| Frazier Life Sciences Management, L.P. | US$2.0億 | 5.11% |
| ORBIMED ADVISORS LLC | US$1.1億 | 2.23% |
| NEA Management Company, LLC | US$1.1億 | 6.13% |
| WELLINGTON MANAGEMENT GROUP LLP | US$9527.6萬 | 0.02% |
| BlackRock, Inc. | US$8780.1萬 | 0.00% |
| FMR LLC | US$8766.0萬 | 0.00% |
| Deep Track Capital, LP | US$8231.3萬 | 1.34% |
| NVP ASSOCIATES, LLC | US$6377.0萬 | 36.20% |
| Polar Capital Holdings Plc | US$4842.2萬 | 0.17% |
| BRAIDWELL LP | US$4455.0萬 | 1.49% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$4410.6萬 | 0.00% |
| Aaron Wealth Advisors LLC | US$3487.0萬 | 1.98% |
| Cormorant Asset Management, LP | US$3343.2萬 | 1.68% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$3071.7萬 | 0.00% |
| Driehaus Capital Management LLC | US$3039.4萬 | 0.22% |
| CITADEL ADVISORS LLC | US$2889.6萬 | 0.00% |
| Kynam Capital Management, LP | US$2790.4萬 | 1.72% |
| Woodline Partners LP | US$2686.7萬 | 0.10% |
| EVENTIDE ASSET MANAGEMENT, LLC | US$2656.7萬 | 0.44% |
| Caligan Partners LP | US$2533.0萬 | 1.69% |
| Parkman Healthcare Partners LLC | US$2388.1萬 | 2.46% |
| STATE STREET CORP | US$2349.8萬 | 0.00% |
| EcoR1 Capital, LLC | US$2319.3萬 | 0.98% |
| GEODE CAPITAL MANAGEMENT, LLC | US$2001.6萬 | 0.00% |
| TCG Crossover Management, LLC | US$1940.3萬 | 0.56% |
| MILLENNIUM MANAGEMENT LLC | US$1684.8萬 | 0.01% |
| STEMPOINT CAPITAL LP | US$1490.9萬 | 2.85% |
| GOLDMAN SACHS GROUP INC | US$1367.0萬 | 0.00% |
| UBS Group AG | US$1035.5萬 | 0.00% |
| Candriam S.C.A. | US$878.7萬 | 0.05% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$875.5萬 | 0.00% |
| D. E. Shaw & Co., Inc. | US$862.3萬 | 0.01% |
| Rock Springs Capital Management LP | US$859.6萬 | 0.51% |
| Opaleye Management Inc. | US$776.1萬 | 1.02% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$641.5萬 | 0.00% |
| Elmind Capital, LP | US$629.8萬 | 1.79% |
| NORTHERN TRUST CORP | US$628.6萬 | 0.00% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$621.0萬 | 0.08% |
| Soleus Capital Management, L.P. | US$534.0萬 | 0.22% |
| DAFNA Capital Management LLC | US$523.8萬 | 1.19% |
| VANGUARD FIDUCIARY TRUST CO | US$507.9萬 | 0.00% |
| Goelzer Investment Management, Inc. | US$490.1萬 | 0.24% |
| Affinity Asset Advisors, LLC | US$447.8萬 | 0.23% |
| Tetragon Partners GP Ltd | US$434.3萬 | 0.84% |
| JPMORGAN CHASE & CO | US$395.9萬 | 0.00% |
| Schonfeld Strategic Advisors LLC | US$369.6萬 | 0.03% |
| KVP Capital Advisors, LP | US$362.7萬 | 2.71% |
| TD Asset Management Inc | US$346.3萬 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$343.5萬 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$305.6萬 | 0.00% |
| Burkehill Global Management, LP | US$298.5萬 | 0.15% |
| Squarepoint Ops LLC | US$290.2萬 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$270.5萬 | 0.00% |
| Nuveen, LLC | US$244.1萬 | 0.00% |
| Bank of New York Mellon Corp | US$239.5萬 | 0.00% |
| PFM Health Sciences, LP | US$214.6萬 | 0.20% |
| VICTORY CAPITAL MANAGEMENT INC | US$212.0萬 | 0.00% |
| MARSHALL WACE, LLP | US$187.2萬 | 0.00% |
| XTX Topco Ltd | US$158.8萬 | 0.03% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$154.3萬 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | US$139.6萬 | 0.00% |
| Swiss National Bank | US$132.5萬 | 0.00% |
| PLATINUM INVESTMENT MANAGEMENT LTD | US$130.1萬 | 0.33% |
| JANE STREET GROUP, LLC | US$124.8萬 | 0.00% |
| ALPS ADVISORS INC | US$109.1萬 | 0.01% |
| ALGERT GLOBAL LLC | US$107.5萬 | 0.02% |
| Creative Planning | US$107.4萬 | 0.00% |
| EXCHANGE TRADED CONCEPTS, LLC | US$102.3萬 | 0.01% |
| RHUMBLINE ADVISERS | US$101.1萬 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | US$96.2萬 | 0.00% |
| MORGAN STANLEY | US$94.2萬 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$85.8萬 | 0.00% |
| ExodusPoint Capital Management, LP | US$83.8萬 | 0.01% |
| Invesco Ltd. | US$82.2萬 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$81.8萬 | 0.00% |
| DEUTSCHE BANK AG\ | US$68.5萬 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$68.0萬 | 0.00% |
| Swiss Life Asset Management Ltd | US$65.7萬 | 0.00% |
| Cerity Partners LLC | US$63.2萬 | 0.00% |
| Legal & General Group Plc | US$57.8萬 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$57.5萬 | 0.00% |
| Koa Wealth Management, LLC | US$53.5萬 | 0.39% |
| Engineers Gate Manager LP | US$51.9萬 | 0.01% |
| Qube Research & Technologies Ltd | US$51.3萬 | 0.00% |
| Vanguard Global Advisers, LLC | US$47.8萬 | 0.00% |
| MetLife Investment Management, LLC | US$47.8萬 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$44.0萬 | 0.00% |
| Optimize Financial Inc | US$43.3萬 | 0.21% |
| CITIGROUP INC | US$40.3萬 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$39.8萬 | 0.00% |
| Jump Financial, LLC | US$37.9萬 | 0.01% |
| BARCLAYS PLC | US$35.3萬 | 0.00% |
| HighVista Strategies LLC | US$34.2萬 | 0.09% |
| CANADA PENSION PLAN INVESTMENT BOARD | US$32.5萬 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$32.1萬 | 0.00% |
| JANUS HENDERSON GROUP PLC | US$30.8萬 | 0.00% |
| Verition Fund Management LLC | US$30.5萬 | 0.00% |
| Aquatic Capital Management LLC | US$30.3萬 | 0.01% |
| Virtus Investment Advisers, LLC | US$27.3萬 | 0.08% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$26.9萬 | 0.00% |
| ACT CAPITAL MANAGEMENT, LLC | US$26.9萬 | 0.21% |
| SEI INVESTMENTS CO | US$26.8萬 | 0.00% |
| Tidal Investments LLC | US$26.5萬 | 0.00% |
| Tema ETFs LLC | US$26.5萬 | 0.02% |
| ACADIAN ASSET MANAGEMENT LLC | US$26.2萬 | 0.00% |
| AMERICAN CENTURY COMPANIES INC | US$26.0萬 | 0.00% |
| PROFUND ADVISORS LLC | US$25.0萬 | 0.01% |
| China Universal Asset Management Co., Ltd. | US$23.8萬 | 0.02% |
| Orion Porfolio Solutions, LLC | US$23.7萬 | 0.00% |
| State of New Jersey Common Pension Fund D | US$22.9萬 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$22.4萬 | 0.00% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | US$22.4萬 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$21.6萬 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$20.4萬 | 0.00% |
| GROUP ONE TRADING LLC | US$18.7萬 | 0.00% |
| Vanguard Investments Australia, Ltd. | US$18.2萬 | 0.00% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | US$16.7萬 | 0.00% |
| KLP KAPITALFORVALTNING AS | US$14.6萬 | 0.00% |
| Russell Investments Group, Ltd. | US$11.5萬 | 0.00% |
| SG Americas Securities, LLC | US$10.1萬 | 0.00% |
| Rockefeller Capital Management L.P. | US$9.6萬 | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | US$7.0萬 | 0.00% |
| Ameritas Investment Partners, Inc. | US$6.9萬 | 0.00% |
| Cygnus Capital Advisors, LLC | US$5.4萬 | 0.04% |
| CWM, LLC | US$5.3萬 | 0.00% |
| STRS OHIO | US$4.8萬 | 0.00% |
| NISA INVESTMENT ADVISORS, LLC | US$4.8萬 | 0.00% |
| Tower Research Capital LLC (TRC) | US$4.2萬 | 0.00% |
| SIMPLEX TRADING, LLC | US$3.9萬 | 0.00% |
| GF FUND MANAGEMENT CO. LTD. | US$3.0萬 | 0.00% |
| Sterling Capital Management LLC | US$2.8萬 | 0.00% |
| KBC Group NV | US$2.4萬 | 0.00% |
| ROYAL BANK OF CANADA | US$2.2萬 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$1.4萬 | 0.00% |
| GAMMA Investing LLC | US$8925.0 | 0.00% |
| US BANCORP \DE\ | US$8477.0 | 0.00% |
| OSAIC HOLDINGS, INC. | US$8029.0 | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | US$6178.0 | 0.00% |
| SIGNATUREFD, LLC | US$5343.0 | 0.00% |
| FIL Ltd | US$5313.0 | 0.00% |
| Physician Wealth Advisors, Inc. | US$3254.0 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | US$3099.6 | 0.00% |
| JONES FINANCIAL COMPANIES LLLP | US$2280.0 | 0.00% |
| Allworth Financial LP | US$2090.0 | 0.00% |
| Parallel Advisors, LLC | US$1821.0 | 0.00% |
| Larson Financial Group LLC | US$1463.0 | 0.00% |
| Cornerstone Financial Management LLC | US$1015.0 | 0.00% |
| EverSource Wealth Advisors, LLC | US$746.0 | 0.00% |
| ROTHSCHILD INVESTMENT LLC | US$716.0 | 0.00% |
| Versant Capital Management, Inc | US$716.0 | 0.00% |