| BlackRock, Inc. | US$10.7億 | 0.02% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$6.5億 | 0.08% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$5.4億 | 0.03% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$5.2億 | 0.01% |
| Invesco Ltd. | US$4.6億 | 0.07% |
| GOLDMAN SACHS GROUP INC | US$4.1億 | 0.05% |
| TWO SIGMA INVESTMENTS, LP | US$3.9億 | 0.32% |
| FMR LLC | US$3.8億 | 0.02% |
| BAILLIE GIFFORD & CO | US$3.6億 | 0.36% |
| GEODE CAPITAL MANAGEMENT, LLC | US$3.2億 | 0.02% |
| Capital International Investors | US$3.2億 | 0.08% |
| FRANKLIN RESOURCES INC | US$3.2億 | 0.08% |
| Deep Track Capital, LP | US$3.1億 | 5.04% |
| STATE STREET CORP | US$2.7億 | 0.01% |
| FULLER & THALER ASSET MANAGEMENT, INC. | US$2.4億 | 0.79% |
| EVENTIDE ASSET MANAGEMENT, LLC | US$2.2億 | 3.61% |
| ALLIANCEBERNSTEIN L.P. | US$1.9億 | 0.06% |
| LORD, ABBETT & CO. LLC | US$1.8億 | 0.57% |
| FEDERATED HERMES, INC. | US$1.7億 | 0.28% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$1.5億 | 0.03% |
| Driehaus Capital Management LLC | US$1.4億 | 1.03% |
| Alyeska Investment Group, L.P. | US$1.4億 | 0.39% |
| MORGAN STANLEY | US$1.4億 | 0.01% |
| RTW INVESTMENTS, LP | US$1.4億 | 1.36% |
| AMERIPRISE FINANCIAL INC | US$1.3億 | 0.03% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$1.3億 | 0.02% |
| UBS Group AG | US$1.3億 | 0.02% |
| Bank of New York Mellon Corp | US$1.3億 | 0.02% |
| WESTFIELD CAPITAL MANAGEMENT CO LP | US$1.3億 | 0.53% |
| Hood River Capital Management LLC | US$1.2億 | 1.21% |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | US$1.1億 | 3.01% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$1.1億 | 0.10% |
| NORTHERN TRUST CORP | US$1.0億 | 0.01% |
| MILLENNIUM MANAGEMENT LLC | US$9390.3萬 | 0.04% |
| Temasek Holdings (Private) Ltd | US$9103.7萬 | 0.30% |
| WELLINGTON MANAGEMENT GROUP LLP | US$8983.6萬 | 0.02% |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | US$8785.4萬 | 0.29% |
| CITADEL ADVISORS LLC | US$8666.5萬 | 0.01% |
| BANK OF AMERICA CORP /DE/ | US$8269.2萬 | 0.01% |
| VANGUARD FIDUCIARY TRUST CO | US$8220.3萬 | 0.02% |
| AMERICAN CENTURY COMPANIES INC | US$8013.4萬 | 0.04% |
| EMERALD ADVISERS, LLC | US$7776.8萬 | 2.46% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$7538.3萬 | 0.12% |
| Artisan Partners Limited Partnership | US$7524.2萬 | 0.12% |
| CADIAN CAPITAL MANAGEMENT, LP | US$7201.6萬 | 8.77% |
| Erste Asset Management GmbH | US$7033.2萬 | 0.65% |
| T. Rowe Price Investment Management, Inc. | US$6980.5萬 | 0.05% |
| Point72 Asset Management, L.P. | US$6935.5萬 | 0.09% |
| FRED ALGER MANAGEMENT, LLC | US$5747.8萬 | 0.25% |
| Allspring Global Investments Holdings, LLC | US$5549.4萬 | 0.09% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$5378.6萬 | 0.01% |
| EMERALD MUTUAL FUND ADVISERS TRUST | US$4799.0萬 | 2.33% |
| VOYA INVESTMENT MANAGEMENT LLC | US$4665.0萬 | 0.05% |
| BRAIDWELL LP | US$4615.8萬 | 1.54% |
| ARK Investment Management LLC | US$4495.4萬 | 0.35% |
| Sumitomo Mitsui Trust Group, Inc. | US$4468.6萬 | 0.03% |
| Amova Asset Management Americas, Inc. | US$4460.8萬 | 0.63% |
| Aristotle Atlantic Partners, LLC | US$4115.4萬 | 1.93% |
| D. E. Shaw & Co., Inc. | US$4095.5萬 | 0.02% |
| Nuveen, LLC | US$4049.1萬 | 0.01% |
| ORBIMED ADVISORS LLC | US$4019.9萬 | 0.82% |
| VICTORY CAPITAL MANAGEMENT INC | US$3637.9萬 | 0.02% |
| SEI INVESTMENTS CO | US$3149.9萬 | 0.03% |
| RENAISSANCE TECHNOLOGIES LLC | US$3118.4萬 | 0.05% |
| BROWN ADVISORY INC | US$3044.2萬 | 0.05% |
| RAYMOND JAMES FINANCIAL INC | US$2999.8萬 | 0.01% |
| Casdin Capital, LLC | US$2909.7萬 | 2.20% |
| Eagle Health Investments LP | US$2866.1萬 | 5.01% |
| Walleye Capital LLC | US$2794.4萬 | 0.12% |
| Styrax Capital, LP | US$2771.1萬 | 1.94% |
| PERCEPTIVE ADVISORS LLC | US$2771.1萬 | 0.54% |
| JPMORGAN CHASE & CO | US$2623.2萬 | 0.00% |
| First Light Asset Management, LLC | US$2589.1萬 | 2.32% |
| DEUTSCHE BANK AG\ | US$2357.2萬 | 0.01% |
| Connor, Clark & Lunn Investment Management Ltd. | US$2353.5萬 | 0.05% |
| BARCLAYS PLC | US$2345.8萬 | 0.01% |
| PICTON MAHONEY ASSET MANAGEMENT | US$2309.2萬 | 0.17% |
| SAMLYN CAPITAL, LLC | US$2301.3萬 | 0.39% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$2254.3萬 | 0.04% |
| Blue Water Life Science Advisors, LP | US$2237.6萬 | 17.94% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | US$2202.7萬 | 0.01% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | US$2164.9萬 | 0.04% |
| SEGALL BRYANT & HAMILL, LLC | US$2145.0萬 | 0.31% |
| Sicart Associates LLC | US$2125.5萬 | 5.46% |
| Swiss National Bank | US$2051.5萬 | 0.01% |
| California Public Employees Retirement System | US$1990.3萬 | 0.01% |
| JENNISON ASSOCIATES LLC | US$1882.3萬 | 0.01% |
| TD Asset Management Inc | US$1804.0萬 | 0.01% |
| Squarepoint Ops LLC | US$1771.1萬 | 0.02% |
| AGF MANAGEMENT LTD | US$1754.6萬 | 0.08% |
| Russell Investments Group, Ltd. | US$1737.9萬 | 0.02% |
| PRINCIPAL FINANCIAL GROUP INC | US$1707.4萬 | 0.01% |
| DIMENSIONAL FUND ADVISORS LP | US$1685.7萬 | 0.00% |
| Parallax Volatility Advisers, L.P. | US$1671.7萬 | 0.04% |
| CITIGROUP INC | US$1607.9萬 | 0.01% |
| Polar Capital Holdings Plc | US$1601.0萬 | 0.06% |
| JANE STREET GROUP, LLC | US$1566.6萬 | 0.00% |
| Rathbones Group PLC | US$1538.0萬 | 0.07% |
| CASTLEARK MANAGEMENT LLC | US$1480.5萬 | 0.49% |
| WCM INVESTMENT MANAGEMENT, LLC | US$1463.1萬 | 0.03% |
| RHUMBLINE ADVISERS | US$1458.6萬 | 0.01% |
| AXIOM INVESTORS LLC /DE | US$1422.7萬 | 0.16% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | US$1415.5萬 | 0.11% |
| ExodusPoint Capital Management, LP | US$1410.5萬 | 0.11% |
| Burkehill Global Management, LP | US$1385.6萬 | 0.69% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$1382.0萬 | 0.02% |
| OSTERWEIS CAPITAL MANAGEMENT INC | US$1375.8萬 | 0.71% |
| ROYAL BANK OF CANADA | US$1352.3萬 | 0.00% |
| Rhenman & Partners Asset Management AB | US$1339.4萬 | 1.65% |
| NEUBERGER BERMAN GROUP LLC | US$1299.7萬 | 0.01% |
| JANUS HENDERSON GROUP PLC | US$1296.0萬 | 0.01% |
| Legal & General Group Plc | US$1261.8萬 | 0.00% |
| FIRST TRUST ADVISORS LP | US$1255.7萬 | 0.01% |
| AQR CAPITAL MANAGEMENT LLC | US$1212.8萬 | 0.01% |
| Allianz Asset Management GmbH | US$1209.9萬 | 0.01% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$1206.3萬 | 0.01% |
| Kinetic Partners Management, LP | US$1199.9萬 | 0.67% |
| Hillsdale Investment Management Inc. | US$1148.9萬 | 0.31% |
| Pictet Asset Management Holding SA | US$1141.8萬 | 0.01% |
| Handelsbanken Fonder AB | US$1070.0萬 | 0.04% |
| Caption Management, LLC | US$1063.9萬 | 0.06% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$1016.6萬 | 0.02% |
| Cerity Partners LLC | US$1009.1萬 | 0.01% |
| Susquehanna Portfolio Strategies, LLC | US$1002.0萬 | 0.15% |
| LAZARD ASSET MANAGEMENT LLC | US$973.8萬 | 0.02% |
| BLAIR WILLIAM & CO/IL | US$957.4萬 | 0.03% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$949.1萬 | 0.01% |
| Portman Square Capital LLP | US$923.7萬 | 0.36% |
| HSBC HOLDINGS PLC | US$913.0萬 | 0.00% |
| SILVERARC CAPITAL MANAGEMENT, LLC | US$910.0萬 | 0.93% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$901.9萬 | 0.01% |
| Granite Investment Partners, LLC | US$884.2萬 | 0.54% |
| CANADA PENSION PLAN INVESTMENT BOARD | US$874.7萬 | 0.01% |
| WELLS FARGO & COMPANY/MN | US$854.9萬 | 0.00% |
| Atika Capital Management LLC | US$840.6萬 | 1.32% |
| Aberdeen Group plc | US$832.5萬 | 0.01% |
| Candriam S.C.A. | US$824.1萬 | 0.04% |
| PRUDENTIAL FINANCIAL INC | US$823.1萬 | 0.01% |
| Trexquant Investment LP | US$793.5萬 | 0.06% |
| Mitsubishi UFJ Trust & Banking Corp | US$789.6萬 | 0.02% |
| Exome Asset Management LLC | US$764.2萬 | 3.95% |
| JUPITER ASSET MANAGEMENT LTD | US$734.6萬 | 0.04% |
| SWS Partners | US$734.2萬 | 1.81% |
| Creative Planning | US$723.9萬 | 0.00% |
| GUGGENHEIM CAPITAL LLC | US$720.6萬 | 0.06% |
| Schonfeld Strategic Advisors LLC | US$662.1萬 | 0.05% |
| Engineers Gate Manager LP | US$655.8萬 | 0.08% |
| Walleye Trading LLC | US$652.1萬 | 0.01% |
| MetLife Investment Management, LLC | US$626.5萬 | 0.03% |
| Thrivent Financial for Lutherans | US$583.6萬 | 0.01% |