| SUVRETTA CAPITAL MANAGEMENT, LLC | US$2.9億 | 7.42% |
| Frazier Life Sciences Management, L.P. | US$2.3億 | 5.99% |
| BlackRock, Inc. | US$2.2億 | 0.00% |
| Rubric Capital Management LP | US$1.9億 | 2.06% |
| STATE STREET CORP | US$1.5億 | 0.01% |
| Polar Capital Holdings Plc | US$1.3億 | 0.47% |
| JENNISON ASSOCIATES LLC | US$1.2億 | 0.08% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$1.1億 | 0.00% |
| GILDER GAGNON HOWE & CO LLC | US$1.0億 | 1.22% |
| MORGAN STANLEY | US$9939.8萬 | 0.01% |
| UBS Group AG | US$7843.7萬 | 0.01% |
| GEODE CAPITAL MANAGEMENT, LLC | US$7175.9萬 | 0.00% |
| D. E. Shaw & Co., Inc. | US$5881.1萬 | 0.04% |
| MARSHALL WACE, LLP | US$5729.3萬 | 0.06% |
| FRANKLIN RESOURCES INC | US$5414.0萬 | 0.01% |
| Driehaus Capital Management LLC | US$5244.5萬 | 0.39% |
| BANK OF AMERICA CORP /DE/ | US$5233.4萬 | 0.00% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$4605.2萬 | 0.00% |
| JANUS HENDERSON GROUP PLC | US$4368.4萬 | 0.02% |
| GOLDMAN SACHS GROUP INC | US$3776.7萬 | 0.00% |
| AMERICAN CENTURY COMPANIES INC | US$3447.4萬 | 0.02% |
| OBERWEIS ASSET MANAGEMENT INC/ | US$3218.2萬 | 0.95% |
| Pivotal bioVenture Partners Investment Advisor LLC | US$3194.5萬 | 11.42% |
| Ensign Peak Advisors, Inc | US$2931.8萬 | 0.05% |
| Squarepoint Ops LLC | US$2599.8萬 | 0.03% |
| Candriam S.C.A. | US$2560.1萬 | 0.13% |
| FEDERATED HERMES, INC. | US$2538.0萬 | 0.04% |
| BAMCO INC /NY/ | US$2526.1萬 | 0.08% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$2385.6萬 | 0.00% |
| GW&K Investment Management, LLC | US$2328.6萬 | 0.21% |
| NORTHERN TRUST CORP | US$2300.7萬 | 0.00% |
| Perpetual Ltd | US$2142.9萬 | 0.33% |
| Nuveen, LLC | US$2125.4萬 | 0.01% |
| VANGUARD FIDUCIARY TRUST CO | US$1818.3萬 | 0.00% |
| MPM BIOIMPACT LLC | US$1729.2萬 | 1.34% |
| Qube Research & Technologies Ltd | US$1705.9萬 | 0.02% |
| Aberdeen Group plc | US$1519.8萬 | 0.02% |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | US$1498.9萬 | 0.02% |
| Nearwater Capital Markets, Ltd | US$1430.8萬 | 0.34% |
| Point72 Asset Management, L.P. | US$1392.1萬 | 0.02% |
| Eversept Partners, LP | US$1358.4萬 | 0.72% |
| FISHMAN JAY A LTD/MI | US$1335.2萬 | 1.19% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | US$1273.4萬 | 0.05% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$1187.1萬 | 0.01% |
| CAPITOLIS LIQUID GLOBAL MARKETS LLC | US$1178.0萬 | 0.07% |
| M&G PLC | US$1125.8萬 | 0.06% |
| AQR CAPITAL MANAGEMENT LLC | US$1103.2萬 | 0.01% |
| JANE STREET GROUP, LLC | US$1084.5萬 | 0.00% |
| Cormorant Asset Management, LP | US$1060.2萬 | 0.53% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$1056.0萬 | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | US$1039.0萬 | 0.02% |
| STEMPOINT CAPITAL LP | US$974.9萬 | 1.87% |
| Patient Square Capital LP | US$943.9萬 | 1.67% |
| DEUTSCHE BANK AG\ | US$918.5萬 | 0.00% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$862.3萬 | 0.01% |
| FIRST TRUST ADVISORS LP | US$827.5萬 | 0.01% |
| Penn Capital Management Company, LLC | US$786.5萬 | 0.61% |
| Privium Fund Management B.V. | US$756.2萬 | 1.57% |
| PEREGRINE CAPITAL MANAGEMENT LLC | US$721.6萬 | 0.27% |
| Bank of New York Mellon Corp | US$719.8萬 | 0.00% |
| CASTLEARK MANAGEMENT LLC | US$691.4萬 | 0.23% |
| FMR LLC | US$656.7萬 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$626.2萬 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$604.6萬 | 0.01% |
| PRUDENTIAL FINANCIAL INC | US$604.4萬 | 0.01% |
| MYDA Advisors LLC | US$565.4萬 | 0.93% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$558.8萬 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$552.0萬 | 0.00% |
| Swiss National Bank | US$514.1萬 | 0.00% |
| JUPITER ASSET MANAGEMENT LTD | US$511.9萬 | 0.03% |
| SEI INVESTMENTS CO | US$485.7萬 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$466.0萬 | 0.00% |
| Woodline Partners LP | US$459.5萬 | 0.02% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$447.7萬 | 0.01% |
| Hillsdale Investment Management Inc. | US$443.4萬 | 0.12% |
| NORDEA INVESTMENT MANAGEMENT AB | US$440.6萬 | 0.00% |
| Rafferty Asset Management, LLC | US$431.2萬 | 0.02% |
| KORNITZER CAPITAL MANAGEMENT INC /KS | US$414.3萬 | 0.09% |
| PRINCIPAL FINANCIAL GROUP INC | US$397.8萬 | 0.00% |
| Tejara Capital Ltd | US$391.5萬 | 1.29% |
| RHUMBLINE ADVISERS | US$379.6萬 | 0.00% |
| PDT Partners, LLC | US$365.4萬 | 0.22% |
| LAZARD ASSET MANAGEMENT LLC | US$364.2萬 | 0.01% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | US$363.8萬 | 0.01% |
| RAYMOND JAMES FINANCIAL INC | US$353.1萬 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | US$343.3萬 | 0.00% |
| ESSEX INVESTMENT MANAGEMENT CO LLC | US$339.1萬 | 0.54% |
| Invesco Ltd. | US$329.5萬 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$302.3萬 | 0.00% |
| Pictet Asset Management Holding SA | US$298.4萬 | 0.00% |
| Voleon Capital Management LP | US$291.4萬 | 0.06% |
| LPL Financial LLC | US$281.3萬 | 0.00% |
| 1492 Capital Management LLC | US$278.4萬 | 1.06% |
| JPMORGAN CHASE & CO | US$240.9萬 | 0.00% |
| AMERIPRISE FINANCIAL INC | US$239.5萬 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$237.7萬 | 0.01% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | US$232.9萬 | 0.00% |
| CITADEL ADVISORS LLC | US$231.4萬 | 0.00% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$222.6萬 | 0.00% |
| MACKENZIE FINANCIAL CORP | US$207.9萬 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$205.6萬 | 0.00% |
| Legal & General Group Plc | US$199.9萬 | 0.00% |
| PROFUND ADVISORS LLC | US$192.6萬 | 0.07% |
| Advisors Asset Management, Inc. | US$186.4萬 | 0.03% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$171.0萬 | 0.00% |
| Jackson Creek Investment Advisors LLC | US$161.7萬 | 0.48% |
| Erste Asset Management GmbH | US$155.9萬 | 0.01% |
| Engineers Gate Manager LP | US$155.4萬 | 0.02% |
| Focus Partners Wealth | US$154.2萬 | 0.00% |
| Man Group plc | US$151.3萬 | 0.00% |
| Russell Investments Group, Ltd. | US$146.7萬 | 0.00% |
| MetLife Investment Management, LLC | US$143.7萬 | 0.01% |
| VICTORY CAPITAL MANAGEMENT INC | US$142.3萬 | 0.00% |
| Walleye Capital LLC | US$128.8萬 | 0.01% |
| Vanguard Global Advisers, LLC | US$123.1萬 | 0.00% |
| Phocas Financial Corp. | US$118.5萬 | 0.19% |
| Jump Financial, LLC | US$116.8萬 | 0.02% |
| MILLENNIUM MANAGEMENT LLC | US$116.2萬 | 0.00% |
| WESBANCO BANK INC | US$114.3萬 | 0.03% |
| CITIGROUP INC | US$113.9萬 | 0.00% |
| GSA CAPITAL PARTNERS LLP | US$108.6萬 | 0.07% |
| WELLINGTON MANAGEMENT GROUP LLP | US$104.5萬 | 0.00% |
| GUGGENHEIM CAPITAL LLC | US$101.9萬 | 0.01% |
| XTX Topco Ltd | US$100.6萬 | 0.02% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$99.3萬 | 0.00% |
| Handelsbanken Fonder AB | US$97.3萬 | 0.00% |
| SG Americas Securities, LLC | US$93.8萬 | 0.00% |
| State of New Jersey Common Pension Fund D | US$88.8萬 | 0.00% |
| ALGERT GLOBAL LLC | US$86.5萬 | 0.01% |
| Invst, LLC | US$82.9萬 | 0.09% |
| Vontobel Holding Ltd. | US$81.5萬 | 0.00% |
| Aquatic Capital Management LLC | US$81.5萬 | 0.02% |
| Independent Advisor Alliance | US$74.4萬 | 0.01% |
| Campbell & CO Investment Adviser LLC | US$74.3萬 | 0.04% |
| INTECH INVESTMENT MANAGEMENT LLC | US$73.2萬 | 0.01% |
| OpenArc Corporate Advisory, LLC | US$72.1萬 | 0.01% |
| ARIZONA STATE RETIREMENT SYSTEM | US$71.3萬 | 0.00% |
| Creative Planning | US$69.9萬 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$68.9萬 | 0.01% |
| Virtus Investment Advisers, LLC | US$68.5萬 | 0.19% |
| BARCLAYS PLC | US$68.2萬 | 0.00% |
| ENVESTNET ASSET MANAGEMENT INC | US$68.1萬 | 0.00% |
| SIT INVESTMENT ASSOCIATES INC | US$68.1萬 | 0.01% |
| Vanguard Investments Australia, Ltd. | US$66.2萬 | 0.00% |
| D.A. DAVIDSON & CO. | US$64.7萬 | 0.00% |
| FARALLON CAPITAL MANAGEMENT LLC | US$61.3萬 | 0.00% |
| DNB Asset Management AS | US$59.8萬 | 0.00% |
| KLP KAPITALFORVALTNING AS | US$57.3萬 | 0.00% |
| Cerity Partners LLC | US$56.4萬 | 0.00% |
| Mariner, LLC | US$56.0萬 | 0.00% |