| FMR LLC | US$1.5億 | 0.01% |
| Paradigm Biocapital Advisors LP | US$1.2億 | 2.44% |
| Bain Capital Life Sciences Investors, LLC | US$1.1億 | 10.05% |
| JANUS HENDERSON GROUP PLC | US$1.1億 | 0.05% |
| BlackRock, Inc. | US$8427.3萬 | 0.00% |
| BVF INC/IL | US$7896.2萬 | 2.52% |
| Siren, L.L.C. | US$7092.6萬 | 1.97% |
| Cormorant Asset Management, LP | US$6560.4萬 | 3.29% |
| STATE STREET CORP | US$5871.3萬 | 0.00% |
| Logos Global Management LP | US$4784.4萬 | 2.39% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$4597.5萬 | 0.00% |
| RA CAPITAL MANAGEMENT, L.P. | US$3876.6萬 | 0.41% |
| JENNISON ASSOCIATES LLC | US$2716.8萬 | 0.02% |
| Polar Capital Holdings Plc | US$2390.0萬 | 0.08% |
| GEODE CAPITAL MANAGEMENT, LLC | US$2303.1萬 | 0.00% |
| Defilade Capital Management, L.P. | US$2243.3萬 | 3.15% |
| Woodline Partners LP | US$2209.7萬 | 0.08% |
| LIGHTSPEED MANAGEMENT COMPANY, L.L.C. | US$2020.8萬 | 2.05% |
| GOLDMAN SACHS GROUP INC | US$1867.8萬 | 0.00% |
| FRANKLIN RESOURCES INC | US$1817.5萬 | 0.00% |
| MORGAN STANLEY | US$1812.6萬 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$1800.2萬 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$1763.7萬 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$1743.6萬 | 0.01% |
| Ikarian Capital, LLC | US$1711.8萬 | 1.39% |
| CITADEL ADVISORS LLC | US$1649.5萬 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | US$1613.4萬 | 0.00% |
| Duquesne Family Office LLC | US$1471.4萬 | 0.44% |
| Squarepoint Ops LLC | US$1280.1萬 | 0.02% |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | US$1274.8萬 | 1.40% |
| First Turn Management, LLC | US$1146.1萬 | 1.28% |
| Candriam S.C.A. | US$1132.4萬 | 0.06% |
| Vivo Capital, LLC | US$1001.7萬 | 0.83% |
| WELLINGTON MANAGEMENT GROUP LLP | US$991.0萬 | 0.00% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$884.2萬 | 0.00% |
| NORTHERN TRUST CORP | US$849.8萬 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$758.5萬 | 0.00% |
| Hennion & Walsh Asset Management, Inc. | US$717.9萬 | 0.24% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$695.6萬 | 0.00% |
| Jump Financial, LLC | US$675.4萬 | 0.09% |
| Vestal Point Capital, LP | US$639.0萬 | 0.18% |
| UBS Group AG | US$574.1萬 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$534.2萬 | 0.00% |
| SEB Asset Management AB | US$506.1萬 | 0.02% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$495.0萬 | 0.06% |
| Trexquant Investment LP | US$484.8萬 | 0.03% |
| Caption Management, LLC | US$468.3萬 | 0.03% |
| Qube Research & Technologies Ltd | US$466.4萬 | 0.01% |
| Fisher Asset Management, LLC | US$446.9萬 | 0.00% |
| Nuveen, LLC | US$416.0萬 | 0.00% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$410.0萬 | 0.01% |
| Birchview Capital, LP | US$326.5萬 | 1.86% |
| Pictet Asset Management Holding SA | US$323.6萬 | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | US$304.1萬 | 0.00% |
| Bank of New York Mellon Corp | US$288.5萬 | 0.00% |
| MILLENNIUM MANAGEMENT LLC | US$272.8萬 | 0.00% |
| Rock Springs Capital Management LP | US$254.0萬 | 0.15% |
| DEUTSCHE BANK AG\ | US$240.6萬 | 0.00% |
| Hudson Bay Capital Management LP | US$230.8萬 | 0.01% |
| Integral Health Asset Management, LLC | US$223.7萬 | 0.11% |
| Pier Capital, LLC | US$202.9萬 | 0.33% |
| Rafferty Asset Management, LLC | US$196.1萬 | 0.01% |
| Invesco Ltd. | US$195.2萬 | 0.00% |
| JPMORGAN CHASE & CO | US$191.6萬 | 0.00% |
| Burkehill Global Management, LP | US$186.4萬 | 0.09% |
| XTX Topco Ltd | US$183.7萬 | 0.03% |
| VOYA INVESTMENT MANAGEMENT LLC | US$181.1萬 | 0.00% |
| HighVista Strategies LLC | US$175.3萬 | 0.48% |
| FIDEURAM - INTESA SANPAOLO PRIVATE BANKING S.P.A. | US$174.2萬 | 0.06% |
| Susquehanna Portfolio Strategies, LLC | US$169.7萬 | 0.03% |
| Aquatic Capital Management LLC | US$165.8萬 | 0.05% |
| PRUDENTIAL FINANCIAL INC | US$164.2萬 | 0.00% |
| Point72 Asset Management, L.P. | US$163.6萬 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$163.4萬 | 0.00% |
| TD Asset Management Inc | US$158.4萬 | 0.00% |
| NOMURA HOLDINGS INC | US$149.6萬 | 0.00% |
| SPHERA FUNDS MANAGEMENT LTD. | US$149.1萬 | 0.24% |
| ALLIANCEBERNSTEIN L.P. | US$144.6萬 | 0.00% |
| Ensign Peak Advisors, Inc | US$144.3萬 | 0.00% |
| Quantinno Capital Management LP | US$142.1萬 | 0.00% |
| Y-Intercept (Hong Kong) Ltd | US$134.7萬 | 0.03% |
| Balyasny Asset Management L.P. | US$133.7萬 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$133.5萬 | 0.00% |
| JANE STREET GROUP, LLC | US$132.0萬 | 0.00% |
| Tidal Investments LLC | US$127.0萬 | 0.00% |
| RHUMBLINE ADVISERS | US$125.8萬 | 0.00% |
| DIADEMA PARTNERS LP | US$125.2萬 | 0.21% |
| AMERICAN CENTURY COMPANIES INC | US$121.9萬 | 0.00% |
| Tema ETFs LLC | US$118.2萬 | 0.08% |
| Swiss National Bank | US$111.2萬 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$108.4萬 | 0.00% |
| Creative Planning | US$107.7萬 | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | US$105.4萬 | 0.00% |
| Engineers Gate Manager LP | US$105.1萬 | 0.01% |
| ALPS ADVISORS INC | US$95.5萬 | 0.00% |
| Headlands Technologies LLC | US$88.5萬 | 0.10% |
| PROFUND ADVISORS LLC | US$87.3萬 | 0.03% |
| LPL Financial LLC | US$85.6萬 | 0.00% |
| AMERIPRISE FINANCIAL INC | US$85.5萬 | 0.00% |
| Swedbank AB | US$82.2萬 | 0.00% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | US$74.6萬 | 0.00% |
| PORTLAND INVESTMENT COUNSEL INC. | US$74.6萬 | 0.24% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | US$70.1萬 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$69.2萬 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$61.3萬 | 0.00% |
| Vanguard Global Advisers, LLC | US$60.7萬 | 0.00% |
| D. E. Shaw & Co., Inc. | US$58.5萬 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$58.3萬 | 0.00% |
| MetLife Investment Management, LLC | US$57.4萬 | 0.00% |
| Corient Private Wealth LLC | US$56.6萬 | 0.00% |
| GROUP ONE TRADING LLC | US$55.4萬 | 0.00% |
| Virtu Financial LLC | US$53.9萬 | 0.02% |
| ALGERT GLOBAL LLC | US$53.5萬 | 0.01% |
| Erste Asset Management GmbH | US$51.0萬 | 0.00% |
| Legal & General Group Plc | US$47.2萬 | 0.00% |
| Walleye Capital LLC | US$43.5萬 | 0.00% |
| CITIGROUP INC | US$41.1萬 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$39.2萬 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$37.3萬 | 0.00% |
| ACT CAPITAL MANAGEMENT, LLC | US$37.3萬 | 0.29% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | US$37.3萬 | 0.01% |
| Aristotle Atlantic Partners, LLC | US$37.2萬 | 0.02% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$37.0萬 | 0.00% |
| Jefferies Financial Group Inc. | US$32.8萬 | 0.00% |
| RAYMOND JAMES FINANCIAL INC | US$30.7萬 | 0.00% |
| Optimize Financial Inc | US$30.7萬 | 0.15% |
| Police & Firemen's Retirement System of New Jersey | US$28.6萬 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$28.1萬 | 0.00% |
| Graham Capital Management, L.P. | US$24.9萬 | 0.01% |
| E Fund Management Co., Ltd. | US$24.7萬 | 0.01% |
| Bellevue Group AG | US$24.5萬 | 0.01% |
| Entropy Technologies, LP | US$23.5萬 | 0.01% |
| PDT Partners, LLC | US$22.8萬 | 0.01% |
| Inscription Capital, LLC | US$22.8萬 | 0.02% |
| AXQ CAPITAL, LP | US$21.8萬 | 0.03% |
| China Universal Asset Management Co., Ltd. | US$21.2萬 | 0.02% |
| FEDERATED HERMES, INC. | US$21.0萬 | 0.00% |
| BARCLAYS PLC | US$20.9萬 | 0.00% |
| ProShare Advisors LLC | US$20.4萬 | 0.00% |
| DRW Securities, LLC | US$19.9萬 | 0.00% |
| State of New Jersey Common Pension Fund D | US$19.2萬 | 0.00% |
| TORONTO DOMINION BANK | US$18.8萬 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$16.9萬 | 0.00% |
| SIMPLEX TRADING, LLC | US$16.6萬 | 0.00% |
| STRS OHIO | US$15.7萬 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | US$15.5萬 | 0.00% |
| Wealthspire Advisors, LLC | US$15.2萬 | 0.00% |
| Vanguard Investments Australia, Ltd. | US$14.9萬 | 0.00% |
| PSP Research LLC | US$14.9萬 | 0.11% |
| CONWAY CAPITAL MANAGEMENT, INC. | US$14.9萬 | 0.07% |