| Ikarian Capital, LLC | US$1433.4万 | 1.16% |
| Commodore Capital LP | US$1086.2万 | 0.63% |
| RA CAPITAL MANAGEMENT, L.P. | US$1068.0万 | 0.11% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$1006.1万 | 0.02% |
| T. Rowe Price Investment Management, Inc. | US$859.0万 | 0.01% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$732.5万 | 0.00% |
| Caption Management, LLC | US$658.3万 | 0.04% |
| GOLDMAN SACHS GROUP INC | US$527.8万 | 0.00% |
| Catalio Capital Management, LP | US$500.0万 | 1.04% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$418.0万 | 0.05% |
| Squadron Capital Management LLC | US$417.8万 | 1.53% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$412.0万 | 0.00% |
| JANE STREET GROUP, LLC | US$330.7万 | 0.00% |
| MILLENNIUM MANAGEMENT LLC | US$284.9万 | 0.00% |
| CITADEL ADVISORS LLC | US$282.7万 | 0.00% |
| Affinity Asset Advisors, LLC | US$278.5万 | 0.14% |
| Avidity Partners Management LP | US$258.3万 | 0.52% |
| Soleus Capital Management, L.P. | US$245.1万 | 0.10% |
| ADAR1 Capital Management, LLC | US$190.5万 | 0.11% |
| Boxer Capital Management, LLC | US$168.5万 | 0.22% |
| Davidson Kempner Capital Management LP | US$167.1万 | 0.02% |
| Eversept Partners, LP | US$167.1万 | 0.09% |
| ACORN CAPITAL ADVISORS, LLC | US$160.3万 | 0.46% |
| Jump Financial, LLC | US$146.0万 | 0.02% |
| Trexquant Investment LP | US$143.7万 | 0.01% |
| Ally Bridge Group (NY) LLC | US$139.3万 | 1.12% |
| ACADIAN ASSET MANAGEMENT LLC | US$138.2万 | 0.00% |
| BlackRock, Inc. | US$136.4万 | 0.00% |
| DIADEMA PARTNERS LP | US$134.4万 | 0.23% |
| Brevan Howard Capital Management LP | US$118.3万 | 0.01% |
| GEODE CAPITAL MANAGEMENT, LLC | US$114.9万 | 0.00% |
| UBS Group AG | US$108.1万 | 0.00% |
| GROUP ONE TRADING LLC | US$106.7万 | 0.00% |
| Balyasny Asset Management L.P. | US$95.1万 | 0.00% |
| SILVERBACK ASSET MANAGEMENT LLC | US$91.9万 | 0.13% |
| XTX Topco Ltd | US$91.6万 | 0.02% |
| TWO SIGMA INVESTMENTS, LP | US$84.2万 | 0.00% |
| MARSHALL WACE, LLP | US$71.5万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$64.0万 | 0.00% |
| Engineers Gate Manager LP | US$62.6万 | 0.01% |
| RENAISSANCE TECHNOLOGIES LLC | US$58.7万 | 0.00% |
| Tetragon Partners GP Ltd | US$57.4万 | 0.11% |
| C WorldWide Group Holding A/S | US$55.7万 | 0.01% |
| STATE STREET CORP | US$45.0万 | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | US$44.0万 | 0.00% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | US$40.0万 | 0.01% |
| ROYAL BANK OF CANADA | US$33.6万 | 0.00% |
| DAFNA Capital Management LLC | US$25.5万 | 0.06% |
| NORTHERN TRUST CORP | US$21.5万 | 0.00% |
| Zimmer Partners, LP | US$20.9万 | 0.01% |
| Centiva Capital, LP | US$18.8万 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$16.7万 | 0.01% |
| Point72 Asset Management, L.P. | US$16.7万 | 0.00% |
| Baird Financial Group, Inc. | US$16.6万 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | US$13.9万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$10.8万 | 0.00% |
| OMERS ADMINISTRATION Corp | US$10.8万 | 0.00% |
| MORGAN STANLEY | US$10.3万 | 0.00% |
| Invesco Ltd. | US$9.3万 | 0.00% |
| Velan Capital Investment Management LP | US$8.4万 | 0.05% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$7.5万 | 0.00% |
| HSBC HOLDINGS PLC | US$6.6万 | 0.00% |
| Bank of New York Mellon Corp | US$6.3万 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$6.1万 | 0.00% |
| Vanguard Global Advisers, LLC | US$4.6万 | 0.00% |
| BARCLAYS PLC | US$4.1万 | 0.00% |
| CITIGROUP INC | US$2.8万 | 0.00% |
| TD Waterhouse Canada Inc. | US$1.9万 | 0.00% |
| Rockefeller Capital Management L.P. | US$4083.0 | 0.00% |
| FMR LLC | US$3704.0 | 0.00% |
| JPMORGAN CHASE & CO | US$2496.0 | 0.00% |
| OSAIC HOLDINGS, INC. | US$2239.0 | 0.00% |
| Persistent Asset Partners Ltd | US$2113.0 | 0.00% |
| HARBOUR INVESTMENTS, INC. | US$1587.0 | 0.00% |
| Quent Capital, LLC | US$1309.0 | 0.00% |
| MB, LEVIS & ASSOCIATES, LLC | US$557.0 | 0.00% |
| SBI Securities Co., Ltd. | US$373.0 | 0.00% |
| Activest Wealth Management | US$368.0 | 0.00% |
| Allworth Financial LP | US$145.0 | 0.00% |
| Advisory Services Network, LLC | US$67.0 | 0.00% |
| West Branch Capital LLC | US$17.0 | 0.00% |
| PlanVest Financial, Inc | US$6.0 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | US$4.7 | 0.00% |