| Vivo Capital, LLC | US$4373.9万 | 3.64% |
| Caligan Partners LP | US$3051.4万 | 2.03% |
| PERCEPTIVE ADVISORS LLC | US$2463.4万 | 0.48% |
| Commodore Capital LP | US$1685.8万 | 0.98% |
| RA CAPITAL MANAGEMENT, L.P. | US$1685.8万 | 0.18% |
| Balyasny Asset Management L.P. | US$1440.2万 | 0.02% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$1304.3万 | 0.02% |
| MILLENNIUM MANAGEMENT LLC | US$1161.5万 | 0.00% |
| Woodline Partners LP | US$1092.2万 | 0.04% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$955.1万 | 0.00% |
| Spruce Street Capital LP | US$842.0万 | 2.02% |
| Sessa Capital IM, L.P. | US$842.0万 | 0.15% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$567.5万 | 0.07% |
| AMERIPRISE FINANCIAL INC | US$565.3万 | 0.00% |
| Ensign Peak Advisors, Inc | US$526.9万 | 0.01% |
| Soleus Capital Management, L.P. | US$402.2万 | 0.16% |
| Propel Bio Management, LLC | US$388.6万 | 2.45% |
| Jefferies Financial Group Inc. | US$345.9万 | 0.02% |
| Blackstone Inc. | US$329.4万 | 0.01% |
| ExodusPoint Capital Management, LP | US$294.4万 | 0.02% |
| Affinity Asset Advisors, LLC | US$220.2万 | 0.11% |
| Monashee Investment Management LLC | US$191.5万 | 1.04% |
| MARSHALL WACE, LLP | US$177.7万 | 0.00% |
| DV Trading LLC | US$153.2万 | 0.04% |
| AWM Investment Company, Inc. | US$153.2万 | 0.17% |
| STEMPOINT CAPITAL LP | US$143.6万 | 0.27% |
| HB Wealth Management, LLC | US$117.8万 | 0.01% |
| GEODE CAPITAL MANAGEMENT, LLC | US$115.7万 | 0.00% |
| BlackRock, Inc. | US$115.4万 | 0.00% |
| SEVEN GRAND MANAGERS, LLC | US$105.3万 | 0.07% |
| VANGUARD FIDUCIARY TRUST CO | US$75.7万 | 0.00% |
| Simplify Asset Management Inc. | US$71.7万 | 0.01% |
| TWO SIGMA INVESTMENTS, LP | US$69.4万 | 0.00% |
| GOLDMAN SACHS GROUP INC | US$43.6万 | 0.00% |
| Seven Fleet Capital Management LP | US$38.3万 | 0.12% |
| JANE STREET GROUP, LLC | US$31.6万 | 0.00% |
| STATE STREET CORP | US$28.4万 | 0.00% |
| Persistent Asset Partners Ltd | US$26.7万 | 0.10% |
| CITADEL ADVISORS LLC | US$26.7万 | 0.00% |
| Kestra Advisory Services, LLC | US$23.6万 | 0.00% |
| Brevan Howard Capital Management LP | US$22.7万 | 0.00% |
| NORTHERN TRUST CORP | US$22.0万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$21.3万 | 0.00% |
| Pathstone Holdings, LLC | US$19.4万 | 0.00% |
| Stonepine Capital Management, LLC | US$19.2万 | 0.08% |
| UBS Group AG | US$17.9万 | 0.00% |
| FIFTH LANE CAPITAL, LP | US$17.8万 | 0.22% |
| COMMONWEALTH EQUITY SERVICES, LLC | US$17.8万 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$17.6万 | 0.00% |
| Virtu Financial LLC | US$14.5万 | 0.01% |
| AMERICAN CENTURY COMPANIES INC | US$14.3万 | 0.00% |
| CITIGROUP INC | US$14.1万 | 0.00% |
| Quadrature Capital Ltd | US$13.5万 | 0.00% |
| PRELUDE CAPITAL MANAGEMENT, LLC | US$13.1万 | 0.01% |
| OMERS ADMINISTRATION Corp | US$11.4万 | 0.00% |
| Qube Research & Technologies Ltd | US$9.2万 | 0.00% |
| First PREMIER Bank | US$7.3万 | 0.02% |
| Diametric Capital, LP | US$6.2万 | 0.02% |
| Hudson Bay Capital Management LP | US$6.2万 | 0.00% |
| Catalyst Funds Management Pty Ltd | US$5.8万 | 0.01% |
| Focus Partners Wealth | US$5.4万 | 0.00% |
| Miller Capital Partners, Inc. | US$4.9万 | 0.02% |
| MORGAN STANLEY | US$4.6万 | 0.00% |
| Vanguard Global Advisers, LLC | US$4.5万 | 0.00% |
| Scientech Research LLC | US$4.1万 | 0.03% |
| State of Wyoming | US$3.0万 | 0.00% |
| OSAIC HOLDINGS, INC. | US$3.0万 | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | US$2.9万 | 0.00% |
| Plante Moran Financial Advisors, LLC | US$2.3万 | 0.00% |
| SIMPLEX TRADING, LLC | US$1.8万 | 0.00% |
| Tower Research Capital LLC (TRC) | US$1.3万 | 0.00% |
| BARCLAYS PLC | US$1900.0 | 0.00% |
| MAI Capital Management | US$832.0 | 0.00% |
| GS Investments, Inc. | US$766.0 | 0.00% |
| Caitong International Asset Management Co., Ltd | US$617.0 | 0.00% |
| JPMORGAN CHASE & CO | US$329.0 | 0.00% |
| HARBOUR INVESTMENTS, INC. | US$192.0 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | US$34.1 | 0.00% |
| ROYAL BANK OF CANADA | US$0.0 | 0.00% |