| BlackRock, Inc. | US$8.8億 | 0.02% |
| RTW INVESTMENTS, LP | US$5.3億 | 5.25% |
| JANUS HENDERSON GROUP PLC | US$4.9億 | 0.23% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$3.3億 | 0.02% |
| STATE STREET CORP | US$3.0億 | 0.01% |
| WELLINGTON MANAGEMENT GROUP LLP | US$2.7億 | 0.05% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$2.5億 | 0.01% |
| TORONTO DOMINION BANK | US$2.1億 | 0.30% |
| ARMISTICE CAPITAL, LLC | US$1.7億 | 2.99% |
| GEODE CAPITAL MANAGEMENT, LLC | US$1.5億 | 0.01% |
| BANK OF AMERICA CORP /DE/ | US$1.3億 | 0.01% |
| Hood River Capital Management LLC | US$1.1億 | 1.14% |
| D. E. Shaw & Co., Inc. | US$1.1億 | 0.07% |
| FMR LLC | US$1.0億 | 0.01% |
| TANG CAPITAL MANAGEMENT LLC | US$1.0億 | 5.19% |
| UBS Group AG | US$9298.2萬 | 0.01% |
| Jefferies Financial Group Inc. | US$9227.9萬 | 0.63% |
| Pictet Asset Management Holding SA | US$8006.3萬 | 0.08% |
| FRANKLIN RESOURCES INC | US$7640.0萬 | 0.02% |
| Driehaus Capital Management LLC | US$6920.5萬 | 0.51% |
| Palo Alto Investors LP | US$6278.9萬 | 9.60% |
| DIMENSIONAL FUND ADVISORS LP | US$6067.4萬 | 0.01% |
| SG Americas Securities, LLC | US$5993.4萬 | 0.06% |
| Invesco Ltd. | US$5896.3萬 | 0.01% |
| GOLDMAN SACHS GROUP INC | US$5638.7萬 | 0.01% |
| NORTHERN TRUST CORP | US$5493.2萬 | 0.01% |
| Woodline Partners LP | US$5075.6萬 | 0.19% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$4984.7萬 | 0.01% |
| JUPITER ASSET MANAGEMENT LTD | US$4847.2萬 | 0.26% |
| MORGAN STANLEY | US$4592.9萬 | 0.00% |
| Nuveen, LLC | US$4544.4萬 | 0.01% |
| Boston Partners | US$4411.2萬 | 0.05% |
| LORD, ABBETT & CO. LLC | US$4204.4萬 | 0.14% |
| Defilade Capital Management, L.P. | US$4111.3萬 | 5.77% |
| Ensign Peak Advisors, Inc | US$3967.3萬 | 0.07% |
| VANGUARD FIDUCIARY TRUST CO | US$3772.1萬 | 0.01% |
| RENAISSANCE TECHNOLOGIES LLC | US$3633.4萬 | 0.06% |
| Bank of New York Mellon Corp | US$3561.6萬 | 0.01% |
| PRINCIPAL FINANCIAL GROUP INC | US$3508.7萬 | 0.02% |
| Qube Research & Technologies Ltd | US$3500.7萬 | 0.04% |
| LOOMIS SAYLES & CO L P | US$3362.9萬 | 0.05% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$3237.3萬 | 0.00% |
| MARSHALL WACE, LLP | US$3138.3萬 | 0.03% |
| Balyasny Asset Management L.P. | US$3137.8萬 | 0.04% |
| Parkman Healthcare Partners LLC | US$2938.9萬 | 3.03% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$2897.2萬 | 0.02% |
| CITADEL ADVISORS LLC | US$2817.2萬 | 0.00% |
| Rockefeller Capital Management L.P. | US$2620.8萬 | 0.05% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$2472.7萬 | 0.00% |
| PANAGORA ASSET MANAGEMENT INC | US$2393.9萬 | 0.09% |
| MACKENZIE FINANCIAL CORP | US$2355.1萬 | 0.03% |
| Legal & General Group Plc | US$2339.4萬 | 0.01% |
| VOYA INVESTMENT MANAGEMENT LLC | US$2334.4萬 | 0.02% |
| AQR CAPITAL MANAGEMENT LLC | US$2330.8萬 | 0.01% |
| Russell Investments Group, Ltd. | US$2285.4萬 | 0.02% |
| JPMORGAN CHASE & CO | US$2271.3萬 | 0.00% |
| Public Sector Pension Investment Board | US$2260.9萬 | 0.07% |
| Schonfeld Strategic Advisors LLC | US$2169.3萬 | 0.15% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$2124.4萬 | 0.02% |
| Caption Management, LLC | US$2058.2萬 | 0.12% |
| DEUTSCHE BANK AG\ | US$1626.6萬 | 0.01% |
| HSBC HOLDINGS PLC | US$1547.0萬 | 0.01% |
| FEDERATED HERMES, INC. | US$1539.2萬 | 0.03% |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | US$1453.6萬 | 0.01% |
| RHUMBLINE ADVISERS | US$1447.5萬 | 0.01% |
| Boxer Capital Management, LLC | US$1362.6萬 | 1.79% |
| SEGALL BRYANT & HAMILL, LLC | US$1331.1萬 | 0.19% |
| Blue Sparrow, LLC /DE | US$1298.6萬 | 0.22% |
| ALLIANCEBERNSTEIN L.P. | US$1155.9萬 | 0.00% |
| AMERIPRISE FINANCIAL INC | US$1135.4萬 | 0.00% |
| PRUDENTIAL FINANCIAL INC | US$1121.2萬 | 0.01% |
| Rock Springs Capital Management LP | US$1102.3萬 | 0.65% |
| Swiss National Bank | US$973.3萬 | 0.01% |
| FIRST TRUST ADVISORS LP | US$926.6萬 | 0.01% |
| SEI INVESTMENTS CO | US$887.1萬 | 0.01% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$885.9萬 | 0.01% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$883.5萬 | 0.02% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$865.0萬 | 0.00% |
| NEUBERGER BERMAN GROUP LLC | US$828.1萬 | 0.01% |
| CAPITAL FUND MANAGEMENT S.A. | US$826.3萬 | 0.04% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | US$760.5萬 | 0.00% |
| ROYCE & ASSOCIATES LP | US$632.4萬 | 0.06% |
| CASTLEARK MANAGEMENT LLC | US$626.0萬 | 0.21% |
| WCM INVESTMENT MANAGEMENT, LLC | US$621.5萬 | 0.01% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$574.5萬 | 0.01% |
| BI Asset Management Fondsmaeglerselskab A/S | US$557.8萬 | 0.06% |
| SECTOR GAMMA AS | US$511.0萬 | 1.21% |
| PINNACLE ASSOCIATES LTD | US$510.7萬 | 0.07% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | US$488.2萬 | 0.02% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$470.0萬 | 0.01% |
| Rafferty Asset Management, LLC | US$468.0萬 | 0.02% |
| CANADA LIFE ASSURANCE Co | US$445.2萬 | 0.01% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$444.2萬 | 0.00% |
| Assenagon Asset Management S.A. | US$418.3萬 | 0.01% |
| Empowered Funds, LLC | US$394.5萬 | 0.03% |
| CenterBook Partners LP | US$387.1萬 | 0.21% |
| INTECH INVESTMENT MANAGEMENT LLC | US$381.2萬 | 0.04% |
| Thrivent Financial for Lutherans | US$365.1萬 | 0.01% |
| PICTON MAHONEY ASSET MANAGEMENT | US$363.3萬 | 0.03% |
| BARCLAYS PLC | US$361.6萬 | 0.00% |
| BESSEMER GROUP INC | US$359.8萬 | 0.01% |
| GROUP ONE TRADING LLC | US$359.1萬 | 0.01% |
| RAYMOND JAMES FINANCIAL INC | US$357.4萬 | 0.00% |
| CITIGROUP INC | US$355.3萬 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$346.7萬 | 0.00% |
| CANADA PENSION PLAN INVESTMENT BOARD | US$344.1萬 | 0.00% |
| MERCER GLOBAL ADVISORS INC /ADV | US$343.1萬 | 0.01% |
| ORBIMED ADVISORS LLC | US$334.5萬 | 0.07% |
| Allspring Global Investments Holdings, LLC | US$329.1萬 | 0.01% |
| Engineers Gate Manager LP | US$314.4萬 | 0.04% |
| MARTINGALE ASSET MANAGEMENT L P | US$310.0萬 | 0.08% |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | US$306.3萬 | 0.01% |
| MOORE CAPITAL MANAGEMENT, LP | US$304.5萬 | 0.06% |
| Fisher Asset Management, LLC | US$303.6萬 | 0.00% |
| State of Alaska, Department of Revenue | US$300.4萬 | 0.03% |
| MetLife Investment Management, LLC | US$292.1萬 | 0.01% |
| Illinois Municipal Retirement Fund | US$289.0萬 | 0.04% |
| Creative Planning | US$287.5萬 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | US$287.3萬 | 0.01% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | US$278.4萬 | 0.02% |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | US$270.5萬 | 2.40% |
| Private Capital Advisors, Inc. | US$265.6萬 | 0.30% |
| Vanguard Global Advisers, LLC | US$256.7萬 | 0.00% |
| Louisiana State Employees Retirement System | US$242.5萬 | 0.04% |
| JANE STREET GROUP, LLC | US$231.0萬 | 0.00% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | US$228.7萬 | 0.00% |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | US$227.7萬 | 0.01% |
| PROFUND ADVISORS LLC | US$227.1萬 | 0.08% |
| ACADIAN ASSET MANAGEMENT LLC | US$222.7萬 | 0.00% |
| State of Tennessee, Department of Treasury | US$220.7萬 | 0.01% |
| WELLS FARGO & COMPANY/MN | US$206.6萬 | 0.00% |
| Horizon Investments, LLC | US$199.9萬 | 0.02% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$197.0萬 | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | US$185.7萬 | 0.00% |
| Convergence Investment Partners, LLC | US$185.4萬 | 0.30% |
| TWO SIGMA INVESTMENTS, LP | US$184.7萬 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$183.7萬 | 0.00% |
| GUGGENHEIM CAPITAL LLC | US$179.7萬 | 0.01% |
| CREDIT AGRICOLE S A | US$179.3萬 | 0.00% |
| QRG CAPITAL MANAGEMENT, INC. | US$177.3萬 | 0.02% |
| LAZARD ASSET MANAGEMENT LLC | US$177.1萬 | 0.00% |
| EXCHANGE TRADED CONCEPTS, LLC | US$172.1萬 | 0.01% |
| Handelsbanken Fonder AB | US$171.7萬 | 0.01% |
| State of New Jersey Common Pension Fund D | US$168.2萬 | 0.01% |
| DekaBank Deutsche Girozentrale | US$165.6萬 | 0.00% |
| RITHOLTZ WEALTH MANAGEMENT | US$164.7萬 | 0.03% |
| Rathbones Group PLC | US$160.1萬 | 0.01% |
| AMALGAMATED BANK | US$156.4萬 | 0.01% |
| Pathstone Holdings, LLC | US$153.2萬 | 0.01% |
| IEQ CAPITAL, LLC | US$152.1萬 | 0.01% |