| Medicxi Ventures Management (Jersey) Ltd | US$7.9億 | 80.76% |
| Avoro Capital Advisors LLC | US$4.5億 | 4.47% |
| Index Venture Life Associates VI Ltd | US$4.0億 | 100.00% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$3.5億 | 0.55% |
| Pentwater Capital Management LP | US$3.2億 | 1.68% |
| FMR LLC | US$2.7億 | 0.01% |
| EcoR1 Capital, LLC | US$2.5億 | 10.81% |
| PERCEPTIVE ADVISORS LLC | US$2.1億 | 4.08% |
| Capital World Investors | US$1.9億 | 0.03% |
| FARALLON CAPITAL MANAGEMENT LLC | US$1.9億 | 1.09% |
| TCG Crossover Management, LLC | US$1.7億 | 4.87% |
| MORGAN STANLEY | US$1.7億 | 0.01% |
| Paradigm Biocapital Advisors LP | US$1.4億 | 2.90% |
| JANUS HENDERSON GROUP PLC | US$1.4億 | 0.07% |
| Deep Track Capital, LP | US$1.3億 | 2.05% |
| Logos Global Management LP | US$8440.5萬 | 4.21% |
| RTW INVESTMENTS, LP | US$8159.2萬 | 0.81% |
| FEDERATED HERMES, INC. | US$8140.4萬 | 0.13% |
| BRAIDWELL LP | US$7891.4萬 | 2.63% |
| BANK OF AMERICA CORP /DE/ | US$7675.5萬 | 0.01% |
| MAVERICK CAPITAL LTD | US$7366.0萬 | 0.85% |
| First Light Asset Management, LLC | US$6200.3萬 | 5.56% |
| Affinity Asset Advisors, LLC | US$5560.8萬 | 2.87% |
| Foresite Capital Management VI LLC | US$5417.9萬 | 11.77% |
| GENERAL ATLANTIC, L.P. | US$5381.4萬 | 2.50% |
| GOLDMAN SACHS GROUP INC | US$4658.2萬 | 0.01% |
| Siren, L.L.C. | US$4184.4萬 | 1.16% |
| Cormorant Asset Management, LP | US$4170.6萬 | 2.09% |
| ALPINE ASSOCIATES MANAGEMENT INC. | US$3437.8萬 | 2.03% |
| Woodline Partners LP | US$3412.4萬 | 0.13% |
| Balyasny Asset Management L.P. | US$3387.4萬 | 0.04% |
| MILLENNIUM MANAGEMENT LLC | US$3142.3萬 | 0.01% |
| Octagon Capital Advisors LP | US$2979.0萬 | 3.30% |
| CITADEL ADVISORS LLC | US$2899.5萬 | 0.00% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$2789.4萬 | 0.03% |
| AMERICAN CENTURY COMPANIES INC | US$2730.5萬 | 0.01% |
| FRANKLIN RESOURCES INC | US$2718.8萬 | 0.01% |
| BAKER BROS. ADVISORS LP | US$2664.2萬 | 0.15% |
| EVENTIDE ASSET MANAGEMENT, LLC | US$2653.9萬 | 0.44% |
| TORONTO DOMINION BANK | US$2601.1萬 | 0.04% |
| TIG Advisors, LLC | US$2575.2萬 | 1.19% |
| D. E. Shaw & Co., Inc. | US$2557.2萬 | 0.02% |
| Bain Capital Life Sciences Investors, LLC | US$2522.2萬 | 2.27% |
| Qube Research & Technologies Ltd | US$2494.6萬 | 0.03% |
| BlackRock, Inc. | US$2484.2萬 | 0.00% |
| 5AM Venture Management, LLC | US$2307.5萬 | 6.41% |
| PFM Health Sciences, LP | US$2098.1萬 | 1.91% |
| Weiss Asset Management LP | US$2027.3萬 | 0.34% |
| Spruce Street Capital LP | US$1945.7萬 | 4.68% |
| SILVERARC CAPITAL MANAGEMENT, LLC | US$1852.3萬 | 1.89% |
| Trexquant Investment LP | US$1552.9萬 | 0.11% |
| UBS Group AG | US$1429.7萬 | 0.00% |
| Rock Springs Capital Management LP | US$1397.5萬 | 0.82% |
| JPMORGAN CHASE & CO | US$1317.2萬 | 0.00% |
| GLAZER CAPITAL, LLC | US$1290.9萬 | 0.27% |
| Alyeska Investment Group, L.P. | US$1272.7萬 | 0.04% |
| Point72 Asset Management, L.P. | US$1244.2萬 | 0.02% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$1231.1萬 | 0.00% |
| Caption Management, LLC | US$1120.6萬 | 0.07% |
| ROYCE & ASSOCIATES LP | US$1104.5萬 | 0.11% |
| Nantahala Capital Management, LLC | US$1012.1萬 | 0.37% |
| TD Asset Management Inc | US$961.4萬 | 0.01% |
| HighMark Wealth Management LLC | US$940.5萬 | 3.83% |
| Eagle Health Investments LP | US$851.2萬 | 1.49% |
| SummitTX Capital, L.P. | US$821.6萬 | 0.26% |
| DEUTSCHE BANK AG\ | US$754.5萬 | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | US$734.8萬 | 0.01% |
| JANE STREET GROUP, LLC | US$693.0萬 | 0.00% |
| Schonfeld Strategic Advisors LLC | US$682.9萬 | 0.05% |
| T. Rowe Price Investment Management, Inc. | US$675.4萬 | 0.00% |
| MARSHALL WACE, LLP | US$668.0萬 | 0.01% |
| FRED ALGER MANAGEMENT, LLC | US$668.0萬 | 0.03% |
| Holocene Advisors, LP | US$639.3萬 | 0.02% |
| Atom Investors LP | US$629.6萬 | 0.45% |
| Burkehill Global Management, LP | US$595.8萬 | 0.30% |
| PLATINUM INVESTMENT MANAGEMENT LTD | US$547.1萬 | 1.38% |
| LMR Partners LLP | US$496.5萬 | 0.01% |
| HRT FINANCIAL LP | US$464.6萬 | 0.01% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | US$444.7萬 | 0.02% |
| Freestone Grove Partners LP | US$434.2萬 | 0.03% |
| Legal & General Group Plc | US$432.2萬 | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | US$428.1萬 | 0.00% |
| AQR Arbitrage LLC | US$389.4萬 | 0.06% |
| Y-Intercept (Hong Kong) Ltd | US$382.8萬 | 0.07% |
| Caitong International Asset Management Co., Ltd | US$372.1萬 | 0.69% |
| HARVEST MANAGEMENT LLC | US$317.8萬 | 1.54% |
| CSS LLC/IL | US$313.4萬 | 0.15% |
| CITIGROUP INC | US$295.0萬 | 0.00% |
| Jain Global LLC | US$284.0萬 | 0.01% |
| Virtu Financial LLC | US$269.2萬 | 0.11% |
| Pictet Asset Management Holding SA | US$267.3萬 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$237.7萬 | 0.00% |
| Squarepoint Ops LLC | US$201.0萬 | 0.00% |
| WATER ISLAND CAPITAL LLC | US$162.9萬 | 0.18% |
| J. Goldman & Co LP | US$160.9萬 | 0.05% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$157.5萬 | 0.02% |
| Knott David M Jr | US$154.9萬 | 0.92% |
| Russell Investments Group, Ltd. | US$154.2萬 | 0.00% |
| ADAR1 Capital Management, LLC | US$153.2萬 | 0.09% |
| Candriam S.C.A. | US$144.0萬 | 0.01% |
| Buckland Partners Management Co LLC | US$119.2萬 | 0.72% |
| VOYA INVESTMENT MANAGEMENT LLC | US$117.8萬 | 0.00% |
| Cinctive Capital Management LP | US$100.7萬 | 0.07% |
| Voleon Capital Management LP | US$96.0萬 | 0.02% |
| Yakira Capital Management, Inc. | US$95.3萬 | 0.28% |
| China Universal Asset Management Co., Ltd. | US$84.3萬 | 0.06% |
| JBF Capital, Inc. | US$83.0萬 | 0.12% |
| TORNO CAPITAL, LLC | US$79.4萬 | 0.11% |
| Fortress Investment Group LLC | US$79.4萬 | 0.20% |
| Crossmark Global Holdings, Inc. | US$77.2萬 | 0.01% |
| Ikarian Capital, LLC | US$71.9萬 | 0.06% |
| Meridian Wealth Partners, LLC | US$71.9萬 | 0.10% |
| GABELLI FUNDS LLC | US$69.9萬 | 0.00% |
| AMERIPRISE FINANCIAL INC | US$67.1萬 | 0.00% |
| TD Waterhouse Canada Inc. | US$62.2萬 | 0.00% |
| Greenland Capital Management LP | US$59.6萬 | 0.08% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$55.5萬 | 0.00% |
| Coastal Bridge Advisors, LLC | US$52.0萬 | 0.04% |
| Aquatic Capital Management LLC | US$50.4萬 | 0.01% |
| Atria Investments, Inc | US$49.0萬 | 0.01% |
| DNB Asset Management AS | US$41.3萬 | 0.00% |
| FOX RUN MANAGEMENT, L.L.C. | US$41.1萬 | 0.07% |
| Virtus Investment Advisers, LLC | US$40.9萬 | 0.11% |
| GABELLI & Co INVESTMENT ADVISERS, INC. | US$37.3萬 | 0.06% |
| Bellevue Group AG | US$35.9萬 | 0.01% |
| Rangeley Capital, LLC | US$35.7萬 | 0.35% |
| AXQ CAPITAL, LP | US$33.0萬 | 0.04% |
| Bank of New York Mellon Corp | US$33.0萬 | 0.00% |
| Brooklyn Investment Group | US$29.6萬 | 0.01% |
| Invesco Ltd. | US$27.9萬 | 0.00% |
| Headlands Technologies LLC | US$27.8萬 | 0.03% |
| ENVESTNET ASSET MANAGEMENT INC | US$27.7萬 | 0.00% |
| BARCLAYS PLC | US$27.5萬 | 0.00% |
| Allianz Asset Management GmbH | US$27.4萬 | 0.00% |
| BBR PARTNERS, LLC | US$26.0萬 | 0.01% |
| Mirae Asset Global Investments Co., Ltd. | US$24.8萬 | 0.00% |
| Private Advisor Group, LLC | US$23.8萬 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$23.8萬 | 0.00% |
| HighVista Strategies LLC | US$23.7萬 | 0.07% |
| ProShare Advisors LLC | US$21.3萬 | 0.00% |
| Empirical Asset Management, LLC | US$20.2萬 | 0.05% |
| GAMMA Investing LLC | US$15.8萬 | 0.01% |
| SG Americas Securities, LLC | US$12.2萬 | 0.00% |
| GF FUND MANAGEMENT CO. LTD. | US$8.6萬 | 0.00% |
| Bayforest Capital Ltd | US$7.7萬 | 0.09% |
| ROYAL BANK OF CANADA | US$4.6萬 | 0.00% |
| ADIRONDACK TRUST CO | US$3.7萬 | 0.01% |
| J.Safra Asset Management Corp | US$1.6萬 | 0.00% |
| JONES FINANCIAL COMPANIES LLLP | US$7950.0 | 0.00% |
| Basecamp Wealth Advisors LLC | US$5084.0 | 0.00% |