| FMR LLC | US$5.7億 | 0.03% |
| BlackRock, Inc. | US$3.1億 | 0.01% |
| FARALLON CAPITAL MANAGEMENT LLC | US$3.0億 | 1.73% |
| WELLINGTON MANAGEMENT GROUP LLP | US$3.0億 | 0.06% |
| Driehaus Capital Management LLC | US$2.3億 | 1.71% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$1.9億 | 0.02% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$1.7億 | 0.00% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$1.7億 | 0.01% |
| JANUS HENDERSON GROUP PLC | US$1.6億 | 0.08% |
| EcoR1 Capital, LLC | US$1.6億 | 6.61% |
| Bellevue Group AG | US$1.2億 | 2.84% |
| GEODE CAPITAL MANAGEMENT, LLC | US$9011.9萬 | 0.01% |
| STATE STREET CORP | US$8727.9萬 | 0.00% |
| BAKER BROS. ADVISORS LP | US$8540.5萬 | 0.49% |
| T. Rowe Price Investment Management, Inc. | US$7048.4萬 | 0.05% |
| Siren, L.L.C. | US$6914.0萬 | 1.92% |
| Pictet Asset Management Holding SA | US$6820.4萬 | 0.07% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$6234.1萬 | 0.07% |
| GW&K Investment Management, LLC | US$5879.1萬 | 0.52% |
| NOVO HOLDINGS A/S | US$5629.6萬 | 4.56% |
| RTW INVESTMENTS, LP | US$5271.2萬 | 0.52% |
| JPMORGAN CHASE & CO | US$4539.6萬 | 0.00% |
| ADAR1 Capital Management, LLC | US$4138.1萬 | 2.44% |
| First Light Asset Management, LLC | US$3957.7萬 | 3.55% |
| AMERICAN CENTURY COMPANIES INC | US$3824.0萬 | 0.02% |
| SUVRETTA CAPITAL MANAGEMENT, LLC | US$3791.4萬 | 0.97% |
| ORBIMED ADVISORS LLC | US$3628.4萬 | 0.74% |
| MORGAN STANLEY | US$3340.3萬 | 0.00% |
| Hood River Capital Management LLC | US$3295.7萬 | 0.33% |
| JENNISON ASSOCIATES LLC | US$3285.8萬 | 0.02% |
| DIMENSIONAL FUND ADVISORS LP | US$3093.5萬 | 0.01% |
| NORTHERN TRUST CORP | US$3055.6萬 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$3027.0萬 | 0.00% |
| Candriam S.C.A. | US$3018.1萬 | 0.16% |
| Aberdeen Group plc | US$2979.7萬 | 0.05% |
| AMERIPRISE FINANCIAL INC | US$2899.6萬 | 0.01% |
| Fisher Asset Management, LLC | US$2770.1萬 | 0.01% |
| BANK OF AMERICA CORP /DE/ | US$2601.0萬 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$2573.2萬 | 0.01% |
| MARSHALL WACE, LLP | US$2484.7萬 | 0.02% |
| GOLDMAN SACHS GROUP INC | US$2281.5萬 | 0.00% |
| Fiera Capital Corp | US$2141.6萬 | 0.07% |
| UBS Group AG | US$2077.1萬 | 0.00% |
| Nuveen, LLC | US$2002.9萬 | 0.01% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$1545.8萬 | 0.03% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$1310.4萬 | 0.01% |
| Bank of New York Mellon Corp | US$1302.9萬 | 0.00% |
| Prosight Management, LP | US$1271.2萬 | 2.08% |
| Impax Asset Management Group plc | US$1271.2萬 | 0.09% |
| CITADEL ADVISORS LLC | US$1257.2萬 | 0.00% |
| BRAUN STACEY ASSOCIATES INC | US$1179.7萬 | 0.39% |
| VOYA INVESTMENT MANAGEMENT LLC | US$1111.5萬 | 0.01% |
| DEUTSCHE BANK AG\ | US$935.3萬 | 0.00% |
| Cormorant Asset Management, LP | US$908.0萬 | 0.46% |
| Sio Capital Management, LLC | US$907.6萬 | 1.30% |
| TD Asset Management Inc | US$853.1萬 | 0.01% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$835.8萬 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | US$795.8萬 | 0.00% |
| SEB Asset Management AB | US$776.9萬 | 0.03% |
| Foresite Capital Management VI LLC | US$770.0萬 | 1.67% |
| RICE HALL JAMES & ASSOCIATES, LLC | US$710.8萬 | 0.40% |
| Moody Aldrich Partners LLC | US$666.2萬 | 1.20% |
| SEGALL BRYANT & HAMILL, LLC | US$654.2萬 | 0.09% |
| Swiss National Bank | US$641.0萬 | 0.00% |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | US$594.3萬 | 0.04% |
| ENVESTNET ASSET MANAGEMENT INC | US$547.2萬 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$536.4萬 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$514.4萬 | 0.01% |
| Invesco Ltd. | US$484.7萬 | 0.00% |
| GordonMD Global Investments LP | US$461.2萬 | 3.21% |
| RHUMBLINE ADVISERS | US$430.1萬 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$425.5萬 | 0.00% |
| Russell Investments Group, Ltd. | US$391.8萬 | 0.00% |
| BARCLAYS PLC | US$387.7萬 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$383.4萬 | 0.00% |
| AWM Investment Company, Inc. | US$363.2萬 | 0.40% |
| Burkehill Global Management, LP | US$363.2萬 | 0.18% |
| VICTORY CAPITAL MANAGEMENT INC | US$360.9萬 | 0.00% |
| ALGERT GLOBAL LLC | US$355.2萬 | 0.05% |
| XTX Topco Ltd | US$352.9萬 | 0.06% |
| SECTOR GAMMA AS | US$342.1萬 | 0.81% |
| TWO SIGMA INVESTMENTS, LP | US$317.1萬 | 0.00% |
| ALPS ADVISORS INC | US$309.6萬 | 0.01% |
| Campbell & CO Investment Adviser LLC | US$303.7萬 | 0.17% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$292.5萬 | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | US$289.7萬 | 0.01% |
| Ensign Peak Advisors, Inc | US$273.9萬 | 0.01% |
| Affinity Asset Advisors, LLC | US$272.4萬 | 0.14% |
| Legal & General Group Plc | US$270.1萬 | 0.00% |
| SEI INVESTMENTS CO | US$268.6萬 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$267.5萬 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$236.9萬 | 0.01% |
| MILLENNIUM MANAGEMENT LLC | US$226.5萬 | 0.00% |
| MetLife Investment Management, LLC | US$197.3萬 | 0.01% |
| Creative Planning | US$194.8萬 | 0.00% |
| FIRST TRUST ADVISORS LP | US$186.6萬 | 0.00% |
| ROYAL BANK OF CANADA | US$180.8萬 | 0.00% |
| Vestmark Advisory Solutions, Inc. | US$177.0萬 | 0.02% |
| Man Group plc | US$172.8萬 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | US$167.1萬 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$166.5萬 | 0.00% |
| RAYMOND JAMES FINANCIAL INC | US$164.1萬 | 0.00% |
| Vanguard Global Advisers, LLC | US$148.0萬 | 0.00% |
| Checkpoint Capital L.P. | US$146.1萬 | 0.52% |
| Walleye Capital LLC | US$143.6萬 | 0.01% |
| Orion Porfolio Solutions, LLC | US$136.2萬 | 0.01% |
| Quantinno Capital Management LP | US$122.5萬 | 0.00% |
| Woodline Partners LP | US$119.2萬 | 0.00% |
| JANE STREET GROUP, LLC | US$118.8萬 | 0.00% |
| CAPITAL FUND MANAGEMENT S.A. | US$111.6萬 | 0.01% |
| State of New Jersey Common Pension Fund D | US$111.1萬 | 0.00% |
| Handelsbanken Fonder AB | US$107.1萬 | 0.00% |
| GLENMEDE TRUST CO NA | US$106.2萬 | 0.01% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | US$103.4萬 | 0.01% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$96.0萬 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$95.9萬 | 0.01% |
| Lewis Asset Management, LLC | US$95.0萬 | 0.39% |
| CITIGROUP INC | US$91.1萬 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | US$89.3萬 | 0.01% |
| Progeny 3, Inc. | US$87.2萬 | 0.05% |
| INTECH INVESTMENT MANAGEMENT LLC | US$85.5萬 | 0.01% |
| Pathstone Holdings, LLC | US$84.4萬 | 0.00% |
| Vanguard Investments Australia, Ltd. | US$79.7萬 | 0.00% |
| OPPENHEIMER ASSET MANAGEMENT INC. | US$78.9萬 | 0.01% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$78.2萬 | 0.00% |
| SANDERS MORRIS HARRIS LLC | US$76.6萬 | 0.12% |
| STIFEL FINANCIAL CORP | US$76.5萬 | 0.00% |
| Cerity Partners LLC | US$74.7萬 | 0.00% |
| HighMark Wealth Management LLC | US$74.4萬 | 0.30% |
| KLP KAPITALFORVALTNING AS | US$71.6萬 | 0.00% |
| ProShare Advisors LLC | US$68.5萬 | 0.00% |
| FRANKLIN RESOURCES INC | US$68.0萬 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$67.5萬 | 0.05% |
| Corient Private Wealth LLC | US$67.2萬 | 0.00% |
| NATIXIS ADVISORS, LLC | US$67.0萬 | 0.00% |
| DNB Asset Management AS | US$62.3萬 | 0.00% |
| Virtus Investment Advisers, LLC | US$60.7萬 | 0.17% |
| ASSETMARK, INC | US$59.2萬 | 0.00% |
| FEDERATED HERMES, INC. | US$59.0萬 | 0.00% |
| Jump Financial, LLC | US$58.1萬 | 0.01% |
| Cresset Asset Management, LLC | US$56.4萬 | 0.00% |
| PRUDENTIAL FINANCIAL INC | US$55.6萬 | 0.00% |
| JONES FINANCIAL COMPANIES LLLP | US$54.8萬 | 0.00% |
| OXFORD ASSET MANAGEMENT LLP | US$53.3萬 | 0.23% |
| Amundi | US$47.3萬 | 0.00% |
| TRUIST FINANCIAL CORP | US$42.6萬 | 0.00% |
| Jackson Creek Investment Advisors LLC | US$41.9萬 | 0.12% |
| TEACHER RETIREMENT SYSTEM OF TEXAS | US$41.8萬 | 0.00% |
| PSP Research LLC | US$40.0萬 | 0.28% |
| CANADA LIFE ASSURANCE Co | US$38.7萬 | 0.00% |