| Lynx1 Capital Management LP | US$1.3億 | 20.13% |
| MPM BIOIMPACT LLC | US$1.1億 | 8.39% |
| BVF INC/IL | US$8171.7萬 | 2.60% |
| BlackRock, Inc. | US$6323.4萬 | 0.00% |
| Kynam Capital Management, LP | US$4425.2萬 | 2.73% |
| STATE STREET CORP | US$3615.2萬 | 0.00% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$3528.4萬 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$2884.3萬 | 0.00% |
| Blue Owl Capital Holdings LP | US$2713.8萬 | 7.29% |
| RTW INVESTMENTS, LP | US$2424.2萬 | 0.24% |
| Venrock Adviser, LLC | US$1960.9萬 | 0.73% |
| GEODE CAPITAL MANAGEMENT, LLC | US$1944.7萬 | 0.00% |
| Siren, L.L.C. | US$1695.8萬 | 0.47% |
| Nextech Invest, Ltd. | US$1621.6萬 | 1.14% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$1581.3萬 | 0.21% |
| MARSHALL WACE, LLP | US$1491.5萬 | 0.01% |
| DIMENSIONAL FUND ADVISORS LP | US$1287.0萬 | 0.00% |
| Point72 Asset Management, L.P. | US$1286.5萬 | 0.02% |
| Nuveen, LLC | US$1144.9萬 | 0.00% |
| Affinity Asset Advisors, LLC | US$1110.2萬 | 0.57% |
| TWIN FOCUS CAPITAL PARTNERS, LLC | US$846.2萬 | 0.97% |
| MORGAN STANLEY | US$837.7萬 | 0.00% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$785.2萬 | 0.00% |
| Elmind Capital, LP | US$753.1萬 | 2.14% |
| TWO SIGMA INVESTMENTS, LP | US$741.8萬 | 0.01% |
| BANK OF AMERICA CORP /DE/ | US$734.3萬 | 0.00% |
| GOLDMAN SACHS GROUP INC | US$647.2萬 | 0.00% |
| NORTHERN TRUST CORP | US$638.4萬 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$615.1萬 | 0.00% |
| Soleus Capital Management, L.P. | US$582.9萬 | 0.24% |
| TCG Crossover Management, LLC | US$578.0萬 | 0.17% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | US$548.7萬 | 0.06% |
| DEUTSCHE BANK AG\ | US$522.8萬 | 0.00% |
| MILLENNIUM MANAGEMENT LLC | US$520.9萬 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$512.8萬 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$487.2萬 | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | US$460.6萬 | 0.01% |
| GREAT POINT PARTNERS LLC | US$426.3萬 | 0.98% |
| CITADEL ADVISORS LLC | US$415.5萬 | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | US$410.8萬 | 0.01% |
| JPMORGAN CHASE & CO | US$398.9萬 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$354.2萬 | 0.00% |
| Invesco Ltd. | US$346.9萬 | 0.00% |
| ORBIMED ADVISORS LLC | US$345.3萬 | 0.07% |
| Susquehanna Portfolio Strategies, LLC | US$332.3萬 | 0.05% |
| PFM Health Sciences, LP | US$323.1萬 | 0.29% |
| UBS Group AG | US$287.6萬 | 0.00% |
| Jump Financial, LLC | US$275.4萬 | 0.04% |
| Longaeva Partners L.P. | US$261.0萬 | 0.10% |
| Trexquant Investment LP | US$239.4萬 | 0.02% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$233.2萬 | 0.00% |
| WELLINGTON MANAGEMENT GROUP LLP | US$212.6萬 | 0.00% |
| PRUDENTIAL FINANCIAL INC | US$212.4萬 | 0.00% |
| CITIGROUP INC | US$204.8萬 | 0.00% |
| AMERICAN CENTURY COMPANIES INC | US$204.8萬 | 0.00% |
| Bank of New York Mellon Corp | US$204.2萬 | 0.00% |
| BARCLAYS PLC | US$199.4萬 | 0.00% |
| Assenagon Asset Management S.A. | US$197.1萬 | 0.00% |
| TD Asset Management Inc | US$162.6萬 | 0.00% |
| ALGERT GLOBAL LLC | US$155.9萬 | 0.02% |
| MOORE CAPITAL MANAGEMENT, LP | US$150.6萬 | 0.03% |
| Bleichroeder LP | US$142.1萬 | 0.25% |
| Y-Intercept (Hong Kong) Ltd | US$135.6萬 | 0.03% |
| Cinctive Capital Management LP | US$134.2萬 | 0.09% |
| Qube Research & Technologies Ltd | US$128.3萬 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$107.0萬 | 0.00% |
| Quantinno Capital Management LP | US$102.7萬 | 0.00% |
| Rafferty Asset Management, LLC | US$98.7萬 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$96.1萬 | 0.00% |
| RHUMBLINE ADVISERS | US$95.9萬 | 0.00% |
| Engineers Gate Manager LP | US$94.2萬 | 0.01% |
| Mariner, LLC | US$89.1萬 | 0.00% |
| Tema ETFs LLC | US$88.7萬 | 0.06% |
| Tidal Investments LLC | US$88.7萬 | 0.00% |
| Apis Capital Advisors, LLC | US$85.3萬 | 0.13% |
| Creative Planning | US$85.2萬 | 0.00% |
| SUPERSTRING CAPITAL MANAGEMENT LP | US$84.5萬 | 0.60% |
| Swiss National Bank | US$82.8萬 | 0.00% |
| KENNEDY CAPITAL MANAGEMENT LLC | US$73.2萬 | 0.02% |
| ADAR1 Capital Management, LLC | US$71.1萬 | 0.04% |
| GSA CAPITAL PARTNERS LLP | US$61.6萬 | 0.04% |
| HRT FINANCIAL LP | US$54.8萬 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | US$49.3萬 | 0.00% |
| PROFUND ADVISORS LLC | US$44.4萬 | 0.02% |
| MetLife Investment Management, LLC | US$43.8萬 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$43.2萬 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$42.5萬 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | US$41.2萬 | 0.00% |
| Optimize Financial Inc | US$40.0萬 | 0.20% |
| Corient Private Wealth LLC | US$39.6萬 | 0.00% |
| IEQ CAPITAL, LLC | US$39.4萬 | 0.00% |
| Vanguard Global Advisers, LLC | US$38.5萬 | 0.00% |
| XTX Topco Ltd | US$37.4萬 | 0.01% |
| Knott David M Jr | US$34.4萬 | 0.20% |
| Voleon Capital Management LP | US$34.2萬 | 0.01% |
| Brevan Howard Capital Management LP | US$34.2萬 | 0.00% |
| Virtus Investment Advisers, LLC | US$32.5萬 | 0.09% |
| JANE STREET GROUP, LLC | US$32.4萬 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$29.8萬 | 0.00% |
| AlphaCentric Advisors LLC | US$28.6萬 | 0.29% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$28.5萬 | 0.00% |
| Birchview Capital, LP | US$28.4萬 | 0.16% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$27.1萬 | 0.00% |
| Legal & General Group Plc | US$26.6萬 | 0.00% |
| JANUS HENDERSON GROUP PLC | US$26.3萬 | 0.00% |
| SIMPLEX TRADING, LLC | US$25.1萬 | 0.00% |
| SG Americas Securities, LLC | US$22.0萬 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$21.3萬 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$21.2萬 | 0.00% |
| Pale Fire Capital SE | US$20.2萬 | 0.02% |
| MERCER GLOBAL ADVISORS INC /ADV | US$20.0萬 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$18.4萬 | 0.00% |
| Verdad Advisers, LP | US$17.9萬 | 0.20% |
| CWM, LLC | US$17.3萬 | 0.00% |
| GREAT LAKES ADVISORS, LLC | US$16.8萬 | 0.00% |
| Inscription Capital, LLC | US$16.6萬 | 0.02% |
| Quadrature Capital Ltd | US$15.0萬 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$14.9萬 | 0.01% |
| ProShare Advisors LLC | US$14.9萬 | 0.00% |
| State of New Jersey Common Pension Fund D | US$14.3萬 | 0.00% |
| Leonteq Securities AG | US$14.2萬 | 0.01% |
| Quarry LP | US$13.6萬 | 0.02% |
| GROUP ONE TRADING LLC | US$12.6萬 | 0.00% |
| Vanguard Investments Australia, Ltd. | US$10.3萬 | 0.00% |
| FMR LLC | US$10.3萬 | 0.00% |
| KLP KAPITALFORVALTNING AS | US$9.7萬 | 0.00% |
| NISA INVESTMENT ADVISORS, LLC | US$8.2萬 | 0.00% |
| SIGNATUREFD, LLC | US$7.9萬 | 0.00% |
| Ameritas Investment Partners, Inc. | US$6.1萬 | 0.00% |
| Russell Investments Group, Ltd. | US$6.1萬 | 0.00% |
| Tower Research Capital LLC (TRC) | US$5.9萬 | 0.00% |
| ROYAL BANK OF CANADA | US$5.8萬 | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | US$4.4萬 | 0.00% |
| Federation des caisses Desjardins du Quebec | US$2.8萬 | 0.00% |
| Parallel Advisors, LLC | US$2.7萬 | 0.00% |
| Seven Fleet Capital Management LP | US$2.6萬 | 0.01% |
| Sterling Capital Management LLC | US$2.6萬 | 0.00% |
| GAMMA Investing LLC | US$2.5萬 | 0.00% |
| Capital Advisors, Ltd. LLC | US$2.3萬 | 0.00% |
| GF FUND MANAGEMENT CO. LTD. | US$1.9萬 | 0.00% |
| Allworth Financial LP | US$1.6萬 | 0.00% |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | US$1.6萬 | 0.00% |
| EverSource Wealth Advisors, LLC | US$1.6萬 | 0.00% |
| MAI Capital Management | US$1.3萬 | 0.00% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$1.3萬 | 0.00% |
| Bangor Savings Bank | US$1.2萬 | 0.00% |
| Essential Partners LLC | US$1.1萬 | 0.00% |
| QUADRANT CAPITAL GROUP LLC | US$1.1萬 | 0.00% |
| UMB Bank, n.a. | US$9734.0 | 0.00% |
| Rockefeller Capital Management L.P. | US$9222.0 | 0.00% |