| JANUS HENDERSON GROUP PLC | US$1.5億 | 0.07% |
| BlackRock, Inc. | US$9494.2萬 | 0.00% |
| SUVRETTA CAPITAL MANAGEMENT, LLC | US$8702.7萬 | 2.22% |
| STIFEL FINANCIAL CORP | US$8410.0萬 | 0.08% |
| STATE STREET CORP | US$5599.5萬 | 0.00% |
| INFINITUM ASSET MANAGEMENT, LLC | US$5287.5萬 | 6.60% |
| TCG Crossover Management, LLC | US$3918.1萬 | 1.12% |
| Royalty Pharma Sub-Manager, LLC | US$2484.3萬 | 14.38% |
| D. E. Shaw & Co., Inc. | US$2408.7萬 | 0.01% |
| GEODE CAPITAL MANAGEMENT, LLC | US$2342.0萬 | 0.00% |
| GOLDMAN SACHS GROUP INC | US$2126.2萬 | 0.00% |
| Balyasny Asset Management L.P. | US$2068.8萬 | 0.03% |
| FMR LLC | US$1995.8萬 | 0.00% |
| Knoll Capital Management, LLC | US$1970.0萬 | 10.93% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$1928.3萬 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$1875.8萬 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$1671.3萬 | 0.01% |
| CITADEL ADVISORS LLC | US$1653.4萬 | 0.00% |
| Cormorant Asset Management, LP | US$1489.0萬 | 0.75% |
| STEMPOINT CAPITAL LP | US$1348.9萬 | 2.58% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$1310.2萬 | 0.00% |
| Qube Research & Technologies Ltd | US$1303.2萬 | 0.01% |
| ExodusPoint Capital Management, LP | US$1269.9萬 | 0.10% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$1267.1萬 | 0.02% |
| MILLENNIUM MANAGEMENT LLC | US$1224.9萬 | 0.01% |
| UBS Group AG | US$1206.8萬 | 0.00% |
| ARS Investment Partners, LLC | US$1166.5萬 | 0.61% |
| Capital Research Global Investors | US$1127.5萬 | 0.00% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$1074.3萬 | 0.00% |
| MYDA Advisors LLC | US$1036.4萬 | 1.70% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | US$1032.0萬 | 0.04% |
| TWO SIGMA INVESTMENTS, LP | US$1004.0萬 | 0.01% |
| Sio Capital Management, LLC | US$984.7萬 | 1.41% |
| MORGAN STANLEY | US$868.8萬 | 0.00% |
| NORTHERN TRUST CORP | US$847.2萬 | 0.00% |
| Integral Health Asset Management, LLC | US$846.0萬 | 0.40% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$796.2萬 | 0.00% |
| Simplify Asset Management Inc. | US$760.0萬 | 0.12% |
| Trexquant Investment LP | US$742.6萬 | 0.05% |
| DAFNA Capital Management LLC | US$715.5萬 | 1.63% |
| HRT FINANCIAL LP | US$705.2萬 | 0.02% |
| Fiera Capital Corp | US$654.9萬 | 0.02% |
| Aberdeen Group plc | US$652.6萬 | 0.01% |
| BANK OF AMERICA CORP /DE/ | US$642.5萬 | 0.00% |
| Nuveen, LLC | US$630.9萬 | 0.00% |
| 5AM Venture Management, LLC | US$625.2萬 | 1.74% |
| Kynam Capital Management, LP | US$594.6萬 | 0.37% |
| VANGUARD FIDUCIARY TRUST CO | US$593.5萬 | 0.00% |
| Erste Asset Management GmbH | US$560.9萬 | 0.05% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$523.0萬 | 0.00% |
| SPHERA FUNDS MANAGEMENT LTD. | US$502.5萬 | 0.80% |
| Sarissa Capital Management LP | US$476.5萬 | 3.02% |
| Pfizer Inc | US$423.2萬 | 1.77% |
| Burkehill Global Management, LP | US$423.0萬 | 0.21% |
| JPMORGAN CHASE & CO | US$407.4萬 | 0.00% |
| RAYMOND JAMES FINANCIAL INC | US$377.8萬 | 0.00% |
| QTR Family Wealth, LLC | US$350.8萬 | 1.46% |
| Ikarian Capital, LLC | US$349.0萬 | 0.28% |
| Caption Management, LLC | US$347.1萬 | 0.02% |
| XTX Topco Ltd | US$345.6萬 | 0.06% |
| READYSTATE ASSET MANAGEMENT LP | US$328.4萬 | 0.15% |
| Point72 Asset Management, L.P. | US$315.6萬 | 0.00% |
| JANE STREET GROUP, LLC | US$314.4萬 | 0.00% |
| MARSHALL WACE, LLP | US$298.3萬 | 0.00% |
| ALGERT GLOBAL LLC | US$273.0萬 | 0.04% |
| DIADEMA PARTNERS LP | US$268.2萬 | 0.46% |
| Defilade Capital Management, L.P. | US$267.3萬 | 0.38% |
| Susquehanna Portfolio Strategies, LLC | US$262.8萬 | 0.04% |
| Bank of New York Mellon Corp | US$259.9萬 | 0.00% |
| Woodline Partners LP | US$254.1萬 | 0.01% |
| IEQ CAPITAL, LLC | US$235.8萬 | 0.01% |
| Swiss National Bank | US$218.8萬 | 0.00% |
| DCF Advisers, LLC | US$218.3萬 | 0.58% |
| Invesco Ltd. | US$214.0萬 | 0.00% |
| Walleye Capital LLC | US$209.2萬 | 0.01% |
| NewEdge Wealth, LLC | US$208.5萬 | 0.02% |
| Jump Financial, LLC | US$200.8萬 | 0.03% |
| Rafferty Asset Management, LLC | US$173.0萬 | 0.01% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$171.7萬 | 0.00% |
| Squarepoint Ops LLC | US$150.3萬 | 0.00% |
| TD Asset Management Inc | US$150.1萬 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$145.8萬 | 0.00% |
| QVT Financial LP | US$143.8萬 | 0.11% |
| DEUTSCHE BANK AG\ | US$137.7萬 | 0.00% |
| Y-Intercept (Hong Kong) Ltd | US$136.9萬 | 0.03% |
| RENAISSANCE TECHNOLOGIES LLC | US$136.2萬 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$135.6萬 | 0.00% |
| Empowered Funds, LLC | US$125.8萬 | 0.01% |
| CWM, LLC | US$117.1萬 | 0.00% |
| RHUMBLINE ADVISERS | US$115.8萬 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | US$112.9萬 | 0.00% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$108.2萬 | 0.01% |
| BARCLAYS PLC | US$106.4萬 | 0.00% |
| ROYAL BANK OF CANADA | US$103.6萬 | 0.00% |
| Quantinno Capital Management LP | US$102.8萬 | 0.00% |
| Voleon Capital Management LP | US$98.9萬 | 0.02% |
| GSA CAPITAL PARTNERS LLP | US$98.8萬 | 0.06% |
| Cerity Partners LLC | US$95.4萬 | 0.00% |
| SG Americas Securities, LLC | US$86.4萬 | 0.00% |
| Greenland Capital Management LP | US$85.6萬 | 0.11% |
| TUDOR INVESTMENT CORP ET AL | US$83.0萬 | 0.00% |
| Legal & General Group Plc | US$81.2萬 | 0.00% |
| Mariner, LLC | US$80.7萬 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$78.7萬 | 0.00% |
| PROFUND ADVISORS LLC | US$77.2萬 | 0.03% |
| Fund 1 Investments, LLC | US$76.1萬 | 0.09% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$75.3萬 | 0.00% |
| PDT Partners, LLC | US$71.7萬 | 0.04% |
| Bridgefront Capital, LLC | US$68.8萬 | 0.17% |
| ACADIAN ASSET MANAGEMENT LLC | US$68.8萬 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$60.5萬 | 0.00% |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | US$59.8萬 | 0.00% |
| Brevan Howard Capital Management LP | US$58.5萬 | 0.01% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$58.4萬 | 0.00% |
| CANADA PENSION PLAN INVESTMENT BOARD | US$57.3萬 | 0.00% |
| Entropy Technologies, LP | US$55.5萬 | 0.03% |
| MetLife Investment Management, LLC | US$54.8萬 | 0.00% |
| Quinn Opportunity Partners LLC | US$54.4萬 | 0.03% |
| Steward Partners Investment Advisory, LLC | US$51.8萬 | 0.00% |
| ENVESTNET ASSET MANAGEMENT INC | US$48.3萬 | 0.00% |
| Creative Planning | US$47.5萬 | 0.00% |
| Graham Capital Management, L.P. | US$46.9萬 | 0.01% |
| AMERIPRISE FINANCIAL INC | US$46.8萬 | 0.00% |
| EXCHANGE TRADED CONCEPTS, LLC | US$44.9萬 | 0.00% |
| Walleye Trading LLC | US$44.7萬 | 0.00% |
| Kennondale Capital Management LLC | US$44.6萬 | 0.32% |
| NOVEM GROUP | US$44.0萬 | 0.05% |
| Lion Point Capital, LP | US$43.7萬 | 2.61% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$43.3萬 | 0.00% |
| Marex Group plc | US$42.5萬 | 0.00% |
| MERCER GLOBAL ADVISORS INC /ADV | US$41.6萬 | 0.00% |
| LPL Financial LLC | US$41.3萬 | 0.00% |
| TWINBEECH CAPITAL LP | US$39.3萬 | 0.04% |
| HSBC HOLDINGS PLC | US$37.9萬 | 0.00% |
| Hennion & Walsh Asset Management, Inc. | US$37.9萬 | 0.01% |
| ADAR1 Capital Management, LLC | US$37.9萬 | 0.02% |
| Optimize Financial Inc | US$37.8萬 | 0.19% |
| State of New Jersey Common Pension Fund D | US$37.8萬 | 0.00% |
| Vanguard Global Advisers, LLC | US$37.4萬 | 0.00% |
| Headlands Technologies LLC | US$35.9萬 | 0.04% |
| Russell Investments Group, Ltd. | US$34.0萬 | 0.00% |
| Cinctive Capital Management LP | US$31.3萬 | 0.02% |
| Vanguard Investments Australia, Ltd. | US$31.1萬 | 0.00% |
| Handelsbanken Fonder AB | US$31.0萬 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | US$30.3萬 | 0.00% |
| CITIGROUP INC | US$29.8萬 | 0.00% |
| SIMPLEX TRADING, LLC | US$29.6萬 | 0.00% |
| SEI INVESTMENTS CO | US$28.3萬 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$27.0萬 | 0.00% |
| GROUP ONE TRADING LLC | US$26.5萬 | 0.00% |