| JANUS HENDERSON GROUP PLC | US$11.1億 | 0.53% |
| Orbis Allan Gray Ltd | US$8.0億 | 3.36% |
| BlackRock, Inc. | US$7.5億 | 0.01% |
| FMR LLC | US$7.0億 | 0.04% |
| PERCEPTIVE ADVISORS LLC | US$6.6億 | 12.82% |
| BAKER BROS. ADVISORS LP | US$5.6億 | 3.24% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$3.9億 | 0.01% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | US$3.1億 | 3.66% |
| Driehaus Capital Management LLC | US$3.1億 | 2.25% |
| Cormorant Asset Management, LP | US$2.9億 | 14.33% |
| STATE STREET CORP | US$2.8億 | 0.01% |
| MORGAN STANLEY | US$2.7億 | 0.02% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$2.6億 | 0.41% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$2.4億 | 0.01% |
| GOLDMAN SACHS GROUP INC | US$2.3億 | 0.03% |
| GEODE CAPITAL MANAGEMENT, LLC | US$2.1億 | 0.01% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$2.0億 | 0.02% |
| BANK OF AMERICA CORP /DE/ | US$1.7億 | 0.01% |
| RA CAPITAL MANAGEMENT, L.P. | US$1.2億 | 1.28% |
| Hood River Capital Management LLC | US$1.2億 | 1.16% |
| Vivo Capital, LLC | US$1.1億 | 9.08% |
| Soleus Capital Management, L.P. | US$1.1億 | 4.31% |
| Logos Global Management LP | US$9182.4萬 | 4.58% |
| Pictet Asset Management Holding SA | US$9142.8萬 | 0.10% |
| FRANKLIN RESOURCES INC | US$8896.4萬 | 0.02% |
| NORTHERN TRUST CORP | US$7343.8萬 | 0.01% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$6941.5萬 | 0.01% |
| Caption Management, LLC | US$6733.8萬 | 0.39% |
| Woodline Partners LP | US$6444.2萬 | 0.24% |
| T. Rowe Price Investment Management, Inc. | US$5646.0萬 | 0.04% |
| WELLINGTON MANAGEMENT GROUP LLP | US$5617.4萬 | 0.01% |
| ORBIMED ADVISORS LLC | US$5557.8萬 | 1.14% |
| Aberdeen Group plc | US$5557.3萬 | 0.09% |
| Affinity Asset Advisors, LLC | US$5477.2萬 | 2.83% |
| VANGUARD FIDUCIARY TRUST CO | US$5474.1萬 | 0.01% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$4643.3萬 | 0.01% |
| AMERICAN CENTURY COMPANIES INC | US$4132.3萬 | 0.02% |
| Qube Research & Technologies Ltd | US$4131.4萬 | 0.05% |
| ArrowMark Colorado Holdings LLC | US$3797.0萬 | 1.01% |
| 683 Capital Management, LLC | US$3631.1萬 | 1.90% |
| UBS Group AG | US$3494.0萬 | 0.01% |
| Velan Capital Investment Management LP | US$3247.1萬 | 20.34% |
| JANE STREET GROUP, LLC | US$3044.7萬 | 0.00% |
| Bank of New York Mellon Corp | US$2804.6萬 | 0.01% |
| ACUTA CAPITAL PARTNERS, LLC | US$2735.4萬 | 19.45% |
| MetLife Investment Management, LLC | US$2607.5萬 | 0.13% |
| CITADEL ADVISORS LLC | US$2464.8萬 | 0.00% |
| Alyeska Investment Group, L.P. | US$2325.5萬 | 0.07% |
| Nuveen, LLC | US$2321.2萬 | 0.01% |
| Ikarian Capital, LLC | US$2306.3萬 | 1.87% |
| SILVERARC CAPITAL MANAGEMENT, LLC | US$2305.3萬 | 2.35% |
| JPMORGAN CHASE & CO | US$2216.5萬 | 0.00% |
| Ensign Peak Advisors, Inc | US$2203.2萬 | 0.04% |
| 72 Investment Holdings, LLC | US$2124.3萬 | 42.83% |
| Sofinnova Investments, Inc. | US$2051.7萬 | 0.78% |
| Candriam S.C.A. | US$2050.0萬 | 0.11% |
| Invesco Ltd. | US$1978.1萬 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$1889.8萬 | 0.01% |
| DEUTSCHE BANK AG\ | US$1861.6萬 | 0.01% |
| STEMPOINT CAPITAL LP | US$1812.9萬 | 3.47% |
| FRONTIER CAPITAL MANAGEMENT CO LLC | US$1719.4萬 | 0.18% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$1528.2萬 | 0.03% |
| Swiss National Bank | US$1504.6萬 | 0.01% |
| Boxer Capital Management, LLC | US$1496.8萬 | 1.97% |
| Exome Asset Management LLC | US$1465.0萬 | 7.58% |
| MARSHALL WACE, LLP | US$1454.7萬 | 0.01% |
| Ishara Investments LP | US$1387.0萬 | 13.13% |
| KVP Capital Advisors, LP | US$1382.2萬 | 10.32% |
| First Turn Management, LLC | US$1367.4萬 | 1.53% |
| California Public Employees Retirement System | US$1358.4萬 | 0.01% |
| CANADA PENSION PLAN INVESTMENT BOARD | US$1292.9萬 | 0.01% |
| Integral Health Asset Management, LLC | US$1288.8萬 | 0.62% |
| EVENTIDE ASSET MANAGEMENT, LLC | US$1243.4萬 | 0.21% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$1229.0萬 | 0.00% |
| SummitTX Capital, L.P. | US$1186.9萬 | 0.37% |
| PFM Health Sciences, LP | US$1141.8萬 | 1.04% |
| TD Asset Management Inc | US$1132.4萬 | 0.01% |
| Burkehill Global Management, LP | US$1127.7萬 | 0.56% |
| FIRST TRUST ADVISORS LP | US$1074.0萬 | 0.01% |
| B Group, Inc. | US$1070.9萬 | 7.94% |
| RHUMBLINE ADVISERS | US$1059.3萬 | 0.01% |
| Ally Bridge Group (NY) LLC | US$1057.1萬 | 8.54% |
| AMERIPRISE FINANCIAL INC | US$1005.9萬 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | US$1004.0萬 | 0.00% |
| PRUDENTIAL FINANCIAL INC | US$983.0萬 | 0.01% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$969.6萬 | 0.01% |
| LORD, ABBETT & CO. LLC | US$954.3萬 | 0.03% |
| SEI INVESTMENTS CO | US$951.3萬 | 0.01% |
| J. Goldman & Co LP | US$942.9萬 | 0.27% |
| VOYA INVESTMENT MANAGEMENT LLC | US$906.4萬 | 0.01% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$889.0萬 | 0.01% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$885.3萬 | 0.01% |
| HighVista Strategies LLC | US$848.1萬 | 2.34% |
| NEUBERGER BERMAN GROUP LLC | US$836.4萬 | 0.01% |
| ALLIANCEBERNSTEIN L.P. | US$816.4萬 | 0.00% |
| University of Wisconsin Foundation | US$812.4萬 | 7.21% |
| CONGRESS ASSET MANAGEMENT CO | US$800.3萬 | 0.06% |
| Susquehanna Portfolio Strategies, LLC | US$749.1萬 | 0.11% |
| Russell Investments Group, Ltd. | US$744.7萬 | 0.01% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$708.8萬 | 0.01% |
| Moody Aldrich Partners LLC | US$698.8萬 | 1.26% |
| Atom Investors LP | US$682.9萬 | 0.49% |
| Informed Momentum Co LLC | US$612.0萬 | 0.71% |
| Legal & General Group Plc | US$595.5萬 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$567.0萬 | 0.00% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$566.6萬 | 0.07% |
| Creative Planning | US$524.7萬 | 0.00% |
| ALGERT GLOBAL LLC | US$520.9萬 | 0.08% |
| Tetragon Partners GP Ltd | US$514.0萬 | 1.00% |
| Rafferty Asset Management, LLC | US$489.3萬 | 0.02% |
| Eversept Partners, LP | US$476.8萬 | 0.25% |
| ExodusPoint Capital Management, LP | US$475.0萬 | 0.04% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$471.8萬 | 0.01% |
| VICTORY CAPITAL MANAGEMENT INC | US$455.3萬 | 0.00% |
| Allianz Asset Management GmbH | US$452.0萬 | 0.00% |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | US$401.9萬 | 0.05% |
| Squarepoint Ops LLC | US$387.0萬 | 0.00% |
| NOMURA HOLDINGS INC | US$386.6萬 | 0.01% |
| WELLS FARGO & COMPANY/MN | US$374.2萬 | 0.00% |
| Vanguard Global Advisers, LLC | US$365.2萬 | 0.00% |
| MILLENNIUM MANAGEMENT LLC | US$342.5萬 | 0.00% |
| POLEN CAPITAL MANAGEMENT LLC | US$323.6萬 | 0.02% |
| BRAIDWELL LP | US$321.4萬 | 0.11% |
| DRW Securities, LLC | US$319.0萬 | 0.04% |
| PRELUDE CAPITAL MANAGEMENT, LLC | US$292.0萬 | 0.22% |
| Erste Asset Management GmbH | US$290.3萬 | 0.03% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$281.9萬 | 0.00% |
| Allspring Global Investments Holdings, LLC | US$272.5萬 | 0.00% |
| State of New Jersey Common Pension Fund D | US$259.6萬 | 0.01% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | US$238.0萬 | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | US$231.8萬 | 0.01% |
| PROFUND ADVISORS LLC | US$228.1萬 | 0.08% |
| Police & Firemen's Retirement System of New Jersey | US$225.2萬 | 0.02% |
| BARCLAYS PLC | US$224.9萬 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$224.8萬 | 0.02% |
| Vestmark Advisory Solutions, Inc. | US$215.3萬 | 0.02% |
| Trexquant Investment LP | US$213.5萬 | 0.02% |
| ARIZONA STATE RETIREMENT SYSTEM | US$208.7萬 | 0.01% |
| NISA INVESTMENT ADVISORS, LLC | US$202.3萬 | 0.01% |
| Vanguard Investments Australia, Ltd. | US$191.3萬 | 0.01% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$190.2萬 | 0.00% |
| CITIGROUP INC | US$181.9萬 | 0.00% |
| RAYMOND JAMES FINANCIAL INC | US$171.4萬 | 0.00% |
| Quarry LP | US$169.1萬 | 0.30% |
| KLP KAPITALFORVALTNING AS | US$167.5萬 | 0.01% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | US$163.0萬 | 0.01% |
| D. E. Shaw & Co., Inc. | US$161.1萬 | 0.00% |
| Ghisallo Capital Management LLC | US$161.1萬 | 0.04% |
| ProShare Advisors LLC | US$160.7萬 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$159.2萬 | 0.12% |