| GordonMD Global Investments LP | US$3663.3万 | 25.51% |
| GILEAD SCIENCES, INC. | US$3560.8万 | 1.68% |
| Bain Capital Life Sciences Investors, LLC | US$2683.9万 | 2.42% |
| AIGH Capital Management LLC | US$1726.0万 | 2.35% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | US$1726.0万 | 0.20% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$1539.0万 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$1342.3万 | 0.00% |
| Balyasny Asset Management L.P. | US$971.2万 | 0.01% |
| MILLENNIUM MANAGEMENT LLC | US$867.8万 | 0.00% |
| Insight Holdings Group, LLC | US$853.6万 | 0.60% |
| MORGAN STANLEY | US$843.4万 | 0.00% |
| BlackRock, Inc. | US$756.9万 | 0.00% |
| Woodline Partners LP | US$729.5万 | 0.03% |
| D. E. Shaw & Co., Inc. | US$622.7万 | 0.00% |
| Propel Bio Management, LLC | US$558.6万 | 3.52% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$546.6万 | 0.00% |
| MBB PUBLIC MARKETS I LLC | US$530.3万 | 0.63% |
| MARSHALL WACE, LLP | US$522.6万 | 0.01% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$431.5万 | 0.01% |
| UBS Group AG | US$388.1万 | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | US$366.0万 | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | US$317.1万 | 0.00% |
| Qube Research & Technologies Ltd | US$288.0万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$193.8万 | 0.00% |
| Point72 Asset Management, L.P. | US$192.4万 | 0.00% |
| GOLDMAN SACHS GROUP INC | US$183.7万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$182.2万 | 0.00% |
| Burkehill Global Management, LP | US$172.6万 | 0.09% |
| Invesco Ltd. | US$161.1万 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$156.7万 | 0.00% |
| Simplify Asset Management Inc. | US$149.4万 | 0.02% |
| TD Asset Management Inc | US$145.9万 | 0.00% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | US$129.4万 | 0.03% |
| Squarepoint Ops LLC | US$126.8万 | 0.00% |
| STATE STREET CORP | US$119.4万 | 0.00% |
| BARCLAYS PLC | US$117.7万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$116.1万 | 0.00% |
| STIFEL FINANCIAL CORP | US$112.6万 | 0.00% |
| JANE STREET GROUP, LLC | US$103.3万 | 0.00% |
| Y-Intercept (Hong Kong) Ltd | US$99.1万 | 0.02% |
| WELLS FARGO & COMPANY/MN | US$98.7万 | 0.00% |
| WESBANCO BANK INC | US$95.2万 | 0.03% |
| Kera Capital Partners, Inc. | US$93.3万 | 0.11% |
| CITADEL ADVISORS LLC | US$75.6万 | 0.00% |
| 683 Capital Management, LLC | US$73.4万 | 0.04% |
| DIMENSIONAL FUND ADVISORS LP | US$67.7万 | 0.00% |
| NORTHERN TRUST CORP | US$67.4万 | 0.00% |
| Hudson Bay Capital Management LP | US$61.3万 | 0.00% |
| Brevan Howard Capital Management LP | US$54.8万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$48.1万 | 0.00% |
| Man Group plc | US$46.2万 | 0.00% |
| AMERICAN CENTURY COMPANIES INC | US$45.9万 | 0.00% |
| Jump Financial, LLC | US$45.5万 | 0.01% |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P | US$44.9万 | 0.42% |
| ExodusPoint Capital Management, LP | US$42.3万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | US$38.0万 | 0.00% |
| CITIGROUP INC | US$36.5万 | 0.00% |
| Peapod Lane Capital LLC | US$33.6万 | 0.28% |
| Quadrature Capital Ltd | US$33.1万 | 0.00% |
| Walleye Capital LLC | US$33.0万 | 0.00% |
| Banque Cantonale Vaudoise | US$26.3万 | 0.01% |
| ACT CAPITAL MANAGEMENT, LLC | US$25.9万 | 0.20% |
| Susquehanna Portfolio Strategies, LLC | US$24.0万 | 0.00% |
| MANGROVE PARTNERS IM, LLC | US$23.3万 | 0.02% |
| Jefferies Financial Group Inc. | US$20.6万 | 0.00% |
| ADAR1 Capital Management, LLC | US$19.4万 | 0.01% |
| FEDERATED HERMES, INC. | US$17.9万 | 0.00% |
| Schonfeld Strategic Advisors LLC | US$17.4万 | 0.00% |
| Phoenix Wealth Advisors | US$17.1万 | 0.07% |
| CAXTON CORP | US$16.2万 | 4.03% |
| Vanguard Personalized Indexing Management, LLC | US$16.2万 | 0.00% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | US$14.3万 | 0.00% |
| GSA CAPITAL PARTNERS LLP | US$13.9万 | 0.01% |
| RAYMOND JAMES FINANCIAL INC | US$13.9万 | 0.00% |
| Diametric Capital, LP | US$13.9万 | 0.04% |
| Vanguard Global Advisers, LLC | US$12.9万 | 0.00% |
| OMERS ADMINISTRATION Corp | US$12.8万 | 0.00% |
| CANADA PENSION PLAN INVESTMENT BOARD | US$12.0万 | 0.00% |
| Graham Capital Management, L.P. | US$10.3万 | 0.00% |
| Ethic Inc. | US$10.3万 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$8.7万 | 0.01% |
| Grey Ledge Advisors, LLC | US$8.6万 | 0.02% |
| CAPITAL ADVISORS INC/OK | US$8.6万 | 0.00% |
| FOX RUN MANAGEMENT, L.L.C. | US$8.4万 | 0.01% |
| FMR LLC | US$5.9万 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | US$3.6万 | 0.00% |
| JPMORGAN CHASE & CO | US$3.5万 | 0.00% |
| SIMPLEX TRADING, LLC | US$3.5万 | 0.00% |
| DEUTSCHE BANK AG\ | US$3.4万 | 0.00% |
| Tower Research Capital LLC (TRC) | US$2.7万 | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | US$2.6万 | 0.00% |
| ROYAL BANK OF CANADA | US$2.3万 | 0.00% |
| Caitong International Asset Management Co., Ltd | US$1.8万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$1.4万 | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | US$1.3万 | 0.00% |
| Russell Investments Group, Ltd. | US$1.1万 | 0.00% |
| GF FUND MANAGEMENT CO. LTD. | US$8432.0 | 0.00% |
| Quantbot Technologies LP | US$7094.0 | 0.00% |
| OSAIC HOLDINGS, INC. | US$6256.0 | 0.00% |
| NATIONAL BANK OF CANADA /FI/ | US$3452.0 | 0.00% |
| NISA INVESTMENT ADVISORS, LLC | US$2598.0 | 0.00% |
| TFC Financial Management, Inc. | US$2589.0 | 0.00% |
| Fourth Dimension Wealth, LLC | US$2158.0 | 0.00% |
| CWM, LLC | US$2045.0 | 0.00% |
| EverSource Wealth Advisors, LLC | US$1165.0 | 0.00% |
| Fortitude Family Office, LLC | US$1087.0 | 0.00% |
| Advisory Services Network, LLC | US$742.0 | 0.00% |
| Allworth Financial LP | US$467.0 | 0.00% |
| Larson Financial Group LLC | US$345.0 | 0.00% |
| JONES FINANCIAL COMPANIES LLLP | US$289.0 | 0.00% |
| Arax Advisory Partners | US$95.0 | 0.00% |