| ARK Investment Management LLC | US$5.4億 | 4.19% |
| BlackRock, Inc. | US$3.7億 | 0.01% |
| Orbis Allan Gray Ltd | US$2.9億 | 1.23% |
| Capital World Investors | US$2.2億 | 0.03% |
| STATE STREET CORP | US$1.9億 | 0.01% |
| GSK plc | US$1.5億 | 25.57% |
| T. Rowe Price Investment Management, Inc. | US$1.4億 | 0.10% |
| GEODE CAPITAL MANAGEMENT, LLC | US$1.1億 | 0.01% |
| SR One Capital Management, LP | US$9698.4萬 | 10.59% |
| FMR LLC | US$9298.5萬 | 0.00% |
| Amova Asset Management Americas, Inc. | US$8818.9萬 | 1.25% |
| Sumitomo Mitsui Trust Group, Inc. | US$8818.9萬 | 0.06% |
| UBS Group AG | US$8384.4萬 | 0.01% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$7835.3萬 | 0.01% |
| TWO SIGMA INVESTMENTS, LP | US$7054.9萬 | 0.06% |
| EcoR1 Capital, LLC | US$6608.8萬 | 2.80% |
| CITADEL ADVISORS LLC | US$6410.3萬 | 0.01% |
| Capital International Investors | US$5645.6萬 | 0.01% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$5435.1萬 | 0.00% |
| NEA Management Company, LLC | US$5035.6萬 | 2.86% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$4944.2萬 | 0.01% |
| BANK OF AMERICA CORP /DE/ | US$4676.5萬 | 0.00% |
| LOOMIS SAYLES & CO L P | US$4605.4萬 | 0.06% |
| JANE STREET GROUP, LLC | US$3939.3萬 | 0.01% |
| NORTHERN TRUST CORP | US$3816.0萬 | 0.01% |
| MORGAN STANLEY | US$3178.4萬 | 0.00% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$2601.3萬 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$2581.5萬 | 0.01% |
| DIMENSIONAL FUND ADVISORS LP | US$2348.8萬 | 0.00% |
| PEAK6 LLC | US$2262.9萬 | 0.05% |
| JPMORGAN CHASE & CO | US$2171.1萬 | 0.00% |
| GOLDMAN SACHS GROUP INC | US$1970.4萬 | 0.00% |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | US$1907.0萬 | 1.45% |
| MILLENNIUM MANAGEMENT LLC | US$1794.2萬 | 0.01% |
| IMC-Chicago, LLC | US$1498.0萬 | 0.01% |
| Bank of New York Mellon Corp | US$1481.2萬 | 0.00% |
| AMERIPRISE FINANCIAL INC | US$1364.1萬 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$1335.3萬 | 0.00% |
| GROUP ONE TRADING LLC | US$1275.4萬 | 0.02% |
| Vestmark Advisory Solutions, Inc. | US$1221.5萬 | 0.14% |
| RAYMOND JAMES FINANCIAL INC | US$1047.8萬 | 0.00% |
| Nuveen, LLC | US$907.5萬 | 0.00% |
| Squarepoint Ops LLC | US$826.2萬 | 0.01% |
| Swiss National Bank | US$807.3萬 | 0.00% |
| ROYAL BANK OF CANADA | US$778.9萬 | 0.00% |
| TD Asset Management Inc | US$753.6萬 | 0.01% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$748.7萬 | 0.00% |
| LPL Financial LLC | US$723.3萬 | 0.00% |
| Affinity Asset Advisors, LLC | US$713.6萬 | 0.37% |
| Versant Venture Management, LLC | US$708.0萬 | 5.01% |
| Pictet Asset Management Holding SA | US$687.4萬 | 0.01% |
| D. E. Shaw & Co., Inc. | US$678.8萬 | 0.00% |
| ExodusPoint Capital Management, LP | US$642.8萬 | 0.05% |
| Marex Group plc | US$637.9萬 | 0.04% |
| Trexquant Investment LP | US$605.0萬 | 0.04% |
| Reynders McVeigh Capital Management, LLC | US$587.2萬 | 0.30% |
| AMERICAN CENTURY COMPANIES INC | US$573.2萬 | 0.00% |
| Walleye Trading LLC | US$556.5萬 | 0.01% |
| KBC Group NV | US$555.8萬 | 0.01% |
| California Public Employees Retirement System | US$552.3萬 | 0.00% |
| RHUMBLINE ADVISERS | US$546.2萬 | 0.00% |
| CONGRESS ASSET MANAGEMENT CO | US$515.5萬 | 0.04% |
| Jump Financial, LLC | US$511.1萬 | 0.07% |
| Private Advisor Group, LLC | US$507.4萬 | 0.02% |
| DIADEMA PARTNERS LP | US$505.7萬 | 0.86% |
| ALLIANCEBERNSTEIN L.P. | US$505.3萬 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | US$501.3萬 | 0.07% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$499.5萬 | 0.00% |
| CAPITAL INTERNATIONAL SARL | US$486.5萬 | 0.08% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$481.6萬 | 0.01% |
| CITIGROUP INC | US$480.3萬 | 0.00% |
| ALGERT GLOBAL LLC | US$460.6萬 | 0.07% |
| CAPITAL FUND MANAGEMENT S.A. | US$455.6萬 | 0.02% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$448.5萬 | 0.01% |
| Baker Chad R | US$443.8萬 | 0.84% |
| HIMENSION CAPITAL (SINGAPORE) PTE. LTD. | US$439.9萬 | 0.34% |
| Slow Capital, Inc. | US$433.9萬 | 0.56% |
| Rafferty Asset Management, LLC | US$429.7萬 | 0.02% |
| Man Group plc | US$428.4萬 | 0.01% |
| EverSource Wealth Advisors, LLC | US$426.6萬 | 0.13% |
| TUDOR INVESTMENT CORP ET AL | US$421.5萬 | 0.01% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$409.2萬 | 0.01% |
| VAN ECK ASSOCIATES CORP | US$405.7萬 | 0.00% |
| DEUTSCHE BANK AG\ | US$396.5萬 | 0.00% |
| ENVESTNET ASSET MANAGEMENT INC | US$391.1萬 | 0.00% |
| COMMONWEALTH EQUITY SERVICES, LLC | US$373.4萬 | 0.01% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$365.6萬 | 0.00% |
| Legal & General Group Plc | US$359.8萬 | 0.00% |
| Rockefeller Capital Management L.P. | US$348.8萬 | 0.01% |
| HRT FINANCIAL LP | US$335.5萬 | 0.01% |
| SIMPLEX TRADING, LLC | US$308.3萬 | 0.00% |
| Invesco Ltd. | US$305.0萬 | 0.00% |
| Concurrent Investment Advisors, LLC | US$296.9萬 | 0.03% |
| JONES FINANCIAL COMPANIES LLLP | US$291.3萬 | 0.00% |
| OSAIC HOLDINGS, INC. | US$285.7萬 | 0.00% |
| Cetera Investment Advisers | US$281.8萬 | 0.00% |
| BARCLAYS PLC | US$272.4萬 | 0.00% |
| Green Alpha Advisors, LLC | US$271.3萬 | 2.67% |
| Caption Management, LLC | US$271.1萬 | 0.02% |
| CAPITAL INTERNATIONAL LTD /CA/ | US$266.7萬 | 0.10% |
| BENJAMIN EDWARDS INC | US$264.0萬 | 0.03% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$250.0萬 | 0.01% |
| Monashee Investment Management LLC | US$237.9萬 | 1.29% |
| Curi Capital, LLC | US$236.5萬 | 0.04% |
| MetLife Investment Management, LLC | US$236.1萬 | 0.01% |
| Walleye Capital LLC | US$233.2萬 | 0.01% |
| Quantinno Capital Management LP | US$228.3萬 | 0.00% |
| Patriot Financial Group Insurance Agency, LLC | US$226.2萬 | 0.13% |
| Russell Investments Group, Ltd. | US$225.7萬 | 0.00% |
| LAZARD ASSET MANAGEMENT LLC | US$223.9萬 | 0.00% |
| Point72 Asset Management, L.P. | US$208.8萬 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$208.2萬 | 0.00% |
| Privium Fund Management B.V. | US$204.0萬 | 0.42% |
| PROFUND ADVISORS LLC | US$195.1萬 | 0.07% |
| JANUS HENDERSON GROUP PLC | US$191.6萬 | 0.00% |
| Palo Alto Investors LP | US$188.4萬 | 0.29% |
| Vanguard Global Advisers, LLC | US$186.6萬 | 0.00% |
| Wealth Enhancement Trust Services, Inc. | US$184.8萬 | 0.22% |
| STIFEL FINANCIAL CORP | US$181.6萬 | 0.00% |
| Cambridge Investment Research Advisors, Inc. | US$180.7萬 | 0.00% |
| Creative Planning | US$178.9萬 | 0.00% |
| GUGGENHEIM CAPITAL LLC | US$169.7萬 | 0.01% |
| West Family Investments, Inc. | US$168.9萬 | 0.59% |
| Canal Insurance CO | US$167.0萬 | 0.36% |
| WELLINGTON MANAGEMENT GROUP LLP | US$165.9萬 | 0.00% |
| Corient Private Wealth LLC | US$165.6萬 | 0.00% |
| BRAVE ASSET MANAGEMENT INC | US$165.2萬 | 0.39% |
| Capital International, Inc./CA/ | US$163.4萬 | 0.01% |
| Bouvel Investment Partners, LLC | US$154.7萬 | 0.45% |
| LMR Partners LLP | US$150.3萬 | 0.00% |
| BLAIR WILLIAM & CO/IL | US$150.1萬 | 0.00% |
| State of New Jersey Common Pension Fund D | US$139.4萬 | 0.01% |
| FRANKLIN RESOURCES INC | US$135.0萬 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$133.2萬 | 0.00% |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | US$132.1萬 | 0.00% |
| Handelsbanken Fonder AB | US$128.0萬 | 0.00% |
| Hennion & Walsh Asset Management, Inc. | US$124.1萬 | 0.04% |
| HSBC HOLDINGS PLC | US$121.3萬 | 0.00% |
| Moran Wealth Management, LLC | US$120.4萬 | 0.04% |
| HighTower Advisors, LLC | US$118.9萬 | 0.00% |
| Deuterium Capital Management, LLC | US$118.9萬 | 1.38% |
| INTECH INVESTMENT MANAGEMENT LLC | US$118.9萬 | 0.01% |
| Police & Firemen's Retirement System of New Jersey | US$117.6萬 | 0.01% |
| CLOUGH CAPITAL PARTNERS L P | US$117.4萬 | 0.11% |
| CAPTRUST FINANCIAL ADVISORS | US$117.1萬 | 0.00% |
| LEAVELL INVESTMENT MANAGEMENT, INC. | US$116.9萬 | 0.05% |
| VOYA INVESTMENT MANAGEMENT LLC | US$112.8萬 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | US$112.1萬 | 0.01% |
| Ipswich Investment Management Co., Inc. | US$111.9萬 | 0.26% |
| Janney Montgomery Scott LLC | US$106.1萬 | 0.00% |