| FMR LLC | US$3.8億 | 0.02% |
| ARK Investment Management LLC | US$2.5億 | 1.93% |
| BlackRock, Inc. | US$2.1億 | 0.00% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$1.5億 | 0.01% |
| Quantinno Capital Management LP | US$1.1億 | 0.19% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$1.1億 | 0.00% |
| Sumitomo Mitsui Trust Group, Inc. | US$1.1億 | 0.07% |
| Amova Asset Management Americas, Inc. | US$1.1億 | 1.53% |
| GOLDMAN SACHS GROUP INC | US$8723.6萬 | 0.01% |
| GEODE CAPITAL MANAGEMENT, LLC | US$6166.9萬 | 0.00% |
| MORGAN STANLEY | US$5639.4萬 | 0.00% |
| STATE STREET CORP | US$5496.0萬 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$5365.9萬 | 0.02% |
| MILLENNIUM MANAGEMENT LLC | US$5192.3萬 | 0.02% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | US$4847.7萬 | 0.20% |
| Casdin Capital, LLC | US$4829.8萬 | 3.66% |
| DIMENSIONAL FUND ADVISORS LP | US$4335.7萬 | 0.01% |
| Capital World Investors | US$3083.2萬 | 0.00% |
| T. Rowe Price Investment Management, Inc. | US$2716.2萬 | 0.02% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$2392.7萬 | 0.00% |
| Blue Water Life Science Advisors, LP | US$2314.1萬 | 18.56% |
| NORTHERN TRUST CORP | US$2224.9萬 | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | US$2141.6萬 | 0.03% |
| Balyasny Asset Management L.P. | US$2100.8萬 | 0.03% |
| BANK OF AMERICA CORP /DE/ | US$2047.8萬 | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | US$1992.2萬 | 0.05% |
| CITADEL ADVISORS LLC | US$1978.1萬 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$1653.6萬 | 0.00% |
| JPMORGAN CHASE & CO | US$1556.1萬 | 0.00% |
| IEQ CAPITAL, LLC | US$1487.6萬 | 0.07% |
| Freshford Capital Management, LLC | US$1428.7萬 | 7.14% |
| Nuveen, LLC | US$1328.6萬 | 0.00% |
| FEDERATED HERMES, INC. | US$1298.5萬 | 0.02% |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | US$1152.3萬 | 0.87% |
| Trexquant Investment LP | US$1132.2萬 | 0.08% |
| Meridiem Capital Partners LP | US$1112.4萬 | 0.72% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | US$1055.5萬 | 0.04% |
| UBS Group AG | US$1050.4萬 | 0.00% |
| Sands Capital Alternatives, LLC | US$1022.8萬 | 2.43% |
| Russell Investments Group, Ltd. | US$1020.4萬 | 0.01% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$994.8萬 | 0.00% |
| Quantedge Capital Pte Ltd | US$884.3萬 | 4.84% |
| TWO SIGMA INVESTMENTS, LP | US$854.4萬 | 0.01% |
| Simplify Asset Management Inc. | US$753.0萬 | 0.12% |
| Bank of New York Mellon Corp | US$737.9萬 | 0.00% |
| AMERIPRISE FINANCIAL INC | US$705.9萬 | 0.00% |
| Bellevue Group AG | US$699.5萬 | 0.17% |
| LORD, ABBETT & CO. LLC | US$699.1萬 | 0.02% |
| Allianz Asset Management GmbH | US$679.4萬 | 0.01% |
| Invesco Ltd. | US$674.4萬 | 0.00% |
| JANUS HENDERSON GROUP PLC | US$648.1萬 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | US$633.1萬 | 0.09% |
| AMERICAN CENTURY COMPANIES INC | US$620.3萬 | 0.00% |
| FRANKLIN RESOURCES INC | US$608.0萬 | 0.00% |
| HSBC HOLDINGS PLC | US$594.5萬 | 0.00% |
| Summit Trail Advisors, LLC | US$572.7萬 | 0.08% |
| Man Group plc | US$571.6萬 | 0.01% |
| Vestmark Advisory Solutions, Inc. | US$532.9萬 | 0.06% |
| OSSIAM | US$486.8萬 | 0.09% |
| Focus Partners Wealth | US$483.0萬 | 0.01% |
| PRINCIPAL FINANCIAL GROUP INC | US$481.6萬 | 0.00% |
| ARCH Venture Management, LLC | US$462.5萬 | 0.68% |
| Tao Capital Management LP | US$447.7萬 | 3.77% |
| Swiss National Bank | US$440.3萬 | 0.00% |
| Corient Private Wealth LLC | US$436.6萬 | 0.01% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$436.4萬 | 0.00% |
| Pictet Asset Management Holding SA | US$436.1萬 | 0.00% |
| LAZARD ASSET MANAGEMENT LLC | US$388.5萬 | 0.01% |
| Caprock Group, LLC | US$386.0萬 | 0.09% |
| HARVARD MANAGEMENT CO INC | US$360.9萬 | 0.20% |
| Caisse de depot et placement du Quebec | US$350.8萬 | 0.01% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$346.6萬 | 0.00% |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | US$339.8萬 | 0.01% |
| FINANCIAL CONSULATE, INC | US$332.2萬 | 0.41% |
| Exome Asset Management LLC | US$327.4萬 | 1.69% |
| ALGERT GLOBAL LLC | US$312.7萬 | 0.05% |
| RHUMBLINE ADVISERS | US$304.4萬 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$297.5萬 | 0.00% |
| Cerity Partners LLC | US$284.1萬 | 0.00% |
| PRELUDE CAPITAL MANAGEMENT, LLC | US$282.4萬 | 0.22% |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | US$270.2萬 | 0.01% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$268.2萬 | 0.00% |
| CWM, LLC | US$265.0萬 | 0.01% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$261.4萬 | 0.00% |
| DEUTSCHE BANK AG\ | US$246.0萬 | 0.00% |
| MERCER GLOBAL ADVISORS INC /ADV | US$244.1萬 | 0.00% |
| Gotham Asset Management, LLC | US$244.0萬 | 0.01% |
| Schonfeld Strategic Advisors LLC | US$241.4萬 | 0.02% |
| VOYA INVESTMENT MANAGEMENT LLC | US$240.6萬 | 0.00% |
| FRED ALGER MANAGEMENT, LLC | US$237.5萬 | 0.01% |
| ENVESTNET ASSET MANAGEMENT INC | US$230.6萬 | 0.00% |
| ROYAL BANK OF CANADA | US$229.7萬 | 0.00% |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | US$227.6萬 | 0.14% |
| MARSHALL WACE, LLP | US$217.1萬 | 0.00% |
| Capricorn Fund Managers Ltd | US$216.1萬 | 0.34% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$211.6萬 | 0.00% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$204.5萬 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | US$204.1萬 | 0.00% |
| Engineers Gate Manager LP | US$196.4萬 | 0.02% |
| Legal & General Group Plc | US$195.2萬 | 0.00% |
| Creative Planning | US$193.9萬 | 0.00% |
| Cambridge Investment Research Advisors, Inc. | US$186.9萬 | 0.00% |
| MARTINGALE ASSET MANAGEMENT L P | US$180.9萬 | 0.05% |
| CANADA PENSION PLAN INVESTMENT BOARD | US$176.0萬 | 0.00% |
| PEAK6 LLC | US$173.9萬 | 0.00% |
| HRT FINANCIAL LP | US$171.8萬 | 0.00% |
| Mirador Capital Partners LP | US$164.1萬 | 0.23% |
| NOMURA HOLDINGS INC | US$163.5萬 | 0.00% |
| CIBC WORLD MARKET INC. | US$150.5萬 | 0.00% |
| Inscription Capital, LLC | US$147.6萬 | 0.16% |
| D. E. Shaw & Co., Inc. | US$145.5萬 | 0.00% |
| MetLife Investment Management, LLC | US$135.4萬 | 0.01% |
| LPL Financial LLC | US$134.3萬 | 0.00% |
| PRUDENTIAL FINANCIAL INC | US$134.1萬 | 0.00% |
| HUSSMAN STRATEGIC ADVISORS, INC. | US$133.7萬 | 0.29% |
| ACADIAN ASSET MANAGEMENT LLC | US$131.5萬 | 0.00% |
| Vanguard Global Advisers, LLC | US$127.4萬 | 0.00% |
| JENNISON ASSOCIATES LLC | US$125.4萬 | 0.00% |
| Edgestream Partners, L.P. | US$123.3萬 | 0.04% |
| BENJAMIN EDWARDS INC | US$123.2萬 | 0.01% |
| JANE STREET GROUP, LLC | US$123.1萬 | 0.00% |
| Jefferies Financial Group Inc. | US$118.5萬 | 0.01% |
| SYON CAPITAL LLC | US$116.6萬 | 0.06% |
| Chicago Partners Investment Group LLC | US$114.0萬 | 0.03% |
| CITIGROUP INC | US$107.2萬 | 0.00% |
| Odyssean, LLC | US$104.8萬 | 0.38% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$104.1萬 | 0.00% |
| Kera Capital Partners, Inc. | US$103.9萬 | 0.13% |
| Pallas Capital Advisors LLC | US$103.9萬 | 0.04% |
| STRS OHIO | US$102.1萬 | 0.00% |
| Handelsbanken Fonder AB | US$99.4萬 | 0.00% |
| Aaron Wealth Advisors LLC | US$98.5萬 | 0.06% |
| SEI INVESTMENTS CO | US$94.9萬 | 0.00% |
| Versant Capital Management, Inc | US$94.4萬 | 0.09% |
| STIFEL FINANCIAL CORP | US$93.0萬 | 0.00% |
| KLP KAPITALFORVALTNING AS | US$92.4萬 | 0.00% |
| CAPTRUST FINANCIAL ADVISORS | US$87.8萬 | 0.00% |
| Integrated Quantitative Investments LLC | US$85.5萬 | 0.16% |
| Jasper Ridge Partners, L.P. | US$83.8萬 | 0.02% |
| SG Americas Securities, LLC | US$81.0萬 | 0.00% |
| Baker Avenue Asset Management, LP | US$80.5萬 | 0.02% |
| Qube Research & Technologies Ltd | US$79.9萬 | 0.00% |
| LEVEL FOUR ADVISORY SERVICES, LLC | US$76.7萬 | 0.03% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$76.5萬 | 0.00% |
| Marex Group plc | US$75.8萬 | 0.00% |
| Empirical Financial Services, LLC d.b.a. Empirical Wealth Management | US$74.7萬 | 0.01% |
| Merit Financial Group, LLC | US$74.7萬 | 0.01% |
| Bridgewater Associates, LP | US$74.5萬 | 0.00% |
| OSAIC HOLDINGS, INC. | US$74.1萬 | 0.00% |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P | US$69.0萬 | 0.65% |