| RTW INVESTMENTS, LP | US$4.7億 | 4.70% |
| T. Rowe Price Investment Management, Inc. | US$4.5億 | 0.31% |
| Decheng Capital LLC | US$4.3億 | 65.21% |
| WELLINGTON MANAGEMENT GROUP LLP | US$3.6億 | 0.07% |
| BlackRock, Inc. | US$3.4億 | 0.01% |
| FMR LLC | US$2.5億 | 0.01% |
| TCG Crossover Management, LLC | US$2.5億 | 7.11% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$2.5億 | 0.03% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$2.1億 | 0.01% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$2.1億 | 0.01% |
| Caption Management, LLC | US$1.9億 | 1.09% |
| STATE STREET CORP | US$1.8億 | 0.01% |
| Foresite Capital Management VI LLC | US$1.5億 | 32.67% |
| GEODE CAPITAL MANAGEMENT, LLC | US$1.1億 | 0.01% |
| FRANKLIN RESOURCES INC | US$1.0億 | 0.02% |
| BANK OF AMERICA CORP /DE/ | US$9809.3萬 | 0.01% |
| DV Trading LLC | US$9741.8萬 | 2.31% |
| UBS Group AG | US$8879.5萬 | 0.01% |
| Avidity Partners Management LP | US$8723.6萬 | 17.67% |
| GOLDMAN SACHS GROUP INC | US$7845.7萬 | 0.01% |
| ACORN CAPITAL ADVISORS, LLC | US$7658.0萬 | 21.77% |
| EcoR1 Capital, LLC | US$7458.3萬 | 3.17% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$7207.7萬 | 0.01% |
| Foresite Capital Management V, LLC | US$6795.4萬 | 25.08% |
| Driehaus Capital Management LLC | US$6765.4萬 | 0.50% |
| BRAIDWELL LP | US$6665.0萬 | 2.22% |
| ORBIMED ADVISORS LLC | US$6417.9萬 | 1.32% |
| Caligan Partners LP | US$6091.2萬 | 4.05% |
| ALLIANCEBERNSTEIN L.P. | US$5356.4萬 | 0.02% |
| Clearbridge Investments, LLC | US$4942.6萬 | 0.04% |
| Polar Capital Holdings Plc | US$4767.8萬 | 0.17% |
| FARALLON CAPITAL MANAGEMENT LLC | US$4561.6萬 | 0.26% |
| Logos Global Management LP | US$3891.6萬 | 1.94% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$3670.8萬 | 0.01% |
| Candriam S.C.A. | US$3668.5萬 | 0.19% |
| JPMORGAN CHASE & CO | US$3579.1萬 | 0.00% |
| MORGAN STANLEY | US$3520.8萬 | 0.00% |
| NORTHERN TRUST CORP | US$3517.1萬 | 0.00% |
| Woodline Partners LP | US$3335.9萬 | 0.13% |
| JENNISON ASSOCIATES LLC | US$3222.5萬 | 0.02% |
| VANGUARD FIDUCIARY TRUST CO | US$3182.7萬 | 0.01% |
| Fisher Asset Management, LLC | US$3147.3萬 | 0.01% |
| Ensign Peak Advisors, Inc | US$3086.3萬 | 0.06% |
| DIMENSIONAL FUND ADVISORS LP | US$2968.9萬 | 0.01% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$2928.5萬 | 0.00% |
| Point72 Asset Management, L.P. | US$2878.4萬 | 0.04% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$2706.2萬 | 0.04% |
| Pictet Asset Management Holding SA | US$2693.7萬 | 0.03% |
| EVENTIDE ASSET MANAGEMENT, LLC | US$2502.7萬 | 0.41% |
| LORD, ABBETT & CO. LLC | US$2302.5萬 | 0.08% |
| FIRST TRUST ADVISORS LP | US$2255.0萬 | 0.02% |
| AMERIPRISE FINANCIAL INC | US$2108.4萬 | 0.00% |
| Elmind Capital, LP | US$1974.9萬 | 5.61% |
| TD Asset Management Inc | US$1954.3萬 | 0.02% |
| CITADEL ADVISORS LLC | US$1812.6萬 | 0.00% |
| TimesSquare Capital Management, LLC | US$1717.1萬 | 0.29% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$1549.2萬 | 0.20% |
| STEMPOINT CAPITAL LP | US$1391.6萬 | 2.66% |
| HSBC HOLDINGS PLC | US$1270.8萬 | 0.01% |
| ArrowMark Colorado Holdings LLC | US$1261.0萬 | 0.34% |
| ADAR1 Capital Management, LLC | US$1256.8萬 | 0.74% |
| Bank of New York Mellon Corp | US$1130.5萬 | 0.00% |
| SILVERARC CAPITAL MANAGEMENT, LLC | US$1125.9萬 | 1.15% |
| PFM Health Sciences, LP | US$1123.0萬 | 1.02% |
| Russell Investments Group, Ltd. | US$1104.4萬 | 0.01% |
| DEUTSCHE BANK AG\ | US$1058.9萬 | 0.00% |
| FEDERATED HERMES, INC. | US$1006.7萬 | 0.02% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$999.9萬 | 0.01% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$975.3萬 | 0.02% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | US$926.1萬 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$924.1萬 | 0.01% |
| Nuveen, LLC | US$869.1萬 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$773.9萬 | 0.00% |
| Rosalind Advisors, Inc. | US$676.8萬 | 2.72% |
| Opaleye Management Inc. | US$641.6萬 | 0.85% |
| Invesco Ltd. | US$622.6萬 | 0.00% |
| JANE STREET GROUP, LLC | US$617.2萬 | 0.00% |
| Swiss National Bank | US$571.2萬 | 0.00% |
| Seven Fleet Capital Management LP | US$512.7萬 | 1.63% |
| RHUMBLINE ADVISERS | US$481.1萬 | 0.00% |
| ALPS ADVISORS INC | US$465.2萬 | 0.02% |
| Rafferty Asset Management, LLC | US$460.1萬 | 0.02% |
| PICTON MAHONEY ASSET MANAGEMENT | US$456.2萬 | 0.03% |
| Blackstone Inc. | US$434.0萬 | 0.02% |
| Tema ETFs LLC | US$427.5萬 | 0.29% |
| Tidal Investments LLC | US$427.5萬 | 0.01% |
| Affinity Asset Advisors, LLC | US$406.1萬 | 0.21% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$390.7萬 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | US$387.7萬 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$348.5萬 | 0.00% |
| Aquatic Capital Management LLC | US$335.9萬 | 0.10% |
| Nantahala Capital Management, LLC | US$334.7萬 | 0.12% |
| D. E. Shaw & Co., Inc. | US$315.5萬 | 0.00% |
| Informed Momentum Co LLC | US$312.0萬 | 0.36% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$306.9萬 | 0.00% |
| SummitTX Capital, L.P. | US$274.6萬 | 0.09% |
| Legal & General Group Plc | US$257.2萬 | 0.00% |
| MetLife Investment Management, LLC | US$220.7萬 | 0.01% |
| Lynx1 Capital Management LP | US$213.8萬 | 0.34% |
| PROFUND ADVISORS LLC | US$207.7萬 | 0.08% |
| Vanguard Global Advisers, LLC | US$204.8萬 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$195.9萬 | 0.00% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | US$187.8萬 | 0.01% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$181.7萬 | 0.00% |
| Cinctive Capital Management LP | US$169.3萬 | 0.11% |
| Sicart Associates LLC | US$169.2萬 | 0.43% |
| SG Americas Securities, LLC | US$166.7萬 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$166.5萬 | 0.00% |
| Knights of Columbus Asset Advisors LLC | US$157.0萬 | 0.09% |
| WESBANCO BANK INC | US$150.9萬 | 0.04% |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | US$147.4萬 | 0.00% |
| Handelsbanken Fonder AB | US$140.1萬 | 0.00% |
| AMI ASSET MANAGEMENT CORP | US$136.2萬 | 0.09% |
| Soleus Capital Management, L.P. | US$135.4萬 | 0.05% |
| MILLENNIUM MANAGEMENT LLC | US$135.4萬 | 0.00% |
| HighVista Strategies LLC | US$134.8萬 | 0.37% |
| ALGERT GLOBAL LLC | US$131.2萬 | 0.02% |
| JANUS HENDERSON GROUP PLC | US$125.3萬 | 0.00% |
| SEI INVESTMENTS CO | US$122.5萬 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$120.4萬 | 0.00% |
| Creative Planning | US$113.9萬 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$111.6萬 | 0.01% |
| Police & Firemen's Retirement System of New Jersey | US$109.7萬 | 0.01% |
| China Universal Asset Management Co., Ltd. | US$101.4萬 | 0.08% |
| State of New Jersey Common Pension Fund D | US$98.9萬 | 0.00% |
| Bridgefront Capital, LLC | US$97.5萬 | 0.24% |
| CITIGROUP INC | US$96.1萬 | 0.00% |
| Balyasny Asset Management L.P. | US$95.9萬 | 0.00% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$87.2萬 | 0.00% |
| Voleon Capital Management LP | US$87.1萬 | 0.02% |
| ProShare Advisors LLC | US$83.6萬 | 0.00% |
| Allianz Asset Management GmbH | US$83.2萬 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | US$79.5萬 | 0.00% |
| Persistent Asset Partners Ltd | US$78.8萬 | 0.29% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$78.6萬 | 0.00% |
| Brevan Howard Capital Management LP | US$78.5萬 | 0.01% |
| BARCLAYS PLC | US$77.8萬 | 0.00% |
| ROYAL BANK OF CANADA | US$77.4萬 | 0.00% |
| SBI Okasan Asset Management Co.Ltd. | US$77.4萬 | 0.03% |
| PDT Partners, LLC | US$75.7萬 | 0.04% |
| RAYMOND JAMES FINANCIAL INC | US$75.1萬 | 0.00% |
| Vanguard Investments Australia, Ltd. | US$74.4萬 | 0.00% |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | US$71.3萬 | 0.00% |
| PRUDENTIAL FINANCIAL INC | US$65.6萬 | 0.00% |
| KLP KAPITALFORVALTNING AS | US$64.3萬 | 0.00% |
| E Fund Management Co., Ltd. | US$59.4萬 | 0.02% |
| Eleva Capital SAS | US$56.1萬 | 0.16% |
| Tower Research Capital LLC (TRC) | US$56.1萬 | 0.01% |
| Jackson Creek Investment Advisors LLC | US$52.9萬 | 0.16% |
| Hudson Bay Capital Management LP | US$50.6萬 | 0.00% |