| FMR LLC | US$4.4億 | 0.02% |
| BlackRock, Inc. | US$2.8億 | 0.00% |
| JANUS HENDERSON GROUP PLC | US$2.4億 | 0.12% |
| Capital Research Global Investors | US$1.7億 | 0.03% |
| BAKER BROS. ADVISORS LP | US$1.3億 | 0.76% |
| STATE STREET CORP | US$1.3億 | 0.00% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$1.2億 | 0.00% |
| Logos Global Management LP | US$1.1億 | 5.74% |
| FEDERATED HERMES, INC. | US$9953.0萬 | 0.16% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$9407.9萬 | 0.15% |
| Fiera Capital Corp | US$8420.2萬 | 0.29% |
| GEODE CAPITAL MANAGEMENT, LLC | US$8333.7萬 | 0.01% |
| GOLDMAN SACHS GROUP INC | US$6376.2萬 | 0.01% |
| MORGAN STANLEY | US$6199.0萬 | 0.00% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | US$5098.0萬 | 0.60% |
| GSK plc | US$4442.7萬 | 7.41% |
| DIMENSIONAL FUND ADVISORS LP | US$4441.8萬 | 0.01% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$4384.5萬 | 0.01% |
| Sofinnova Investments, Inc. | US$3771.1萬 | 1.43% |
| Candriam S.C.A. | US$3690.9萬 | 0.19% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$3669.0萬 | 0.04% |
| Caption Management, LLC | US$3588.6萬 | 0.21% |
| BANK OF AMERICA CORP /DE/ | US$3139.0萬 | 0.00% |
| Ensign Peak Advisors, Inc | US$2997.1萬 | 0.06% |
| Fisher Asset Management, LLC | US$2941.2萬 | 0.01% |
| First Turn Management, LLC | US$2911.6萬 | 3.25% |
| CITADEL ADVISORS LLC | US$2576.0萬 | 0.00% |
| UBS Group AG | US$2540.8萬 | 0.00% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$2484.3萬 | 0.00% |
| NORTHERN TRUST CORP | US$2446.1萬 | 0.00% |
| Pictet Asset Management Holding SA | US$2385.4萬 | 0.03% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$2384.1萬 | 0.00% |
| Qube Research & Technologies Ltd | US$1946.0萬 | 0.02% |
| VANGUARD FIDUCIARY TRUST CO | US$1871.1萬 | 0.00% |
| Aberdeen Group plc | US$1818.0萬 | 0.03% |
| Redmile Group, LLC | US$1736.4萬 | 1.15% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$1717.5萬 | 0.02% |
| DAFNA Capital Management LLC | US$1588.5萬 | 3.61% |
| TANG CAPITAL MANAGEMENT LLC | US$1499.4萬 | 0.76% |
| Nuveen, LLC | US$1493.6萬 | 0.00% |
| DEUTSCHE BANK AG\ | US$1261.0萬 | 0.00% |
| MILLENNIUM MANAGEMENT LLC | US$1185.5萬 | 0.00% |
| Point72 Asset Management, L.P. | US$1092.6萬 | 0.01% |
| GENERAL AMERICAN INVESTORS CO INC | US$933.8萬 | 0.61% |
| JPMORGAN CHASE & CO | US$918.7萬 | 0.00% |
| JANE STREET GROUP, LLC | US$890.1萬 | 0.00% |
| ENVESTNET ASSET MANAGEMENT INC | US$854.1萬 | 0.00% |
| JENNISON ASSOCIATES LLC | US$852.2萬 | 0.01% |
| Rhenman & Partners Asset Management AB | US$851.3萬 | 1.05% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$839.7萬 | 0.00% |
| Bank of New York Mellon Corp | US$834.1萬 | 0.00% |
| Nicholas Investment Partners, LP | US$827.0萬 | 0.60% |
| WELLS FARGO & COMPANY/MN | US$810.8萬 | 0.00% |
| AMERICAN CENTURY COMPANIES INC | US$804.7萬 | 0.00% |
| FRANKLIN RESOURCES INC | US$767.3萬 | 0.00% |
| Squadron Capital Management LLC | US$747.4萬 | 2.74% |
| Balyasny Asset Management L.P. | US$694.2萬 | 0.01% |
| Susquehanna Portfolio Strategies, LLC | US$674.5萬 | 0.10% |
| Woodline Partners LP | US$672.0萬 | 0.03% |
| Hudson Bay Capital Management LP | US$646.4萬 | 0.02% |
| Alyeska Investment Group, L.P. | US$640.8萬 | 0.02% |
| Connor, Clark & Lunn Investment Management Ltd. | US$590.7萬 | 0.01% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$583.6萬 | 0.00% |
| Man Group plc | US$572.6萬 | 0.01% |
| WCM INVESTMENT MANAGEMENT, LLC | US$571.1萬 | 0.01% |
| SummitTX Capital, L.P. | US$542.2萬 | 0.17% |
| ROYAL BANK OF CANADA | US$539.2萬 | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | US$524.0萬 | 0.00% |
| Swiss National Bank | US$518.5萬 | 0.00% |
| Creative Planning | US$483.2萬 | 0.00% |
| GREAT LAKES ADVISORS, LLC | US$470.0萬 | 0.04% |
| Russell Investments Group, Ltd. | US$449.6萬 | 0.00% |
| FIDEURAM - INTESA SANPAOLO PRIVATE BANKING S.P.A. | US$406.7萬 | 0.14% |
| NEUBERGER BERMAN GROUP LLC | US$401.8萬 | 0.00% |
| Atle Fund Management AB | US$401.1萬 | 1.30% |
| TWO SIGMA INVESTMENTS, LP | US$396.9萬 | 0.00% |
| Tema ETFs LLC | US$374.2萬 | 0.25% |
| Tidal Investments LLC | US$374.2萬 | 0.01% |
| Invesco Ltd. | US$370.2萬 | 0.00% |
| RHUMBLINE ADVISERS | US$357.8萬 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | US$348.4萬 | 0.00% |
| Squarepoint Ops LLC | US$330.8萬 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$322.1萬 | 0.00% |
| PLATINUM INVESTMENT MANAGEMENT LTD | US$305.3萬 | 0.77% |
| CITIGROUP INC | US$296.1萬 | 0.00% |
| Rafferty Asset Management, LLC | US$288.8萬 | 0.01% |
| Seven Fleet Capital Management LP | US$287.5萬 | 0.91% |
| SEI INVESTMENTS CO | US$282.5萬 | 0.00% |
| KVP Capital Advisors, LP | US$265.6萬 | 1.98% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$242.9萬 | 0.00% |
| ALPS ADVISORS INC | US$238.2萬 | 0.01% |
| Legal & General Group Plc | US$234.9萬 | 0.00% |
| Mitsubishi UFJ Asset Management Co., Ltd. | US$220.1萬 | 0.00% |
| ASSETMARK, INC | US$218.7萬 | 0.00% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$207.4萬 | 0.00% |
| MML INVESTORS SERVICES, LLC | US$196.4萬 | 0.01% |
| AlphaCore Capital LLC | US$191.3萬 | 0.05% |
| XTX Topco Ltd | US$188.7萬 | 0.03% |
| Lido Advisors, LLC | US$184.8萬 | 0.01% |
| Y-Intercept (Hong Kong) Ltd | US$182.0萬 | 0.03% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$174.7萬 | 0.00% |
| DekaBank Deutsche Girozentrale | US$167.8萬 | 0.00% |
| Orion Porfolio Solutions, LLC | US$164.5萬 | 0.01% |
| ACUTA CAPITAL PARTNERS, LLC | US$161.9萬 | 1.15% |
| FIRST TRUST ADVISORS LP | US$155.6萬 | 0.00% |
| MetLife Investment Management, LLC | US$154.6萬 | 0.01% |
| MARTINGALE ASSET MANAGEMENT L P | US$153.7萬 | 0.04% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$151.7萬 | 0.00% |
| AMERIPRISE FINANCIAL INC | US$150.8萬 | 0.00% |
| TD Asset Management Inc | US$145.5萬 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$143.2萬 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | US$142.3萬 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$140.5萬 | 0.00% |
| WESBANCO BANK INC | US$132.3萬 | 0.04% |
| Knights of Columbus Asset Advisors LLC | US$131.7萬 | 0.07% |
| PROFUND ADVISORS LLC | US$130.9萬 | 0.05% |
| FLAX POND CAPITAL, LLC | US$130.8萬 | 1.05% |
| Atom Investors LP | US$125.9萬 | 0.09% |
| Vanguard Global Advisers, LLC | US$122.2萬 | 0.00% |
| SG Americas Securities, LLC | US$109.8萬 | 0.00% |
| WELLINGTON MANAGEMENT GROUP LLP | US$109.5萬 | 0.00% |
| Handelsbanken Fonder AB | US$103.0萬 | 0.00% |
| STRS OHIO | US$99.3萬 | 0.00% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$92.5萬 | 0.01% |
| State of New Jersey Common Pension Fund D | US$89.8萬 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$87.9萬 | 0.00% |
| STIFEL FINANCIAL CORP | US$85.7萬 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$84.3萬 | 0.01% |
| Ishara Investments LP | US$82.0萬 | 0.78% |
| Quantinno Capital Management LP | US$77.2萬 | 0.00% |
| Quantedge Capital Pte Ltd | US$77.0萬 | 0.42% |
| Police & Firemen's Retirement System of New Jersey | US$76.8萬 | 0.01% |
| Palumbo Wealth Management LLC | US$76.3萬 | 0.19% |
| ARIZONA STATE RETIREMENT SYSTEM | US$72.2萬 | 0.00% |
| Vanguard Investments Australia, Ltd. | US$69.8萬 | 0.00% |
| ADAR1 Capital Management, LLC | US$66.6萬 | 0.04% |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P | US$66.6萬 | 0.62% |
| HSBC HOLDINGS PLC | US$64.5萬 | 0.00% |
| Snowden Capital Advisors LLC | US$64.1萬 | 0.02% |
| Cetera Investment Advisers | US$62.9萬 | 0.00% |
| PRUDENTIAL FINANCIAL INC | US$58.2萬 | 0.00% |
| KLP KAPITALFORVALTNING AS | US$57.6萬 | 0.00% |
| GUGGENHEIM CAPITAL LLC | US$57.0萬 | 0.00% |
| Birchview Capital, LP | US$56.2萬 | 0.32% |
| ProShare Advisors LLC | US$54.0萬 | 0.00% |
| BARCLAYS PLC | US$53.2萬 | 0.00% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$52.1萬 | 0.00% |
| Vanguard Personalized Indexing Management, LLC | US$52.0萬 | 0.01% |
| China Universal Asset Management Co., Ltd. | US$51.9萬 | 0.04% |
| OPPENHEIMER ASSET MANAGEMENT INC. | US$51.5萬 | 0.01% |