| FMR LLC | US$3.0億 | 0.02% |
| BlackRock, Inc. | US$1.5億 | 0.00% |
| Bellevue Group AG | US$1.3億 | 3.13% |
| STATE STREET CORP | US$9140.2萬 | 0.00% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$8151.0萬 | 0.00% |
| Fairmount Funds Management LLC | US$7656.7萬 | 5.53% |
| Venrock Adviser, LLC | US$7594.6萬 | 2.83% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$6271.1萬 | 0.01% |
| Paradigm Biocapital Advisors LP | US$6159.2萬 | 1.26% |
| WELLINGTON MANAGEMENT GROUP LLP | US$6021.7萬 | 0.01% |
| CITADEL ADVISORS LLC | US$4661.0萬 | 0.01% |
| Kynam Capital Management, LP | US$4580.3萬 | 2.83% |
| GEODE CAPITAL MANAGEMENT, LLC | US$4564.6萬 | 0.00% |
| Balyasny Asset Management L.P. | US$4530.0萬 | 0.06% |
| ALLIANCEBERNSTEIN L.P. | US$4332.1萬 | 0.01% |
| NOVO HOLDINGS A/S | US$3912.0萬 | 3.17% |
| BAKER BROS. ADVISORS LP | US$3856.6萬 | 0.22% |
| TANG CAPITAL MANAGEMENT LLC | US$3506.4萬 | 1.78% |
| Fisher Asset Management, LLC | US$3458.8萬 | 0.01% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$3210.7萬 | 0.00% |
| GOLDMAN SACHS GROUP INC | US$3113.8萬 | 0.00% |
| Avoro Capital Advisors LLC | US$2934.0萬 | 0.29% |
| Deep Track Capital, LP | US$2726.6萬 | 0.45% |
| D. E. Shaw & Co., Inc. | US$2469.5萬 | 0.01% |
| PERCEPTIVE ADVISORS LLC | US$2290.1萬 | 0.45% |
| BANK OF AMERICA CORP /DE/ | US$2276.0萬 | 0.00% |
| DEUTSCHE BANK AG\ | US$2019.2萬 | 0.01% |
| JPMORGAN CHASE & CO | US$1963.9萬 | 0.00% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$1897.4萬 | 0.03% |
| LOOMIS SAYLES & CO L P | US$1814.6萬 | 0.02% |
| First Turn Management, LLC | US$1782.6萬 | 1.99% |
| RICE HALL JAMES & ASSOCIATES, LLC | US$1757.7萬 | 0.98% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$1737.5萬 | 0.00% |
| MORGAN STANLEY | US$1702.0萬 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$1423.8萬 | 0.00% |
| Eversept Partners, LP | US$1395.2萬 | 0.74% |
| Candriam S.C.A. | US$1392.2萬 | 0.07% |
| MetLife Investment Management, LLC | US$1385.9萬 | 0.07% |
| Woodline Partners LP | US$1371.0萬 | 0.05% |
| NORTHERN TRUST CORP | US$1363.3萬 | 0.00% |
| FEDERATED HERMES, INC. | US$1308.5萬 | 0.02% |
| MPM BIOIMPACT LLC | US$1271.2萬 | 0.98% |
| Nuveen, LLC | US$1183.2萬 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$1156.4萬 | 0.00% |
| ALGERT GLOBAL LLC | US$1103.2萬 | 0.17% |
| Parkman Healthcare Partners LLC | US$1091.3萬 | 1.13% |
| Elmind Capital, LP | US$1046.3萬 | 2.97% |
| DIMENSIONAL FUND ADVISORS LP | US$1035.5萬 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$903.0萬 | 0.00% |
| ExodusPoint Capital Management, LP | US$646.2萬 | 0.05% |
| Point72 Asset Management, L.P. | US$631.5萬 | 0.01% |
| Pictet Asset Management Holding SA | US$614.2萬 | 0.01% |
| PANAGORA ASSET MANAGEMENT INC | US$613.6萬 | 0.02% |
| UBS Group AG | US$600.8萬 | 0.00% |
| ADAR1 Capital Management, LLC | US$595.4萬 | 0.35% |
| Davern Capital Partners, LP | US$591.6萬 | 1.62% |
| FIRST TRUST ADVISORS LP | US$589.8萬 | 0.00% |
| RAYMOND JAMES FINANCIAL INC | US$544.8萬 | 0.00% |
| Voleon Capital Management LP | US$527.6萬 | 0.11% |
| MARSHALL WACE, LLP | US$527.3萬 | 0.01% |
| VOYA INVESTMENT MANAGEMENT LLC | US$512.5萬 | 0.01% |
| XTX Topco Ltd | US$496.8萬 | 0.09% |
| Rosalind Advisors, Inc. | US$489.8萬 | 1.97% |
| Affinity Asset Advisors, LLC | US$489.0萬 | 0.25% |
| Russell Investments Group, Ltd. | US$458.8萬 | 0.00% |
| Qube Research & Technologies Ltd | US$452.4萬 | 0.01% |
| Bank of New York Mellon Corp | US$423.5萬 | 0.00% |
| JANE STREET GROUP, LLC | US$414.5萬 | 0.00% |
| Propel Bio Management, LLC | US$408.8萬 | 2.58% |
| Yiheng Capital Management, L.P. | US$408.3萬 | 1.77% |
| RENAISSANCE TECHNOLOGIES LLC | US$397.3萬 | 0.01% |
| VICTORY CAPITAL MANAGEMENT INC | US$368.1萬 | 0.00% |
| Knott David M Jr | US$354.0萬 | 2.11% |
| Hennion & Walsh Asset Management, Inc. | US$342.1萬 | 0.12% |
| Privium Fund Management B.V. | US$339.4萬 | 0.71% |
| Vivo Capital, LLC | US$325.3萬 | 0.27% |
| FRONTIER CAPITAL MANAGEMENT CO LLC | US$309.8萬 | 0.03% |
| SEB Asset Management AB | US$307.0萬 | 0.01% |
| Invesco Ltd. | US$298.5萬 | 0.00% |
| Rafferty Asset Management, LLC | US$277.7萬 | 0.01% |
| MILLENNIUM MANAGEMENT LLC | US$275.0萬 | 0.00% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$274.3萬 | 0.00% |
| HighVista Strategies LLC | US$262.6萬 | 0.72% |
| Swiss National Bank | US$251.5萬 | 0.00% |
| KVP Capital Advisors, LP | US$244.5萬 | 1.83% |
| Nicholas Investment Partners, LP | US$243.0萬 | 0.18% |
| BARCLAYS PLC | US$196.8萬 | 0.00% |
| RHUMBLINE ADVISERS | US$195.7萬 | 0.00% |
| Moody Aldrich Partners LLC | US$186.3萬 | 0.34% |
| Merck & Co., Inc. | US$182.7萬 | 0.52% |
| WELLS FARGO & COMPANY/MN | US$182.3萬 | 0.00% |
| Velan Capital Investment Management LP | US$178.2萬 | 1.12% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | US$167.0萬 | 0.00% |
| J. Goldman & Co LP | US$162.5萬 | 0.05% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$159.3萬 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$158.5萬 | 0.00% |
| TWINBEECH CAPITAL LP | US$150.4萬 | 0.16% |
| PRINCIPAL FINANCIAL GROUP INC | US$147.1萬 | 0.00% |
| J. Safra Sarasin Holding AG | US$142.9萬 | 0.02% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$137.4萬 | 0.00% |
| FIDEURAM - INTESA SANPAOLO PRIVATE BANKING S.P.A. | US$136.0萬 | 0.05% |
| Aquatic Capital Management LLC | US$133.9萬 | 0.04% |
| LMR Partners LLP | US$130.6萬 | 0.00% |
| SEI INVESTMENTS CO | US$128.7萬 | 0.00% |
| Scientech Research LLC | US$127.3萬 | 1.06% |
| Burkehill Global Management, LP | US$127.1萬 | 0.06% |
| Caitong International Asset Management Co., Ltd | US$127.1萬 | 0.23% |
| Jump Financial, LLC | US$125.4萬 | 0.02% |
| PROFUND ADVISORS LLC | US$123.9萬 | 0.05% |
| SG Americas Securities, LLC | US$117.4萬 | 0.00% |
| Legal & General Group Plc | US$116.6萬 | 0.00% |
| Knights of Columbus Asset Advisors LLC | US$113.0萬 | 0.06% |
| Simplify Asset Management Inc. | US$110.0萬 | 0.02% |
| TD Asset Management Inc | US$108.3萬 | 0.00% |
| Kopp Family Office, LLC | US$108.2萬 | 0.74% |
| Greenland Capital Management LP | US$107.6萬 | 0.14% |
| Walleye Capital LLC | US$106.4萬 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | US$102.8萬 | 0.02% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$95.5萬 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$93.2萬 | 0.00% |
| CenterBook Partners LP | US$88.7萬 | 0.05% |
| INTECH INVESTMENT MANAGEMENT LLC | US$88.4萬 | 0.01% |
| Caption Management, LLC | US$88.3萬 | 0.01% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$86.8萬 | 0.00% |
| Squarepoint Ops LLC | US$85.9萬 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$85.2萬 | 0.00% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | US$75.2萬 | 0.01% |
| Virtu Financial LLC | US$74.8萬 | 0.03% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$73.3萬 | 0.00% |
| Vanguard Global Advisers, LLC | US$69.1萬 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$68.7萬 | 0.00% |
| CAPTRUST FINANCIAL ADVISORS | US$68.4萬 | 0.00% |
| Headlands Technologies LLC | US$65.0萬 | 0.07% |
| DCF Advisers, LLC | US$62.9萬 | 0.17% |
| Verdad Advisers, LP | US$61.0萬 | 0.69% |
| Campbell & CO Investment Adviser LLC | US$59.0萬 | 0.03% |
| JENNISON ASSOCIATES LLC | US$54.9萬 | 0.00% |
| JANUS HENDERSON GROUP PLC | US$53.7萬 | 0.00% |
| CITIGROUP INC | US$45.9萬 | 0.00% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | US$45.5萬 | 0.00% |
| AMERIPRISE FINANCIAL INC | US$44.6萬 | 0.00% |
| State of New Jersey Common Pension Fund D | US$43.6萬 | 0.00% |
| NOMURA HOLDINGS INC | US$43.4萬 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$42.0萬 | 0.00% |
| 71 West Capital Partners | US$41.9萬 | 0.02% |
| STRS OHIO | US$41.7萬 | 0.00% |
| SBI Okasan Asset Management Co.Ltd. | US$41.1萬 | 0.02% |
| EntryPoint Capital, LLC | US$40.0萬 | 0.12% |
| AQR CAPITAL MANAGEMENT LLC | US$39.5萬 | 0.00% |
| Birchview Capital, LP | US$39.3萬 | 0.22% |