| FMR LLC | US$9.7億 | 0.05% |
| BAKER BROS. ADVISORS LP | US$7.2億 | 4.14% |
| Avoro Capital Advisors LLC | US$6.2億 | 6.12% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$5.0億 | 0.06% |
| BVF INC/IL | US$4.6億 | 14.60% |
| T. Rowe Price Investment Management, Inc. | US$4.6億 | 0.31% |
| BlackRock, Inc. | US$4.2億 | 0.01% |
| Atlas Venture Life Science Advisors, LLC | US$3.8億 | 48.26% |
| WELLINGTON MANAGEMENT GROUP LLP | US$3.2億 | 0.06% |
| Siren, L.L.C. | US$2.7億 | 7.36% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$2.4億 | 0.01% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$2.4億 | 0.01% |
| STATE STREET CORP | US$2.0億 | 0.01% |
| Capital Research Global Investors | US$1.4億 | 0.02% |
| GEODE CAPITAL MANAGEMENT, LLC | US$1.4億 | 0.01% |
| Driehaus Capital Management LLC | US$8692.0萬 | 0.64% |
| UBS Group AG | US$8527.7萬 | 0.01% |
| GOLDMAN SACHS GROUP INC | US$7399.6萬 | 0.01% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$7295.1萬 | 0.02% |
| Holocene Advisors, LP | US$6969.4萬 | 0.17% |
| ALLIANCEBERNSTEIN L.P. | US$6909.8萬 | 0.02% |
| Merck & Co., Inc. | US$6431.4萬 | 18.40% |
| FRONTIER CAPITAL MANAGEMENT CO LLC | US$6328.8萬 | 0.65% |
| Commodore Capital LP | US$6246.8萬 | 3.61% |
| EVENTIDE ASSET MANAGEMENT, LLC | US$5221.3萬 | 0.86% |
| DIMENSIONAL FUND ADVISORS LP | US$4935.9萬 | 0.01% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | US$4674.0萬 | 0.55% |
| FEDERATED HERMES, INC. | US$4470.0萬 | 0.07% |
| JENNISON ASSOCIATES LLC | US$4239.5萬 | 0.03% |
| Rock Springs Capital Management LP | US$4138.4萬 | 2.44% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$4125.0萬 | 0.01% |
| NORTHERN TRUST CORP | US$4118.2萬 | 0.01% |
| Pictet Asset Management Holding SA | US$3876.0萬 | 0.04% |
| VANGUARD FIDUCIARY TRUST CO | US$3559.7萬 | 0.01% |
| Octagon Capital Advisors LP | US$3539.8萬 | 3.92% |
| FRANKLIN RESOURCES INC | US$3013.2萬 | 0.01% |
| Alyeska Investment Group, L.P. | US$2854.3萬 | 0.08% |
| BRAIDWELL LP | US$2811.5萬 | 0.94% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$2790.2萬 | 0.04% |
| Boxer Capital Management, LLC | US$2741.1萬 | 3.60% |
| BANK OF AMERICA CORP /DE/ | US$2410.5萬 | 0.00% |
| TD Asset Management Inc | US$2391.3萬 | 0.02% |
| Nextech Invest, Ltd. | US$2322.9萬 | 1.63% |
| TWO SIGMA INVESTMENTS, LP | US$2136.4萬 | 0.02% |
| First Turn Management, LLC | US$2121.2萬 | 2.37% |
| RTW INVESTMENTS, LP | US$1999.0萬 | 0.20% |
| GILDER GAGNON HOWE & CO LLC | US$1960.9萬 | 0.24% |
| Polar Capital Holdings Plc | US$1792.4萬 | 0.06% |
| MORGAN STANLEY | US$1771.6萬 | 0.00% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | US$1740.8萬 | 0.01% |
| Woodline Partners LP | US$1695.7萬 | 0.06% |
| Candriam S.C.A. | US$1679.7萬 | 0.09% |
| VOYA INVESTMENT MANAGEMENT LLC | US$1655.9萬 | 0.02% |
| Bank of New York Mellon Corp | US$1609.2萬 | 0.00% |
| TimesSquare Capital Management, LLC | US$1406.3萬 | 0.24% |
| Freestone Grove Partners LP | US$1305.7萬 | 0.09% |
| CITADEL ADVISORS LLC | US$1296.8萬 | 0.00% |
| Foresite Capital Management VI LLC | US$1218.8萬 | 2.65% |
| Eagle Health Investments LP | US$1214.5萬 | 2.12% |
| WCM INVESTMENT MANAGEMENT, LLC | US$1211.1萬 | 0.03% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$1116.1萬 | 0.00% |
| Nuveen, LLC | US$1066.9萬 | 0.00% |
| Deer Management Co. LLC | US$1048.6萬 | 1.69% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$1000.7萬 | 0.01% |
| JPMORGAN CHASE & CO | US$996.8萬 | 0.00% |
| Ensign Peak Advisors, Inc | US$948.2萬 | 0.02% |
| Invesco Ltd. | US$919.6萬 | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | US$868.5萬 | 0.02% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$859.6萬 | 0.01% |
| Patient Square Capital LP | US$832.9萬 | 1.48% |
| Swiss National Bank | US$787.1萬 | 0.00% |
| FIRST TRUST ADVISORS LP | US$779.7萬 | 0.01% |
| DEUTSCHE BANK AG\ | US$765.3萬 | 0.00% |
| ARMISTICE CAPITAL, LLC | US$698.6萬 | 0.12% |
| Burkehill Global Management, LP | US$624.7萬 | 0.31% |
| Yiheng Capital Management, L.P. | US$611.7萬 | 2.65% |
| RHUMBLINE ADVISERS | US$597.0萬 | 0.01% |
| NEUBERGER BERMAN GROUP LLC | US$592.3萬 | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | US$566.3萬 | 0.00% |
| ALPS ADVISORS INC | US$553.5萬 | 0.03% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$536.9萬 | 0.01% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$468.8萬 | 0.00% |
| Rafferty Asset Management, LLC | US$460.9萬 | 0.02% |
| FIFTH THIRD BANCORP | US$426.8萬 | 0.01% |
| Ikarian Capital, LLC | US$419.8萬 | 0.34% |
| Russell Investments Group, Ltd. | US$406.6萬 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$374.7萬 | 0.00% |
| Informed Momentum Co LLC | US$352.7萬 | 0.41% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$343.7萬 | 0.00% |
| Moody Aldrich Partners LLC | US$318.1萬 | 0.57% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$317.5萬 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$309.7萬 | 0.01% |
| Legal & General Group Plc | US$306.0萬 | 0.00% |
| Monashee Investment Management LLC | US$292.3萬 | 1.59% |
| HARBOR CAPITAL ADVISORS, INC. | US$282.8萬 | 0.23% |
| Rockefeller Capital Management L.P. | US$269.6萬 | 0.00% |
| Sio Capital Management, LLC | US$268.5萬 | 0.39% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$267.0萬 | 0.01% |
| MetLife Investment Management, LLC | US$262.4萬 | 0.01% |
| Nan Fung Group Holdings Ltd | US$257.2萬 | 2.12% |
| SEVEN GRAND MANAGERS, LLC | US$249.9萬 | 0.17% |
| ExodusPoint Capital Management, LP | US$235.9萬 | 0.02% |
| Creative Planning | US$235.3萬 | 0.00% |
| Nicholas Investment Partners, LP | US$227.8萬 | 0.16% |
| Vanguard Global Advisers, LLC | US$226.1萬 | 0.00% |
| Neo Ivy Capital Management | US$225.2萬 | 0.59% |
| WELLS FARGO & COMPANY/MN | US$222.9萬 | 0.00% |
| E Fund Management Co., Ltd. | US$218.5萬 | 0.06% |
| Erste Asset Management GmbH | US$214.6萬 | 0.02% |
| PROFUND ADVISORS LLC | US$209.4萬 | 0.08% |
| JANE STREET GROUP, LLC | US$206.1萬 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$182.1萬 | 0.00% |
| DARK FOREST CAPITAL MANAGEMENT LP | US$181.2萬 | 0.16% |
| JANUS HENDERSON GROUP PLC | US$175.4萬 | 0.00% |
| BAMCO INC /NY/ | US$166.6萬 | 0.01% |
| AJU IB Investment Co., Ltd. | US$163.6萬 | 5.36% |
| LBP AM SA | US$157.3萬 | 0.02% |
| Handelsbanken Fonder AB | US$149.9萬 | 0.00% |
| State of New Jersey Common Pension Fund D | US$135.9萬 | 0.01% |
| AQR CAPITAL MANAGEMENT LLC | US$132.9萬 | 0.00% |
| Knights of Columbus Asset Advisors LLC | US$132.2萬 | 0.07% |
| Police & Firemen's Retirement System of New Jersey | US$129.0萬 | 0.01% |
| Odyssean, LLC | US$123.4萬 | 0.45% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$123.3萬 | 0.02% |
| China Universal Asset Management Co., Ltd. | US$120.7萬 | 0.09% |
| BARCLAYS PLC | US$118.7萬 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | US$114.7萬 | 0.02% |
| INTECH INVESTMENT MANAGEMENT LLC | US$113.9萬 | 0.01% |
| KENNEDY CAPITAL MANAGEMENT LLC | US$113.8萬 | 0.02% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$113.6萬 | 0.00% |
| Man Group plc | US$111.1萬 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | US$109.2萬 | 0.01% |
| GUGGENHEIM CAPITAL LLC | US$109.0萬 | 0.01% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | US$108.5萬 | 0.01% |
| Squarepoint Ops LLC | US$106.9萬 | 0.00% |
| GSA CAPITAL PARTNERS LLP | US$105.4萬 | 0.07% |
| Schonfeld Strategic Advisors LLC | US$104.8萬 | 0.01% |
| Vanguard Investments Australia, Ltd. | US$103.7萬 | 0.00% |
| CITIGROUP INC | US$102.1萬 | 0.00% |
| B. Metzler seel. Sohn & Co. AG | US$100.6萬 | 0.01% |
| ProShare Advisors LLC | US$99.6萬 | 0.00% |
| SEI INVESTMENTS CO | US$93.5萬 | 0.00% |
| Proficio Capital Partners LLC | US$90.3萬 | 0.05% |
| KLP KAPITALFORVALTNING AS | US$87.5萬 | 0.00% |
| PRUDENTIAL FINANCIAL INC | US$74.5萬 | 0.00% |
| Vident Advisory, LLC | US$70.3萬 | 0.01% |
| BRANDYWINE MANAGERS, LLC | US$63.1萬 | 0.37% |
| Keudell/Morrison Wealth Management | US$58.2萬 | 0.12% |
| GLENMEDE TRUST CO NA | US$56.5萬 | 0.00% |
| Blackstone Inc. | US$55.5萬 | 0.00% |