| RTW INVESTMENTS, LP | US$2.8亿 | 2.77% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$2.7亿 | 0.41% |
| Boxer Capital Management, LLC | US$2.3亿 | 29.87% |
| TCG Crossover Management, LLC | US$2.2亿 | 6.30% |
| FMR LLC | US$2.1亿 | 0.01% |
| FARALLON CAPITAL MANAGEMENT LLC | US$1.9亿 | 1.08% |
| BlackRock, Inc. | US$1.8亿 | 0.00% |
| Woodline Partners LP | US$1.7亿 | 0.63% |
| Nextech Invest, Ltd. | US$1.5亿 | 10.70% |
| TRV GP IV, LLC | US$1.3亿 | 49.96% |
| Siren, L.L.C. | US$1.2亿 | 3.28% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$1.1亿 | 0.00% |
| GOLDMAN SACHS GROUP INC | US$1.1亿 | 0.01% |
| STATE STREET CORP | US$9731.8万 | 0.00% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | US$8675.1万 | 1.02% |
| Paradigm Biocapital Advisors LP | US$8388.2万 | 1.71% |
| Holocene Advisors, LP | US$8227.0万 | 0.20% |
| Balyasny Asset Management L.P. | US$8005.4万 | 0.10% |
| Logos Global Management LP | US$6276.0万 | 3.13% |
| Deep Track Capital, LP | US$5753.0万 | 0.94% |
| GEODE CAPITAL MANAGEMENT, LLC | US$5599.0万 | 0.00% |
| Caligan Partners LP | US$5039.2万 | 3.35% |
| Bellevue Group AG | US$5020.8万 | 1.19% |
| JANUS HENDERSON GROUP PLC | US$5006.7万 | 0.02% |
| Vivo Capital, LLC | US$4507.8万 | 3.75% |
| MORGAN STANLEY | US$3090.9万 | 0.00% |
| Cormorant Asset Management, LP | US$2981.1万 | 1.50% |
| FRANKLIN RESOURCES INC | US$2711.8万 | 0.01% |
| Candriam S.C.A. | US$2655.3万 | 0.14% |
| Nantahala Capital Management, LLC | US$2615.9万 | 0.96% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$1885.9万 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$1860.8万 | 0.00% |
| NORTHERN TRUST CORP | US$1805.3万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$1754.5万 | 0.00% |
| PERCEPTIVE ADVISORS LLC | US$1690.7万 | 0.33% |
| BESSEMER GROUP INC | US$1482.0万 | 0.02% |
| ArrowMark Colorado Holdings LLC | US$1481.9万 | 0.39% |
| UBS Group AG | US$1463.0万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$1386.8万 | 0.00% |
| Invesco Ltd. | US$1214.3万 | 0.00% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$1195.3万 | 0.16% |
| Point72 Asset Management, L.P. | US$1117.0万 | 0.01% |
| AMERIPRISE FINANCIAL INC | US$1058.9万 | 0.00% |
| Seven Fleet Capital Management LP | US$1050.2万 | 3.33% |
| DIMENSIONAL FUND ADVISORS LP | US$1023.7万 | 0.00% |
| Soleus Capital Management, L.P. | US$941.4万 | 0.38% |
| Integral Health Asset Management, LLC | US$941.4万 | 0.45% |
| ACUTA CAPITAL PARTNERS, LLC | US$924.3万 | 6.57% |
| T. Rowe Price Investment Management, Inc. | US$920.6万 | 0.01% |
| MILLENNIUM MANAGEMENT LLC | US$890.4万 | 0.00% |
| PFM Health Sciences, LP | US$849.9万 | 0.77% |
| Sofinnova Investments, Inc. | US$826.5万 | 0.31% |
| Rock Springs Capital Management LP | US$809.4万 | 0.48% |
| Nuveen, LLC | US$754.8万 | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | US$743.1万 | 0.02% |
| Mass General Brigham, Inc | US$741.0万 | 1.58% |
| SPHERA FUNDS MANAGEMENT LTD. | US$718.7万 | 1.14% |
| CONGRESS ASSET MANAGEMENT CO | US$714.1万 | 0.05% |
| BANK OF AMERICA CORP /DE/ | US$684.4万 | 0.00% |
| Bank of New York Mellon Corp | US$666.2万 | 0.00% |
| DV Trading LLC | US$629.0万 | 0.15% |
| WELLINGTON MANAGEMENT GROUP LLP | US$605.0万 | 0.00% |
| Parkman Healthcare Partners LLC | US$556.7万 | 0.57% |
| CITADEL ADVISORS LLC | US$522.8万 | 0.00% |
| KVP Capital Advisors, LP | US$481.7万 | 3.60% |
| Cinctive Capital Management LP | US$464.7万 | 0.30% |
| STEMPOINT CAPITAL LP | US$420.3万 | 0.80% |
| TRV GP VI, LLC | US$406.2万 | 3.00% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$398.6万 | 0.00% |
| Squarepoint Ops LLC | US$374.3万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | US$367.1万 | 0.00% |
| Atle Fund Management AB | US$363.0万 | 1.17% |
| TWO SIGMA INVESTMENTS, LP | US$362.2万 | 0.00% |
| Informed Momentum Co LLC | US$351.5万 | 0.41% |
| Fisher Asset Management, LLC | US$339.7万 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$336.9万 | 0.00% |
| FRED ALGER MANAGEMENT, LLC | US$313.9万 | 0.01% |
| ALGERT GLOBAL LLC | US$304.7万 | 0.05% |
| RHUMBLINE ADVISERS | US$264.9万 | 0.00% |
| Schonfeld Strategic Advisors LLC | US$252.5万 | 0.02% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$226.4万 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$224.4万 | 0.00% |
| Rafferty Asset Management, LLC | US$219.6万 | 0.01% |
| HighVista Strategies LLC | US$218.0万 | 0.60% |
| TD Asset Management Inc | US$214.6万 | 0.00% |
| DEUTSCHE BANK AG\ | US$188.2万 | 0.00% |
| Swiss National Bank | US$183.7万 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$158.4万 | 0.00% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | US$132.3万 | 0.01% |
| JPMORGAN CHASE & CO | US$129.3万 | 0.00% |
| MetLife Investment Management, LLC | US$127.0万 | 0.01% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$123.3万 | 0.00% |
| Vanguard Global Advisers, LLC | US$116.6万 | 0.00% |
| Creative Planning | US$110.7万 | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | US$110.5万 | 0.00% |
| Atom Investors LP | US$110.4万 | 0.08% |
| ADAR1 Capital Management, LLC | US$104.6万 | 0.06% |
| ALLIANCEBERNSTEIN L.P. | US$104.2万 | 0.00% |
| PROFUND ADVISORS LLC | US$99.9万 | 0.04% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$99.8万 | 0.00% |
| SmartHarvest Portfolios, LLC | US$97.0万 | 0.40% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$94.9万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$87.8万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$79.4万 | 0.01% |
| Rockefeller Capital Management L.P. | US$76.0万 | 0.00% |
| Janney Montgomery Scott LLC | US$75.3万 | 0.00% |
| Legal & General Group Plc | US$74.0万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$70.0万 | 0.00% |
| JANE STREET GROUP, LLC | US$68.6万 | 0.00% |
| ALLSTATE CORP | US$67.0万 | 0.01% |
| SEI INVESTMENTS CO | US$66.9万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$63.5万 | 0.01% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$61.9万 | 0.00% |
| Virtus Investment Advisers, LLC | US$61.0万 | 0.17% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | US$57.1万 | 0.00% |
| EverSource Wealth Advisors, LLC | US$54.4万 | 0.02% |
| Harvest Investment Services, LLC | US$53.1万 | 0.10% |
| SG Americas Securities, LLC | US$50.7万 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$50.0万 | 0.04% |
| Vanguard Personalized Indexing Management, LLC | US$49.2万 | 0.00% |
| Persistent Asset Partners Ltd | US$48.4万 | 0.18% |
| ProShare Advisors LLC | US$46.3万 | 0.00% |
| BARCLAYS PLC | US$45.3万 | 0.00% |
| Mitsubishi UFJ Asset Management Co., Ltd. | US$44.7万 | 0.00% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$44.0万 | 0.00% |
| Entropy Technologies, LP | US$43.2万 | 0.02% |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | US$42.8万 | 0.38% |
| Jain Global LLC | US$42.6万 | 0.00% |
| CITIGROUP INC | US$41.1万 | 0.00% |
| PRUDENTIAL FINANCIAL INC | US$40.1万 | 0.00% |
| Gotham Asset Management, LLC | US$40.0万 | 0.00% |
| Quantinno Capital Management LP | US$38.6万 | 0.00% |
| Alyeska Investment Group, L.P. | US$36.0万 | 0.00% |
| State of New Jersey Common Pension Fund D | US$31.8万 | 0.00% |
| PSP Research LLC | US$30.1万 | 0.21% |
| XTX Topco Ltd | US$29.5万 | 0.01% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | US$29.3万 | 0.01% |
| CANADA PENSION PLAN INVESTMENT BOARD | US$29.1万 | 0.00% |
| E Fund Management Co., Ltd. | US$27.6万 | 0.01% |
| Russell Investments Group, Ltd. | US$26.9万 | 0.00% |
| MANGROVE PARTNERS IM, LLC | US$26.3万 | 0.02% |
| Tower Research Capital LLC (TRC) | US$26.2万 | 0.01% |
| SummitTX Capital, L.P. | US$26.2万 | 0.01% |
| Bleakley Financial Group, LLC | US$25.9万 | 0.00% |
| Vanguard Investments Australia, Ltd. | US$25.6万 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | US$25.6万 | 0.00% |
| Bridgefront Capital, LLC | US$22.7万 | 0.06% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$22.3万 | 0.00% |
| XPONANCE LLC | US$21.4万 | 0.00% |
| Hudson Bay Capital Management LP | US$21.3万 | 0.00% |