| FARALLON CAPITAL MANAGEMENT LLC | US$13.2億 | 7.54% |
| BlackRock, Inc. | US$10.9億 | 0.02% |
| JANUS HENDERSON GROUP PLC | US$9.5億 | 0.45% |
| BAKER BROS. ADVISORS LP | US$9.3億 | 5.34% |
| FMR LLC | US$8.2億 | 0.04% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$8.1億 | 0.02% |
| Nextech Invest, Ltd. | US$7.4億 | 52.02% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$7.3億 | 0.04% |
| Paradigm Biocapital Advisors LP | US$6.5億 | 13.23% |
| WELLINGTON MANAGEMENT GROUP LLP | US$5.9億 | 0.11% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$5.3億 | 0.82% |
| STATE STREET CORP | US$4.3億 | 0.01% |
| UBS Group AG | US$4.3億 | 0.06% |
| GEODE CAPITAL MANAGEMENT, LLC | US$3.2億 | 0.02% |
| Alphabet Inc. | US$3.2億 | 7.97% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$3.1億 | 0.04% |
| BVF INC/IL | US$2.8億 | 8.85% |
| Integral Health Asset Management, LLC | US$2.7億 | 12.79% |
| Casdin Capital, LLC | US$2.5億 | 18.98% |
| Woodline Partners LP | US$2.4億 | 0.92% |
| Holocene Advisors, LP | US$2.4億 | 0.58% |
| Vestal Point Capital, LP | US$2.3億 | 6.46% |
| Avoro Capital Advisors LLC | US$2.3億 | 2.24% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | US$2.2億 | 2.64% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$2.2億 | 0.02% |
| GOLDMAN SACHS GROUP INC | US$2.1億 | 0.02% |
| Darwin Global Management, Ltd. | US$2.0億 | 5.44% |
| Logos Global Management LP | US$1.9億 | 9.71% |
| Alyeska Investment Group, L.P. | US$1.8億 | 0.52% |
| Caligan Partners LP | US$1.8億 | 12.18% |
| NATIONAL BANK OF CANADA /FI/ | US$1.7億 | 0.17% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$1.7億 | 0.03% |
| AMERIPRISE FINANCIAL INC | US$1.5億 | 0.04% |
| TWO SIGMA INVESTMENTS, LP | US$1.5億 | 0.12% |
| WESTFIELD CAPITAL MANAGEMENT CO LP | US$1.5億 | 0.64% |
| Caption Management, LLC | US$1.5億 | 0.88% |
| Bellevue Group AG | US$1.5億 | 3.57% |
| Rock Springs Capital Management LP | US$1.2億 | 6.93% |
| Polar Capital Holdings Plc | US$1.1億 | 0.39% |
| FRANKLIN RESOURCES INC | US$1.1億 | 0.03% |
| VANGUARD FIDUCIARY TRUST CO | US$1.1億 | 0.03% |
| Siren, L.L.C. | US$1.1億 | 3.00% |
| D. E. Shaw & Co., Inc. | US$1.0億 | 0.06% |
| CITADEL ADVISORS LLC | US$9768.3萬 | 0.02% |
| NORTHERN TRUST CORP | US$9280.1萬 | 0.01% |
| a16z Capital Management, L.L.C. | US$8957.7萬 | 6.94% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$8274.0萬 | 1.07% |
| DIMENSIONAL FUND ADVISORS LP | US$8207.2萬 | 0.02% |
| AIHC Capital Management Ltd | US$8061.8萬 | 67.37% |
| MIC Capital Management UK LLP | US$7738.5萬 | 21.95% |
| GENERAL ATLANTIC, L.P. | US$6883.3萬 | 3.20% |
| MORGAN STANLEY | US$6863.8萬 | 0.00% |
| Nearwater Capital Markets, Ltd | US$6593.6萬 | 1.56% |
| Frazier Life Sciences Management, L.P. | US$6571.0萬 | 1.69% |
| T. Rowe Price Investment Management, Inc. | US$6457.9萬 | 0.04% |
| Bank of New York Mellon Corp | US$6178.9萬 | 0.01% |
| WORLDQUANT MILLENNIUM ADVISORS LLC | US$6051.9萬 | 0.23% |
| BANK OF AMERICA CORP /DE/ | US$5972.7萬 | 0.00% |
| DAFNA Capital Management LLC | US$5647.1萬 | 12.85% |
| Candriam S.C.A. | US$5647.1萬 | 0.29% |
| TCG Crossover Management, LLC | US$5606.2萬 | 1.60% |
| Qube Research & Technologies Ltd | US$5380.7萬 | 0.06% |
| Pictet Asset Management Holding SA | US$5359.2萬 | 0.06% |
| Lunate Capital Ltd | US$5339.5萬 | 44.36% |
| MPM BIOIMPACT LLC | US$4928.4萬 | 3.81% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$4868.3萬 | 0.01% |
| Boxer Capital Management, LLC | US$4862.5萬 | 6.38% |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | US$4659.1萬 | 3.95% |
| First Turn Management, LLC | US$4555.0萬 | 5.09% |
| DEUTSCHE BANK AG\ | US$4529.5萬 | 0.01% |
| Swiss National Bank | US$4137.3萬 | 0.02% |
| Invesco Ltd. | US$3820.4萬 | 0.01% |
| BARCLAYS PLC | US$3726.4萬 | 0.01% |
| MILLENNIUM MANAGEMENT LLC | US$3669.6萬 | 0.02% |
| SAMLYN CAPITAL, LLC | US$3617.2萬 | 0.62% |
| ROYAL BANK OF CANADA | US$3615.1萬 | 0.01% |
| JANE STREET GROUP, LLC | US$3599.3萬 | 0.00% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | US$3582.0萬 | 0.14% |
| Mass General Brigham, Inc | US$3346.3萬 | 7.14% |
| Legal & General Group Plc | US$3317.7萬 | 0.01% |
| Nuveen, LLC | US$3312.4萬 | 0.01% |
| LMR Partners LLP | US$3306.5萬 | 0.07% |
| AMERICAN CENTURY COMPANIES INC | US$3263.0萬 | 0.02% |
| TD Asset Management Inc | US$3090.7萬 | 0.03% |
| Defilade Capital Management, L.P. | US$3072.8萬 | 4.31% |
| Duquesne Family Office LLC | US$3071.7萬 | 0.91% |
| JENNISON ASSOCIATES LLC | US$2989.2萬 | 0.02% |
| JPMORGAN CHASE & CO | US$2794.2萬 | 0.00% |
| STEMPOINT CAPITAL LP | US$2791.4萬 | 5.34% |
| California Public Employees Retirement System | US$2742.1萬 | 0.02% |
| Man Group plc | US$2677.0萬 | 0.05% |
| Sumitomo Mitsui Trust Group, Inc. | US$2635.2萬 | 0.02% |
| Melqart Asset Management (UK) Ltd | US$2629.3萬 | 2.59% |
| Checkpoint Capital L.P. | US$2553.2萬 | 9.16% |
| EVENTIDE ASSET MANAGEMENT, LLC | US$2540.5萬 | 0.42% |
| Nicholas Investment Partners, LP | US$2539.8萬 | 1.83% |
| PERCEPTIVE ADVISORS LLC | US$2514.9萬 | 0.49% |
| Ikarian Capital, LLC | US$2510.4萬 | 2.04% |
| Trails Edge Capital Partners, LP | US$2382.6萬 | 5.46% |
| FRONTIER CAPITAL MANAGEMENT CO LLC | US$2371.0萬 | 0.24% |
| Ensign Peak Advisors, Inc | US$2216.7萬 | 0.04% |
| MARSICO CAPITAL MANAGEMENT LLC | US$2134.2萬 | 0.63% |
| MARSHALL WACE, LLP | US$2107.0萬 | 0.02% |
| Fisher Asset Management, LLC | US$2100.1萬 | 0.01% |
| Verition Fund Management LLC | US$2042.3萬 | 0.13% |
| Kynam Capital Management, LP | US$2017.9萬 | 1.24% |
| DIADEMA PARTNERS LP | US$2007.0萬 | 3.41% |
| Affinity Asset Advisors, LLC | US$1945.0萬 | 1.00% |
| Abu Dhabi Investment Council Co P.J.S.C | US$1907.8萬 | 1.96% |
| BAILLIE GIFFORD & CO | US$1819.3萬 | 0.02% |
| RHUMBLINE ADVISERS | US$1749.9萬 | 0.01% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$1607.3萬 | 0.02% |
| Mitsubishi UFJ Asset Management Co., Ltd. | US$1604.5萬 | 0.01% |
| Birnam Oak Advisors, LP | US$1550.3萬 | 3.52% |
| Squarepoint Ops LLC | US$1508.0萬 | 0.02% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$1409.0萬 | 0.03% |
| VICTORY CAPITAL MANAGEMENT INC | US$1386.6萬 | 0.01% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$1374.1萬 | 0.01% |
| PFM Health Sciences, LP | US$1369.0萬 | 1.25% |
| Amundi | US$1347.5萬 | 0.00% |
| PSquared Asset Management AG | US$1344.9萬 | 4.68% |
| RAYMOND JAMES FINANCIAL INC | US$1333.9萬 | 0.00% |
| Tidal Investments LLC | US$1320.6萬 | 0.03% |
| LORD, ABBETT & CO. LLC | US$1305.4萬 | 0.04% |
| ADAR1 Capital Management, LLC | US$1302.1萬 | 0.77% |
| Gotham Asset Management, LLC | US$1224.4萬 | 0.04% |
| Artia Global Partners LP | US$1215.5萬 | 2.43% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$1212.8萬 | 0.02% |
| Balyasny Asset Management L.P. | US$1203.9萬 | 0.02% |
| Eagle Health Investments LP | US$1161.8萬 | 2.03% |
| AQR CAPITAL MANAGEMENT LLC | US$1135.7萬 | 0.01% |
| Aberdeen Group plc | US$1116.1萬 | 0.02% |
| VAN ECK ASSOCIATES CORP | US$1063.6萬 | 0.01% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$1035.7萬 | 0.01% |
| a16z Perennial Management, L.P. | US$1013.5萬 | 0.84% |
| ING GROEP NV | US$1001.7萬 | 0.06% |
| Empyrean Capital Partners, LP | US$995.8萬 | 0.32% |
| WCM INVESTMENT MANAGEMENT, LLC | US$973.4萬 | 0.02% |
| Kite Lake Capital Management (UK) LLP | US$972.5萬 | 7.80% |
| Opaleye Management Inc. | US$972.5萬 | 1.28% |
| Russell Investments Group, Ltd. | US$963.9萬 | 0.01% |
| Tema ETFs LLC | US$954.8萬 | 0.64% |
| Cinctive Capital Management LP | US$912.8萬 | 0.59% |
| Decheng Capital LLC | US$909.3萬 | 1.37% |
| Atle Fund Management AB | US$907.7萬 | 2.93% |
| Connor, Clark & Lunn Investment Management Ltd. | US$892.0萬 | 0.02% |
| CITIGROUP INC | US$872.7萬 | 0.00% |
| CANADA PENSION PLAN INVESTMENT BOARD | US$865.5萬 | 0.01% |
| TUDOR INVESTMENT CORP ET AL | US$854.4萬 | 0.02% |
| BRAIDWELL LP | US$825.7萬 | 0.28% |