| BlackRock, Inc. | US$11.2億 | 0.02% |
| Dodge & Cox | US$8.2億 | 0.45% |
| PRIMECAP MANAGEMENT CO/CA/ | US$8.0億 | 0.63% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$4.9億 | 0.01% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$4.7億 | 0.02% |
| AQR CAPITAL MANAGEMENT LLC | US$4.3億 | 0.20% |
| STATE STREET CORP | US$4.1億 | 0.01% |
| VIKING GLOBAL INVESTORS LP | US$4.0億 | 1.12% |
| CITADEL ADVISORS LLC | US$2.7億 | 0.04% |
| GEODE CAPITAL MANAGEMENT, LLC | US$2.2億 | 0.01% |
| DIMENSIONAL FUND ADVISORS LP | US$2.1億 | 0.04% |
| Vestal Point Capital, LP | US$2.0億 | 5.65% |
| FMR LLC | US$2.0億 | 0.01% |
| Capital Research Global Investors | US$2.0億 | 0.03% |
| MILLENNIUM MANAGEMENT LLC | US$1.7億 | 0.07% |
| UBS Group AG | US$1.1億 | 0.02% |
| Assenagon Asset Management S.A. | US$1.1億 | 0.16% |
| FIRST TRUST ADVISORS LP | US$9447.9萬 | 0.07% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$8968.8萬 | 0.01% |
| NORTHERN TRUST CORP | US$8961.5萬 | 0.01% |
| Balyasny Asset Management L.P. | US$7698.2萬 | 0.10% |
| MORGAN STANLEY | US$7466.1萬 | 0.00% |
| Point72 Asset Management, L.P. | US$7339.2萬 | 0.09% |
| Jones Hill Capital LP | US$7165.1萬 | 15.36% |
| DNB Asset Management AS | US$6899.6萬 | 0.25% |
| VANGUARD FIDUCIARY TRUST CO | US$6745.6萬 | 0.02% |
| Pictet Asset Management Holding SA | US$6710.4萬 | 0.07% |
| AMERIPRISE FINANCIAL INC | US$6629.2萬 | 0.02% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$6626.9萬 | 0.01% |
| Deep Track Capital, LP | US$6496.4萬 | 1.06% |
| Bank of New York Mellon Corp | US$6467.5萬 | 0.01% |
| RENAISSANCE TECHNOLOGIES LLC | US$5789.5萬 | 0.09% |
| Hudson Bay Capital Management LP | US$5506.5萬 | 0.19% |
| Caisse de depot et placement du Quebec | US$5341.7萬 | 0.09% |
| BANK OF AMERICA CORP /DE/ | US$5292.8萬 | 0.00% |
| FRANKLIN RESOURCES INC | US$5275.5萬 | 0.01% |
| River Road Asset Management, LLC | US$5183.6萬 | 0.59% |
| LSV ASSET MANAGEMENT | US$4998.2萬 | 0.11% |
| JANUS HENDERSON GROUP PLC | US$4841.0萬 | 0.02% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | US$4810.4萬 | 0.57% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$4806.3萬 | 0.01% |
| Swedbank AB | US$4475.1萬 | 0.05% |
| Sofinnova Investments, Inc. | US$4417.4萬 | 1.68% |
| WELLINGTON MANAGEMENT GROUP LLP | US$4047.6萬 | 0.01% |
| FORT WASHINGTON INVESTMENT ADVISORS INC /OH/ | US$4036.4萬 | 0.22% |
| LOOMIS SAYLES & CO L P | US$4032.2萬 | 0.05% |
| Nuveen, LLC | US$3983.7萬 | 0.01% |
| Qube Research & Technologies Ltd | US$3896.2萬 | 0.04% |
| EDMOND DE ROTHSCHILD HOLDING S.A. | US$3875.4萬 | 0.56% |
| Palo Alto Investors LP | US$3870.6萬 | 5.92% |
| NOVO HOLDINGS A/S | US$3728.3萬 | 3.02% |
| Soleus Capital Management, L.P. | US$3675.1萬 | 1.49% |
| Thrivent Financial for Lutherans | US$3545.9萬 | 0.07% |
| Freestone Grove Partners LP | US$3424.4萬 | 0.24% |
| Russell Investments Group, Ltd. | US$3423.8萬 | 0.04% |
| Legal & General Group Plc | US$3249.2萬 | 0.01% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$3245.1萬 | 0.04% |
| BOONE CAPITAL MANAGEMENT LLC | US$3094.9萬 | 9.48% |
| Robeco Institutional Asset Management B.V. | US$3079.5萬 | 0.04% |
| JPMORGAN CHASE & CO | US$3056.4萬 | 0.00% |
| Krensavage Asset Management, LLC | US$2964.5萬 | 11.59% |
| RHUMBLINE ADVISERS | US$2949.5萬 | 0.03% |
| Eagle Health Investments LP | US$2857.3萬 | 5.00% |
| BRAIDWELL LP | US$2807.7萬 | 0.94% |
| California Public Employees Retirement System | US$2772.0萬 | 0.02% |
| Jefferies Financial Group Inc. | US$2644.6萬 | 0.18% |
| CITIGROUP INC | US$2564.1萬 | 0.01% |
| MACKENZIE FINANCIAL CORP | US$2493.7萬 | 0.03% |
| Rubric Capital Management LP | US$2488.7萬 | 0.26% |
| Engineers Gate Manager LP | US$2467.8萬 | 0.31% |
| PRINCIPAL FINANCIAL GROUP INC | US$2421.2萬 | 0.01% |
| Invesco Ltd. | US$2369.3萬 | 0.00% |
| DEUTSCHE BANK AG\ | US$2323.4萬 | 0.01% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | US$2301.3萬 | 0.09% |
| Walleye Capital LLC | US$2279.6萬 | 0.09% |
| IEQ CAPITAL, LLC | US$2268.7萬 | 0.11% |
| Allianz Asset Management GmbH | US$2259.7萬 | 0.02% |
| GOLDMAN SACHS GROUP INC | US$2144.3萬 | 0.00% |
| Rockefeller Capital Management L.P. | US$2102.5萬 | 0.04% |
| Swiss National Bank | US$2039.9萬 | 0.01% |
| Squarepoint Ops LLC | US$2032.0萬 | 0.02% |
| RAYMOND JAMES FINANCIAL INC | US$1871.9萬 | 0.01% |
| LAZARD ASSET MANAGEMENT LLC | US$1840.7萬 | 0.03% |
| LMR Partners LLP | US$1835.6萬 | 0.04% |
| Man Group plc | US$1749.3萬 | 0.03% |
| SEB Asset Management AB | US$1656.7萬 | 0.07% |
| D. E. Shaw & Co., Inc. | US$1595.6萬 | 0.01% |
| DekaBank Deutsche Girozentrale | US$1591.4萬 | 0.03% |
| Mariner, LLC | US$1518.9萬 | 0.02% |
| C WorldWide Group Holding A/S | US$1513.1萬 | 0.32% |
| Caption Management, LLC | US$1495.9萬 | 0.09% |
| Cerity Partners LLC | US$1487.9萬 | 0.02% |
| ALLIANCEBERNSTEIN L.P. | US$1474.8萬 | 0.00% |
| SYSTEMATIC FINANCIAL MANAGEMENT LP | US$1442.5萬 | 0.33% |
| SEI INVESTMENTS CO | US$1420.6萬 | 0.01% |
| Motley Fool Wealth Management, LLC | US$1400.3萬 | 1.58% |
| EASTERLY INVESTMENT PARTNERS LLC | US$1389.1萬 | 1.06% |
| SECTOR GAMMA AS | US$1355.3萬 | 3.20% |
| Retirement Systems of Alabama | US$1330.5萬 | 0.04% |
| CANADA PENSION PLAN INVESTMENT BOARD | US$1297.0萬 | 0.01% |
| M&G PLC | US$1268.6萬 | 0.07% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$1213.7萬 | 0.01% |
| CIBC Bancorp USA Inc. | US$1173.8萬 | 0.02% |
| Eversept Partners, LP | US$1173.7萬 | 0.62% |
| Rhenman & Partners Asset Management AB | US$1169.3萬 | 1.44% |
| Bridgewater Associates, LP | US$1168.8萬 | 0.05% |
| CAPITAL FUND MANAGEMENT S.A. | US$1102.5萬 | 0.05% |
| Sio Capital Management, LLC | US$1097.2萬 | 1.57% |
| Amundi | US$1065.0萬 | 0.00% |
| VAN ECK ASSOCIATES CORP | US$1027.5萬 | 0.01% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$995.9萬 | 0.00% |
| Gotham Asset Management, LLC | US$983.4萬 | 0.03% |
| Redmile Group, LLC | US$982.1萬 | 0.65% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$973.2萬 | 0.01% |
| ALGERT GLOBAL LLC | US$941.0萬 | 0.14% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | US$924.2萬 | 0.02% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$917.2萬 | 0.02% |
| FEDERATED HERMES, INC. | US$915.7萬 | 0.01% |
| CWM, LLC | US$901.9萬 | 0.02% |
| DIADEMA PARTNERS LP | US$837.3萬 | 1.42% |
| HSBC HOLDINGS PLC | US$836.1萬 | 0.00% |
| SG Americas Securities, LLC | US$830.2萬 | 0.01% |
| PEREGRINE CAPITAL MANAGEMENT LLC | US$830.0萬 | 0.31% |
| JANE STREET GROUP, LLC | US$814.2萬 | 0.00% |
| Covea Finance | US$793.7萬 | 0.28% |
| SPHERA FUNDS MANAGEMENT LTD. | US$790.3萬 | 1.26% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$755.6萬 | 0.01% |
| Illinois Municipal Retirement Fund | US$750.7萬 | 0.10% |
| KBC Group NV | US$718.5萬 | 0.02% |
| BARCLAYS PLC | US$693.9萬 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$689.1萬 | 0.02% |
| PRUDENTIAL FINANCIAL INC | US$677.7萬 | 0.01% |
| AMERICAN CENTURY COMPANIES INC | US$654.6萬 | 0.00% |
| Creative Planning | US$638.9萬 | 0.00% |
| NORDEA INVESTMENT MANAGEMENT AB | US$632.4萬 | 0.01% |
| CANADA LIFE ASSURANCE Co | US$631.3萬 | 0.01% |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | US$615.9萬 | 0.01% |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | US$595.7萬 | 0.01% |
| RICE HALL JAMES & ASSOCIATES, LLC | US$591.2萬 | 0.33% |
| Continuum Advisory, LLC | US$590.5萬 | 0.57% |
| VICTORY CAPITAL MANAGEMENT INC | US$582.8萬 | 0.00% |
| Walleye Trading LLC | US$568.3萬 | 0.01% |
| MetLife Investment Management, LLC | US$567.5萬 | 0.03% |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | US$564.2萬 | 0.01% |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | US$553.8萬 | 0.06% |
| Vanguard Global Advisers, LLC | US$550.6萬 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$542.3萬 | 0.01% |
| XTX Topco Ltd | US$528.8萬 | 0.09% |
| Privium Fund Management B.V. | US$521.4萬 | 1.09% |
| State of Tennessee, Department of Treasury | US$515.5萬 | 0.02% |