| BAKER BROS. ADVISORS LP | US$6401.8万 | 0.37% |
| 5AM Venture Management, LLC | US$5119.2万 | 14.21% |
| BlackRock, Inc. | US$2976.8万 | 0.00% |
| TCG Crossover Management, LLC | US$2886.8万 | 0.83% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$1585.1万 | 0.00% |
| WELLINGTON MANAGEMENT GROUP LLP | US$1305.9万 | 0.00% |
| StepStone Group LP | US$960.7万 | 4.63% |
| GEODE CAPITAL MANAGEMENT, LLC | US$842.4万 | 0.00% |
| STATE STREET CORP | US$673.7万 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$663.9万 | 0.00% |
| MILLENNIUM MANAGEMENT LLC | US$655.4万 | 0.00% |
| Jones Hill Capital LP | US$472.0万 | 1.01% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | US$421.4万 | 0.02% |
| ACADIAN ASSET MANAGEMENT LLC | US$420.1万 | 0.01% |
| DIMENSIONAL FUND ADVISORS LP | US$409.2万 | 0.00% |
| NORTHERN TRUST CORP | US$296.6万 | 0.00% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$278.3万 | 0.00% |
| Woodline Partners LP | US$272.6万 | 0.01% |
| CITADEL ADVISORS LLC | US$271.4万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$271.0万 | 0.00% |
| GOLDMAN SACHS GROUP INC | US$268.5万 | 0.00% |
| Lynx1 Capital Management LP | US$267.2万 | 0.42% |
| Longaeva Partners L.P. | US$258.7万 | 0.10% |
| RENAISSANCE TECHNOLOGIES LLC | US$255.0万 | 0.00% |
| MORGAN STANLEY | US$222.3万 | 0.00% |
| Nuveen, LLC | US$221.7万 | 0.00% |
| Nantahala Capital Management, LLC | US$201.1万 | 0.07% |
| VANGUARD FIDUCIARY TRUST CO | US$198.0万 | 0.00% |
| XTX Topco Ltd | US$163.5万 | 0.03% |
| ROYCE & ASSOCIATES LP | US$152.5万 | 0.02% |
| MOORE CAPITAL MANAGEMENT, LP | US$132.5万 | 0.03% |
| ACUTA CAPITAL PARTNERS, LLC | US$112.8万 | 0.80% |
| Qube Research & Technologies Ltd | US$110.4万 | 0.00% |
| Trexquant Investment LP | US$104.4万 | 0.01% |
| AQR CAPITAL MANAGEMENT LLC | US$100.3万 | 0.00% |
| D. E. Shaw & Co., Inc. | US$99.8万 | 0.00% |
| AMERICAN CENTURY COMPANIES INC | US$98.4万 | 0.00% |
| Bank of New York Mellon Corp | US$96.5万 | 0.00% |
| Quantinno Capital Management LP | US$89.6万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$89.2万 | 0.00% |
| AMERIPRISE FINANCIAL INC | US$88.7万 | 0.00% |
| MARSHALL WACE, LLP | US$67.9万 | 0.00% |
| TD Asset Management Inc | US$67.6万 | 0.00% |
| Nan Fung Group Holdings Ltd | US$61.9万 | 0.51% |
| CANTOR FITZGERALD, L. P. | US$59.3万 | 0.01% |
| TWO SIGMA INVESTMENTS, LP | US$56.3万 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$54.8万 | 0.00% |
| Invesco Ltd. | US$52.9万 | 0.00% |
| MARTINGALE ASSET MANAGEMENT L P | US$52.7万 | 0.01% |
| GREAT LAKES ADVISORS, LLC | US$52.4万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$49.5万 | 0.00% |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | US$47.3万 | 0.00% |
| HSBC HOLDINGS PLC | US$47.2万 | 0.00% |
| JANE STREET GROUP, LLC | US$47.0万 | 0.00% |
| RHUMBLINE ADVISERS | US$45.4万 | 0.00% |
| UBS Group AG | US$40.4万 | 0.00% |
| ADAR1 Capital Management, LLC | US$38.5万 | 0.02% |
| BARCLAYS PLC | US$36.2万 | 0.00% |
| Brevan Howard Capital Management LP | US$33.3万 | 0.00% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | US$31.6万 | 0.01% |
| DEUTSCHE BANK AG\ | US$31.1万 | 0.00% |
| Creative Planning | US$28.1万 | 0.00% |
| Shay Capital LLC | US$27.2万 | 0.02% |
| ALLIANCEBERNSTEIN L.P. | US$25.0万 | 0.00% |
| Allspring Global Investments Holdings, LLC | US$24.6万 | 0.00% |
| Vanguard Global Advisers, LLC | US$23.2万 | 0.00% |
| HARBOR CAPITAL ADVISORS, INC. | US$22.9万 | 0.02% |
| MetLife Investment Management, LLC | US$22.5万 | 0.00% |
| CANADA PENSION PLAN INVESTMENT BOARD | US$22.3万 | 0.00% |
| Quadrature Capital Ltd | US$22.1万 | 0.00% |
| FMR LLC | US$21.4万 | 0.00% |
| Dynamic Technology Lab Private Ltd | US$20.8万 | 0.03% |
| JPMORGAN CHASE & CO | US$17.5万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$17.1万 | 0.00% |
| ExodusPoint Capital Management, LP | US$15.2万 | 0.00% |
| Inscription Capital, LLC | US$14.9万 | 0.02% |
| Russell Investments Group, Ltd. | US$14.7万 | 0.00% |
| FRANKLIN RESOURCES INC | US$14.0万 | 0.00% |
| IHT Wealth Management, LLC | US$14.0万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$13.9万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$12.0万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$11.2万 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$8.6万 | 0.01% |
| CWM, LLC | US$8.6万 | 0.00% |
| CITIGROUP INC | US$6.1万 | 0.00% |
| Versant Capital Management, Inc | US$5.1万 | 0.01% |
| Legal & General Group Plc | US$3.2万 | 0.00% |
| Ameritas Investment Partners, Inc. | US$3.1万 | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | US$2.5万 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | US$2.3万 | 0.00% |
| Tower Research Capital LLC (TRC) | US$2.1万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$1.9万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$1.8万 | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | US$1.4万 | 0.00% |
| Sterling Capital Management LLC | US$1.2万 | 0.00% |
| Arax Advisory Partners | US$1.2万 | 0.00% |
| GF FUND MANAGEMENT CO. LTD. | US$1.1万 | 0.00% |
| GAMMA Investing LLC | US$6058.0 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$5490.0 | 0.00% |
| EverSource Wealth Advisors, LLC | US$5301.0 | 0.00% |
| Allworth Financial LP | US$3900.0 | 0.00% |
| Optiver Holding B.V. | US$3256.0 | 0.00% |
| Private Wealth Management Group, LLC | US$2676.0 | 0.00% |
| SIGNATUREFD, LLC | US$2625.0 | 0.00% |
| MassMutual Private Wealth & Trust, FSB | US$2347.0 | 0.00% |
| NISA INVESTMENT ADVISORS, LLC | US$2032.0 | 0.00% |
| Essential Partners LLC | US$1943.0 | 0.00% |
| Cornerstone Financial Management LLC | US$1148.0 | 0.00% |
| US BANCORP \DE\ | US$883.0 | 0.00% |
| MAI Capital Management | US$682.0 | 0.00% |
| True Wealth Design, LLC | US$303.0 | 0.00% |
| Wealth Preservation Advisors, LLC | US$278.0 | 0.00% |
| ROTHSCHILD INVESTMENT LLC | US$252.0 | 0.00% |
| Farther Finance Advisors, LLC | US$229.0 | 0.00% |
| QUADRANT CAPITAL GROUP LLC | US$228.0 | 0.00% |
| OSAIC HOLDINGS, INC. | US$63.0 | 0.00% |
| SJS Investment Consulting Inc. | US$26.0 | 0.00% |
| IFP Advisors, Inc | US$13.0 | 0.00% |
| ROYAL BANK OF CANADA | US$0.0 | 0.00% |