| Siren, L.L.C. | US$1657.1万 | 0.46% |
| SOFTBANK GROUP CORP. | US$1187.6万 | 0.10% |
| PERCEPTIVE ADVISORS LLC | US$995.3万 | 0.19% |
| MIC Capital Management UK LLP | US$869.8万 | 2.47% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$758.9万 | 0.00% |
| FMR LLC | US$682.2万 | 0.00% |
| WELLCOME TRUST LTD | US$645.3万 | 0.08% |
| MILLENNIUM MANAGEMENT LLC | US$537.2万 | 0.00% |
| ICONIQ Capital, LLC | US$499.0万 | 0.11% |
| Lunate Capital Ltd | US$414.2万 | 3.44% |
| BlackRock, Inc. | US$400.6万 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$397.2万 | 0.00% |
| JOHNSON & JOHNSON | US$360.6万 | 0.55% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$297.4万 | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | US$270.9万 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | US$258.7万 | 0.00% |
| Ikarian Capital, LLC | US$249.3万 | 0.20% |
| MARSHALL WACE, LLP | US$233.1万 | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | US$212.0万 | 0.00% |
| Caption Management, LLC | US$203.6万 | 0.01% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$195.0万 | 0.00% |
| SILVERARC CAPITAL MANAGEMENT, LLC | US$159.5万 | 0.16% |
| JANE STREET GROUP, LLC | US$145.8万 | 0.00% |
| AlphaCore Capital LLC | US$124.6万 | 0.03% |
| Point72 Asset Management, L.P. | US$117.5万 | 0.00% |
| Stonepine Capital Management, LLC | US$117.0万 | 0.47% |
| GOLDMAN SACHS GROUP INC | US$110.8万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$104.3万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$100.7万 | 0.00% |
| FRANKLIN RESOURCES INC | US$99.7万 | 0.00% |
| MORGAN STANLEY | US$98.2万 | 0.00% |
| TANG CAPITAL MANAGEMENT LLC | US$85.8万 | 0.04% |
| CITADEL ADVISORS LLC | US$82.1万 | 0.00% |
| STATE STREET CORP | US$77.8万 | 0.00% |
| ACADIAN ASSET MANAGEMENT LLC | US$73.8万 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | US$69.2万 | 0.00% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$65.4万 | 0.01% |
| FEDERATED HERMES, INC. | US$61.3万 | 0.00% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | US$53.4万 | 0.00% |
| JPMORGAN CHASE & CO | US$52.9万 | 0.00% |
| Cerity Partners LLC | US$50.8万 | 0.00% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | US$43.9万 | 0.01% |
| XTX Topco Ltd | US$43.3万 | 0.01% |
| GSA CAPITAL PARTNERS LLP | US$42.5万 | 0.03% |
| Invesco Ltd. | US$40.2万 | 0.00% |
| HRT FINANCIAL LP | US$38.7万 | 0.00% |
| Qube Research & Technologies Ltd | US$38.5万 | 0.00% |
| NORTHERN TRUST CORP | US$38.4万 | 0.00% |
| ExodusPoint Capital Management, LP | US$37.4万 | 0.00% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$36.0万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$34.5万 | 0.00% |
| Addis & Hill, Inc | US$31.9万 | 0.19% |
| Susquehanna Portfolio Strategies, LLC | US$31.3万 | 0.00% |
| Maniro Ltd | US$30.9万 | 0.09% |
| Squarepoint Ops LLC | US$30.5万 | 0.00% |
| SkyOak Wealth, LLC | US$29.3万 | 0.05% |
| CANADA PENSION PLAN INVESTMENT BOARD | US$27.3万 | 0.00% |
| SIMPLEX TRADING, LLC | US$25.2万 | 0.00% |
| EntryPoint Capital, LLC | US$21.6万 | 0.06% |
| Meridian Wealth Management, LLC | US$20.0万 | 0.01% |
| Brevan Howard Capital Management LP | US$18.9万 | 0.00% |
| Voleon Capital Management LP | US$18.3万 | 0.00% |
| RBF Capital, LLC | US$17.6万 | 0.01% |
| Quadrature Capital Ltd | US$16.6万 | 0.00% |
| Velan Capital Investment Management LP | US$15.6万 | 0.10% |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | US$15.0万 | 0.00% |
| DAFNA Capital Management LLC | US$13.7万 | 0.03% |
| Vanguard Personalized Indexing Management, LLC | US$12.1万 | 0.00% |
| UBS Group AG | US$11.6万 | 0.00% |
| Balyasny Asset Management L.P. | US$11.2万 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$10.9万 | 0.00% |
| OMERS ADMINISTRATION Corp | US$9.9万 | 0.00% |
| CITIGROUP INC | US$9.5万 | 0.00% |
| GROUP ONE TRADING LLC | US$9.0万 | 0.00% |
| AMG National Trust Bank | US$8.5万 | 0.00% |
| AMERICAN CENTURY COMPANIES INC | US$7.8万 | 0.00% |
| Bank of New York Mellon Corp | US$7.6万 | 0.00% |
| BARCLAYS PLC | US$6.7万 | 0.00% |
| Catalyst Funds Management Pty Ltd | US$6.5万 | 0.01% |
| ADAR1 Capital Management, LLC | US$6.5万 | 0.00% |
| Jefferies Financial Group Inc. | US$6.4万 | 0.00% |
| Diametric Capital, LP | US$6.4万 | 0.02% |
| Vanguard Global Advisers, LLC | US$6.0万 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$5.8万 | 0.00% |
| SIG BROKERAGE, LP | US$5.4万 | 0.00% |
| Virtu Financial LLC | US$5.0万 | 0.00% |
| Atom Investors LP | US$4.6万 | 0.00% |
| Legacy Private Trust Co. | US$3.7万 | 0.00% |
| SG Americas Securities, LLC | US$3.3万 | 0.00% |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | US$3.1万 | 0.03% |
| HBK Sorce Advisory LLC | US$3.1万 | 0.00% |
| Woodline Partners LP | US$2.9万 | 0.00% |
| Walleye Capital LLC | US$2.7万 | 0.00% |
| HSBC HOLDINGS PLC | US$2.3万 | 0.00% |
| WINTON GROUP Ltd | US$2.0万 | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | US$1.7万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$1.1万 | 0.00% |
| Tower Research Capital LLC (TRC) | US$7933.0 | 0.00% |
| GF FUND MANAGEMENT CO. LTD. | US$7287.0 | 0.00% |
| CWM, LLC | US$6135.0 | 0.00% |
| RHUMBLINE ADVISERS | US$5032.0 | 0.00% |
| NISA INVESTMENT ADVISORS, LLC | US$2859.0 | 0.00% |
| Physician Wealth Advisors, Inc. | US$2574.0 | 0.00% |
| ROYAL BANK OF CANADA | US$2000.0 | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | US$1950.0 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | US$654.1 | 0.00% |
| EverSource Wealth Advisors, LLC | US$582.0 | 0.00% |
| Parallel Advisors, LLC | US$544.0 | 0.00% |
| SIGNATUREFD, LLC | US$515.0 | 0.00% |
| Fortitude Family Office, LLC | US$326.0 | 0.00% |
| Caitong International Asset Management Co., Ltd | US$41.0 | 0.00% |
| SBI Securities Co., Ltd. | US$35.0 | 0.00% |
| Capital Advisors, Ltd. LLC | US$0.0 | 0.00% |
| Centerpoint Advisors, LLC | US$0.0 | 0.00% |