| BVF INC/IL | US$3.0億 | 9.50% |
| Deep Track Capital, LP | US$1.2億 | 1.95% |
| Cormorant Asset Management, LP | US$8351.5萬 | 4.19% |
| JANUS HENDERSON GROUP PLC | US$6430.4萬 | 0.03% |
| D. E. Shaw & Co., Inc. | US$4456.2萬 | 0.03% |
| CITADEL ADVISORS LLC | US$3880.3萬 | 0.01% |
| MPM BIOIMPACT LLC | US$3375.9萬 | 2.61% |
| Weiss Asset Management LP | US$3184.3萬 | 0.54% |
| Logos Global Management LP | US$2796.0萬 | 1.40% |
| Point72 Asset Management, L.P. | US$2550.9萬 | 0.03% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$2413.7萬 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$2252.9萬 | 0.00% |
| GOLDMAN SACHS GROUP INC | US$2106.8萬 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$2092.0萬 | 0.02% |
| Balyasny Asset Management L.P. | US$1986.3萬 | 0.03% |
| BlackRock, Inc. | US$1904.7萬 | 0.00% |
| Vivo Capital, LLC | US$1864.0萬 | 1.55% |
| JPMORGAN CHASE & CO | US$1842.9萬 | 0.00% |
| Candriam S.C.A. | US$1525.0萬 | 0.08% |
| BANK OF AMERICA CORP /DE/ | US$1351.0萬 | 0.00% |
| MORGAN STANLEY | US$1145.4萬 | 0.00% |
| Holocene Advisors, LP | US$1118.4萬 | 0.03% |
| MILLENNIUM MANAGEMENT LLC | US$1073.8萬 | 0.00% |
| JANE STREET GROUP, LLC | US$1067.2萬 | 0.00% |
| GREAT POINT PARTNERS LLC | US$932.0萬 | 2.14% |
| Jefferies Financial Group Inc. | US$932.0萬 | 0.06% |
| Trexquant Investment LP | US$923.3萬 | 0.07% |
| HRT FINANCIAL LP | US$908.8萬 | 0.02% |
| ADAR1 Capital Management, LLC | US$889.4萬 | 0.52% |
| Casdin Capital, LLC | US$838.8萬 | 0.64% |
| Longaeva Partners L.P. | US$764.2萬 | 0.28% |
| Walleye Capital LLC | US$704.0萬 | 0.03% |
| Voleon Capital Management LP | US$695.3萬 | 0.15% |
| Jump Financial, LLC | US$607.6萬 | 0.08% |
| First Turn Management, LLC | US$588.2萬 | 0.66% |
| RENAISSANCE TECHNOLOGIES LLC | US$515.9萬 | 0.01% |
| Boxer Capital Management, LLC | US$512.6萬 | 0.67% |
| Susquehanna Portfolio Strategies, LLC | US$473.4萬 | 0.07% |
| Rhenman & Partners Asset Management AB | US$446.4萬 | 0.55% |
| Granahan Investment Management, LLC | US$411.2萬 | 0.20% |
| Exome Asset Management LLC | US$401.5萬 | 2.08% |
| HighVista Strategies LLC | US$361.5萬 | 1.00% |
| ACUTA CAPITAL PARTNERS, LLC | US$357.4萬 | 2.54% |
| CONGRESS ASSET MANAGEMENT CO | US$332.8萬 | 0.02% |
| Kalehua Capital Management LLC | US$327.6萬 | 2.32% |
| Ishara Investments LP | US$324.8萬 | 3.08% |
| RICE HALL JAMES & ASSOCIATES, LLC | US$312.7萬 | 0.17% |
| ALGERT GLOBAL LLC | US$281.9萬 | 0.04% |
| READYSTATE ASSET MANAGEMENT LP | US$268.9萬 | 0.12% |
| FMR LLC | US$267.6萬 | 0.00% |
| TD Asset Management Inc | US$266.0萬 | 0.00% |
| Invesco Ltd. | US$260.2萬 | 0.00% |
| J. Goldman & Co LP | US$255.2萬 | 0.07% |
| Y-Intercept (Hong Kong) Ltd | US$236.9萬 | 0.04% |
| ExodusPoint Capital Management, LP | US$224.3萬 | 0.02% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$221.7萬 | 0.00% |
| Centiva Capital, LP | US$216.0萬 | 0.02% |
| XTX Topco Ltd | US$208.9萬 | 0.04% |
| MARSHALL WACE, LLP | US$207.5萬 | 0.00% |
| Squarepoint Ops LLC | US$205.4萬 | 0.00% |
| Headlands Technologies LLC | US$181.1萬 | 0.21% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$177.7萬 | 0.00% |
| GSA CAPITAL PARTNERS LLP | US$149.6萬 | 0.09% |
| TUDOR INVESTMENT CORP ET AL | US$143.5萬 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$138.2萬 | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | US$134.6萬 | 0.00% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | US$130.7萬 | 0.00% |
| Lion Point Capital, LP | US$125.8萬 | 7.52% |
| Rock Springs Capital Management LP | US$115.0萬 | 0.07% |
| Swiss National Bank | US$114.6萬 | 0.00% |
| ALPS ADVISORS INC | US$108.8萬 | 0.01% |
| STATE STREET CORP | US$105.3萬 | 0.00% |
| Avidity Partners Management LP | US$93.2萬 | 0.19% |
| PRELUDE CAPITAL MANAGEMENT, LLC | US$91.1萬 | 0.07% |
| AQR CAPITAL MANAGEMENT LLC | US$86.1萬 | 0.00% |
| Mariner, LLC | US$83.8萬 | 0.00% |
| Qube Research & Technologies Ltd | US$80.0萬 | 0.00% |
| Nuveen, LLC | US$62.3萬 | 0.00% |
| Brevan Howard Capital Management LP | US$60.6萬 | 0.01% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$54.6萬 | 0.00% |
| Schonfeld Strategic Advisors LLC | US$53.5萬 | 0.00% |
| BARCLAYS PLC | US$51.5萬 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | US$49.0萬 | 0.00% |
| Optimize Financial Inc | US$45.5萬 | 0.22% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$44.4萬 | 0.00% |
| GROUP ONE TRADING LLC | US$40.2萬 | 0.00% |
| Quarry LP | US$39.6萬 | 0.07% |
| Graham Capital Management, L.P. | US$39.3萬 | 0.01% |
| Legal & General Group Plc | US$38.3萬 | 0.00% |
| NORTHERN TRUST CORP | US$36.3萬 | 0.00% |
| AXQ CAPITAL, LP | US$35.9萬 | 0.05% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$35.8萬 | 0.00% |
| Virtus Investment Advisers, LLC | US$34.4萬 | 0.09% |
| Vident Advisory, LLC | US$33.9萬 | 0.00% |
| ACADIAN ASSET MANAGEMENT LLC | US$30.5萬 | 0.00% |
| OSAIC HOLDINGS, INC. | US$29.6萬 | 0.00% |
| WINTON GROUP Ltd | US$29.2萬 | 0.01% |
| Jain Global LLC | US$28.6萬 | 0.00% |
| FOX RUN MANAGEMENT, L.L.C. | US$28.0萬 | 0.05% |
| CITIGROUP INC | US$25.5萬 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$23.5萬 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$23.3萬 | 0.00% |
| Entropy Technologies, LP | US$22.1萬 | 0.01% |
| CAPTRUST FINANCIAL ADVISORS | US$21.3萬 | 0.00% |
| IMC-Chicago, LLC | US$21.2萬 | 0.00% |
| CAPITAL FUND MANAGEMENT S.A. | US$21.0萬 | 0.00% |
| State of New Jersey Common Pension Fund D | US$20.3萬 | 0.00% |
| Virtu Financial LLC | US$19.6萬 | 0.01% |
| SIG BROKERAGE, LP | US$18.6萬 | 0.00% |
| Crystal Cove Asset Management, LLC | US$18.6萬 | 0.22% |
| SG Americas Securities, LLC | US$17.4萬 | 0.00% |
| Vanguard Investments Australia, Ltd. | US$16.7萬 | 0.00% |
| KLP KAPITALFORVALTNING AS | US$12.7萬 | 0.00% |
| Ensign Peak Advisors, Inc | US$8.4萬 | 0.00% |
| Advisors Asset Management, Inc. | US$7.3萬 | 0.00% |
| UBS Group AG | US$7.2萬 | 0.00% |
| Russell Investments Group, Ltd. | US$6.4萬 | 0.00% |
| SIMPLEX TRADING, LLC | US$5.7萬 | 0.00% |
| Caitong International Asset Management Co., Ltd | US$5.7萬 | 0.01% |
| EverSource Wealth Advisors, LLC | US$5.3萬 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | US$4.5萬 | 0.00% |
| US BANCORP \DE\ | US$4.3萬 | 0.00% |
| SIGNATUREFD, LLC | US$4.2萬 | 0.00% |
| DEUTSCHE BANK AG\ | US$3.8萬 | 0.00% |
| Parallel Advisors, LLC | US$3.1萬 | 0.00% |
| DecisionPoint Financial, LLC | US$2.3萬 | 0.00% |
| Delos Wealth Advisors, LLC | US$1.9萬 | 0.01% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$1.7萬 | 0.00% |
| Allworth Financial LP | US$1.2萬 | 0.00% |
| Farther Finance Advisors, LLC | US$1.2萬 | 0.00% |
| SUMMIT SECURITIES GROUP LLC | US$9618.0 | 0.00% |
| Avion Wealth | US$9000.0 | 0.00% |
| QUADRANT CAPITAL GROUP LLC | US$7140.0 | 0.00% |
| CWM, LLC | US$5667.0 | 0.00% |
| Basecamp Wealth Advisors LLC | US$4660.0 | 0.00% |
| Steward Partners Investment Advisory, LLC | US$4548.0 | 0.00% |
| SBI Securities Co., Ltd. | US$3970.0 | 0.00% |
| ROYAL BANK OF CANADA | US$2000.0 | 0.00% |
| Quantbot Technologies LP | US$1845.0 | 0.00% |
| CVA Family Office, LLC | US$1118.0 | 0.00% |
| JONES FINANCIAL COMPANIES LLLP | US$901.0 | 0.00% |
| Cornerstone Financial Management LLC | US$522.0 | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | US$224.0 | 0.00% |
| Essential Partners LLC | US$149.0 | 0.00% |
| MAI Capital Management | US$131.0 | 0.00% |
| ROTHSCHILD INVESTMENT LLC | US$112.0 | 0.00% |
| HUNTINGTON NATIONAL BANK | US$112.0 | 0.00% |
| Arax Advisory Partners | US$93.0 | 0.00% |
| Sunbelt Securities, Inc. | US$19.0 | 0.00% |