| ARK Investment Management LLC | US$1.9億 | 1.45% |
| BlackRock, Inc. | US$1.6億 | 0.00% |
| STATE STREET CORP | US$8874.9萬 | 0.00% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$7978.3萬 | 0.00% |
| D. E. Shaw & Co., Inc. | US$7343.5萬 | 0.04% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$6517.8萬 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$6033.0萬 | 0.05% |
| REGENERON PHARMACEUTICALS, INC. | US$4747.2萬 | 99.14% |
| UBS Group AG | US$4177.1萬 | 0.01% |
| GEODE CAPITAL MANAGEMENT, LLC | US$3656.3萬 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$3464.8萬 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | US$2970.9萬 | 0.01% |
| MORGAN STANLEY | US$2668.4萬 | 0.00% |
| FMR LLC | US$2650.2萬 | 0.00% |
| Sumitomo Mitsui Trust Group, Inc. | US$2529.5萬 | 0.02% |
| Amova Asset Management Americas, Inc. | US$2527.5萬 | 0.36% |
| Contrarius Group Holdings Ltd | US$2451.0萬 | 1.39% |
| JUPITER ASSET MANAGEMENT LTD | US$2283.3萬 | 0.12% |
| GOLDMAN SACHS GROUP INC | US$2087.4萬 | 0.00% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | US$2066.0萬 | 0.08% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | US$1791.3萬 | 0.01% |
| BANK OF AMERICA CORP /DE/ | US$1771.3萬 | 0.00% |
| JANE STREET GROUP, LLC | US$1732.1萬 | 0.00% |
| CITADEL ADVISORS LLC | US$1432.8萬 | 0.00% |
| STIFEL FINANCIAL CORP | US$1298.3萬 | 0.01% |
| NORTHERN TRUST CORP | US$1238.8萬 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$1206.7萬 | 0.00% |
| CAPITAL FUND MANAGEMENT S.A. | US$1021.3萬 | 0.05% |
| Connor, Clark & Lunn Investment Management Ltd. | US$959.8萬 | 0.02% |
| VANGUARD FIDUCIARY TRUST CO | US$959.1萬 | 0.00% |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | US$928.5萬 | 0.71% |
| AQR CAPITAL MANAGEMENT LLC | US$808.3萬 | 0.00% |
| Marex Group plc | US$799.5萬 | 0.05% |
| Caption Management, LLC | US$749.8萬 | 0.04% |
| RAYMOND JAMES FINANCIAL INC | US$739.6萬 | 0.00% |
| Vestmark Advisory Solutions, Inc. | US$705.3萬 | 0.08% |
| HRT FINANCIAL LP | US$643.9萬 | 0.02% |
| JPMORGAN CHASE & CO | US$639.0萬 | 0.00% |
| ROYAL BANK OF CANADA | US$596.8萬 | 0.00% |
| Birchview Capital, LP | US$571.0萬 | 3.25% |
| Invesco Ltd. | US$557.4萬 | 0.00% |
| HIMENSION CAPITAL (SINGAPORE) PTE. LTD. | US$550.7萬 | 0.42% |
| FEDERATED HERMES, INC. | US$472.6萬 | 0.01% |
| Casdin Capital, LLC | US$455.1萬 | 0.34% |
| ARMISTICE CAPITAL, LLC | US$430.8萬 | 0.08% |
| WELLS FARGO & COMPANY/MN | US$428.1萬 | 0.00% |
| Bank of New York Mellon Corp | US$420.5萬 | 0.00% |
| Point72 Asset Management, L.P. | US$380.8萬 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$364.0萬 | 0.00% |
| WASATCH ADVISORS LP | US$335.7萬 | 0.02% |
| Opaleye Management Inc. | US$314.1萬 | 0.41% |
| Nuveen, LLC | US$308.7萬 | 0.00% |
| Canal Insurance CO | US$294.9萬 | 0.63% |
| Swiss National Bank | US$279.2萬 | 0.00% |
| Squarepoint Ops LLC | US$269.2萬 | 0.00% |
| AMERICAN CENTURY COMPANIES INC | US$267.0萬 | 0.00% |
| Woodline Partners LP | US$257.7萬 | 0.01% |
| DIADEMA PARTNERS LP | US$256.4萬 | 0.44% |
| Rafferty Asset Management, LLC | US$256.1萬 | 0.01% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$239.5萬 | 0.00% |
| GSA CAPITAL PARTNERS LLP | US$228.6萬 | 0.14% |
| Balyasny Asset Management L.P. | US$217.0萬 | 0.00% |
| ELEVATION POINT WEALTH PARTNERS, LLC | US$215.1萬 | 0.05% |
| DEUTSCHE BANK AG\ | US$210.5萬 | 0.00% |
| Hennion & Walsh Asset Management, Inc. | US$204.9萬 | 0.07% |
| BARCLAYS PLC | US$188.8萬 | 0.00% |
| CREDIT AGRICOLE S A | US$187.8萬 | 0.00% |
| PINNACLE ASSOCIATES LTD | US$186.5萬 | 0.02% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$183.1萬 | 0.00% |
| Rockefeller Capital Management L.P. | US$181.4萬 | 0.00% |
| Y-Intercept (Hong Kong) Ltd | US$180.9萬 | 0.03% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$177.2萬 | 0.00% |
| MARSHALL WACE, LLP | US$176.2萬 | 0.00% |
| RHUMBLINE ADVISERS | US$175.1萬 | 0.00% |
| Jefferies Financial Group Inc. | US$170.5萬 | 0.01% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$170.1萬 | 0.00% |
| AMERIPRISE FINANCIAL INC | US$164.4萬 | 0.00% |
| LPL Financial LLC | US$157.5萬 | 0.00% |
| Engineers Gate Manager LP | US$154.3萬 | 0.02% |
| PDT Partners, LLC | US$149.5萬 | 0.09% |
| Susquehanna Portfolio Strategies, LLC | US$146.0萬 | 0.02% |
| Havemeyer Place LP | US$140.3萬 | 0.16% |
| ENVESTNET ASSET MANAGEMENT INC | US$140.1萬 | 0.00% |
| OPPENHEIMER & CO INC | US$137.1萬 | 0.02% |
| Elmwood Wealth Management, Inc. | US$131.9萬 | 0.36% |
| Aquatic Capital Management LLC | US$122.0萬 | 0.04% |
| COMMONWEALTH EQUITY SERVICES, LLC | US$120.7萬 | 0.00% |
| LAZARD ASSET MANAGEMENT LLC | US$120.0萬 | 0.00% |
| Legal & General Group Plc | US$120.0萬 | 0.00% |
| D.A. DAVIDSON & CO. | US$119.6萬 | 0.01% |
| GROUP ONE TRADING LLC | US$115.4萬 | 0.00% |
| SG Americas Securities, LLC | US$115.0萬 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | US$114.4萬 | 0.00% |
| PROFUND ADVISORS LLC | US$114.2萬 | 0.04% |
| BENJAMIN EDWARDS INC | US$105.8萬 | 0.01% |
| Orchard Capital Management, LLC | US$105.2萬 | 1.10% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$103.7萬 | 0.00% |
| Quadrature Capital Ltd | US$96.2萬 | 0.01% |
| Avidity Partners Management LP | US$96.2萬 | 0.19% |
| Brevan Howard Capital Management LP | US$94.8萬 | 0.01% |
| Jump Financial, LLC | US$94.0萬 | 0.01% |
| ALLIANCEBERNSTEIN L.P. | US$92.7萬 | 0.00% |
| MILLENNIUM MANAGEMENT LLC | US$90.5萬 | 0.00% |
| DekaBank Deutsche Girozentrale | US$88.9萬 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$88.9萬 | 0.00% |
| Torrey Growth & Income Advisors | US$88.6萬 | 0.37% |
| WESBANCO BANK INC | US$82.0萬 | 0.02% |
| VICTORY CAPITAL MANAGEMENT INC | US$80.1萬 | 0.00% |
| Hudson Bay Capital Management LP | US$76.9萬 | 0.00% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | US$76.9萬 | 0.00% |
| Russell Investments Group, Ltd. | US$76.2萬 | 0.00% |
| MetLife Investment Management, LLC | US$75.7萬 | 0.00% |
| GUGGENHEIM CAPITAL LLC | US$70.7萬 | 0.01% |
| Intellectus Partners, LLC | US$69.8萬 | 0.14% |
| XTX Topco Ltd | US$69.2萬 | 0.01% |
| Man Group plc | US$69.0萬 | 0.00% |
| Cetera Investment Advisers | US$69.0萬 | 0.00% |
| IEQ CAPITAL, LLC | US$68.1萬 | 0.00% |
| Creative Planning | US$67.2萬 | 0.00% |
| JONES FINANCIAL COMPANIES LLLP | US$66.5萬 | 0.00% |
| Mariner, LLC | US$66.5萬 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$66.4萬 | 0.00% |
| GRANDFIELD & DODD, LLC | US$62.1萬 | 0.04% |
| JANUS HENDERSON GROUP PLC | US$61.5萬 | 0.00% |
| HSBC HOLDINGS PLC | US$61.4萬 | 0.00% |
| Gen-Wealth Partners Inc | US$60.5萬 | 0.19% |
| Vanguard Global Advisers, LLC | US$59.9萬 | 0.00% |
| Wellington Grp LLC | US$59.4萬 | 0.18% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$59.3萬 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | US$57.8萬 | 0.00% |
| CWM, LLC | US$57.6萬 | 0.00% |
| WELLINGTON MANAGEMENT GROUP LLP | US$54.3萬 | 0.00% |
| Generali Investments Towarzystwo Funduszy Inwestycyjnych | US$51.3萬 | 0.26% |
| Quantinno Capital Management LP | US$50.9萬 | 0.00% |
| MARTINGALE ASSET MANAGEMENT L P | US$49.6萬 | 0.01% |
| State of New Jersey Common Pension Fund D | US$48.2萬 | 0.00% |
| CITIGROUP INC | US$47.1萬 | 0.00% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | US$44.2萬 | 0.00% |
| Handelsbanken Fonder AB | US$43.3萬 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$43.2萬 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$42.9萬 | 0.03% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$41.9萬 | 0.00% |
| Seven Fleet Capital Management LP | US$40.4萬 | 0.13% |
| GWN SECURITIES INC. | US$40.4萬 | 0.08% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$40.1萬 | 0.00% |
| Mitsubishi UFJ Asset Management Co., Ltd. | US$39.0萬 | 0.00% |
| Virtus Investment Advisers, LLC | US$38.8萬 | 0.11% |
| ARIZONA STATE RETIREMENT SYSTEM | US$38.7萬 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$38.5萬 | 0.00% |
| Advisor OS, LLC | US$38.5萬 | 0.03% |