| BlackRock, Inc. | US$2.2億 | 0.00% |
| RA CAPITAL MANAGEMENT, L.P. | US$1.5億 | 1.60% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | US$1.4億 | 1.69% |
| STATE STREET CORP | US$1.2億 | 0.00% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$1.1億 | 0.01% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$1.1億 | 0.00% |
| TCG Crossover Management, LLC | US$1.0億 | 3.00% |
| JANUS HENDERSON GROUP PLC | US$8485.4萬 | 0.04% |
| PERCEPTIVE ADVISORS LLC | US$7077.2萬 | 1.38% |
| Vestal Point Capital, LP | US$6687.8萬 | 1.87% |
| TWO SIGMA INVESTMENTS, LP | US$6085.8萬 | 0.05% |
| GEODE CAPITAL MANAGEMENT, LLC | US$5506.3萬 | 0.00% |
| Kynam Capital Management, LP | US$5408.1萬 | 3.34% |
| BANK OF AMERICA CORP /DE/ | US$4847.4萬 | 0.00% |
| Aberdeen Group plc | US$4798.7萬 | 0.08% |
| UBS Group AG | US$4706.7萬 | 0.01% |
| Frazier Life Sciences Management, L.P. | US$3816.8萬 | 0.98% |
| Royalty Pharma Sub-Manager, LLC | US$3661.5萬 | 21.19% |
| Nuveen, LLC | US$3635.9萬 | 0.01% |
| GW&K Investment Management, LLC | US$3085.0萬 | 0.27% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$3000.4萬 | 0.00% |
| Eversept Partners, LP | US$2893.9萬 | 1.53% |
| RFG Advisory, LLC | US$2732.9萬 | 0.50% |
| Fisher Asset Management, LLC | US$2602.1萬 | 0.01% |
| DIMENSIONAL FUND ADVISORS LP | US$2561.5萬 | 0.01% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$2237.6萬 | 0.00% |
| GOLDMAN SACHS GROUP INC | US$2234.8萬 | 0.00% |
| Candriam S.C.A. | US$2177.1萬 | 0.11% |
| RICE HALL JAMES & ASSOCIATES, LLC | US$2123.1萬 | 1.18% |
| NORTHERN TRUST CORP | US$2003.7萬 | 0.00% |
| MORGAN STANLEY | US$1925.9萬 | 0.00% |
| Nantahala Capital Management, LLC | US$1892.0萬 | 0.70% |
| STIFEL FINANCIAL CORP | US$1737.6萬 | 0.02% |
| Parkman Healthcare Partners LLC | US$1626.1萬 | 1.68% |
| VANGUARD FIDUCIARY TRUST CO | US$1584.4萬 | 0.00% |
| Pacer Advisors, Inc. | US$1488.0萬 | 0.04% |
| JPMORGAN CHASE & CO | US$1457.2萬 | 0.00% |
| ORBIMED ADVISORS LLC | US$1356.8萬 | 0.28% |
| Legal & General Group Plc | US$1343.5萬 | 0.00% |
| Schonfeld Strategic Advisors LLC | US$1273.5萬 | 0.09% |
| Invesco Ltd. | US$1246.0萬 | 0.00% |
| Man Group plc | US$1231.2萬 | 0.02% |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | US$1168.1萬 | 0.02% |
| JANE STREET GROUP, LLC | US$1164.5萬 | 0.00% |
| CITADEL ADVISORS LLC | US$1156.6萬 | 0.00% |
| JUPITER ASSET MANAGEMENT LTD | US$1138.9萬 | 0.06% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | US$956.2萬 | 0.04% |
| Elmind Capital, LP | US$952.0萬 | 2.70% |
| Rosalind Advisors, Inc. | US$878.8萬 | 3.53% |
| SPHERA FUNDS MANAGEMENT LTD. | US$824.9萬 | 1.31% |
| DEUTSCHE BANK AG\ | US$781.9萬 | 0.00% |
| FIRST TRUST ADVISORS LP | US$762.5萬 | 0.01% |
| RENAISSANCE TECHNOLOGIES LLC | US$739.7萬 | 0.01% |
| Hillsdale Investment Management Inc. | US$608.4萬 | 0.17% |
| Bridgewater Associates, LP | US$607.4萬 | 0.03% |
| Bank of New York Mellon Corp | US$607.1萬 | 0.00% |
| FMR LLC | US$602.7萬 | 0.00% |
| IMC-Chicago, LLC | US$601.0萬 | 0.00% |
| PDT Partners, LLC | US$536.4萬 | 0.32% |
| VOYA INVESTMENT MANAGEMENT LLC | US$510.6萬 | 0.01% |
| FRANKLIN RESOURCES INC | US$498.2萬 | 0.00% |
| Hudson Bay Capital Management LP | US$466.8萬 | 0.02% |
| Pictet Asset Management Holding SA | US$445.9萬 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$419.0萬 | 0.00% |
| PRINCIPAL FINANCIAL GROUP INC | US$409.9萬 | 0.00% |
| DAFNA Capital Management LLC | US$409.6萬 | 0.93% |
| Swiss National Bank | US$389.1萬 | 0.00% |
| DOLIVER ADVISORS, LP | US$356.4萬 | 0.81% |
| Susquehanna Portfolio Strategies, LLC | US$356.1萬 | 0.05% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$351.3萬 | 0.00% |
| Rafferty Asset Management, LLC | US$337.3萬 | 0.01% |
| MILLENNIUM MANAGEMENT LLC | US$302.5萬 | 0.00% |
| Gotham Asset Management, LLC | US$297.9萬 | 0.01% |
| FEDERATED HERMES, INC. | US$291.8萬 | 0.00% |
| D. E. Shaw & Co., Inc. | US$287.6萬 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$265.7萬 | 0.01% |
| Russell Investments Group, Ltd. | US$258.6萬 | 0.00% |
| RHUMBLINE ADVISERS | US$253.4萬 | 0.00% |
| CITIGROUP INC | US$248.6萬 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$245.9萬 | 0.00% |
| MARSHALL WACE, LLP | US$234.6萬 | 0.00% |
| MACKENZIE FINANCIAL CORP | US$231.7萬 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$225.6萬 | 0.00% |
| Assenagon Asset Management S.A. | US$221.8萬 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$220.0萬 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | US$205.7萬 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$198.9萬 | 0.00% |
| Capricorn Fund Managers Ltd | US$193.2萬 | 0.30% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$186.9萬 | 0.00% |
| Phocas Financial Corp. | US$186.2萬 | 0.29% |
| Engineers Gate Manager LP | US$185.1萬 | 0.02% |
| ExodusPoint Capital Management, LP | US$180.9萬 | 0.01% |
| NOMURA HOLDINGS INC | US$180.7萬 | 0.01% |
| Balyasny Asset Management L.P. | US$177.2萬 | 0.00% |
| ACADIAN ASSET MANAGEMENT LLC | US$171.1萬 | 0.00% |
| Janney Montgomery Scott LLC | US$155.4萬 | 0.00% |
| RAYMOND JAMES FINANCIAL INC | US$152.8萬 | 0.00% |
| QTR Family Wealth, LLC | US$151.9萬 | 0.63% |
| PROFUND ADVISORS LLC | US$150.9萬 | 0.06% |
| SEI INVESTMENTS CO | US$143.1萬 | 0.00% |
| GROUP ONE TRADING LLC | US$129.7萬 | 0.00% |
| BARCLAYS PLC | US$127.2萬 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$124.7萬 | 0.00% |
| MetLife Investment Management, LLC | US$123.9萬 | 0.01% |
| FRED ALGER MANAGEMENT, LLC | US$118.0萬 | 0.01% |
| CANADA PENSION PLAN INVESTMENT BOARD | US$112.3萬 | 0.00% |
| Hennion & Walsh Asset Management, Inc. | US$108.4萬 | 0.04% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$108.3萬 | 0.00% |
| Virtus Investment Advisers, LLC | US$106.2萬 | 0.29% |
| Jump Financial, LLC | US$104.2萬 | 0.01% |
| ADAR1 Capital Management, LLC | US$100.0萬 | 0.06% |
| State of Wyoming | US$98.9萬 | 0.12% |
| Seven Fleet Capital Management LP | US$97.6萬 | 0.31% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$97.1萬 | 0.00% |
| WELLINGTON MANAGEMENT GROUP LLP | US$94.1萬 | 0.00% |
| Vanguard Global Advisers, LLC | US$93.5萬 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | US$91.1萬 | 0.00% |
| Corient Private Wealth LLC | US$90.9萬 | 0.00% |
| Counterweight Ventures, LLC | US$90.8萬 | 0.51% |
| Marble Bar Asset Management LLP | US$89.9萬 | 0.88% |
| UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO | US$86.6萬 | 0.13% |
| PANAGORA ASSET MANAGEMENT INC | US$84.6萬 | 0.00% |
| Weiss Asset Management LP | US$78.2萬 | 0.01% |
| Quantinno Capital Management LP | US$76.2萬 | 0.00% |
| DARK FOREST CAPITAL MANAGEMENT LP | US$74.4萬 | 0.07% |
| Entropy Technologies, LP | US$72.3萬 | 0.03% |
| OSAIC HOLDINGS, INC. | US$71.8萬 | 0.00% |
| DekaBank Deutsche Girozentrale | US$71.4萬 | 0.00% |
| Cresset Asset Management, LLC | US$71.2萬 | 0.00% |
| Headlands Technologies LLC | US$69.2萬 | 0.08% |
| State of New Jersey Common Pension Fund D | US$67.4萬 | 0.00% |
| Quinn Opportunity Partners LLC | US$67.4萬 | 0.04% |
| COMMONWEALTH EQUITY SERVICES, LLC | US$63.3萬 | 0.00% |
| Integrated Quantitative Investments LLC | US$62.2萬 | 0.11% |
| Police & Firemen's Retirement System of New Jersey | US$60.9萬 | 0.01% |
| Creative Planning | US$58.7萬 | 0.00% |
| ALPS ADVISORS INC | US$57.4萬 | 0.00% |
| Vinva Investment Management Ltd | US$55.6萬 | 0.01% |
| CAPITAL FUND MANAGEMENT S.A. | US$54.4萬 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | US$54.2萬 | 0.00% |
| MARTINGALE ASSET MANAGEMENT L P | US$53.8萬 | 0.01% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$53.7萬 | 0.00% |
| Elo Mutual Pension Insurance Co | US$53.4萬 | 0.01% |
| Sanctuary Advisors, LLC | US$53.0萬 | 0.00% |
| SIMPLEX TRADING, LLC | US$51.4萬 | 0.00% |
| PRUDENTIAL FINANCIAL INC | US$51.2萬 | 0.00% |
| WINTON GROUP Ltd | US$50.7萬 | 0.02% |
| Vanguard Investments Australia, Ltd. | US$49.4萬 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$47.7萬 | 0.00% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | US$46.6萬 | 0.00% |