| FMR LLC | US$4.1億 | 0.02% |
| WELLINGTON MANAGEMENT GROUP LLP | US$3.5億 | 0.07% |
| Avoro Capital Advisors LLC | US$3.2億 | 3.11% |
| JANUS HENDERSON GROUP PLC | US$2.6億 | 0.12% |
| Deep Track Capital, LP | US$2.1億 | 3.37% |
| BVF INC/IL | US$1.7億 | 5.31% |
| MORGAN STANLEY | US$1.1億 | 0.01% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$9643.4萬 | 0.01% |
| PRINCIPAL FINANCIAL GROUP INC | US$8453.1萬 | 0.05% |
| Driehaus Capital Management LLC | US$7602.9萬 | 0.56% |
| ORBIMED ADVISORS LLC | US$7111.4萬 | 1.46% |
| AMERICAN CENTURY COMPANIES INC | US$6931.3萬 | 0.04% |
| BAKER BROS. ADVISORS LP | US$6904.8萬 | 0.40% |
| Siren, L.L.C. | US$6404.3萬 | 1.78% |
| Casdin Capital, LLC | US$5663.5萬 | 4.29% |
| CAPITOLIS LIQUID GLOBAL MARKETS LLC | US$5549.3萬 | 0.35% |
| ALLIANCEBERNSTEIN L.P. | US$4442.9萬 | 0.01% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | US$3701.7萬 | 0.44% |
| Pacific Heights Asset Management LLC | US$3615.0萬 | 1.21% |
| Rock Springs Capital Management LP | US$3085.8萬 | 1.82% |
| Paradigm Biocapital Advisors LP | US$2628.3萬 | 0.54% |
| FRANKLIN RESOURCES INC | US$2562.3萬 | 0.01% |
| Logos Global Management LP | US$2410.0萬 | 1.20% |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | US$2254.8萬 | 0.04% |
| BlackRock, Inc. | US$2130.3萬 | 0.00% |
| GOLDMAN SACHS GROUP INC | US$2092.1萬 | 0.00% |
| Aberdeen Group plc | US$1888.5萬 | 0.03% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$1831.8萬 | 0.00% |
| DEUTSCHE BANK AG\ | US$1599.6萬 | 0.01% |
| NATIONAL BANK OF CANADA /FI/ | US$1472.0萬 | 0.01% |
| Balyasny Asset Management L.P. | US$1469.8萬 | 0.02% |
| Catalio Capital Management, LP | US$1230.9萬 | 2.57% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | US$1229.0萬 | 0.05% |
| SEB Asset Management AB | US$1181.1萬 | 0.05% |
| Pentwater Capital Management LP | US$1180.9萬 | 0.06% |
| Parkman Healthcare Partners LLC | US$1118.7萬 | 1.15% |
| BANK OF AMERICA CORP /DE/ | US$1094.8萬 | 0.00% |
| AMERIPRISE FINANCIAL INC | US$1058.1萬 | 0.00% |
| UBS Group AG | US$1026.3萬 | 0.00% |
| Sio Capital Management, LLC | US$1007.8萬 | 1.45% |
| D. E. Shaw & Co., Inc. | US$987.1萬 | 0.01% |
| TD Asset Management Inc | US$987.0萬 | 0.01% |
| STEMPOINT CAPITAL LP | US$965.3萬 | 1.85% |
| DIADEMA PARTNERS LP | US$962.7萬 | 1.64% |
| JPMORGAN CHASE & CO | US$935.1萬 | 0.00% |
| Woodline Partners LP | US$919.7萬 | 0.03% |
| ArrowMark Colorado Holdings LLC | US$907.1萬 | 0.24% |
| TWO SIGMA INVESTMENTS, LP | US$874.4萬 | 0.01% |
| Cormorant Asset Management, LP | US$843.5萬 | 0.42% |
| MILLENNIUM MANAGEMENT LLC | US$814.2萬 | 0.00% |
| Schonfeld Strategic Advisors LLC | US$797.4萬 | 0.06% |
| Holocene Advisors, LP | US$766.4萬 | 0.02% |
| TCG Crossover Management, LLC | US$676.8萬 | 0.19% |
| Eversept Partners, LP | US$665.3萬 | 0.35% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | US$646.0萬 | 0.01% |
| NEXTBio Capital Management LP | US$642.2萬 | 2.98% |
| HSG Holding Ltd | US$620.5萬 | 0.38% |
| Rhenman & Partners Asset Management AB | US$617.4萬 | 0.76% |
| B Group, Inc. | US$614.6萬 | 4.56% |
| Davern Capital Partners, LP | US$609.5萬 | 1.67% |
| PFM Health Sciences, LP | US$609.2萬 | 0.56% |
| HighVista Strategies LLC | US$597.2萬 | 1.65% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$553.4萬 | 0.00% |
| CITADEL ADVISORS LLC | US$551.4萬 | 0.00% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$528.5萬 | 0.01% |
| Trexquant Investment LP | US$520.0萬 | 0.04% |
| Jump Financial, LLC | US$519.9萬 | 0.07% |
| Jones Hill Capital LP | US$484.9萬 | 1.04% |
| Birchview Capital, LP | US$482.0萬 | 2.74% |
| PEREGRINE CAPITAL MANAGEMENT LLC | US$468.1萬 | 0.17% |
| JANE STREET GROUP, LLC | US$431.9萬 | 0.00% |
| Soleus Capital Management, L.P. | US$385.6萬 | 0.16% |
| TUDOR INVESTMENT CORP ET AL | US$363.0萬 | 0.01% |
| Boxer Capital Management, LLC | US$361.5萬 | 0.47% |
| Qube Research & Technologies Ltd | US$354.7萬 | 0.00% |
| MARSHALL WACE, LLP | US$333.1萬 | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | US$327.1萬 | 0.00% |
| PLATINUM INVESTMENT MANAGEMENT LTD | US$322.3萬 | 0.81% |
| Jefferies Financial Group Inc. | US$301.7萬 | 0.02% |
| Susquehanna Portfolio Strategies, LLC | US$291.7萬 | 0.04% |
| Burkehill Global Management, LP | US$289.2萬 | 0.14% |
| ALPS ADVISORS INC | US$278.0萬 | 0.01% |
| RENAISSANCE TECHNOLOGIES LLC | US$269.0萬 | 0.00% |
| SPHERA FUNDS MANAGEMENT LTD. | US$244.9萬 | 0.39% |
| Monashee Investment Management LLC | US$241.0萬 | 1.31% |
| SEVEN GRAND MANAGERS, LLC | US$241.0萬 | 0.16% |
| Buckland Partners Management Co LLC | US$241.0萬 | 1.46% |
| BANQUE PICTET & CIE SA | US$237.9萬 | 0.02% |
| STATE STREET CORP | US$229.3萬 | 0.00% |
| Pier Capital, LLC | US$229.2萬 | 0.38% |
| DAFNA Capital Management LLC | US$224.1萬 | 0.51% |
| Walleye Capital LLC | US$223.5萬 | 0.01% |
| Brevan Howard Capital Management LP | US$219.9萬 | 0.02% |
| ANTIPODES PARTNERS Ltd | US$218.6萬 | 0.04% |
| RAYMOND JAMES FINANCIAL INC | US$217.6萬 | 0.00% |
| OSAIC HOLDINGS, INC. | US$214.1萬 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | US$214.1萬 | 0.00% |
| BANK OF MONTREAL /CAN/ | US$192.7萬 | 0.00% |
| Headlands Technologies LLC | US$179.1萬 | 0.20% |
| FLAX POND CAPITAL, LLC | US$173.5萬 | 1.40% |
| PSquared Asset Management AG | US$168.7萬 | 0.59% |
| Mariner, LLC | US$166.2萬 | 0.00% |
| TrueMark Investments, LLC | US$165.7萬 | 0.32% |
| NOMURA ASSET MANAGEMENT CO LTD | US$158.0萬 | 0.00% |
| CAPITAL FUND MANAGEMENT S.A. | US$156.3萬 | 0.01% |
| XTX Topco Ltd | US$149.0萬 | 0.03% |
| Avidity Partners Management LP | US$144.6萬 | 0.29% |
| Verition Fund Management LLC | US$135.3萬 | 0.01% |
| DCF Advisers, LLC | US$132.6萬 | 0.35% |
| EXCHANGE TRADED CONCEPTS, LLC | US$122.3萬 | 0.01% |
| Squarepoint Ops LLC | US$109.2萬 | 0.00% |
| CenterBook Partners LP | US$102.4萬 | 0.05% |
| CITIGROUP INC | US$98.8萬 | 0.00% |
| BARCLAYS PLC | US$92.5萬 | 0.00% |
| Persistent Asset Partners Ltd | US$92.3萬 | 0.34% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | US$83.4萬 | 0.01% |
| Walleye Trading LLC | US$76.6萬 | 0.00% |
| Aquatic Capital Management LLC | US$71.4萬 | 0.02% |
| SECTORAL ASSET MANAGEMENT INC | US$71.1萬 | 0.59% |
| SEI INVESTMENTS CO | US$67.4萬 | 0.00% |
| MML INVESTORS SERVICES, LLC | US$66.9萬 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$66.6萬 | 0.05% |
| GSA CAPITAL PARTNERS LLP | US$66.6萬 | 0.04% |
| WEXFORD CAPITAL LP | US$66.1萬 | 0.10% |
| BRANDYWINE MANAGERS, LLC | US$64.4萬 | 0.38% |
| ENVESTNET ASSET MANAGEMENT INC | US$54.8萬 | 0.00% |
| STIFEL FINANCIAL CORP | US$54.7萬 | 0.00% |
| Verdad Advisers, LP | US$54.6萬 | 0.62% |
| Russell Investments Group, Ltd. | US$51.6萬 | 0.00% |
| Quinn Opportunity Partners LLC | US$48.2萬 | 0.03% |
| HighTower Advisors, LLC | US$46.4萬 | 0.00% |
| LPL Financial LLC | US$44.6萬 | 0.00% |
| Gilbert & Cook, Inc. | US$44.3萬 | 0.06% |
| SmartHarvest Portfolios, LLC | US$43.6萬 | 0.18% |
| Seven Fleet Capital Management LP | US$43.4萬 | 0.14% |
| Cinctive Capital Management LP | US$42.0萬 | 0.03% |
| Allianz Asset Management GmbH | US$41.5萬 | 0.00% |
| DNB Asset Management AS | US$39.5萬 | 0.00% |
| AXQ CAPITAL, LP | US$38.2萬 | 0.05% |
| WELLS FARGO & COMPANY/MN | US$37.7萬 | 0.00% |
| Cetera Investment Advisers | US$37.2萬 | 0.00% |
| MISSION WEALTH MANAGEMENT, LP | US$36.6萬 | 0.01% |
| Vestmark Advisory Solutions, Inc. | US$36.3萬 | 0.00% |
| Independent Advisor Alliance | US$35.9萬 | 0.00% |
| Parallel Advisors, LLC | US$35.4萬 | 0.01% |
| Scientech Research LLC | US$33.5萬 | 0.28% |
| Janney Montgomery Scott LLC | US$32.9萬 | 0.00% |
| Bellevue Group AG | US$32.8萬 | 0.01% |
| Mirae Asset Global Investments Co., Ltd. | US$30.9萬 | 0.00% |
| PEAK6 LLC | US$29.2萬 | 0.00% |