| JANUS HENDERSON GROUP PLC | US$4886.8萬 | 0.02% |
| RA CAPITAL MANAGEMENT, L.P. | US$4701.3萬 | 0.50% |
| GOLDMAN SACHS GROUP INC | US$3915.3萬 | 0.00% |
| BlackRock, Inc. | US$3859.3萬 | 0.00% |
| NOVO HOLDINGS A/S | US$3398.8萬 | 2.75% |
| BVF INC/IL | US$2680.6萬 | 0.85% |
| STATE STREET CORP | US$2521.0萬 | 0.00% |
| ARMISTICE CAPITAL, LLC | US$1862.0萬 | 0.33% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$1494.4萬 | 0.02% |
| FEDERATED HERMES, INC. | US$1333.4萬 | 0.02% |
| Trails Edge Capital Partners, LP | US$1213.0萬 | 2.78% |
| GEODE CAPITAL MANAGEMENT, LLC | US$992.1萬 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$907.0萬 | 0.00% |
| Evergreen Quality Fund GP, Ltd. | US$885.8萬 | 0.20% |
| DEUTSCHE BANK AG\ | US$659.2萬 | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | US$538.4萬 | 0.01% |
| Nuveen, LLC | US$523.0萬 | 0.00% |
| Parkman Healthcare Partners LLC | US$486.5萬 | 0.50% |
| DIMENSIONAL FUND ADVISORS LP | US$486.3萬 | 0.00% |
| RTW INVESTMENTS, LP | US$442.9萬 | 0.04% |
| Propel Bio Management, LLC | US$358.1萬 | 2.26% |
| JPMORGAN CHASE & CO | US$356.2萬 | 0.00% |
| MORGAN STANLEY | US$321.6萬 | 0.00% |
| NORTHERN TRUST CORP | US$318.4萬 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$305.7萬 | 0.00% |
| CITADEL ADVISORS LLC | US$295.2萬 | 0.00% |
| Invesco Ltd. | US$289.2萬 | 0.00% |
| Burkehill Global Management, LP | US$256.0萬 | 0.13% |
| RAYMOND JAMES FINANCIAL INC | US$247.8萬 | 0.00% |
| Peapod Lane Capital LLC | US$221.0萬 | 1.81% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$193.7萬 | 0.00% |
| ArrowMark Colorado Holdings LLC | US$188.9萬 | 0.05% |
| Woodline Partners LP | US$186.2萬 | 0.01% |
| Privium Fund Management B.V. | US$158.5萬 | 0.33% |
| UBS Group AG | US$147.2萬 | 0.00% |
| Perigon Wealth Management, LLC | US$136.1萬 | 0.02% |
| Bank of New York Mellon Corp | US$124.4萬 | 0.00% |
| Exome Asset Management LLC | US$121.6萬 | 0.63% |
| TWO SIGMA INVESTMENTS, LP | US$115.7萬 | 0.00% |
| JANE STREET GROUP, LLC | US$110.5萬 | 0.00% |
| ADAR1 Capital Management, LLC | US$108.7萬 | 0.06% |
| Opaleye Management Inc. | US$104.5萬 | 0.14% |
| WELLINGTON MANAGEMENT GROUP LLP | US$101.4萬 | 0.00% |
| AMERICAN CENTURY COMPANIES INC | US$94.5萬 | 0.00% |
| Schonfeld Strategic Advisors LLC | US$94.1萬 | 0.01% |
| XTX Topco Ltd | US$77.7萬 | 0.01% |
| Assenagon Asset Management S.A. | US$77.6萬 | 0.00% |
| Rafferty Asset Management, LLC | US$66.5萬 | 0.00% |
| Simplify Asset Management Inc. | US$65.6萬 | 0.01% |
| FMR LLC | US$65.3萬 | 0.00% |
| Squarepoint Ops LLC | US$58.2萬 | 0.00% |
| RHUMBLINE ADVISERS | US$50.4萬 | 0.00% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | US$46.6萬 | 0.01% |
| PANAGORA ASSET MANAGEMENT INC | US$44.1萬 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$42.6萬 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | US$42.2萬 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | US$41.3萬 | 0.00% |
| Quantinno Capital Management LP | US$40.5萬 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$39.6萬 | 0.00% |
| Quadrature Capital Ltd | US$30.3萬 | 0.00% |
| PROFUND ADVISORS LLC | US$29.7萬 | 0.01% |
| Rangeley Capital, LLC | US$29.3萬 | 0.28% |
| Engineers Gate Manager LP | US$27.4萬 | 0.00% |
| Creative Planning | US$27.1萬 | 0.00% |
| Man Group plc | US$27.0萬 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | US$26.5萬 | 0.00% |
| COMMONWEALTH EQUITY SERVICES, LLC | US$26.3萬 | 0.00% |
| DekaBank Deutsche Girozentrale | US$26.1萬 | 0.00% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | US$25.7萬 | 0.00% |
| Virtu Financial LLC | US$24.5萬 | 0.01% |
| CITIGROUP INC | US$24.4萬 | 0.00% |
| BARCLAYS PLC | US$23.7萬 | 0.00% |
| Y-Intercept (Hong Kong) Ltd | US$23.7萬 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$23.7萬 | 0.00% |
| Virtus Investment Advisers, LLC | US$23.4萬 | 0.06% |
| STRS OHIO | US$23.4萬 | 0.00% |
| Peloton Wealth Strategists | US$23.3萬 | 0.09% |
| TRUIST FINANCIAL CORP | US$23.3萬 | 0.00% |
| MetLife Investment Management, LLC | US$22.9萬 | 0.00% |
| Kera Capital Partners, Inc. | US$22.4萬 | 0.03% |
| D. E. Shaw & Co., Inc. | US$22.4萬 | 0.00% |
| Mitsubishi UFJ Asset Management Co., Ltd. | US$21.7萬 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$21.4萬 | 0.00% |
| SIMPLEX TRADING, LLC | US$20.2萬 | 0.00% |
| EntryPoint Capital, LLC | US$20.1萬 | 0.06% |
| ACADIAN ASSET MANAGEMENT LLC | US$18.6萬 | 0.00% |
| Landing Point Financial Group, LLC | US$17.7萬 | 0.09% |
| WELLS FARGO & COMPANY/MN | US$17.0萬 | 0.00% |
| Parallel Advisors, LLC | US$16.7萬 | 0.00% |
| Rockefeller Capital Management L.P. | US$16.6萬 | 0.00% |
| MARSHALL WACE, LLP | US$15.6萬 | 0.00% |
| Ballentine Partners, LLC | US$15.2萬 | 0.00% |
| Headlands Technologies LLC | US$14.9萬 | 0.02% |
| ExodusPoint Capital Management, LP | US$14.5萬 | 0.00% |
| SEI INVESTMENTS CO | US$12.0萬 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$11.7萬 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$11.4萬 | 0.00% |
| MARTINGALE ASSET MANAGEMENT L P | US$11.0萬 | 0.00% |
| PRELUDE CAPITAL MANAGEMENT, LLC | US$10.1萬 | 0.01% |
| Inscription Capital, LLC | US$10.0萬 | 0.01% |
| INTECH INVESTMENT MANAGEMENT LLC | US$10.0萬 | 0.00% |
| nVerses Capital, LLC | US$9.4萬 | 0.09% |
| Police & Firemen's Retirement System of New Jersey | US$9.3萬 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$8.4萬 | 0.01% |
| Tower Research Capital LLC (TRC) | US$5.6萬 | 0.00% |
| NISA INVESTMENT ADVISORS, LLC | US$5.4萬 | 0.00% |
| CWM, LLC | US$4.5萬 | 0.00% |
| Legal & General Group Plc | US$3.4萬 | 0.00% |
| Ameritas Investment Partners, Inc. | US$3.1萬 | 0.00% |
| Russell Investments Group, Ltd. | US$2.9萬 | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | US$2.5萬 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$2.3萬 | 0.00% |
| GROUP ONE TRADING LLC | US$1.9萬 | 0.00% |
| Sterling Capital Management LLC | US$1.4萬 | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | US$1.4萬 | 0.00% |
| GF FUND MANAGEMENT CO. LTD. | US$1.2萬 | 0.00% |
| GAMMA Investing LLC | US$1.1萬 | 0.00% |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | US$1.0萬 | 0.00% |
| ROYAL BANK OF CANADA | US$9000.0 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$6433.0 | 0.00% |
| Versant Capital Management, Inc | US$5726.0 | 0.00% |
| Allworth Financial LP | US$4739.0 | 0.00% |
| Steward Partners Investment Advisory, LLC | US$4655.0 | 0.00% |
| Arax Advisory Partners | US$2496.0 | 0.00% |
| Pacific Center for Financial Services | US$1928.0 | 0.00% |
| Basecamp Wealth Advisors LLC | US$1350.0 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | US$1236.7 | 0.00% |
| Farther Finance Advisors, LLC | US$1234.0 | 0.00% |
| Essential Partners LLC | US$968.0 | 0.00% |
| Pinnacle Wealth Planning Services, Inc. | US$931.0 | 0.00% |
| Marshall & Sterling Wealth Advisors Inc. | US$931.0 | 0.00% |
| QUADRANT CAPITAL GROUP LLC | US$885.0 | 0.00% |
| IFP Advisors, Inc | US$726.0 | 0.00% |
| Fortitude Family Office, LLC | US$521.0 | 0.00% |
| True Wealth Design, LLC | US$503.0 | 0.00% |
| OSAIC HOLDINGS, INC. | US$493.0 | 0.00% |
| EverSource Wealth Advisors, LLC | US$401.0 | 0.00% |
| SBI Securities Co., Ltd. | US$326.0 | 0.00% |
| US BANCORP \DE\ | US$326.0 | 0.00% |
| FIFTH THIRD BANCORP | US$326.0 | 0.00% |
| Sound Income Strategies, LLC | US$247.0 | 0.00% |
| MAI Capital Management | US$168.0 | 0.00% |
| Root Financial Partners, LLC | US$102.0 | 0.00% |
| Advisory Services Network, LLC | US$74.0 | 0.00% |
| ROTHSCHILD INVESTMENT LLC | US$56.0 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$9.0 | 0.00% |
| Covestor Ltd | US$0.0 | 0.00% |