
| ENAVATE SCIENCES GP, LLC | US$7903.4萬 | 22.48% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$6252.5萬 | 0.01% |
| MORGAN STANLEY | US$6214.6萬 | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | US$5601.3萬 | 0.00% |
| JPMORGAN CHASE & CO | US$5361.2萬 | 0.00% |
| Jefferies Financial Group Inc. | US$5076.9萬 | 0.35% |
| SILVERARC CAPITAL MANAGEMENT, LLC | US$4046.6萬 | 4.13% |
| Sofinnova Investments, Inc. | US$3722.1萬 | 1.41% |
| Woodline Partners LP | US$3445.4萬 | 0.13% |
| MARSHALL WACE, LLP | US$3238.5萬 | 0.03% |
| PRINCIPAL FINANCIAL GROUP INC | US$3011.2萬 | 0.02% |
| READYSTATE ASSET MANAGEMENT LP | US$2847.2萬 | 1.28% |
| GOLDMAN SACHS GROUP INC | US$2408.9萬 | 0.00% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$2401.0萬 | 0.03% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$2202.3萬 | 0.00% |
| NORTHERN TRUST CORP | US$1966.4萬 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$1862.9萬 | 0.00% |
| Polar Capital Holdings Plc | US$1857.8萬 | 0.07% |
| JANUS HENDERSON GROUP PLC | US$1767.2萬 | 0.01% |
| BANK OF AMERICA CORP /DE/ | US$1709.4萬 | 0.00% |
| Pivotal bioVenture Partners Investment Advisor LLC | US$1602.0萬 | 5.73% |
| VANGUARD FIDUCIARY TRUST CO | US$1566.8萬 | 0.00% |
| NAN FUNG TRINITY (HK) LTD | US$1562.7萬 | 1.72% |
| TD Asset Management Inc | US$1519.8萬 | 0.01% |
| Candriam S.C.A. | US$1180.7萬 | 0.06% |
| UBS Group AG | US$946.8萬 | 0.00% |
| Parkman Healthcare Partners LLC | US$882.4萬 | 0.91% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$787.1萬 | 0.00% |
| Rock Springs Capital Management LP | US$760.3萬 | 0.45% |
| Granahan Investment Management, LLC | US$671.5萬 | 0.32% |
| Atom Investors LP | US$671.1萬 | 0.48% |
| Nuveen, LLC | US$667.6萬 | 0.00% |
| KENNEDY CAPITAL MANAGEMENT LLC | US$627.7萬 | 0.13% |
| Bank of New York Mellon Corp | US$603.8萬 | 0.00% |
| Tema ETFs LLC | US$603.4萬 | 0.41% |
| Tidal Investments LLC | US$603.4萬 | 0.01% |
| Atika Capital Management LLC | US$575.0萬 | 0.91% |
| Balyasny Asset Management L.P. | US$549.8萬 | 0.01% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$504.6萬 | 0.01% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$452.3萬 | 0.00% |
| Burkehill Global Management, LP | US$437.4萬 | 0.22% |
| Qube Research & Technologies Ltd | US$411.7萬 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$409.0萬 | 0.00% |
| Swiss National Bank | US$404.6萬 | 0.00% |
| CITADEL ADVISORS LLC | US$384.2萬 | 0.00% |
| GILDER GAGNON HOWE & CO LLC | US$370.2萬 | 0.04% |
| Trexquant Investment LP | US$364.8萬 | 0.03% |
| Sio Capital Management, LLC | US$361.1萬 | 0.52% |
| ALLIANCEBERNSTEIN L.P. | US$351.1萬 | 0.00% |
| Rafferty Asset Management, LLC | US$341.7萬 | 0.01% |
| MILLENNIUM MANAGEMENT LLC | US$285.1萬 | 0.00% |
| AMERIPRISE FINANCIAL INC | US$283.2萬 | 0.00% |
| Aristotle Atlantic Partners, LLC | US$273.4萬 | 0.13% |
| RHUMBLINE ADVISERS | US$264.4萬 | 0.00% |
| ExodusPoint Capital Management, LP | US$252.3萬 | 0.02% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$243.7萬 | 0.00% |
| Walleye Capital LLC | US$243.2萬 | 0.01% |
| LMR Partners LLP | US$221.8萬 | 0.00% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | US$212.4萬 | 0.00% |
| RAYMOND JAMES FINANCIAL INC | US$210.8萬 | 0.00% |
| SummitTX Capital, L.P. | US$203.1萬 | 0.06% |
| DEUTSCHE BANK AG\ | US$194.9萬 | 0.00% |
| JANE STREET GROUP, LLC | US$186.6萬 | 0.00% |
| Cerity Partners LLC | US$182.8萬 | 0.00% |
| Legal & General Group Plc | US$178.4萬 | 0.00% |
| Informed Momentum Co LLC | US$156.9萬 | 0.18% |
| PROFUND ADVISORS LLC | US$152.9萬 | 0.06% |
| RENAISSANCE TECHNOLOGIES LLC | US$150.7萬 | 0.00% |
| Squarepoint Ops LLC | US$148.2萬 | 0.00% |
| Invesco Ltd. | US$145.6萬 | 0.00% |
| Schonfeld Strategic Advisors LLC | US$136.5萬 | 0.01% |
| Freestone Capital Holdings, LLC | US$134.5萬 | 0.04% |
| XTX Topco Ltd | US$132.3萬 | 0.02% |
| Edgestream Partners, L.P. | US$131.0萬 | 0.04% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$129.9萬 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$126.1萬 | 0.00% |
| MetLife Investment Management, LLC | US$122.2萬 | 0.01% |
| SEI INVESTMENTS CO | US$115.4萬 | 0.00% |
| Vanguard Global Advisers, LLC | US$109.8萬 | 0.00% |
| Birchview Capital, LP | US$109.4萬 | 0.62% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$107.1萬 | 0.00% |
| Lido Advisors, LLC | US$107.1萬 | 0.00% |
| NISA INVESTMENT ADVISORS, LLC | US$104.9萬 | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | US$103.6萬 | 0.00% |
| Erste Asset Management GmbH | US$100.4萬 | 0.01% |
| Magnus Financial Group LLC | US$100.1萬 | 0.08% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$97.3萬 | 0.00% |
| Scharf Investments, LLC | US$97.1萬 | 0.03% |
| Susquehanna Portfolio Strategies, LLC | US$96.6萬 | 0.01% |
| Corient Private Wealth LLC | US$95.1萬 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$91.3萬 | 0.00% |
| Three Bridge Wealth Advisors, LLC | US$82.3萬 | 0.23% |
| FRANKLIN RESOURCES INC | US$78.8萬 | 0.00% |
| SG Americas Securities, LLC | US$78.7萬 | 0.00% |
| Private Capital Advisors, Inc. | US$74.5萬 | 0.09% |
| DIMENSIONAL FUND ADVISORS LP | US$73.1萬 | 0.00% |
| State of New Jersey Common Pension Fund D | US$70.1萬 | 0.00% |
| Palumbo Wealth Management LLC | US$70.1萬 | 0.17% |
| INTECH INVESTMENT MANAGEMENT LLC | US$67.9萬 | 0.01% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$64.5萬 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$60.6萬 | 0.01% |
| Baldwin Investment Management, LLC | US$57.0萬 | 0.07% |
| CITIGROUP INC | US$56.8萬 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | US$56.3萬 | 0.00% |
| Creative Planning | US$55.8萬 | 0.00% |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | US$53.1萬 | 0.00% |
| BARCLAYS PLC | US$52.2萬 | 0.00% |
| Jump Financial, LLC | US$51.6萬 | 0.01% |
| Vanguard Investments Australia, Ltd. | US$51.2萬 | 0.00% |
| Brevan Howard Capital Management LP | US$46.5萬 | 0.00% |
| Tower Research Capital LLC (TRC) | US$44.6萬 | 0.01% |
| KLP KAPITALFORVALTNING AS | US$44.6萬 | 0.00% |
| PSP Research LLC | US$43.7萬 | 0.31% |
| CITIZENS FINANCIAL GROUP INC/RI | US$43.6萬 | 0.01% |
| E Fund Management Co., Ltd. | US$42.9萬 | 0.01% |
| Sequoia Financial Advisors, LLC | US$41.8萬 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$41.0萬 | 0.00% |
| Campbell & CO Investment Adviser LLC | US$39.4萬 | 0.02% |
| VOYA INVESTMENT MANAGEMENT LLC | US$37.7萬 | 0.00% |
| Y-Intercept (Hong Kong) Ltd | US$34.9萬 | 0.01% |
| PRUDENTIAL FINANCIAL INC | US$34.5萬 | 0.00% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$34.4萬 | 0.00% |
| Maltin Wealth Management, Inc. | US$32.8萬 | 0.13% |
| ProShare Advisors LLC | US$32.4萬 | 0.00% |
| CAPSTONE INVESTMENT ADVISORS, LLC | US$32.1萬 | 0.00% |
| Pictet Asset Management Holding SA | US$32.0萬 | 0.00% |
| Virtus Investment Advisers, LLC | US$30.5萬 | 0.08% |
| Anfield Capital Management, LLC | US$29.8萬 | 0.08% |
| Caitong International Asset Management Co., Ltd | US$28.1萬 | 0.05% |
| US BANCORP \DE\ | US$26.9萬 | 0.00% |
| AMERICAN CENTURY COMPANIES INC | US$26.6萬 | 0.00% |
| TEACHER RETIREMENT SYSTEM OF TEXAS | US$26.5萬 | 0.00% |
| Cetera Investment Advisers | US$26.2萬 | 0.00% |
| GSA CAPITAL PARTNERS LLP | US$24.2萬 | 0.02% |
| Quantinno Capital Management LP | US$22.2萬 | 0.00% |
| Gotham Asset Management, LLC | US$22.1萬 | 0.00% |
| Velan Capital Investment Management LP | US$21.9萬 | 0.14% |
| Sterling Investment Advisors, Ltd. | US$21.7萬 | 0.04% |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | US$20.8萬 | 0.01% |
| HighTower Advisors, LLC | US$20.6萬 | 0.00% |
| XPONANCE LLC | US$20.5萬 | 0.00% |