| FMR LLC | US$8705.8万 | 0.00% |
| TCG Crossover Management, LLC | US$3724.3万 | 1.07% |
| Aberdeen Group plc | US$3529.4万 | 0.06% |
| BlackRock, Inc. | US$2659.3万 | 0.00% |
| BRAIDWELL LP | US$2618.5万 | 0.87% |
| First Light Asset Management, LLC | US$2002.2万 | 1.79% |
| BAKER BROS. ADVISORS LP | US$1878.7万 | 0.11% |
| 5AM Venture Management, LLC | US$1875.2万 | 5.21% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$1463.7万 | 0.00% |
| Vestal Point Capital, LP | US$1013.8万 | 0.28% |
| Bollard Group LLC | US$936.4万 | 0.28% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$907.1万 | 0.00% |
| KENNEDY CAPITAL MANAGEMENT LLC | US$886.1万 | 0.19% |
| GEODE CAPITAL MANAGEMENT, LLC | US$829.4万 | 0.00% |
| MARSHALL WACE, LLP | US$709.7万 | 0.01% |
| ORBIMED ADVISORS LLC | US$700.4万 | 0.14% |
| STATE STREET CORP | US$659.9万 | 0.00% |
| Squarepoint Ops LLC | US$508.2万 | 0.01% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$507.2万 | 0.00% |
| Ikarian Capital, LLC | US$486.9万 | 0.40% |
| AMERIPRISE FINANCIAL INC | US$443.3万 | 0.00% |
| Opaleye Management Inc. | US$380.2万 | 0.50% |
| Soleus Capital Management, L.P. | US$376.1万 | 0.15% |
| D. E. Shaw & Co., Inc. | US$358.9万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$348.2万 | 0.00% |
| Woodline Partners LP | US$309.1万 | 0.01% |
| ExodusPoint Capital Management, LP | US$258.7万 | 0.02% |
| Prosight Management, LP | US$246.9万 | 0.40% |
| NORTHERN TRUST CORP | US$242.2万 | 0.00% |
| JANE STREET GROUP, LLC | US$213.3万 | 0.00% |
| Point72 Asset Management, L.P. | US$212.0万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$209.9万 | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | US$207.1万 | 0.00% |
| MORGAN STANLEY | US$200.4万 | 0.00% |
| RAYMOND JAMES FINANCIAL INC | US$198.4万 | 0.00% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$196.6万 | 0.00% |
| GOLDMAN SACHS GROUP INC | US$193.0万 | 0.00% |
| MILLENNIUM MANAGEMENT LLC | US$180.4万 | 0.00% |
| JPMORGAN CHASE & CO | US$170.0万 | 0.00% |
| CITADEL ADVISORS LLC | US$162.0万 | 0.00% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$142.6万 | 0.02% |
| PFM Health Sciences, LP | US$142.6万 | 0.13% |
| Jump Financial, LLC | US$133.2万 | 0.02% |
| Tetragon Partners GP Ltd | US$116.2万 | 0.23% |
| Aldebaran Capital, LLC | US$114.9万 | 0.88% |
| SEI INVESTMENTS CO | US$114.0万 | 0.00% |
| UBS Group AG | US$92.7万 | 0.00% |
| WELLINGTON MANAGEMENT GROUP LLP | US$90.4万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$90.0万 | 0.00% |
| Clearstead Advisors, LLC | US$82.7万 | 0.01% |
| MONIMUS CAPITAL MANAGEMENT, LP | US$82.7万 | 0.23% |
| Caption Management, LLC | US$81.8万 | 0.00% |
| Bank of New York Mellon Corp | US$76.5万 | 0.00% |
| TD Asset Management Inc | US$63.1万 | 0.00% |
| SECTORAL ASSET MANAGEMENT INC | US$62.8万 | 0.52% |
| GSA CAPITAL PARTNERS LLP | US$58.3万 | 0.04% |
| AQR CAPITAL MANAGEMENT LLC | US$52.3万 | 0.00% |
| ALPS ADVISORS INC | US$47.2万 | 0.00% |
| RHUMBLINE ADVISERS | US$43.4万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$43.1万 | 0.00% |
| Virtus Investment Advisers, LLC | US$42.7万 | 0.12% |
| ADAR1 Capital Management, LLC | US$40.2万 | 0.02% |
| AMERICAN CENTURY COMPANIES INC | US$38.7万 | 0.00% |
| Creative Planning | US$38.5万 | 0.00% |
| Nuveen, LLC | US$37.2万 | 0.00% |
| XTX Topco Ltd | US$35.9万 | 0.01% |
| BANK OF AMERICA CORP /DE/ | US$35.4万 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | US$31.1万 | 0.00% |
| DEUTSCHE BANK AG\ | US$28.9万 | 0.00% |
| Invesco Ltd. | US$23.7万 | 0.00% |
| AlphaCentric Advisors LLC | US$21.2万 | 0.21% |
| MetLife Investment Management, LLC | US$20.8万 | 0.00% |
| BARCLAYS PLC | US$20.7万 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$19.6万 | 0.01% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$16.1万 | 0.00% |
| NISA INVESTMENT ADVISORS, LLC | US$15.5万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$14.2万 | 0.00% |
| Vanguard Global Advisers, LLC | US$12.3万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$8.2万 | 0.00% |
| CWM, LLC | US$5.7万 | 0.00% |
| SIMPLEX TRADING, LLC | US$4.2万 | 0.00% |
| CITIGROUP INC | US$3.5万 | 0.00% |
| US BANCORP \DE\ | US$3.5万 | 0.00% |
| Ameritas Investment Partners, Inc. | US$3.5万 | 0.00% |
| Legal & General Group Plc | US$3.1万 | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | US$3.0万 | 0.00% |
| Tower Research Capital LLC (TRC) | US$2.8万 | 0.00% |
| Russell Investments Group, Ltd. | US$2.6万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$1.8万 | 0.00% |
| HighMark Wealth Management LLC | US$1.8万 | 0.01% |
| Federation des caisses Desjardins du Quebec | US$1.5万 | 0.00% |
| GF FUND MANAGEMENT CO. LTD. | US$1.3万 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$1.2万 | 0.00% |
| Rockefeller Capital Management L.P. | US$1.1万 | 0.00% |
| GAMMA Investing LLC | US$1.0万 | 0.00% |
| Sterling Capital Management LLC | US$9675.0 | 0.00% |
| Farther Finance Advisors, LLC | US$3140.0 | 0.00% |
| Allworth Financial LP | US$2010.0 | 0.00% |
| Marshall & Sterling Wealth Advisors Inc. | US$1546.0 | 0.00% |
| Essential Partners LLC | US$1144.0 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | US$870.4 | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | US$804.0 | 0.00% |
| Caldwell Trust Co | US$618.0 | 0.00% |
| EverSource Wealth Advisors, LLC | US$588.0 | 0.00% |
| Global Wealth Strategies & Associates | US$556.0 | 0.00% |
| Fortitude Family Office, LLC | US$464.0 | 0.00% |
| HUNTINGTON NATIONAL BANK | US$402.0 | 0.00% |
| ROTHSCHILD INVESTMENT LLC | US$340.0 | 0.00% |
| Sunbelt Securities, Inc. | US$247.0 | 0.00% |
| True Wealth Design, LLC | US$217.0 | 0.00% |
| MAI Capital Management | US$217.0 | 0.00% |
| Root Financial Partners, LLC | US$155.0 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$93.0 | 0.00% |