| FMR LLC | US$8.5億 | 0.04% |
| Siren, L.L.C. | US$5.3億 | 14.75% |
| Redmile Group, LLC | US$4.5億 | 29.51% |
| BlackRock, Inc. | US$3.7億 | 0.01% |
| SAMSARA BIOCAPITAL, LLC | US$3.4億 | 32.95% |
| WELLINGTON MANAGEMENT GROUP LLP | US$3.3億 | 0.06% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$3.1億 | 0.04% |
| Orbis Allan Gray Ltd | US$2.1億 | 0.87% |
| STATE STREET CORP | US$2.0億 | 0.01% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$1.9億 | 0.00% |
| Bellevue Group AG | US$1.8億 | 4.19% |
| JENNISON ASSOCIATES LLC | US$1.6億 | 0.11% |
| JANUS HENDERSON GROUP PLC | US$1.1億 | 0.05% |
| EVENTIDE ASSET MANAGEMENT, LLC | US$1.1億 | 1.78% |
| GEODE CAPITAL MANAGEMENT, LLC | US$1.1億 | 0.01% |
| Hood River Capital Management LLC | US$1.0億 | 1.01% |
| Polar Capital Holdings Plc | US$9751.5萬 | 0.35% |
| Driehaus Capital Management LLC | US$9439.9萬 | 0.69% |
| Holocene Advisors, LP | US$9295.8萬 | 0.22% |
| Woodline Partners LP | US$7376.3萬 | 0.28% |
| GOLDMAN SACHS GROUP INC | US$6939.8萬 | 0.01% |
| BANK OF AMERICA CORP /DE/ | US$6570.9萬 | 0.00% |
| Vestal Point Capital, LP | US$6510.9萬 | 1.82% |
| Paradigm Biocapital Advisors LP | US$6027.4萬 | 1.23% |
| Capital World Investors | US$5548.9萬 | 0.01% |
| MARSHALL WACE, LLP | US$5212.3萬 | 0.05% |
| STEMPOINT CAPITAL LP | US$5149.3萬 | 9.86% |
| CITADEL ADVISORS LLC | US$4849.6萬 | 0.01% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$4827.1萬 | 0.06% |
| Pictet Asset Management Holding SA | US$4301.9萬 | 0.05% |
| FEDERATED HERMES, INC. | US$3922.5萬 | 0.06% |
| NORTHERN TRUST CORP | US$3754.9萬 | 0.00% |
| Rock Springs Capital Management LP | US$3636.9萬 | 2.14% |
| VOYA INVESTMENT MANAGEMENT LLC | US$3566.1萬 | 0.04% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$3548.1萬 | 0.00% |
| Ensign Peak Advisors, Inc | US$3526.0萬 | 0.07% |
| AMERICAN CENTURY COMPANIES INC | US$3476.1萬 | 0.02% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$3446.2萬 | 0.01% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$3441.2萬 | 0.05% |
| JANE STREET GROUP, LLC | US$3423.4萬 | 0.00% |
| Clearbridge Investments, LLC | US$3399.0萬 | 0.03% |
| UBS Group AG | US$3341.8萬 | 0.01% |
| LOOMIS SAYLES & CO L P | US$3139.5萬 | 0.04% |
| VANGUARD FIDUCIARY TRUST CO | US$2895.8萬 | 0.01% |
| Nuveen, LLC | US$2859.4萬 | 0.01% |
| Integral Health Asset Management, LLC | US$2458.0萬 | 1.18% |
| Eagle Health Investments LP | US$2428.6萬 | 4.25% |
| Fisher Asset Management, LLC | US$2251.6萬 | 0.01% |
| First Turn Management, LLC | US$2194.5萬 | 2.45% |
| ADAR1 Capital Management, LLC | US$2002.2萬 | 1.18% |
| Casdin Capital, LLC | US$1720.6萬 | 1.30% |
| SILVERARC CAPITAL MANAGEMENT, LLC | US$1669.5萬 | 1.70% |
| ARMISTICE CAPITAL, LLC | US$1656.5萬 | 0.29% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$1489.7萬 | 0.00% |
| NAN FUNG TRINITY (HK) LTD | US$1403.5萬 | 1.54% |
| RAYMOND JAMES FINANCIAL INC | US$1246.7萬 | 0.00% |
| DEUTSCHE BANK AG\ | US$1188.7萬 | 0.00% |
| Caption Management, LLC | US$1179.8萬 | 0.07% |
| Bank of New York Mellon Corp | US$1143.8萬 | 0.00% |
| Candriam S.C.A. | US$1111.0萬 | 0.06% |
| TD Asset Management Inc | US$1096.6萬 | 0.01% |
| MORGAN STANLEY | US$1076.7萬 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$1042.0萬 | 0.00% |
| BARCLAYS PLC | US$949.0萬 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$878.4萬 | 0.01% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$872.0萬 | 0.02% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$854.2萬 | 0.01% |
| Cinctive Capital Management LP | US$848.2萬 | 0.55% |
| Granahan Investment Management, LLC | US$768.4萬 | 0.37% |
| JPMORGAN CHASE & CO | US$751.4萬 | 0.00% |
| Balyasny Asset Management L.P. | US$736.0萬 | 0.01% |
| PEREGRINE CAPITAL MANAGEMENT LLC | US$720.7萬 | 0.27% |
| SEI INVESTMENTS CO | US$704.7萬 | 0.01% |
| GordonMD Global Investments LP | US$651.4萬 | 4.54% |
| iA Global Asset Management Inc. | US$605.7萬 | 0.09% |
| Swiss National Bank | US$605.7萬 | 0.00% |
| Invesco Ltd. | US$587.9萬 | 0.00% |
| EFG International AG | US$553.6萬 | 0.12% |
| RHUMBLINE ADVISERS | US$553.1萬 | 0.00% |
| Rafferty Asset Management, LLC | US$513.5萬 | 0.02% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$505.9萬 | 0.00% |
| XTX Topco Ltd | US$493.7萬 | 0.09% |
| FIDEURAM - INTESA SANPAOLO PRIVATE BANKING S.P.A. | US$485.2萬 | 0.17% |
| Artia Global Partners LP | US$473.3萬 | 0.95% |
| SPHERA FUNDS MANAGEMENT LTD. | US$463.4萬 | 0.74% |
| ALLIANCEBERNSTEIN L.P. | US$443.5萬 | 0.00% |
| Hudson Bay Capital Management LP | US$410.2萬 | 0.01% |
| Nicholas Investment Partners, LP | US$405.6萬 | 0.29% |
| Aisling Capital Management LP | US$378.7萬 | 0.80% |
| Trexquant Investment LP | US$377.3萬 | 0.03% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$368.3萬 | 0.00% |
| StoneCrest Wealth Management, Inc. | US$348.6萬 | 1.47% |
| ExodusPoint Capital Management, LP | US$329.7萬 | 0.03% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$317.7萬 | 0.00% |
| Man Group plc | US$305.4萬 | 0.01% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$299.8萬 | 0.00% |
| Moody Aldrich Partners LLC | US$295.9萬 | 0.53% |
| NOMURA HOLDINGS INC | US$295.0萬 | 0.01% |
| Ishara Investments LP | US$282.2萬 | 2.67% |
| POLEN CAPITAL MANAGEMENT LLC | US$255.4萬 | 0.02% |
| Squarepoint Ops LLC | US$245.6萬 | 0.00% |
| Legal & General Group Plc | US$245.4萬 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | US$236.9萬 | 0.04% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | US$235.1萬 | 0.00% |
| MetLife Investment Management, LLC | US$233.3萬 | 0.01% |
| PROFUND ADVISORS LLC | US$231.5萬 | 0.08% |
| KVP Capital Advisors, LP | US$221.2萬 | 1.65% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$215.2萬 | 0.00% |
| Jasper Ridge Partners, L.P. | US$208.7萬 | 0.05% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$193.4萬 | 0.00% |
| CITIGROUP INC | US$190.4萬 | 0.00% |
| AMERIPRISE FINANCIAL INC | US$186.3萬 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$185.6萬 | 0.00% |
| KENNEDY CAPITAL MANAGEMENT LLC | US$184.1萬 | 0.04% |
| GUGGENHEIM CAPITAL LLC | US$179.3萬 | 0.01% |
| Vanguard Global Advisers, LLC | US$166.1萬 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$160.7萬 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | US$148.5萬 | 0.00% |
| Creative Planning | US$143.5萬 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$143.4萬 | 0.00% |
| HRT FINANCIAL LP | US$141.1萬 | 0.00% |
| Shay Capital LLC | US$137.6萬 | 0.11% |
| FRANKLIN RESOURCES INC | US$132.2萬 | 0.00% |
| Scientech Research LLC | US$129.2萬 | 1.08% |
| Clearstead Advisors, LLC | US$128.2萬 | 0.01% |
| VICTORY CAPITAL MANAGEMENT INC | US$127.2萬 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$125.5萬 | 0.01% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | US$124.1萬 | 0.01% |
| MILLENNIUM MANAGEMENT LLC | US$122.9萬 | 0.00% |
| D.A. DAVIDSON & CO. | US$122.1萬 | 0.01% |
| Police & Firemen's Retirement System of New Jersey | US$116.1萬 | 0.01% |
| Handelsbanken Fonder AB | US$115.5萬 | 0.00% |
| E. Ohman J:or Asset Management AB | US$108.8萬 | 0.03% |
| DNB Asset Management AS | US$107.9萬 | 0.00% |
| State of New Jersey Common Pension Fund D | US$105.0萬 | 0.00% |
| GSA CAPITAL PARTNERS LLP | US$100.6萬 | 0.06% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$97.1萬 | 0.00% |
| ENVESTNET ASSET MANAGEMENT INC | US$95.8萬 | 0.00% |
| Values First Advisors, Inc. | US$92.7萬 | 0.48% |
| Caitong International Asset Management Co., Ltd | US$89.3萬 | 0.17% |
| China Universal Asset Management Co., Ltd. | US$89.0萬 | 0.07% |
| ProShare Advisors LLC | US$84.6萬 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | US$84.4萬 | 0.00% |
| LPL Financial LLC | US$83.4萬 | 0.00% |
| Virtu Financial LLC | US$81.3萬 | 0.03% |
| Erste Asset Management GmbH | US$80.1萬 | 0.01% |
| DARK FOREST CAPITAL MANAGEMENT LP | US$79.8萬 | 0.07% |
| 683 Capital Management, LLC | US$79.6萬 | 0.04% |
| Vanguard Investments Australia, Ltd. | US$77.2萬 | 0.00% |
| Point72 Asset Management, L.P. | US$74.7萬 | 0.00% |