| Caligan Partners LP | US$2764.1万 | 1.84% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$2743.5万 | 0.04% |
| BIOS Capital Management, LP | US$1676.0万 | 31.70% |
| Balyasny Asset Management L.P. | US$1236.7万 | 0.02% |
| MILLENNIUM MANAGEMENT LLC | US$1196.8万 | 0.00% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$1114.7万 | 0.00% |
| MARSHALL WACE, LLP | US$1052.6万 | 0.01% |
| Boxer Capital Management, LLC | US$1023.8万 | 1.34% |
| ADAR1 Capital Management, LLC | US$841.3万 | 0.50% |
| PERCEPTIVE ADVISORS LLC | US$835.3万 | 0.16% |
| Nantahala Capital Management, LLC | US$765.0万 | 0.28% |
| Woodline Partners LP | US$616.1万 | 0.02% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$541.0万 | 0.07% |
| FARALLON CAPITAL MANAGEMENT LLC | US$455.0万 | 0.03% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$411.7万 | 0.00% |
| Bleichroeder LP | US$335.3万 | 0.58% |
| Mink Brook Asset Management LLC | US$268.7万 | 1.50% |
| GEODE CAPITAL MANAGEMENT, LLC | US$245.1万 | 0.00% |
| Trails Edge Capital Partners, LP | US$227.5万 | 0.52% |
| Opaleye Management Inc. | US$225.1万 | 0.30% |
| AMERIPRISE FINANCIAL INC | US$176.8万 | 0.00% |
| GOLDMAN SACHS GROUP INC | US$148.7万 | 0.00% |
| GREAT POINT PARTNERS LLC | US$147.6万 | 0.34% |
| VANGUARD FIDUCIARY TRUST CO | US$128.2万 | 0.00% |
| UBS Group AG | US$117.2万 | 0.00% |
| JANE STREET GROUP, LLC | US$91.7万 | 0.00% |
| STATE STREET CORP | US$91.0万 | 0.00% |
| BlackRock, Inc. | US$67.2万 | 0.00% |
| Voleon Capital Management LP | US$65.4万 | 0.01% |
| Seven Fleet Capital Management LP | US$61.1万 | 0.19% |
| Creative Planning | US$58.4万 | 0.00% |
| CITADEL ADVISORS LLC | US$55.0万 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$49.4万 | 0.00% |
| NORTHERN TRUST CORP | US$43.0万 | 0.00% |
| Texas Capital Bank Wealth Management Services Inc | US$40.3万 | 0.02% |
| SIMPLEX TRADING, LLC | US$37.5万 | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | US$33.3万 | 0.00% |
| Stonepine Capital Management, LLC | US$31.3万 | 0.13% |
| Regency Capital Management Inc.\DE | US$30.9万 | 0.14% |
| HRT FINANCIAL LP | US$30.7万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$30.5万 | 0.00% |
| Palogic Value Management, L.P. | US$29.6万 | 0.12% |
| Brevan Howard Capital Management LP | US$27.9万 | 0.00% |
| Empowered Funds, LLC | US$19.1万 | 0.00% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | US$19.1万 | 0.00% |
| MANGROVE PARTNERS IM, LLC | US$19.0万 | 0.02% |
| OMERS ADMINISTRATION Corp | US$18.9万 | 0.00% |
| MORGAN STANLEY | US$18.0万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$15.9万 | 0.00% |
| CAPTRUST FINANCIAL ADVISORS | US$14.6万 | 0.00% |
| Tower Research Capital LLC (TRC) | US$13.1万 | 0.00% |
| nVerses Capital, LLC | US$13.0万 | 0.12% |
| Vanguard Global Advisers, LLC | US$10.1万 | 0.00% |
| Miller Financial Services LLC | US$10.0万 | 0.11% |
| RAYMOND JAMES FINANCIAL INC | US$8.9万 | 0.00% |
| Persistent Asset Partners Ltd | US$8.2万 | 0.03% |
| XTX Topco Ltd | US$7.6万 | 0.00% |
| JAMES INVESTMENT RESEARCH, INC. | US$7.4万 | 0.01% |
| Bedel Financial Consulting, Inc. | US$6.8万 | 0.01% |
| KESTRA PRIVATE WEALTH SERVICES, LLC | US$5.8万 | 0.00% |
| BLAIR WILLIAM & CO/IL | US$5.7万 | 0.00% |
| Stokes Family Office, LLC | US$5.5万 | 0.01% |
| SANDERS MORRIS HARRIS LLC | US$5.5万 | 0.01% |
| First City Capital Management, Inc. | US$5.4万 | 0.03% |
| GROUP ONE TRADING LLC | US$4.8万 | 0.00% |
| Annandale Capital, LLC | US$4.6万 | 0.01% |
| Reliant Investment Partners, LLC | US$4.6万 | 0.04% |
| Hilton Head Capital Partners, LLC | US$2.0万 | 0.01% |
| WELLS FARGO & COMPANY/MN | US$1.7万 | 0.00% |
| NewEdge Advisors, LLC | US$1.6万 | 0.00% |
| Farther Finance Advisors, LLC | US$1.1万 | 0.00% |
| OSAIC HOLDINGS, INC. | US$1.0万 | 0.00% |
| NATIONAL BANK OF CANADA /FI/ | US$9144.0 | 0.00% |
| BARCLAYS PLC | US$8645.0 | 0.00% |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | US$2443.0 | 0.00% |
| SBI Securities Co., Ltd. | US$2412.0 | 0.00% |
| FMR LLC | US$36.0 | 0.00% |
| Allworth Financial LP | US$23.0 | 0.00% |
| ROYAL BANK OF CANADA | US$0.0 | 0.00% |