| FMR LLC | US$23.2億 | 0.12% |
| BlackRock, Inc. | US$15.1億 | 0.03% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$11.6億 | 0.03% |
| BAILLIE GIFFORD & CO | US$10.2億 | 1.04% |
| Capital World Investors | US$9.5億 | 0.13% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$7.9億 | 0.04% |
| STATE STREET CORP | US$7.5億 | 0.03% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$6.4億 | 0.07% |
| GEODE CAPITAL MANAGEMENT, LLC | US$4.8億 | 0.03% |
| TWO SIGMA INVESTMENTS, LP | US$4.7億 | 0.38% |
| MORGAN STANLEY | US$4.3億 | 0.03% |
| UBS Group AG | US$4.2億 | 0.06% |
| Theleme Partners LLP | US$4.1億 | 27.24% |
| JANE STREET GROUP, LLC | US$3.7億 | 0.05% |
| CITADEL ADVISORS LLC | US$3.6億 | 0.06% |
| GOLDMAN SACHS GROUP INC | US$3.4億 | 0.04% |
| CITIGROUP INC | US$3.2億 | 0.14% |
| D. E. Shaw & Co., Inc. | US$2.7億 | 0.16% |
| Tidal Investments LLC | US$2.6億 | 0.54% |
| IMC-Chicago, LLC | US$2.6億 | 0.05% |
| Invesco Ltd. | US$2.4億 | 0.04% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$2.4億 | 0.04% |
| Flagship Pioneering, LLC | US$2.4億 | 20.26% |
| Alyeska Investment Group, L.P. | US$2.1億 | 0.58% |
| NATIONAL BANK OF CANADA /FI/ | US$1.7億 | 0.09% |
| NORTHERN TRUST CORP | US$1.5億 | 0.02% |
| BANQUE PICTET & CIE SA | US$1.4億 | 0.98% |
| FIRST TRUST ADVISORS LP | US$1.2億 | 0.09% |
| WELLINGTON MANAGEMENT GROUP LLP | US$1.2億 | 0.02% |
| Merck & Co., Inc. | US$1.2億 | 33.56% |
| JPMORGAN CHASE & CO | US$1.1億 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | US$1.1億 | 0.02% |
| Qube Research & Technologies Ltd | US$1.1億 | 0.12% |
| FEDERATED HERMES, INC. | US$1.0億 | 0.16% |
| VANGUARD FIDUCIARY TRUST CO | US$9988.9萬 | 0.03% |
| Caption Management, LLC | US$9865.9萬 | 0.58% |
| Squarepoint Ops LLC | US$9606.3萬 | 0.11% |
| SIMPLEX TRADING, LLC | US$9544.2萬 | 0.03% |
| Bank of New York Mellon Corp | US$8591.3萬 | 0.02% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$8232.5萬 | 0.02% |
| Douglas Lane & Associates, LLC | US$6662.3萬 | 0.96% |
| GROUP ONE TRADING LLC | US$6490.2萬 | 0.08% |
| MILLENNIUM MANAGEMENT LLC | US$6210.3萬 | 0.03% |
| Walleye Trading LLC | US$5853.5萬 | 0.10% |
| LMR Partners LLP | US$5762.7萬 | 0.13% |
| Two Seas Capital LP | US$5588.0萬 | 0.78% |
| Nuveen, LLC | US$5477.2萬 | 0.01% |
| BARCLAYS PLC | US$5442.0萬 | 0.01% |
| ROYAL BANK OF CANADA | US$5272.3萬 | 0.01% |
| PERCEPTIVE ADVISORS LLC | US$5080.0萬 | 0.99% |
| Allianz Asset Management GmbH | US$5023.7萬 | 0.05% |
| BANK OF AMERICA CORP /DE/ | US$5010.7萬 | 0.00% |
| CAPITAL FUND MANAGEMENT S.A. | US$4933.3萬 | 0.22% |
| Amundi | US$4596.5萬 | 0.01% |
| RENAISSANCE TECHNOLOGIES LLC | US$4476.5萬 | 0.07% |
| Alphadyne Asset Management LP | US$4423.2萬 | 0.77% |
| DEUTSCHE BANK AG\ | US$4116.1萬 | 0.01% |
| Affinity Asset Advisors, LLC | US$4064.0萬 | 2.10% |
| Lingotto Investment Management LLP | US$3880.6萬 | 0.77% |
| Legal & General Group Plc | US$3814.2萬 | 0.01% |
| LETKO, BROSSEAU & ASSOCIATES INC | US$3804.0萬 | 0.61% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$3752.1萬 | 0.00% |
| Vanguard Global Advisers, LLC | US$3738.7萬 | 0.02% |
| Point72 Asset Management, L.P. | US$3628.4萬 | 0.05% |
| Russell Investments Group, Ltd. | US$3607.9萬 | 0.04% |
| Swiss National Bank | US$3536.2萬 | 0.02% |
| Pictet Asset Management Holding SA | US$3279.0萬 | 0.03% |
| Step Capital Management Pte. Ltd. | US$3276.6萬 | 13.15% |
| California Public Employees Retirement System | US$3191.1萬 | 0.02% |
| HSBC HOLDINGS PLC | US$2851.2萬 | 0.01% |
| RHUMBLINE ADVISERS | US$2846.6萬 | 0.02% |
| CAPSTONE INVESTMENT ADVISORS, LLC | US$2657.6萬 | 0.05% |
| PEAK6 LLC | US$2644.6萬 | 0.06% |
| Telemark Asset Management, LLC | US$2540.0萬 | 2.35% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | US$2467.5萬 | 0.10% |
| Trexquant Investment LP | US$2458.6萬 | 0.18% |
| OFI INVEST ASSET MANAGEMENT | US$2415.6萬 | 0.32% |
| Susquehanna Portfolio Strategies, LLC | US$2392.9萬 | 0.36% |
| Walleye Capital LLC | US$2365.1萬 | 0.10% |
| VOYA INVESTMENT MANAGEMENT LLC | US$2230.5萬 | 0.02% |
| Mitsubishi UFJ Asset Management Co., Ltd. | US$2157.1萬 | 0.01% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$2068.5萬 | 0.02% |
| Mount Capital Ltd | US$2007.6萬 | 8.09% |
| HRT FINANCIAL LP | US$1973.5萬 | 0.05% |
| PRINCIPAL FINANCIAL GROUP INC | US$1969.6萬 | 0.01% |
| CWM, LLC | US$1965.5萬 | 0.05% |
| TUDOR INVESTMENT CORP ET AL | US$1899.5萬 | 0.04% |
| Mitsubishi UFJ Trust & Banking Corp | US$1731.8萬 | 0.04% |
| BANK OF MONTREAL /CAN/ | US$1717.6萬 | 0.01% |
| Leonteq Securities AG | US$1622.4萬 | 0.60% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$1619.4萬 | 0.01% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$1599.5萬 | 0.01% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$1534.7萬 | 0.03% |
| SG Americas Securities, LLC | US$1443.8萬 | 0.01% |
| CANADA PENSION PLAN INVESTMENT BOARD | US$1402.4萬 | 0.01% |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | US$1353.3萬 | 0.03% |
| MARSHALL WACE, LLP | US$1266.5萬 | 0.01% |
| VAN ECK ASSOCIATES CORP | US$1251.9萬 | 0.01% |
| ALGERT GLOBAL LLC | US$1206.1萬 | 0.18% |
| Candriam S.C.A. | US$1172.6萬 | 0.06% |
| ALLIANCEBERNSTEIN L.P. | US$1161.8萬 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$1154.0萬 | 0.03% |
| PLUSTICK MANAGEMENT LLC | US$1117.6萬 | 5.40% |
| DekaBank Deutsche Girozentrale | US$1080.3萬 | 0.02% |
| Woodline Partners LP | US$1074.3萬 | 0.04% |
| CREDIT AGRICOLE S A | US$1020.0萬 | 0.03% |
| SHANDA ASSET MANAGEMENT HOLDINGS Ltd | US$1016.0萬 | 0.55% |
| Artia Global Partners LP | US$1016.0萬 | 2.03% |
| RAYMOND JAMES FINANCIAL INC | US$1001.9萬 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$984.3萬 | 0.00% |
| TWIN FOCUS CAPITAL PARTNERS, LLC | US$942.9萬 | 1.08% |
| TD Asset Management Inc | US$912.3萬 | 0.01% |
| LPL Financial LLC | US$904.4萬 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$898.1萬 | 0.01% |
| Chevy Chase Trust Holdings, LLC | US$870.3萬 | 0.03% |
| PRUDENTIAL FINANCIAL INC | US$868.2萬 | 0.01% |
| Bank Pictet & Cie (Europe) AG | US$856.5萬 | 0.18% |
| Quantinno Capital Management LP | US$853.8萬 | 0.01% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | US$850.0萬 | 0.07% |
| Vontobel Holding Ltd. | US$830.2萬 | 0.03% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$813.6萬 | 0.02% |
| Eversept Partners, LP | US$811.3萬 | 0.43% |
| DIADEMA PARTNERS LP | US$809.8萬 | 1.38% |
| JANUS HENDERSON GROUP PLC | US$809.5萬 | 0.00% |
| Crawford Fund Management, LLC | US$803.7萬 | 1.55% |
| 683 Capital Management, LLC | US$792.5萬 | 0.41% |
| Treasurer of the State of North Carolina | US$779.3萬 | 0.02% |
| CANADA LIFE ASSURANCE Co | US$754.6萬 | 0.01% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$748.3萬 | 0.01% |
| GATEWAY INVESTMENT ADVISERS LLC | US$743.0萬 | 0.08% |
| AMERIPRISE FINANCIAL INC | US$728.6萬 | 0.00% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$701.1萬 | 0.01% |
| Centiva Capital, LP | US$698.7萬 | 0.05% |
| Banco Santander, S.A. | US$675.8萬 | 0.05% |
| SEI INVESTMENTS CO | US$657.3萬 | 0.01% |
| Compagnie Lombard Odier SCmA | US$638.7萬 | 0.08% |
| CHAPIN DAVIS, INC. | US$637.7萬 | 1.42% |
| Twin Tree Management, LP | US$636.0萬 | 0.13% |
| State of New Jersey Common Pension Fund D | US$610.5萬 | 0.02% |
| Rafferty Asset Management, LLC | US$580.1萬 | 0.02% |
| Handelsbanken Fonder AB | US$566.9萬 | 0.02% |
| CREDIT INDUSTRIEL ET COMMERCIAL | US$553.9萬 | 0.43% |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | US$529.8萬 | 0.02% |
| Parkman Healthcare Partners LLC | US$508.0萬 | 0.52% |
| TANG CAPITAL MANAGEMENT LLC | US$508.0萬 | 0.26% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | US$507.8萬 | 0.02% |
| South Dakota Investment Council | US$505.7萬 | 0.10% |
| NEUBERGER BERMAN GROUP LLC | US$505.7萬 | 0.00% |
| Public Sector Pension Investment Board | US$502.7萬 | 0.02% |
| CIBC Bancorp USA Inc. | US$500.5萬 | 0.01% |