| BAKER BROS. ADVISORS LP | US$26.1億 | 15.00% |
| PRIMECAP MANAGEMENT CO/CA/ | US$14.8億 | 1.16% |
| Capital International Investors | US$12.3億 | 0.29% |
| FMR LLC | US$11.0億 | 0.06% |
| Capital World Investors | US$4.8億 | 0.07% |
| CITADEL ADVISORS LLC | US$3.1億 | 0.05% |
| HHLR ADVISORS, LTD. | US$3.1億 | 18.36% |
| Temasek Holdings (Private) Ltd | US$2.6億 | 0.84% |
| BlackRock, Inc. | US$2.0億 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$1.6億 | 0.02% |
| Siren, L.L.C. | US$1.4億 | 3.83% |
| MORGAN STANLEY | US$1.4億 | 0.01% |
| UBS Group AG | US$1.2億 | 0.02% |
| BANK OF AMERICA CORP /DE/ | US$1.2億 | 0.01% |
| Baird Financial Group, Inc. | US$1.0億 | 0.16% |
| Capital International, Inc./CA/ | US$8975.7萬 | 0.69% |
| Candriam S.C.A. | US$7713.2萬 | 0.40% |
| Man Group plc | US$7184.4萬 | 0.13% |
| FIRST TRUST ADVISORS LP | US$7169.6萬 | 0.05% |
| MILLENNIUM MANAGEMENT LLC | US$6083.3萬 | 0.03% |
| FRANKLIN RESOURCES INC | US$5995.3萬 | 0.01% |
| Nuveen, LLC | US$5833.4萬 | 0.02% |
| CAPITAL INTERNATIONAL SARL | US$5163.7萬 | 0.85% |
| MARSHALL WACE, LLP | US$5127.0萬 | 0.05% |
| Driehaus Capital Management LLC | US$4603.1萬 | 0.34% |
| JENNISON ASSOCIATES LLC | US$4587.1萬 | 0.03% |
| M&G PLC | US$4103.4萬 | 0.21% |
| Artisan Partners Limited Partnership | US$4074.9萬 | 0.07% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$3555.5萬 | 0.00% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | US$3284.1萬 | 0.02% |
| JANE STREET GROUP, LLC | US$3257.7萬 | 0.00% |
| VAN ECK ASSOCIATES CORP | US$3216.3萬 | 0.02% |
| GOLDMAN SACHS GROUP INC | US$2871.0萬 | 0.00% |
| Patient Square Capital LP | US$2391.9萬 | 4.24% |
| CAPITAL INTERNATIONAL LTD /CA/ | US$2272.3萬 | 0.84% |
| JPMORGAN CHASE & CO | US$2202.8萬 | 0.00% |
| Squarepoint Ops LLC | US$2201.3萬 | 0.03% |
| ROYAL BANK OF CANADA | US$2090.5萬 | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | US$2004.6萬 | 0.03% |
| BARCLAYS PLC | US$1963.6萬 | 0.00% |
| LAZARD ASSET MANAGEMENT LLC | US$1868.4萬 | 0.03% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | US$1787.5萬 | 0.01% |
| Legal & General Group Plc | US$1777.6萬 | 0.00% |
| ENVESTNET ASSET MANAGEMENT INC | US$1770.3萬 | 0.00% |
| PANAGORA ASSET MANAGEMENT INC | US$1702.2萬 | 0.06% |
| DIMENSIONAL FUND ADVISORS LP | US$1685.9萬 | 0.00% |
| SEB Asset Management AB | US$1665.3萬 | 0.07% |
| WELLS FARGO & COMPANY/MN | US$1546.7萬 | 0.00% |
| ABN AMRO INVESTMENT SOLUTIONS | US$1412.5萬 | 0.18% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$1401.8萬 | 0.01% |
| EDMOND DE ROTHSCHILD HOLDING S.A. | US$1289.7萬 | 0.19% |
| BARINGS LLC | US$1271.5萬 | 0.21% |
| Atle Fund Management AB | US$1213.7萬 | 3.92% |
| CITIGROUP INC | US$1134.1萬 | 0.00% |
| NORTHERN TRUST CORP | US$1073.0萬 | 0.00% |
| Fiera Capital Corp | US$1003.2萬 | 0.03% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$1001.6萬 | 0.01% |
| TWO SIGMA INVESTMENTS, LP | US$996.1萬 | 0.01% |
| OPPENHEIMER ASSET MANAGEMENT INC. | US$966.1萬 | 0.11% |
| NOMURA HOLDINGS INC | US$918.9萬 | 0.03% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | US$910.6萬 | 0.02% |
| ASSETMARK, INC | US$878.1萬 | 0.02% |
| Capital Group Private Client Services, Inc. | US$851.0萬 | 0.14% |
| Slow Capital, Inc. | US$846.1萬 | 1.10% |
| DEUTSCHE BANK AG\ | US$827.9萬 | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | US$810.6萬 | 0.00% |
| AIA Group Ltd | US$774.4萬 | 0.11% |
| Mirae Asset Global Investments Co., Ltd. | US$705.0萬 | 0.00% |
| Russell Investments Group, Ltd. | US$693.3萬 | 0.01% |
| Walleye Capital LLC | US$637.0萬 | 0.03% |
| Asset Management One Co., Ltd. | US$633.9萬 | 0.02% |
| Erste Asset Management GmbH | US$622.1萬 | 0.06% |
| WELLINGTON MANAGEMENT GROUP LLP | US$618.5萬 | 0.00% |
| Invesco Ltd. | US$569.5萬 | 0.00% |
| RAYMOND JAMES FINANCIAL INC | US$568.5萬 | 0.00% |
| CAPITAL GROUP INVESTMENT MANAGEMENT PTE. LTD. | US$495.6萬 | 0.85% |
| Nan Fung Group Holdings Ltd | US$466.9萬 | 3.85% |
| Rokos Capital Management LLP | US$425.6萬 | 0.03% |
| Tidal Investments LLC | US$375.2萬 | 0.01% |
| AMERICAN CENTURY COMPANIES INC | US$366.6萬 | 0.00% |
| Caption Management, LLC | US$365.3萬 | 0.02% |
| GUGGENHEIM CAPITAL LLC | US$363.6萬 | 0.03% |
| ADAR1 Capital Management, LLC | US$347.5萬 | 0.20% |
| STIFEL FINANCIAL CORP | US$340.6萬 | 0.00% |
| ExodusPoint Capital Management, LP | US$326.1萬 | 0.03% |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | US$317.5萬 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$311.4萬 | 0.00% |
| Creative Planning | US$302.9萬 | 0.00% |
| TD Asset Management Inc | US$297.4萬 | 0.00% |
| Pinpoint Asset Management (Singapore) Pte. Ltd. | US$285.4萬 | 0.66% |
| KBC Group NV | US$281.8萬 | 0.01% |
| Quantinno Capital Management LP | US$246.9萬 | 0.00% |
| BANK OF MONTREAL /CAN/ | US$245.7萬 | 0.00% |
| Crossmark Global Holdings, Inc. | US$227.5萬 | 0.03% |
| STATE STREET CORP | US$209.8萬 | 0.00% |
| Rockefeller Capital Management L.P. | US$191.2萬 | 0.00% |
| Jefferies Financial Group Inc. | US$184.1萬 | 0.01% |
| JONES FINANCIAL COMPANIES LLLP | US$183.3萬 | 0.00% |
| MACKENZIE FINANCIAL CORP | US$180.6萬 | 0.00% |
| Long Corridor Asset Management Ltd | US$178.8萬 | 0.43% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$174.1萬 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$168.4萬 | 0.13% |
| XTX Topco Ltd | US$162.3萬 | 0.03% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$157.6萬 | 0.00% |
| PARTNERS CAPITAL INVESTMENT GROUP, LLP | US$152.8萬 | 0.06% |
| LPL Financial LLC | US$151.7萬 | 0.00% |
| WESPAC Advisors SoCal, LLC | US$146.3萬 | 0.31% |
| STOREBRAND ASSET MANAGEMENT AS | US$138.6萬 | 0.00% |
| Bank of New York Mellon Corp | US$137.6萬 | 0.00% |
| MML INVESTORS SERVICES, LLC | US$134.8萬 | 0.00% |
| Havemeyer Place LP | US$132.8萬 | 0.15% |
| Banco Santander, S.A. | US$132.7萬 | 0.01% |
| PROFUND ADVISORS LLC | US$132.0萬 | 0.05% |
| TIAA-CREF INDIVIDUAL & INSTITUTIONAL SERVICES, LLC | US$131.8萬 | 0.01% |
| NEUBERGER BERMAN GROUP LLC | US$129.0萬 | 0.00% |
| SEI INVESTMENTS CO | US$128.3萬 | 0.00% |
| Trexquant Investment LP | US$119.9萬 | 0.01% |
| B. Metzler seel. Sohn & Co. AG | US$114.8萬 | 0.01% |
| Bellevue Group AG | US$113.2萬 | 0.03% |
| True Light Capital Pte. Ltd. | US$103.3萬 | 0.52% |
| Focus Partners Wealth | US$99.0萬 | 0.00% |
| GSA CAPITAL PARTNERS LLP | US$98.9萬 | 0.06% |
| Henshaw Capital LLC | US$95.7萬 | 0.04% |
| Vanguard Personalized Indexing Management, LLC | US$94.5萬 | 0.01% |
| Rodgers Brothers Inc. | US$94.5萬 | 0.11% |
| Qtron Investments LLC | US$94.2萬 | 0.13% |
| PORTLAND INVESTMENT COUNSEL INC. | US$89.1萬 | 0.29% |
| Sanctuary Advisors, LLC | US$88.6萬 | 0.00% |
| &PARTNERS | US$85.9萬 | 0.00% |
| Orion Porfolio Solutions, LLC | US$85.4萬 | 0.01% |
| SANDERS MORRIS HARRIS LLC | US$80.2萬 | 0.13% |
| QUADRANT CAPITAL GROUP LLC | US$79.4萬 | 0.02% |
| Virtus Investment Advisers, LLC | US$78.6萬 | 0.22% |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | US$78.5萬 | 0.00% |
| Perigon Wealth Management, LLC | US$75.3萬 | 0.01% |
| Brooklyn Investment Group | US$74.4萬 | 0.02% |
| Vident Advisory, LLC | US$73.8萬 | 0.01% |
| Callan Family Office, LLC | US$72.0萬 | 0.02% |
| AMERIPRISE FINANCIAL INC | US$71.1萬 | 0.00% |
| Cetera Investment Advisers | US$70.4萬 | 0.00% |
| KAYNE ANDERSON RUDNICK INVESTMENT MANAGEMENT LLC | US$67.7萬 | 0.00% |
| SG Americas Securities, LLC | US$65.2萬 | 0.00% |
| Cerity Partners LLC | US$64.9萬 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$63.5萬 | 0.00% |
| SECTORAL ASSET MANAGEMENT INC | US$63.1萬 | 0.52% |
| TD Waterhouse Canada Inc. | US$62.7萬 | 0.00% |
| Laird Norton Wetherby Trust Company, LLC | US$62.7萬 | 0.01% |
| FOX RUN MANAGEMENT, L.L.C. | US$60.7萬 | 0.11% |
| VOYA INVESTMENT MANAGEMENT LLC | US$60.0萬 | 0.00% |
| COMMONWEALTH EQUITY SERVICES, LLC | US$55.2萬 | 0.00% |