| RA CAPITAL MANAGEMENT, L.P. | US$1.7亿 | 1.78% |
| TRV GP V, LLC | US$1.5亿 | 37.25% |
| Driehaus Capital Management LLC | US$1.1亿 | 0.78% |
| TRV GP VI, LLC | US$1.0亿 | 74.64% |
| SAMSARA BIOCAPITAL, LLC | US$7567.4万 | 7.35% |
| GOLDMAN SACHS GROUP INC | US$6984.1万 | 0.01% |
| Siren, L.L.C. | US$4806.0万 | 1.33% |
| BlackRock, Inc. | US$4378.7万 | 0.00% |
| BVF INC/IL | US$3251.9万 | 1.04% |
| Avoro Capital Advisors LLC | US$3214.0万 | 0.32% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$2876.3万 | 0.00% |
| ADAR1 Capital Management, LLC | US$2618.8万 | 1.54% |
| PRIMECAP MANAGEMENT CO/CA/ | US$2520.3万 | 0.02% |
| JANUS HENDERSON GROUP PLC | US$2133.4万 | 0.01% |
| First Light Asset Management, LLC | US$1761.1万 | 1.58% |
| GEODE CAPITAL MANAGEMENT, LLC | US$1550.6万 | 0.00% |
| STATE STREET CORP | US$1517.4万 | 0.00% |
| Casdin Capital, LLC | US$1329.5万 | 1.01% |
| Venrock Adviser, LLC | US$1216.1万 | 0.45% |
| Catalio Capital Management, LP | US$707.3万 | 1.48% |
| Soleus Capital Management, L.P. | US$660.8万 | 0.27% |
| Balyasny Asset Management L.P. | US$568.7万 | 0.01% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$538.3万 | 0.01% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$468.7万 | 0.00% |
| Kalehua Capital Management LLC | US$467.5万 | 3.31% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$436.3万 | 0.00% |
| NORTHERN TRUST CORP | US$395.4万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$371.2万 | 0.00% |
| MILLENNIUM MANAGEMENT LLC | US$298.2万 | 0.00% |
| UBS Group AG | US$281.1万 | 0.00% |
| MORGAN STANLEY | US$265.6万 | 0.00% |
| HUSSMAN STRATEGIC ADVISORS, INC. | US$252.3万 | 0.55% |
| Checkpoint Capital L.P. | US$241.0万 | 0.86% |
| FEDERATED HERMES, INC. | US$214.6万 | 0.00% |
| Invesco Ltd. | US$199.1万 | 0.00% |
| JPMORGAN CHASE & CO | US$197.3万 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$181.1万 | 0.00% |
| Longaeva Partners L.P. | US$179.2万 | 0.07% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$175.4万 | 0.00% |
| AMERICAN CENTURY COMPANIES INC | US$147.3万 | 0.00% |
| Bank of New York Mellon Corp | US$141.1万 | 0.00% |
| Jump Financial, LLC | US$127.4万 | 0.02% |
| Sofinnova Investments, Inc. | US$114.2万 | 0.04% |
| MARSHALL WACE, LLP | US$95.7万 | 0.00% |
| Rangeley Capital, LLC | US$95.6万 | 0.93% |
| RENAISSANCE TECHNOLOGIES LLC | US$90.6万 | 0.00% |
| XTX Topco Ltd | US$88.2万 | 0.02% |
| Trexquant Investment LP | US$84.8万 | 0.01% |
| Alyeska Investment Group, L.P. | US$84.1万 | 0.00% |
| ACADIAN ASSET MANAGEMENT LLC | US$74.1万 | 0.00% |
| Nuveen, LLC | US$70.1万 | 0.00% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | US$68.3万 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$67.5万 | 0.00% |
| RHUMBLINE ADVISERS | US$63.9万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$62.4万 | 0.00% |
| Y-Intercept (Hong Kong) Ltd | US$61.9万 | 0.01% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$57.7万 | 0.00% |
| Logos Global Management LP | US$56.6万 | 0.03% |
| FMR LLC | US$56.3万 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | US$54.6万 | 0.00% |
| BARCLAYS PLC | US$54.6万 | 0.00% |
| Swiss National Bank | US$53.1万 | 0.00% |
| ALGERT GLOBAL LLC | US$50.5万 | 0.01% |
| Squarepoint Ops LLC | US$43.5万 | 0.00% |
| STRS OHIO | US$41.3万 | 0.00% |
| DEUTSCHE BANK AG\ | US$40.5万 | 0.00% |
| VARCOV Co. | US$40.3万 | 0.15% |
| Engineers Gate Manager LP | US$39.7万 | 0.00% |
| Vanguard Global Advisers, LLC | US$39.0万 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$36.9万 | 0.00% |
| Numerai GP LLC | US$36.2万 | 0.04% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | US$34.2万 | 0.00% |
| MetLife Investment Management, LLC | US$32.9万 | 0.00% |
| EntryPoint Capital, LLC | US$30.7万 | 0.09% |
| OSAIC HOLDINGS, INC. | US$30.5万 | 0.00% |
| Verition Fund Management LLC | US$29.7万 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$28.7万 | 0.02% |
| Man Group plc | US$28.5万 | 0.00% |
| Russell Investments Group, Ltd. | US$27.7万 | 0.00% |
| Seven Fleet Capital Management LP | US$27.5万 | 0.09% |
| Virtus Investment Advisers, LLC | US$25.8万 | 0.07% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | US$24.9万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$24.1万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$23.7万 | 0.00% |
| CITIGROUP INC | US$22.1万 | 0.00% |
| WINTON GROUP Ltd | US$21.2万 | 0.01% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$17.8万 | 0.00% |
| Legal & General Group Plc | US$13.8万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$13.5万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$12.4万 | 0.00% |
| Vanguard Investments Australia, Ltd. | US$9.4万 | 0.00% |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | US$8.1万 | 0.00% |
| KLP KAPITALFORVALTNING AS | US$6.0万 | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | US$5.6万 | 0.00% |
| Covestor Ltd | US$5.4万 | 0.04% |
| Ameritas Investment Partners, Inc. | US$4.7万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$2.8万 | 0.00% |
| GAMMA Investing LLC | US$2.7万 | 0.00% |
| GF FUND MANAGEMENT CO. LTD. | US$2.4万 | 0.00% |
| SIGNATUREFD, LLC | US$2.3万 | 0.00% |
| CWM, LLC | US$2.1万 | 0.00% |
| NISA INVESTMENT ADVISORS, LLC | US$2.0万 | 0.00% |
| Tower Research Capital LLC (TRC) | US$1.7万 | 0.00% |
| Sterling Capital Management LLC | US$1.7万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$1.2万 | 0.00% |
| Pinnacle Wealth Planning Services, Inc. | US$7738.0 | 0.00% |
| Versant Capital Management, Inc | US$6272.0 | 0.00% |
| Larson Financial Group LLC | US$4902.0 | 0.00% |
| DIADEMA PARTNERS LP | US$4854.0 | 0.00% |
| US BANCORP \DE\ | US$4734.0 | 0.00% |
| N.E.W. Advisory Services LLC | US$4325.0 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$3725.0 | 0.00% |
| MassMutual Private Wealth & Trust, FSB | US$3244.0 | 0.00% |
| EverSource Wealth Advisors, LLC | US$1634.0 | 0.00% |
| SBI Securities Co., Ltd. | US$1322.0 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | US$1288.3 | 0.00% |
| Cornerstone Financial Management LLC | US$1250.0 | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | US$1033.0 | 0.00% |
| Caitong International Asset Management Co., Ltd | US$913.0 | 0.00% |
| ROTHSCHILD INVESTMENT LLC | US$721.0 | 0.00% |
| Fortitude Family Office, LLC | US$481.0 | 0.00% |
| Allworth Financial LP | US$409.0 | 0.00% |
| Farther Finance Advisors, LLC | US$171.0 | 0.00% |
| QUADRANT CAPITAL GROUP LLC | US$169.0 | 0.00% |
| MAI Capital Management | US$145.0 | 0.00% |