| BAKER BROS. ADVISORS LP | US$28.9億 | 16.62% |
| BlackRock, Inc. | US$17.9億 | 0.03% |
| Dodge & Cox | US$11.5億 | 0.63% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$10.3億 | 0.03% |
| STATE STREET CORP | US$9.1億 | 0.03% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$7.3億 | 0.04% |
| AQR CAPITAL MANAGEMENT LLC | US$5.4億 | 0.25% |
| GEODE CAPITAL MANAGEMENT, LLC | US$4.4億 | 0.03% |
| LSV ASSET MANAGEMENT | US$3.7億 | 0.80% |
| Invesco Ltd. | US$3.6億 | 0.06% |
| RENAISSANCE TECHNOLOGIES LLC | US$3.4億 | 0.54% |
| WELLINGTON MANAGEMENT GROUP LLP | US$3.1億 | 0.06% |
| MORGAN STANLEY | US$2.7億 | 0.02% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | US$2.7億 | 0.14% |
| Robeco Institutional Asset Management B.V. | US$2.4億 | 0.34% |
| GOLDMAN SACHS GROUP INC | US$2.2億 | 0.03% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | US$2.0億 | 0.80% |
| DIMENSIONAL FUND ADVISORS LP | US$1.9億 | 0.04% |
| ACADIAN ASSET MANAGEMENT LLC | US$1.8億 | 0.25% |
| NORTHERN TRUST CORP | US$1.7億 | 0.02% |
| VICTORY CAPITAL MANAGEMENT INC | US$1.6億 | 0.11% |
| Pacer Advisors, Inc. | US$1.6億 | 0.46% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$1.6億 | 0.02% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | US$1.6億 | 0.68% |
| Legal & General Group Plc | US$1.5億 | 0.03% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$1.5億 | 0.03% |
| Caisse de depot et placement du Quebec | US$1.4億 | 0.23% |
| FIRST TRUST ADVISORS LP | US$1.4億 | 0.10% |
| DEUTSCHE BANK AG\ | US$1.2億 | 0.04% |
| MARSHALL WACE, LLP | US$1.2億 | 0.12% |
| PANAGORA ASSET MANAGEMENT INC | US$1.1億 | 0.43% |
| FMR LLC | US$1.1億 | 0.01% |
| UBS Group AG | US$1.1億 | 0.02% |
| AustralianSuper Pty Ltd | US$1.1億 | 0.56% |
| ROYAL BANK OF CANADA | US$9921.2萬 | 0.02% |
| Amundi | US$9449.4萬 | 0.03% |
| Bank of New York Mellon Corp | US$9315.1萬 | 0.02% |
| VANGUARD FIDUCIARY TRUST CO | US$8925.4萬 | 0.02% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$8845.5萬 | 0.10% |
| Man Group plc | US$8754.8萬 | 0.16% |
| BANK OF AMERICA CORP /DE/ | US$8616.9萬 | 0.01% |
| Pictet Asset Management Holding SA | US$8478.8萬 | 0.09% |
| SOUND SHORE MANAGEMENT INC /CT/ | US$7226.8萬 | 2.42% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$7076.5萬 | 0.01% |
| SEI INVESTMENTS CO | US$6725.4萬 | 0.06% |
| FRANKLIN RESOURCES INC | US$6529.9萬 | 0.02% |
| RHUMBLINE ADVISERS | US$6528.8萬 | 0.06% |
| Gotham Asset Management, LLC | US$6368.8萬 | 0.20% |
| ARMISTICE CAPITAL, LLC | US$6182.0萬 | 1.10% |
| SEB Asset Management AB | US$6081.7萬 | 0.26% |
| Russell Investments Group, Ltd. | US$5970.4萬 | 0.06% |
| CANADA PENSION PLAN INVESTMENT BOARD | US$5722.0萬 | 0.04% |
| Woodline Partners LP | US$5701.0萬 | 0.22% |
| AMERIPRISE FINANCIAL INC | US$5698.7萬 | 0.01% |
| CITIGROUP INC | US$5625.1萬 | 0.02% |
| HSBC HOLDINGS PLC | US$5478.1萬 | 0.03% |
| MACKENZIE FINANCIAL CORP | US$5173.1萬 | 0.06% |
| GLENMEDE TRUST CO NA | US$4925.2萬 | 0.24% |
| FEDERATED HERMES, INC. | US$4704.7萬 | 0.08% |
| IEQ CAPITAL, LLC | US$4695.0萬 | 0.22% |
| WORLDQUANT MILLENNIUM ADVISORS LLC | US$4646.8萬 | 0.18% |
| Nuveen, LLC | US$4625.6萬 | 0.01% |
| Swiss National Bank | US$4609.8萬 | 0.03% |
| California Public Employees Retirement System | US$4549.2萬 | 0.03% |
| JUPITER ASSET MANAGEMENT LTD | US$4542.6萬 | 0.24% |
| JPMORGAN CHASE & CO | US$4489.8萬 | 0.00% |
| Sumitomo Mitsui Trust Group, Inc. | US$3975.9萬 | 0.03% |
| TWO SIGMA INVESTMENTS, LP | US$3914.6萬 | 0.03% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | US$3911.6萬 | 0.01% |
| Vanguard Global Advisers, LLC | US$3650.9萬 | 0.02% |
| PRUDENTIAL FINANCIAL INC | US$3522.7萬 | 0.04% |
| BARCLAYS PLC | US$3455.1萬 | 0.01% |
| Mitsubishi UFJ Asset Management Co., Ltd. | US$3453.4萬 | 0.02% |
| Grantham, Mayo, Van Otterloo & Co. LLC | US$3432.2萬 | 0.09% |
| Swedbank AB | US$3411.4萬 | 0.04% |
| Mitsubishi UFJ Trust & Banking Corp | US$3386.1萬 | 0.08% |
| Empowered Funds, LLC | US$3326.1萬 | 0.21% |
| Candriam S.C.A. | US$3219.3萬 | 0.17% |
| AMERICAN CENTURY COMPANIES INC | US$3169.8萬 | 0.02% |
| CAPITAL FUND MANAGEMENT S.A. | US$3054.4萬 | 0.14% |
| Aware Super Pty Ltd as trustee of Aware Super | US$2970.8萬 | 0.45% |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | US$2800.1萬 | 0.05% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$2726.6萬 | 0.02% |
| Vinva Investment Management Ltd | US$2713.6萬 | 0.34% |
| SG Americas Securities, LLC | US$2683.9萬 | 0.03% |
| Arbejdsmarkedets Tillaegspension | US$2631.5萬 | 0.65% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | US$2478.5萬 | 0.19% |
| Andra AP-fonden | US$2438.2萬 | 0.29% |
| WELLS FARGO & COMPANY/MN | US$2400.3萬 | 0.00% |
| Illinois Municipal Retirement Fund | US$2400.0萬 | 0.31% |
| TODD ASSET MANAGEMENT LLC | US$2370.8萬 | 0.46% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$2271.0萬 | 0.02% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$2216.3萬 | 0.04% |
| Ensign Peak Advisors, Inc | US$2142.3萬 | 0.04% |
| Cerity Partners LLC | US$2131.8萬 | 0.03% |
| PRINCIPAL FINANCIAL GROUP INC | US$2122.3萬 | 0.01% |
| Korea Investment CORP | US$2079.4萬 | 0.04% |
| LAZARD ASSET MANAGEMENT LLC | US$2069.5萬 | 0.03% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$2066.6萬 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$1983.9萬 | 0.04% |
| Eurizon Capital SGR S.p.A. | US$1979.5萬 | 0.06% |
| CWM, LLC | US$1908.5萬 | 0.05% |
| SECTOR GAMMA AS | US$1887.2萬 | 4.46% |
| ALLIANCEBERNSTEIN L.P. | US$1824.8萬 | 0.01% |
| KLP KAPITALFORVALTNING AS | US$1810.0萬 | 0.07% |
| ROYAL LONDON ASSET MANAGEMENT LTD | US$1807.6萬 | 0.04% |
| Baird Financial Group, Inc. | US$1758.7萬 | 0.03% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | US$1742.0萬 | 0.03% |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | US$1730.2萬 | 0.02% |
| DIADEMA PARTNERS LP | US$1726.4萬 | 2.94% |
| Catalio Capital Management, LP | US$1713.9萬 | 3.58% |
| Distillate Capital Partners LLC | US$1694.6萬 | 0.89% |
| Point72 Asset Management, L.P. | US$1659.0萬 | 0.02% |
| FJARDE AP-FONDEN /FOURTH SWEDISH NATIONAL PENSION FUND | US$1651.5萬 | 0.09% |
| WINTON GROUP Ltd | US$1628.6萬 | 0.57% |
| MILLENNIUM MANAGEMENT LLC | US$1627.5萬 | 0.01% |
| BANK OF MONTREAL /CAN/ | US$1616.9萬 | 0.01% |
| ASHFORD CAPITAL MANAGEMENT INC | US$1555.3萬 | 1.92% |
| MARTINGALE ASSET MANAGEMENT L P | US$1549.6萬 | 0.39% |
| DekaBank Deutsche Girozentrale | US$1532.1萬 | 0.03% |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | US$1508.7萬 | 0.03% |
| Quantinno Capital Management LP | US$1489.2萬 | 0.02% |
| Edgestream Partners, L.P. | US$1482.1萬 | 0.49% |
| BI Asset Management Fondsmaeglerselskab A/S | US$1461.2萬 | 0.15% |
| APG Asset Management N.V. | US$1440.4萬 | 0.05% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$1408.1萬 | 0.03% |
| AVIVA PLC | US$1393.8萬 | 0.02% |
| TD Asset Management Inc | US$1345.8萬 | 0.01% |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | US$1294.7萬 | 0.03% |
| INTECH INVESTMENT MANAGEMENT LLC | US$1286.7萬 | 0.13% |
| GRIMES & Co WEALTH MANAGEMENT, LLC | US$1283.8萬 | 0.36% |
| Treasurer of the State of North Carolina | US$1282.3萬 | 0.04% |
| CITADEL ADVISORS LLC | US$1277.1萬 | 0.00% |
| Allianz Asset Management GmbH | US$1271.6萬 | 0.01% |
| SAWGRASS ASSET MANAGEMENT LLC | US$1256.8萬 | 1.89% |
| COOKSON PEIRCE & CO INC | US$1229.6萬 | 0.52% |
| Bridgewater Associates, LP | US$1226.3萬 | 0.05% |
| Aberdeen Group plc | US$1224.9萬 | 0.02% |
| Driehaus Capital Management LLC | US$1206.1萬 | 0.09% |
| Allspring Global Investments Holdings, LLC | US$1189.8萬 | 0.02% |
| Applied Finance Capital Management, LLC | US$1189.7萬 | 0.89% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$1181.0萬 | 0.01% |
| LBP AM SA | US$1176.5萬 | 0.16% |
| JANE STREET GROUP, LLC | US$1148.7萬 | 0.00% |
| Mariner, LLC | US$1139.5萬 | 0.01% |
| VAN ECK ASSOCIATES CORP | US$1127.5萬 | 0.01% |
| Vestcor Inc | US$1127.0萬 | 0.31% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$1100.1萬 | 0.03% |
| Focus Partners Wealth | US$1092.5萬 | 0.01% |
| Fisher Asset Management, LLC | US$1061.2萬 | 0.00% |