| SB INVESTMENT ADVISERS (UK) LTD | US$2.8億 | 3.59% |
| Commodore Capital LP | US$1.7億 | 9.79% |
| Casdin Capital, LLC | US$1.4億 | 10.86% |
| BlackRock, Inc. | US$1.3億 | 0.00% |
| PERCEPTIVE ADVISORS LLC | US$9702.4萬 | 1.90% |
| Bellevue Group AG | US$7756.3萬 | 1.85% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$7350.5萬 | 0.00% |
| STATE STREET CORP | US$6202.4萬 | 0.00% |
| Nextech Invest, Ltd. | US$5498.9萬 | 3.87% |
| TCG Crossover Management, LLC | US$4252.0萬 | 1.22% |
| FMR LLC | US$3677.0萬 | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | US$3493.8萬 | 0.00% |
| Balyasny Asset Management L.P. | US$3024.0萬 | 0.04% |
| Spruce Street Capital LP | US$2969.2萬 | 7.14% |
| DIMENSIONAL FUND ADVISORS LP | US$2924.8萬 | 0.01% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$2577.1萬 | 0.04% |
| GOLDMAN SACHS GROUP INC | US$2529.2萬 | 0.00% |
| MPM BIOIMPACT LLC | US$2347.8萬 | 1.81% |
| BANK OF AMERICA CORP /DE/ | US$1928.0萬 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$1915.4萬 | 0.00% |
| EcoR1 Capital, LLC | US$1895.2萬 | 0.80% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$1854.2萬 | 0.00% |
| NORTHERN TRUST CORP | US$1667.0萬 | 0.00% |
| Alphabet Inc. | US$1556.4萬 | 0.39% |
| MORGAN STANLEY | US$1424.8萬 | 0.00% |
| Kynam Capital Management, LP | US$1417.1萬 | 0.87% |
| TWO SIGMA INVESTMENTS, LP | US$1362.3萬 | 0.01% |
| AQR CAPITAL MANAGEMENT LLC | US$1283.6萬 | 0.01% |
| BAKER BROS. ADVISORS LP | US$1154.3萬 | 0.07% |
| Caption Management, LLC | US$1114.4萬 | 0.07% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$1106.3萬 | 0.00% |
| Foresite Capital Management IV, LLC | US$995.0萬 | 4.20% |
| MARSHALL WACE, LLP | US$937.1萬 | 0.01% |
| Kalehua Capital Management LLC | US$896.9萬 | 6.35% |
| VANGUARD FIDUCIARY TRUST CO | US$896.0萬 | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | US$832.9萬 | 0.02% |
| Squadron Capital Management LLC | US$818.4萬 | 3.00% |
| PANAGORA ASSET MANAGEMENT INC | US$814.0萬 | 0.03% |
| Logos Global Management LP | US$746.3萬 | 0.37% |
| Woodline Partners LP | US$675.9萬 | 0.03% |
| RENAISSANCE TECHNOLOGIES LLC | US$670.2萬 | 0.01% |
| Invesco Ltd. | US$666.5萬 | 0.00% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | US$664.9萬 | 0.00% |
| Qube Research & Technologies Ltd | US$616.6萬 | 0.01% |
| CONGRESS ASSET MANAGEMENT CO | US$615.8萬 | 0.04% |
| JPMORGAN CHASE & CO | US$605.4萬 | 0.00% |
| ArrowMark Colorado Holdings LLC | US$538.4萬 | 0.14% |
| Elmind Capital, LP | US$534.3萬 | 1.52% |
| UBS Group AG | US$525.0萬 | 0.00% |
| Longaeva Partners L.P. | US$468.2萬 | 0.17% |
| BESSEMER GROUP INC | US$455.6萬 | 0.01% |
| JANE STREET GROUP, LLC | US$452.6萬 | 0.00% |
| AMERICAN CENTURY COMPANIES INC | US$438.0萬 | 0.00% |
| HighVista Strategies LLC | US$419.8萬 | 1.16% |
| SPHERA FUNDS MANAGEMENT LTD. | US$406.4萬 | 0.65% |
| Affinity Asset Advisors, LLC | US$398.0萬 | 0.21% |
| Bank of New York Mellon Corp | US$381.0萬 | 0.00% |
| Rhenman & Partners Asset Management AB | US$358.2萬 | 0.44% |
| AMERIPRISE FINANCIAL INC | US$355.1萬 | 0.00% |
| MILLENNIUM MANAGEMENT LLC | US$346.0萬 | 0.00% |
| RAYMOND JAMES FINANCIAL INC | US$344.6萬 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | US$337.4萬 | 0.05% |
| Hudson Bay Capital Management LP | US$309.8萬 | 0.01% |
| Nuveen, LLC | US$300.7萬 | 0.00% |
| ACADIAN ASSET MANAGEMENT LLC | US$288.6萬 | 0.00% |
| Exome Asset Management LLC | US$276.9萬 | 1.43% |
| Eversept Partners, LP | US$269.4萬 | 0.14% |
| Seven Fleet Capital Management LP | US$256.4萬 | 0.81% |
| Swiss National Bank | US$236.8萬 | 0.00% |
| RHUMBLINE ADVISERS | US$215.8萬 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | US$215.0萬 | 0.00% |
| TD Asset Management Inc | US$213.1萬 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$209.4萬 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$208.7萬 | 0.00% |
| IEQ CAPITAL, LLC | US$204.3萬 | 0.01% |
| CITADEL ADVISORS LLC | US$201.4萬 | 0.00% |
| SG Americas Securities, LLC | US$196.5萬 | 0.00% |
| XTX Topco Ltd | US$188.0萬 | 0.03% |
| OSAIC HOLDINGS, INC. | US$185.2萬 | 0.00% |
| Tetragon Partners GP Ltd | US$180.6萬 | 0.35% |
| Squarepoint Ops LLC | US$179.4萬 | 0.00% |
| Raiffeisen Bank International AG | US$177.7萬 | 0.03% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$173.2萬 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$161.4萬 | 0.00% |
| Tema ETFs LLC | US$153.3萬 | 0.10% |
| Tidal Investments LLC | US$153.3萬 | 0.00% |
| Rafferty Asset Management, LLC | US$149.9萬 | 0.01% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$146.4萬 | 0.00% |
| ALPS ADVISORS INC | US$144.8萬 | 0.01% |
| Sanctuary Advisors, LLC | US$143.1萬 | 0.01% |
| Engineers Gate Manager LP | US$140.7萬 | 0.02% |
| DEUTSCHE BANK AG\ | US$129.0萬 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | US$122.9萬 | 0.00% |
| Man Group plc | US$112.3萬 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$109.4萬 | 0.00% |
| Creative Planning | US$100.8萬 | 0.00% |
| ICONIQ Capital, LLC | US$94.2萬 | 0.02% |
| Trexquant Investment LP | US$93.8萬 | 0.01% |
| HIMENSION CAPITAL (SINGAPORE) PTE. LTD. | US$93.7萬 | 0.07% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$81.9萬 | 0.00% |
| Legal & General Group Plc | US$81.6萬 | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | US$79.6萬 | 0.00% |
| MetLife Investment Management, LLC | US$78.6萬 | 0.00% |
| Allspring Global Investments Holdings, LLC | US$78.3萬 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$75.6萬 | 0.00% |
| Vanguard Global Advisers, LLC | US$74.7萬 | 0.00% |
| Schonfeld Strategic Advisors LLC | US$71.5萬 | 0.01% |
| CWM, LLC | US$69.6萬 | 0.00% |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | US$69.5萬 | 0.00% |
| PROFUND ADVISORS LLC | US$67.8萬 | 0.02% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$66.4萬 | 0.00% |
| JANUS HENDERSON GROUP PLC | US$65.2萬 | 0.00% |
| J. Goldman & Co LP | US$63.3萬 | 0.02% |
| PRELUDE CAPITAL MANAGEMENT, LLC | US$61.6萬 | 0.05% |
| WELLINGTON MANAGEMENT GROUP LLP | US$59.2萬 | 0.00% |
| DekaBank Deutsche Girozentrale | US$59.1萬 | 0.00% |
| BANK OF MONTREAL /CAN/ | US$52.7萬 | 0.00% |
| FRANKLIN RESOURCES INC | US$48.7萬 | 0.00% |
| ALGERT GLOBAL LLC | US$48.3萬 | 0.01% |
| Aquatic Capital Management LLC | US$47.9萬 | 0.01% |
| Headlands Technologies LLC | US$47.4萬 | 0.05% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$45.6萬 | 0.00% |
| BARCLAYS PLC | US$45.0萬 | 0.00% |
| Intellectus Partners, LLC | US$42.0萬 | 0.09% |
| State of New Jersey Common Pension Fund D | US$41.3萬 | 0.00% |
| LPL Financial LLC | US$40.3萬 | 0.00% |
| BRANDYWINE MANAGERS, LLC | US$38.2萬 | 0.23% |
| Police & Firemen's Retirement System of New Jersey | US$36.8萬 | 0.00% |
| CAPTRUST FINANCIAL ADVISORS | US$36.6萬 | 0.00% |
| Cresset Asset Management, LLC | US$36.3萬 | 0.00% |
| SEI INVESTMENTS CO | US$35.9萬 | 0.00% |
| Mariner, LLC | US$35.8萬 | 0.00% |
| Valeo Financial Advisors, LLC | US$35.5萬 | 0.01% |
| Virtus Investment Advisers, LLC | US$33.8萬 | 0.09% |
| Gotham Asset Management, LLC | US$33.4萬 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | US$33.2萬 | 0.00% |
| Brooklyn Investment Group | US$32.4萬 | 0.01% |
| China Universal Asset Management Co., Ltd. | US$31.6萬 | 0.02% |
| INTECH INVESTMENT MANAGEMENT LLC | US$31.5萬 | 0.00% |
| Vanguard Personalized Indexing Management, LLC | US$31.4萬 | 0.00% |
| Vanguard Investments Australia, Ltd. | US$30.0萬 | 0.00% |
| CITIGROUP INC | US$29.6萬 | 0.00% |
| Pallas Capital Advisors LLC | US$28.4萬 | 0.01% |
| ProShare Advisors LLC | US$28.3萬 | 0.00% |
| Fiduciary Trust Co | US$27.8萬 | 0.00% |
| KLP KAPITALFORVALTNING AS | US$27.1萬 | 0.00% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$25.7萬 | 0.00% |
| NOMURA HOLDINGS INC | US$24.9萬 | 0.00% |
| Cerity Partners LLC | US$24.1萬 | 0.00% |
| OXFORD ASSET MANAGEMENT LLP | US$22.4萬 | 0.10% |