| BlackRock, Inc. | US$32.0億 | 0.06% |
| Avoro Capital Advisors LLC | US$15.7億 | 15.44% |
| WELLINGTON MANAGEMENT GROUP LLP | US$13.4億 | 0.25% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$11.9億 | 0.06% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$11.6億 | 0.03% |
| STATE STREET CORP | US$10.9億 | 0.04% |
| RENAISSANCE TECHNOLOGIES LLC | US$10.6億 | 1.66% |
| GEODE CAPITAL MANAGEMENT, LLC | US$7.3億 | 0.05% |
| Caption Management, LLC | US$6.8億 | 3.99% |
| JANUS HENDERSON GROUP PLC | US$5.1億 | 0.25% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$5.1億 | 0.06% |
| AQR CAPITAL MANAGEMENT LLC | US$4.9億 | 0.22% |
| CITADEL ADVISORS LLC | US$4.1億 | 0.07% |
| ASSETMARK, INC | US$3.7億 | 0.74% |
| Invesco Ltd. | US$3.6億 | 0.06% |
| FMR LLC | US$3.1億 | 0.02% |
| DIMENSIONAL FUND ADVISORS LP | US$3.0億 | 0.06% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | US$2.7億 | 3.20% |
| NORTHERN TRUST CORP | US$2.6億 | 0.03% |
| BAILLIE GIFFORD & CO | US$2.5億 | 0.26% |
| MORGAN STANLEY | US$2.4億 | 0.01% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$2.4億 | 0.03% |
| LSV ASSET MANAGEMENT | US$2.4億 | 0.51% |
| Caisse de depot et placement du Quebec | US$2.0億 | 0.33% |
| Bank of New York Mellon Corp | US$2.0億 | 0.04% |
| Swedbank AB | US$1.9億 | 0.20% |
| Pictet Asset Management Holding SA | US$1.8億 | 0.19% |
| MILLENNIUM MANAGEMENT LLC | US$1.8億 | 0.08% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$1.8億 | 0.03% |
| ACADIAN ASSET MANAGEMENT LLC | US$1.8億 | 0.25% |
| JPMORGAN CHASE & CO | US$1.7億 | 0.01% |
| FULLER & THALER ASSET MANAGEMENT, INC. | US$1.7億 | 0.56% |
| FRANKLIN RESOURCES INC | US$1.6億 | 0.04% |
| FIRST TRUST ADVISORS LP | US$1.6億 | 0.11% |
| VANGUARD FIDUCIARY TRUST CO | US$1.6億 | 0.04% |
| Eversept Partners, LP | US$1.6億 | 8.26% |
| CITIGROUP INC | US$1.5億 | 0.06% |
| FRONTIER CAPITAL MANAGEMENT CO LLC | US$1.5億 | 1.54% |
| LORD, ABBETT & CO. LLC | US$1.5億 | 0.48% |
| Pacer Advisors, Inc. | US$1.4億 | 0.41% |
| Sofinnova Investments, Inc. | US$1.4億 | 5.42% |
| UBS Group AG | US$1.4億 | 0.02% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$1.2億 | 0.03% |
| JANE STREET GROUP, LLC | US$1.2億 | 0.02% |
| BANK OF AMERICA CORP /DE/ | US$1.2億 | 0.01% |
| DEUTSCHE BANK AG\ | US$1.2億 | 0.04% |
| Nuveen, LLC | US$1.1億 | 0.03% |
| Soleus Capital Management, L.P. | US$1.1億 | 4.50% |
| Legal & General Group Plc | US$1.1億 | 0.03% |
| ALLIANCEBERNSTEIN L.P. | US$1.1億 | 0.03% |
| Point72 Asset Management, L.P. | US$1.0億 | 0.13% |
| FIFTH THIRD BANCORP | US$9782.9萬 | 0.18% |
| Amundi | US$8752.3萬 | 0.02% |
| Allspring Global Investments Holdings, LLC | US$8355.8萬 | 0.14% |
| Robeco Institutional Asset Management B.V. | US$7584.3萬 | 0.11% |
| Qube Research & Technologies Ltd | US$7319.8萬 | 0.08% |
| RHUMBLINE ADVISERS | US$7263.2萬 | 0.06% |
| Epoch Investment Partners, Inc. | US$7156.2萬 | 0.43% |
| Swiss National Bank | US$7119.0萬 | 0.04% |
| D. E. Shaw & Co., Inc. | US$7062.7萬 | 0.04% |
| HSBC HOLDINGS PLC | US$7061.7萬 | 0.04% |
| PFM Health Sciences, LP | US$6961.9萬 | 6.35% |
| GOLDMAN SACHS GROUP INC | US$6784.8萬 | 0.01% |
| NOMURA HOLDINGS INC | US$6753.1萬 | 0.19% |
| Bridgewater Associates, LP | US$6592.1萬 | 0.29% |
| Thrivent Financial for Lutherans | US$6311.7萬 | 0.12% |
| First Turn Management, LLC | US$6210.0萬 | 6.94% |
| SEIZERT CAPITAL PARTNERS, LLC | US$6206.5萬 | 2.86% |
| TD Asset Management Inc | US$6201.9萬 | 0.05% |
| PRINCIPAL FINANCIAL GROUP INC | US$6030.1萬 | 0.03% |
| Retirement Systems of Alabama | US$5833.6萬 | 0.19% |
| Polaris Capital Management, LLC | US$5731.2萬 | 4.69% |
| DekaBank Deutsche Girozentrale | US$5596.1萬 | 0.09% |
| STOREBRAND ASSET MANAGEMENT AS | US$5558.8萬 | 0.16% |
| AMERIPRISE FINANCIAL INC | US$5410.1萬 | 0.01% |
| Sumitomo Mitsui Trust Group, Inc. | US$5256.0萬 | 0.03% |
| California Public Employees Retirement System | US$5235.4萬 | 0.03% |
| DIADEMA PARTNERS LP | US$5188.8萬 | 8.83% |
| BOWEN HANES & CO INC | US$5040.3萬 | 1.23% |
| Krensavage Asset Management, LLC | US$4997.8萬 | 19.55% |
| Gotham Asset Management, LLC | US$4766.8萬 | 0.15% |
| Logos Global Management LP | US$4743.8萬 | 2.37% |
| Man Group plc | US$4595.3萬 | 0.08% |
| WELLS FARGO & COMPANY/MN | US$4574.1萬 | 0.01% |
| MARSHALL WACE, LLP | US$4505.3萬 | 0.04% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$4482.9萬 | 0.58% |
| Vestal Point Capital, LP | US$4447.4萬 | 1.24% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$4311.9萬 | 0.05% |
| Aware Super Pty Ltd as trustee of Aware Super | US$4300.9萬 | 0.65% |
| Tri Locum Partners LP | US$4172.8萬 | 5.86% |
| AMERICAN CENTURY COMPANIES INC | US$4113.4萬 | 0.02% |
| Vinva Investment Management Ltd | US$4043.0萬 | 0.50% |
| Russell Investments Group, Ltd. | US$3996.8萬 | 0.04% |
| HRT FINANCIAL LP | US$3963.5萬 | 0.10% |
| Portolan Capital Management, LLC | US$3761.6萬 | 2.00% |
| Candriam S.C.A. | US$3739.7萬 | 0.19% |
| BARCLAYS PLC | US$3736.1萬 | 0.01% |
| Palo Alto Investors LP | US$3724.4萬 | 5.70% |
| ATWOOD & PALMER INC | US$3702.3萬 | 2.09% |
| VICTORY CAPITAL MANAGEMENT INC | US$3590.0萬 | 0.02% |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | US$3574.7萬 | 0.53% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$3548.6萬 | 0.04% |
| ROYAL BANK OF CANADA | US$3507.5萬 | 0.01% |
| Summit Street Capital Management, LLC | US$3372.4萬 | 4.77% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$3342.1萬 | 0.03% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$3251.0萬 | 0.07% |
| WEDGE CAPITAL MANAGEMENT L L P/NC | US$3242.0萬 | 0.60% |
| Centiva Capital, LP | US$3053.8萬 | 0.23% |
| ARDSLEY ADVISORY PARTNERS LP | US$2964.9萬 | 3.78% |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | US$2925.4萬 | 0.06% |
| CAPITAL FUND MANAGEMENT S.A. | US$2903.5萬 | 0.13% |
| LMR Partners LLP | US$2872.2萬 | 0.06% |
| RAYMOND JAMES FINANCIAL INC | US$2821.2萬 | 0.01% |
| Assenagon Asset Management S.A. | US$2797.9萬 | 0.04% |
| Treasurer of the State of North Carolina | US$2740.7萬 | 0.09% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$2684.7萬 | 0.02% |
| Mitsubishi UFJ Asset Management Co., Ltd. | US$2658.2萬 | 0.02% |
| Nepsis Inc. | US$2502.0萬 | 8.38% |
| ENVESTNET ASSET MANAGEMENT INC | US$2498.2萬 | 0.01% |
| TWO SIGMA INVESTMENTS, LP | US$2406.1萬 | 0.02% |
| FJARDE AP-FONDEN /FOURTH SWEDISH NATIONAL PENSION FUND | US$2403.3萬 | 0.13% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$2255.4萬 | 0.04% |
| Allianz Asset Management GmbH | US$2238.4萬 | 0.02% |
| Balyasny Asset Management L.P. | US$2171.7萬 | 0.03% |
| IEQ CAPITAL, LLC | US$2129.7萬 | 0.10% |
| CANADA LIFE ASSURANCE Co | US$2109.1萬 | 0.04% |
| Janney Montgomery Scott LLC | US$2081.6萬 | 0.05% |
| PANAGORA ASSET MANAGEMENT INC | US$2072.6萬 | 0.08% |
| Zurich Insurance Group Ltd/FI | US$2065.2萬 | 0.16% |
| AVIVA PLC | US$2042.9萬 | 0.03% |
| Fisher Asset Management, LLC | US$2040.1萬 | 0.01% |
| VAN ECK ASSOCIATES CORP | US$2033.1萬 | 0.02% |
| PRUDENTIAL FINANCIAL INC | US$2032.8萬 | 0.03% |
| Simplify Asset Management Inc. | US$2031.0萬 | 0.31% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | US$1993.7萬 | 0.15% |
| Tidal Investments LLC | US$1979.5萬 | 0.04% |
| National Pension Service | US$1962.3萬 | 0.01% |
| TUDOR INVESTMENT CORP ET AL | US$1844.2萬 | 0.03% |
| Livforsakringsbolaget Skandia, Omsesidigt | US$1831.6萬 | 0.72% |
| Korea Investment CORP | US$1791.0萬 | 0.04% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | US$1727.0萬 | 0.07% |
| EVENTIDE ASSET MANAGEMENT, LLC | US$1692.9萬 | 0.28% |
| SEI INVESTMENTS CO | US$1685.3萬 | 0.02% |
| Mariner, LLC | US$1656.6萬 | 0.02% |
| STRS OHIO | US$1637.5萬 | 0.06% |
| Mitsubishi UFJ Trust & Banking Corp | US$1633.1萬 | 0.04% |
| United Super Pty Ltd in its capacity as Trustee for the Construction & Building Unions Superannuation Fund | US$1576.3萬 | 0.30% |
| Erste Asset Management GmbH | US$1568.9萬 | 0.15% |
| Andra AP-fonden | US$1550.3萬 | 0.18% |
| Ensign Peak Advisors, Inc | US$1499.8萬 | 0.03% |