| FMR LLC | US$11.3億 | 0.06% |
| BlackRock, Inc. | US$10.2億 | 0.02% |
| Avoro Capital Advisors LLC | US$7.5億 | 7.34% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$3.8億 | 0.02% |
| STATE STREET CORP | US$3.4億 | 0.01% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$3.0億 | 0.01% |
| Soleus Capital Management, L.P. | US$3.0億 | 12.06% |
| Capital World Investors | US$2.1億 | 0.03% |
| Redmile Group, LLC | US$1.7億 | 11.52% |
| GEODE CAPITAL MANAGEMENT, LLC | US$1.7億 | 0.01% |
| Hood River Capital Management LLC | US$1.6億 | 1.60% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$1.3億 | 0.01% |
| Bellevue Group AG | US$1.2億 | 2.96% |
| Frazier Life Sciences Management, L.P. | US$1.2億 | 3.20% |
| DIMENSIONAL FUND ADVISORS LP | US$1.2億 | 0.03% |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | US$1.1億 | 0.35% |
| FIRST TRUST ADVISORS LP | US$9054.7萬 | 0.06% |
| JANUS HENDERSON GROUP PLC | US$6887.9萬 | 0.03% |
| BANK OF AMERICA CORP /DE/ | US$6733.0萬 | 0.00% |
| NORTHERN TRUST CORP | US$6521.6萬 | 0.01% |
| Invesco Ltd. | US$6493.5萬 | 0.01% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$6251.0萬 | 0.01% |
| GOLDMAN SACHS GROUP INC | US$5552.6萬 | 0.01% |
| MORGAN STANLEY | US$5401.0萬 | 0.00% |
| Caption Management, LLC | US$4908.1萬 | 0.29% |
| BRAIDWELL LP | US$4712.4萬 | 1.57% |
| FRANKLIN RESOURCES INC | US$4630.8萬 | 0.01% |
| VANGUARD FIDUCIARY TRUST CO | US$4628.1萬 | 0.01% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$4258.2萬 | 0.00% |
| PRINCIPAL FINANCIAL GROUP INC | US$4186.6萬 | 0.02% |
| UBS Group AG | US$4123.4萬 | 0.01% |
| RAYMOND JAMES FINANCIAL INC | US$3953.5萬 | 0.01% |
| Woodline Partners LP | US$3890.7萬 | 0.15% |
| Bank of New York Mellon Corp | US$3856.9萬 | 0.01% |
| Nuveen, LLC | US$3703.5萬 | 0.01% |
| TimesSquare Capital Management, LLC | US$2902.0萬 | 0.49% |
| Pictet Asset Management Holding SA | US$2858.7萬 | 0.03% |
| VOYA INVESTMENT MANAGEMENT LLC | US$2800.1萬 | 0.03% |
| JPMORGAN CHASE & CO | US$2447.3萬 | 0.00% |
| Public Sector Pension Investment Board | US$2383.9萬 | 0.07% |
| Handelsbanken Fonder AB | US$2361.0萬 | 0.08% |
| S SQUARED TECHNOLOGY, LLC | US$2227.1萬 | 8.43% |
| SEGALL BRYANT & HAMILL, LLC | US$2053.6萬 | 0.29% |
| Biondo Investment Advisors, LLC | US$1861.1萬 | 2.39% |
| ORBIMED ADVISORS LLC | US$1785.0萬 | 0.37% |
| MARSHALL WACE, LLP | US$1765.4萬 | 0.02% |
| RHUMBLINE ADVISERS | US$1759.1萬 | 0.02% |
| C WorldWide Group Holding A/S | US$1751.6萬 | 0.38% |
| ACT CAPITAL MANAGEMENT, LLC | US$1562.2萬 | 12.28% |
| Legal & General Group Plc | US$1525.4萬 | 0.00% |
| AMERIPRISE FINANCIAL INC | US$1287.4萬 | 0.00% |
| SEI INVESTMENTS CO | US$1203.0萬 | 0.01% |
| Bridgewater Associates, LP | US$1197.8萬 | 0.05% |
| SEB Asset Management AB | US$1197.1萬 | 0.05% |
| Palisades Investment Partners, LLC | US$1172.9萬 | 4.60% |
| TD Asset Management Inc | US$1119.0萬 | 0.01% |
| Swiss National Bank | US$1110.8萬 | 0.01% |
| 1832 Asset Management L.P. | US$1100.4萬 | 0.01% |
| VICTORY CAPITAL MANAGEMENT INC | US$1051.7萬 | 0.01% |
| GILDER GAGNON HOWE & CO LLC | US$1036.6萬 | 0.12% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$954.2萬 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$931.7萬 | 0.01% |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | US$926.3萬 | 0.11% |
| FEDERATED HERMES, INC. | US$916.9萬 | 0.01% |
| NEUBERGER BERMAN GROUP LLC | US$854.6萬 | 0.01% |
| CITADEL ADVISORS LLC | US$829.9萬 | 0.00% |
| CASTLEARK MANAGEMENT LLC | US$817.1萬 | 0.27% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$809.6萬 | 0.01% |
| CITIGROUP INC | US$805.2萬 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | US$787.2萬 | 0.00% |
| Aberdeen Group plc | US$779.0萬 | 0.01% |
| PRUDENTIAL FINANCIAL INC | US$765.6萬 | 0.01% |
| Fisher Asset Management, LLC | US$717.7萬 | 0.00% |
| Atle Fund Management AB | US$679.4萬 | 2.19% |
| Russell Investments Group, Ltd. | US$677.1萬 | 0.01% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$676.4萬 | 0.01% |
| JANE STREET GROUP, LLC | US$666.5萬 | 0.00% |
| DEUTSCHE BANK AG\ | US$641.4萬 | 0.00% |
| Granite Investment Partners, LLC | US$627.3萬 | 0.39% |
| Fiera Capital Corp | US$623.7萬 | 0.02% |
| Elmind Capital, LP | US$568.3萬 | 1.61% |
| CANADA LIFE ASSURANCE Co | US$553.0萬 | 0.01% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$534.5萬 | 0.01% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$532.3萬 | 0.00% |
| BESSEMER GROUP INC | US$524.0萬 | 0.01% |
| Pinnacle Financial Partners, Inc. | US$521.3萬 | 0.04% |
| EFG International AG | US$517.9萬 | 0.11% |
| ADAR1 Capital Management, LLC | US$517.0萬 | 0.30% |
| Tetragon Partners GP Ltd | US$508.1萬 | 0.99% |
| GW&K Investment Management, LLC | US$497.1萬 | 0.04% |
| Lisanti Capital Growth, LLC | US$478.3萬 | 1.21% |
| ZACKS INVESTMENT MANAGEMENT | US$462.9萬 | 0.04% |
| Campbell & CO Investment Adviser LLC | US$459.7萬 | 0.26% |
| Rafferty Asset Management, LLC | US$456.9萬 | 0.02% |
| State of Alaska, Department of Revenue | US$451.4萬 | 0.05% |
| Thrivent Financial for Lutherans | US$445.0萬 | 0.01% |
| Rhenman & Partners Asset Management AB | US$430.7萬 | 0.53% |
| Informed Momentum Co LLC | US$425.8萬 | 0.49% |
| Creative Planning | US$411.7萬 | 0.00% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$407.0萬 | 0.01% |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | US$403.9萬 | 0.01% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$389.2萬 | 0.01% |
| CIM, LLC | US$387.2萬 | 0.56% |
| WELLS FARGO & COMPANY/MN | US$387.2萬 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | US$373.9萬 | 0.01% |
| Illinois Municipal Retirement Fund | US$365.5萬 | 0.05% |
| AQR CAPITAL MANAGEMENT LLC | US$364.6萬 | 0.00% |
| MetLife Investment Management, LLC | US$349.8萬 | 0.02% |
| INTECH INVESTMENT MANAGEMENT LLC | US$349.2萬 | 0.03% |
| CREDIT AGRICOLE S A | US$335.2萬 | 0.01% |
| Evolutionary Tree Capital Management, LLC | US$318.1萬 | 5.98% |
| NATIXIS ADVISORS, LLC | US$313.2萬 | 0.00% |
| Bridge City Capital, LLC | US$311.1萬 | 0.86% |
| Torray Investment Partners LLC | US$310.8萬 | 0.46% |
| ENVESTNET ASSET MANAGEMENT INC | US$309.5萬 | 0.00% |
| COMMONWEALTH EQUITY SERVICES, LLC | US$299.4萬 | 0.00% |
| Louisiana State Employees Retirement System | US$294.5萬 | 0.05% |
| Vanguard Global Advisers, LLC | US$291.3萬 | 0.00% |
| Privium Fund Management B.V. | US$288.5萬 | 0.60% |
| Atika Capital Management LLC | US$274.5萬 | 0.43% |
| D. E. Shaw & Co., Inc. | US$268.5萬 | 0.00% |
| State of Tennessee, Department of Treasury | US$264.9萬 | 0.01% |
| WELLINGTON MANAGEMENT GROUP LLP | US$264.2萬 | 0.00% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | US$264.0萬 | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | US$248.0萬 | 0.00% |
| BROWN CAPITAL MANAGEMENT LLC | US$238.9萬 | 0.34% |
| PROFUND ADVISORS LLC | US$227.1萬 | 0.08% |
| CLOUGH CAPITAL PARTNERS L P | US$219.6萬 | 0.21% |
| Erste Asset Management GmbH | US$214.8萬 | 0.02% |
| Aquatic Capital Management LLC | US$213.3萬 | 0.06% |
| TEALWOOD ASSET MANAGEMENT INC | US$198.0萬 | 0.90% |
| XTX Topco Ltd | US$193.2萬 | 0.03% |
| State of New Jersey Common Pension Fund D | US$192.0萬 | 0.01% |
| AMALGAMATED BANK | US$190.6萬 | 0.01% |
| Decheng Capital LLC | US$188.6萬 | 0.29% |
| MARTINGALE ASSET MANAGEMENT L P | US$186.2萬 | 0.05% |
| Quantum Private Wealth, LLC | US$185.5萬 | 0.57% |
| YOUSIF CAPITAL MANAGEMENT, LLC | US$184.2萬 | 0.02% |
| Legato Capital Management LLC | US$180.1萬 | 0.16% |
| Police & Firemen's Retirement System of New Jersey | US$174.3萬 | 0.01% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | US$166.8萬 | 0.01% |
| STRS OHIO | US$165.3萬 | 0.01% |
| COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | US$164.9萬 | 0.01% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$160.9萬 | 0.00% |
| Cetera Investment Advisers | US$160.3萬 | 0.00% |
| Sanctuary Advisors, LLC | US$155.8萬 | 0.01% |
| ARIZONA STATE RETIREMENT SYSTEM | US$154.3萬 | 0.01% |
| OREGON PUBLIC EMPLOYEES RETIREMENT FUND | US$153.7萬 | 0.02% |
| FIFTH THIRD BANCORP | US$153.1萬 | 0.00% |
| SG Americas Securities, LLC | US$152.4萬 | 0.00% |