| JANUS HENDERSON GROUP PLC | US$9.6億 | 0.46% |
| FMR LLC | US$9.6億 | 0.05% |
| T. Rowe Price Investment Management, Inc. | US$7.0億 | 0.49% |
| RA CAPITAL MANAGEMENT, L.P. | US$6.7億 | 7.07% |
| BlackRock, Inc. | US$6.4億 | 0.01% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$3.6億 | 0.02% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$3.6億 | 0.01% |
| WELLINGTON MANAGEMENT GROUP LLP | US$3.3億 | 0.06% |
| Paradigm Biocapital Advisors LP | US$2.8億 | 5.69% |
| STATE STREET CORP | US$2.6億 | 0.01% |
| Deep Track Capital, LP | US$2.5億 | 4.08% |
| WESTFIELD CAPITAL MANAGEMENT CO LP | US$2.1億 | 0.89% |
| GEODE CAPITAL MANAGEMENT, LLC | US$1.9億 | 0.01% |
| Kynam Capital Management, LP | US$1.7億 | 10.48% |
| D. E. Shaw & Co., Inc. | US$1.7億 | 0.10% |
| Caligan Partners LP | US$1.2億 | 7.97% |
| JENNISON ASSOCIATES LLC | US$9867.1萬 | 0.07% |
| Polar Capital Holdings Plc | US$8285.3萬 | 0.29% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$8158.3萬 | 0.01% |
| MAVERICK CAPITAL LTD | US$8006.0萬 | 0.92% |
| EVENTIDE ASSET MANAGEMENT, LLC | US$7984.0萬 | 1.32% |
| Pivotal bioVenture Partners Investment Advisor LLC | US$7975.2萬 | 28.51% |
| UBS Group AG | US$7771.6萬 | 0.01% |
| GOLDMAN SACHS GROUP INC | US$7555.1萬 | 0.01% |
| FARALLON CAPITAL MANAGEMENT LLC | US$7327.7萬 | 0.42% |
| BANK OF AMERICA CORP /DE/ | US$7071.1萬 | 0.01% |
| Bellevue Group AG | US$6919.1萬 | 1.65% |
| Assenagon Asset Management S.A. | US$6768.7萬 | 0.10% |
| NORTHERN TRUST CORP | US$6650.5萬 | 0.01% |
| JANE STREET GROUP, LLC | US$6165.3萬 | 0.01% |
| Aberdeen Group plc | US$5688.8萬 | 0.09% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$5674.1萬 | 0.01% |
| JPMORGAN CHASE & CO | US$5541.7萬 | 0.00% |
| Eversept Partners, LP | US$5370.5萬 | 2.83% |
| Capital Research Global Investors | US$5303.6萬 | 0.01% |
| NOVO HOLDINGS A/S | US$4997.5萬 | 4.05% |
| VANGUARD FIDUCIARY TRUST CO | US$4894.4萬 | 0.01% |
| Saturn V Capital Management LP | US$4791.4萬 | 8.68% |
| BAUPOST GROUP LLC/MA | US$4648.8萬 | 0.91% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$4403.4萬 | 0.00% |
| MORGAN STANLEY | US$4276.4萬 | 0.00% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$4203.2萬 | 0.55% |
| Caption Management, LLC | US$4086.3萬 | 0.24% |
| Pictet Asset Management Holding SA | US$4069.5萬 | 0.04% |
| Trails Edge Capital Partners, LP | US$3849.6萬 | 8.82% |
| Jones Hill Capital LP | US$3747.1萬 | 8.03% |
| Point72 Asset Management, L.P. | US$3605.2萬 | 0.05% |
| FEDERATED HERMES, INC. | US$3293.8萬 | 0.05% |
| Balyasny Asset Management L.P. | US$2990.2萬 | 0.04% |
| BROWN ADVISORY INC | US$2973.5萬 | 0.05% |
| VICTORY CAPITAL MANAGEMENT INC | US$2916.3萬 | 0.02% |
| Bank of New York Mellon Corp | US$2757.5萬 | 0.01% |
| FRANKLIN RESOURCES INC | US$2750.7萬 | 0.01% |
| Ensign Peak Advisors, Inc | US$2591.1萬 | 0.05% |
| Alyeska Investment Group, L.P. | US$2531.2萬 | 0.07% |
| Ikarian Capital, LLC | US$2491.1萬 | 2.02% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$2386.0萬 | 0.00% |
| Soleus Capital Management, L.P. | US$2240.0萬 | 0.91% |
| DIMENSIONAL FUND ADVISORS LP | US$2183.6萬 | 0.00% |
| ALGERT GLOBAL LLC | US$2115.1萬 | 0.32% |
| AMERICAN CENTURY COMPANIES INC | US$2067.9萬 | 0.01% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$2033.9萬 | 0.03% |
| Boxer Capital Management, LLC | US$1888.6萬 | 2.48% |
| Nuveen, LLC | US$1864.1萬 | 0.01% |
| Elmind Capital, LP | US$1839.2萬 | 5.22% |
| Candriam S.C.A. | US$1830.6萬 | 0.10% |
| TD Asset Management Inc | US$1817.5萬 | 0.01% |
| Logos Global Management LP | US$1743.3萬 | 0.87% |
| DEUTSCHE BANK AG\ | US$1741.5萬 | 0.01% |
| Artisan Partners Limited Partnership | US$1728.4萬 | 0.03% |
| MILLENNIUM MANAGEMENT LLC | US$1706.7萬 | 0.01% |
| Rosalind Advisors, Inc. | US$1685.2萬 | 6.77% |
| Woodline Partners LP | US$1596.5萬 | 0.06% |
| Nantahala Capital Management, LLC | US$1591.9萬 | 0.59% |
| FRED ALGER MANAGEMENT, LLC | US$1569.6萬 | 0.07% |
| ADAR1 Capital Management, LLC | US$1505.8萬 | 0.89% |
| RAYMOND JAMES FINANCIAL INC | US$1463.4萬 | 0.00% |
| Spruce Street Capital LP | US$1427.8萬 | 3.43% |
| University of Wisconsin Foundation | US$1393.2萬 | 12.37% |
| Swiss National Bank | US$1354.5萬 | 0.01% |
| Freestone Grove Partners LP | US$1305.9萬 | 0.09% |
| CITADEL ADVISORS LLC | US$1148.3萬 | 0.00% |
| C WorldWide Group Holding A/S | US$1133.1萬 | 0.24% |
| Invesco Ltd. | US$1069.5萬 | 0.00% |
| SEGALL BRYANT & HAMILL, LLC | US$1068.8萬 | 0.15% |
| RHUMBLINE ADVISERS | US$923.0萬 | 0.01% |
| California Public Employees Retirement System | US$880.7萬 | 0.01% |
| Qube Research & Technologies Ltd | US$844.8萬 | 0.01% |
| SILVERARC CAPITAL MANAGEMENT, LLC | US$842.5萬 | 0.86% |
| First Light Asset Management, LLC | US$823.9萬 | 0.74% |
| Creative Planning | US$814.6萬 | 0.01% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$790.9萬 | 0.01% |
| CITIGROUP INC | US$768.1萬 | 0.00% |
| Clearbridge Investments, LLC | US$746.0萬 | 0.01% |
| ExodusPoint Capital Management, LP | US$731.2萬 | 0.06% |
| HighVista Strategies LLC | US$724.3萬 | 2.00% |
| NAN FUNG TRINITY (HK) LTD | US$714.3萬 | 0.78% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$705.0萬 | 0.01% |
| TWO SIGMA INVESTMENTS, LP | US$646.8萬 | 0.01% |
| AMERIPRISE FINANCIAL INC | US$644.9萬 | 0.00% |
| SUPERSTRING CAPITAL MANAGEMENT LP | US$641.8萬 | 4.59% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$634.8萬 | 0.01% |
| ALLIANCEBERNSTEIN L.P. | US$632.5萬 | 0.00% |
| Seven Fleet Capital Management LP | US$630.2萬 | 2.00% |
| WCM INVESTMENT MANAGEMENT, LLC | US$619.0萬 | 0.01% |
| Cormorant Asset Management, LP | US$581.1萬 | 0.29% |
| ENVESTNET ASSET MANAGEMENT INC | US$570.4萬 | 0.00% |
| Legal & General Group Plc | US$565.6萬 | 0.00% |
| NEXTBio Capital Management LP | US$553.3萬 | 2.57% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$501.9萬 | 0.00% |
| Rafferty Asset Management, LLC | US$455.6萬 | 0.02% |
| DIADEMA PARTNERS LP | US$454.3萬 | 0.77% |
| SummitTX Capital, L.P. | US$434.9萬 | 0.14% |
| Cinctive Capital Management LP | US$433.2萬 | 0.28% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$423.6萬 | 0.01% |
| MetLife Investment Management, LLC | US$394.3萬 | 0.02% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$385.9萬 | 0.01% |
| TWINBEECH CAPITAL LP | US$382.9萬 | 0.40% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$369.1萬 | 0.01% |
| BANQUE PICTET & CIE SA | US$359.4萬 | 0.03% |
| VOYA INVESTMENT MANAGEMENT LLC | US$357.7萬 | 0.00% |
| Rock Springs Capital Management LP | US$350.1萬 | 0.21% |
| PRUDENTIAL FINANCIAL INC | US$344.7萬 | 0.00% |
| STEMPOINT CAPITAL LP | US$343.2萬 | 0.66% |
| Ishara Investments LP | US$333.6萬 | 3.16% |
| RENAISSANCE TECHNOLOGIES LLC | US$318.1萬 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$308.6萬 | 0.00% |
| Walleye Capital LLC | US$307.1萬 | 0.01% |
| Vanguard Global Advisers, LLC | US$300.1萬 | 0.00% |
| Sofinnova Investments, Inc. | US$294.0萬 | 0.11% |
| Burkehill Global Management, LP | US$290.6萬 | 0.14% |
| Trexquant Investment LP | US$286.0萬 | 0.02% |
| LAZARD ASSET MANAGEMENT LLC | US$273.3萬 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$264.8萬 | 0.01% |
| Handelsbanken Fonder AB | US$237.7萬 | 0.01% |
| State of New Jersey Common Pension Fund D | US$234.0萬 | 0.01% |
| ArrowMark Colorado Holdings LLC | US$232.4萬 | 0.06% |
| Russell Investments Group, Ltd. | US$221.9萬 | 0.00% |
| BROWN BROTHERS HARRIMAN & CO | US$221.0萬 | 0.01% |
| HRT FINANCIAL LP | US$216.8萬 | 0.01% |
| GUGGENHEIM CAPITAL LLC | US$216.2萬 | 0.02% |
| PROFUND ADVISORS LLC | US$211.5萬 | 0.08% |
| READYSTATE ASSET MANAGEMENT LP | US$209.7萬 | 0.09% |
| Police & Firemen's Retirement System of New Jersey | US$195.7萬 | 0.02% |
| SEI INVESTMENTS CO | US$194.9萬 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | US$188.0萬 | 0.01% |
| SG Americas Securities, LLC | US$187.2萬 | 0.00% |
| BARCLAYS PLC | US$185.9萬 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$181.4萬 | 0.02% |
| Hudson Bay Capital Management LP | US$180.0萬 | 0.01% |