| Frazier Life Sciences Management, L.P. | US$7.1億 | 18.25% |
| JANUS HENDERSON GROUP PLC | US$6.4億 | 0.31% |
| BlackRock, Inc. | US$3.6億 | 0.01% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$2.2億 | 0.01% |
| FMR LLC | US$1.8億 | 0.01% |
| STATE STREET CORP | US$1.8億 | 0.01% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$1.6億 | 0.02% |
| BVF INC/IL | US$1.5億 | 4.66% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$1.3億 | 0.01% |
| EVENTIDE ASSET MANAGEMENT, LLC | US$1.3億 | 2.15% |
| WELLINGTON MANAGEMENT GROUP LLP | US$1.2億 | 0.02% |
| NOVO HOLDINGS A/S | US$1.2億 | 9.92% |
| GEODE CAPITAL MANAGEMENT, LLC | US$1.2億 | 0.01% |
| TANG CAPITAL MANAGEMENT LLC | US$1.1億 | 5.80% |
| CITADEL ADVISORS LLC | US$9825.1萬 | 0.02% |
| TCG Crossover Management, LLC | US$9811.2萬 | 2.81% |
| Rock Springs Capital Management LP | US$7494.7萬 | 4.42% |
| TWO SIGMA INVESTMENTS, LP | US$7158.0萬 | 0.06% |
| Capital World Investors | US$6692.1萬 | 0.01% |
| BANK OF AMERICA CORP /DE/ | US$6671.5萬 | 0.00% |
| FRANKLIN RESOURCES INC | US$6603.4萬 | 0.02% |
| Clearbridge Investments, LLC | US$6206.7萬 | 0.05% |
| GOLDMAN SACHS GROUP INC | US$6118.4萬 | 0.01% |
| Paradigm Biocapital Advisors LP | US$5773.8萬 | 1.18% |
| LORD, ABBETT & CO. LLC | US$5700.4萬 | 0.19% |
| Bank of New York Mellon Corp | US$5399.8萬 | 0.01% |
| RENAISSANCE TECHNOLOGIES LLC | US$5377.3萬 | 0.08% |
| Woodline Partners LP | US$5246.2萬 | 0.20% |
| Balyasny Asset Management L.P. | US$4979.6萬 | 0.06% |
| MORGAN STANLEY | US$4845.9萬 | 0.00% |
| FEDERATED HERMES, INC. | US$4676.4萬 | 0.08% |
| UBS Group AG | US$4572.8萬 | 0.01% |
| Connor, Clark & Lunn Investment Management Ltd. | US$4429.4萬 | 0.10% |
| LOOMIS SAYLES & CO L P | US$4391.0萬 | 0.06% |
| Nuveen, LLC | US$4380.9萬 | 0.01% |
| Candriam S.C.A. | US$4288.4萬 | 0.22% |
| BAKER BROS. ADVISORS LP | US$4119.9萬 | 0.24% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$3945.5萬 | 0.01% |
| Pictet Asset Management Holding SA | US$3912.4萬 | 0.04% |
| BOONE CAPITAL MANAGEMENT LLC | US$3891.4萬 | 11.92% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | US$3744.4萬 | 0.06% |
| First Turn Management, LLC | US$3699.5萬 | 4.13% |
| Soleus Capital Management, L.P. | US$3698.0萬 | 1.50% |
| EMERALD ADVISERS, LLC | US$3669.9萬 | 1.16% |
| NORTHERN TRUST CORP | US$3648.3萬 | 0.00% |
| NEXT CENTURY GROWTH INVESTORS LLC | US$3561.6萬 | 2.58% |
| TimesSquare Capital Management, LLC | US$3477.9萬 | 0.59% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$3464.3萬 | 0.05% |
| MILLENNIUM MANAGEMENT LLC | US$3404.9萬 | 0.01% |
| Point72 Asset Management, L.P. | US$3266.5萬 | 0.04% |
| Octagon Capital Advisors LP | US$3130.8萬 | 3.46% |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | US$3100.9萬 | 0.10% |
| VANGUARD FIDUCIARY TRUST CO | US$3079.3萬 | 0.01% |
| Trails Edge Capital Partners, LP | US$3079.1萬 | 7.05% |
| Palo Alto Investors LP | US$3004.0萬 | 4.59% |
| RA CAPITAL MANAGEMENT, L.P. | US$2942.8萬 | 0.31% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | US$2645.8萬 | 0.01% |
| Hood River Capital Management LLC | US$2636.4萬 | 0.26% |
| Invesco Ltd. | US$2635.0萬 | 0.00% |
| Polar Capital Holdings Plc | US$2618.8萬 | 0.09% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$2453.9萬 | 0.03% |
| Penn Capital Management Company, LLC | US$2377.5萬 | 1.84% |
| EMERALD MUTUAL FUND ADVISERS TRUST | US$2313.2萬 | 1.12% |
| NAN FUNG TRINITY (HK) LTD | US$2149.5萬 | 2.36% |
| Patient Square Capital LP | US$2124.7萬 | 3.77% |
| RAYMOND JAMES FINANCIAL INC | US$2107.9萬 | 0.01% |
| AMERIPRISE FINANCIAL INC | US$2025.5萬 | 0.00% |
| Ensign Peak Advisors, Inc | US$1870.4萬 | 0.03% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$1858.2萬 | 0.03% |
| Logos Global Management LP | US$1847.6萬 | 0.92% |
| Erste Asset Management GmbH | US$1845.9萬 | 0.17% |
| Russell Investments Group, Ltd. | US$1820.8萬 | 0.02% |
| Handelsbanken Fonder AB | US$1792.2萬 | 0.06% |
| SEGALL BRYANT & HAMILL, LLC | US$1624.9萬 | 0.23% |
| D. E. Shaw & Co., Inc. | US$1547.3萬 | 0.01% |
| Legal & General Group Plc | US$1421.5萬 | 0.00% |
| CITIGROUP INC | US$1417.8萬 | 0.01% |
| FIRST TRUST ADVISORS LP | US$1397.5萬 | 0.01% |
| Voleon Capital Management LP | US$1390.4萬 | 0.30% |
| RICE HALL JAMES & ASSOCIATES, LLC | US$1358.3萬 | 0.76% |
| PDT Partners, LLC | US$1343.0萬 | 0.79% |
| Nicholas Investment Partners, LP | US$1213.0萬 | 0.88% |
| PANAGORA ASSET MANAGEMENT INC | US$1192.8萬 | 0.04% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$1183.5萬 | 0.00% |
| Highlander Partners, L.P. | US$1136.1萬 | 4.45% |
| ESSEX INVESTMENT MANAGEMENT CO LLC | US$1000.8萬 | 1.58% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | US$961.7萬 | 0.04% |
| Atle Fund Management AB | US$939.8萬 | 3.03% |
| Caption Management, LLC | US$923.8萬 | 0.05% |
| VICTORY CAPITAL MANAGEMENT INC | US$882.7萬 | 0.01% |
| Hennion & Walsh Asset Management, Inc. | US$864.6萬 | 0.29% |
| Fisher Asset Management, LLC | US$860.1萬 | 0.00% |
| Rhenman & Partners Asset Management AB | US$855.5萬 | 1.06% |
| ExodusPoint Capital Management, LP | US$807.2萬 | 0.07% |
| JPMORGAN CHASE & CO | US$796.9萬 | 0.00% |
| SEI INVESTMENTS CO | US$749.3萬 | 0.01% |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | US$748.2萬 | 0.05% |
| NEUBERGER BERMAN GROUP LLC | US$744.1萬 | 0.01% |
| Swiss National Bank | US$686.4萬 | 0.00% |
| PICTON MAHONEY ASSET MANAGEMENT | US$684.7萬 | 0.05% |
| VOYA INVESTMENT MANAGEMENT LLC | US$635.7萬 | 0.01% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | US$627.1萬 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$615.5萬 | 0.00% |
| Squarepoint Ops LLC | US$569.9萬 | 0.01% |
| Hillsdale Investment Management Inc. | US$551.8萬 | 0.15% |
| PRINCIPAL FINANCIAL GROUP INC | US$530.0萬 | 0.00% |
| Thrivent Financial for Lutherans | US$527.1萬 | 0.01% |
| BANK OF MONTREAL /CAN/ | US$520.9萬 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$514.5萬 | 0.00% |
| RHUMBLINE ADVISERS | US$479.8萬 | 0.00% |
| F/m Investments LLC | US$470.3萬 | 0.31% |
| DEUTSCHE BANK AG\ | US$462.3萬 | 0.00% |
| Rafferty Asset Management, LLC | US$454.1萬 | 0.02% |
| ALPS ADVISORS INC | US$453.8萬 | 0.02% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$410.9萬 | 0.00% |
| Secure Asset Management, LLC | US$403.2萬 | 0.64% |
| Informed Momentum Co LLC | US$402.7萬 | 0.46% |
| ALLIANCEBERNSTEIN L.P. | US$388.5萬 | 0.00% |
| Legato Capital Management LLC | US$385.8萬 | 0.35% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$369.8萬 | 0.01% |
| Lisanti Capital Growth, LLC | US$360.3萬 | 0.91% |
| Cinctive Capital Management LP | US$355.8萬 | 0.23% |
| ZACKS INVESTMENT MANAGEMENT | US$340.8萬 | 0.03% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$315.1萬 | 0.01% |
| Alyeska Investment Group, L.P. | US$314.6萬 | 0.01% |
| TD Asset Management Inc | US$311.2萬 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$293.7萬 | 0.00% |
| Allianz Asset Management GmbH | US$288.7萬 | 0.00% |
| Creative Planning | US$283.2萬 | 0.00% |
| Sofinnova Investments, Inc. | US$254.9萬 | 0.10% |
| MACKENZIE FINANCIAL CORP | US$254.9萬 | 0.00% |
| Faithward Advisors, LLC | US$253.7萬 | 0.36% |
| Pathstone Holdings, LLC | US$236.3萬 | 0.01% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$231.1萬 | 0.00% |
| Knights of Columbus Asset Advisors LLC | US$220.1萬 | 0.12% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$213.4萬 | 0.00% |
| MetLife Investment Management, LLC | US$210.8萬 | 0.01% |
| MARTINGALE ASSET MANAGEMENT L P | US$210.0萬 | 0.05% |
| ENVESTNET ASSET MANAGEMENT INC | US$208.4萬 | 0.00% |
| PROFUND ADVISORS LLC | US$204.9萬 | 0.08% |
| Vanguard Global Advisers, LLC | US$197.1萬 | 0.00% |
| POLEN CAPITAL MANAGEMENT LLC | US$189.7萬 | 0.01% |
| ROYAL BANK OF CANADA | US$186.3萬 | 0.00% |
| CenterBook Partners LP | US$182.0萬 | 0.10% |
| CAPITAL FUND MANAGEMENT S.A. | US$181.4萬 | 0.01% |
| NOMURA HOLDINGS INC | US$181.0萬 | 0.01% |
| BARCLAYS PLC | US$180.4萬 | 0.00% |
| Ascentis Independent Advisors | US$179.0萬 | 0.14% |
| XTX Topco Ltd | US$178.4萬 | 0.03% |
| WELLS FARGO & COMPANY/MN | US$162.8萬 | 0.00% |