| FMR LLC | US$3.1億 | 0.02% |
| BVF INC/IL | US$1.8億 | 5.87% |
| Two Seas Capital LP | US$1.4億 | 1.97% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$8612.8萬 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$6696.7萬 | 0.05% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$6498.5萬 | 0.01% |
| Prosight Management, LP | US$5288.3萬 | 8.67% |
| BlackRock, Inc. | US$4983.6萬 | 0.00% |
| CITADEL ADVISORS LLC | US$4787.8萬 | 0.01% |
| MORGAN STANLEY | US$4744.3萬 | 0.00% |
| ARMISTICE CAPITAL, LLC | US$4158.7萬 | 0.74% |
| Invesco Ltd. | US$4082.9萬 | 0.01% |
| Sofinnova Investments, Inc. | US$3666.2萬 | 1.39% |
| Woodline Partners LP | US$2988.3萬 | 0.11% |
| LORD, ABBETT & CO. LLC | US$2914.6萬 | 0.10% |
| MILLENNIUM MANAGEMENT LLC | US$2908.8萬 | 0.01% |
| Bronte Capital Management Pty Ltd. | US$2883.4萬 | 2.86% |
| EMERALD ADVISERS, LLC | US$2839.2萬 | 0.90% |
| Qube Research & Technologies Ltd | US$2810.9萬 | 0.03% |
| GEODE CAPITAL MANAGEMENT, LLC | US$2496.2萬 | 0.00% |
| UBS Group AG | US$2303.6萬 | 0.00% |
| GREAT POINT PARTNERS LLC | US$2276.9萬 | 5.23% |
| Vestal Point Capital, LP | US$2050.6萬 | 0.57% |
| 22NW, LP | US$2022.6萬 | 13.86% |
| PRIMECAP MANAGEMENT CO/CA/ | US$2008.5萬 | 0.02% |
| ORBIMED ADVISORS LLC | US$1978.6萬 | 0.41% |
| GILDER GAGNON HOWE & CO LLC | US$1955.3萬 | 0.23% |
| Nearwater Capital Markets, Ltd | US$1881.5萬 | 0.44% |
| EMERALD MUTUAL FUND ADVISERS TRUST | US$1842.7萬 | 0.89% |
| Caption Management, LLC | US$1834.7萬 | 0.11% |
| STATE STREET CORP | US$1760.8萬 | 0.00% |
| BRAIDWELL LP | US$1602.3萬 | 0.53% |
| JPMORGAN CHASE & CO | US$1566.7萬 | 0.00% |
| Patient Square Capital LP | US$1511.0萬 | 2.68% |
| JANE STREET GROUP, LLC | US$1474.6萬 | 0.00% |
| Quinn Opportunity Partners LLC | US$1289.7萬 | 0.67% |
| Creek Drive Management Group LLC | US$1269.2萬 | 2.89% |
| VANGUARD FIDUCIARY TRUST CO | US$1218.2萬 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$1208.8萬 | 0.00% |
| DAFNA Capital Management LLC | US$1188.5萬 | 2.70% |
| ADAR1 Capital Management, LLC | US$1160.2萬 | 0.68% |
| MARSHALL WACE, LLP | US$1011.5萬 | 0.01% |
| AMERIPRISE FINANCIAL INC | US$983.8萬 | 0.00% |
| GOLDMAN SACHS GROUP INC | US$913.3萬 | 0.00% |
| Squadron Capital Management LLC | US$899.4萬 | 3.30% |
| SEVEN GRAND MANAGERS, LLC | US$899.4萬 | 0.60% |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | US$880.1萬 | 0.75% |
| Squarepoint Ops LLC | US$772.6萬 | 0.01% |
| Russell Investments Group, Ltd. | US$764.5萬 | 0.01% |
| Tetragon Partners GP Ltd | US$741.4萬 | 1.44% |
| ING GROEP NV | US$719.5萬 | 0.04% |
| Monashee Investment Management LLC | US$719.5萬 | 3.91% |
| Connor, Clark & Lunn Investment Management Ltd. | US$710.5萬 | 0.02% |
| DEUTSCHE BANK AG\ | US$659.6萬 | 0.00% |
| MOODY ALDRICH PARTNERS LLC | US$644.1萬 | 1.16% |
| Stonepine Capital Management, LLC | US$611.6萬 | 2.45% |
| NORTHERN TRUST CORP | US$565.5萬 | 0.00% |
| Jump Financial, LLC | US$556.9萬 | 0.07% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$521.6萬 | 0.00% |
| ACT CAPITAL MANAGEMENT, LLC | US$510.1萬 | 4.01% |
| HRT FINANCIAL LP | US$508.4萬 | 0.01% |
| Voleon Capital Management LP | US$468.1萬 | 0.10% |
| F/m Investments LLC | US$439.6萬 | 0.29% |
| Rhenman & Partners Asset Management AB | US$424.5萬 | 0.52% |
| BANK OF AMERICA CORP /DE/ | US$424.2萬 | 0.00% |
| Aquatic Capital Management LLC | US$410.2萬 | 0.12% |
| Cambridge Investment Research Advisors, Inc. | US$403.3萬 | 0.01% |
| Trexquant Investment LP | US$399.1萬 | 0.03% |
| FRED ALGER MANAGEMENT, LLC | US$382.6萬 | 0.02% |
| Alyeska Investment Group, L.P. | US$359.8萬 | 0.01% |
| Brevan Howard Capital Management LP | US$348.8萬 | 0.03% |
| LMR Partners LLP | US$347.5萬 | 0.01% |
| Swiss National Bank | US$344.6萬 | 0.00% |
| Atom Investors LP | US$311.0萬 | 0.22% |
| SummitTX Capital, L.P. | US$306.7萬 | 0.10% |
| RENAISSANCE TECHNOLOGIES LLC | US$300.6萬 | 0.00% |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | US$265.5萬 | 0.17% |
| Jain Global LLC | US$260.3萬 | 0.01% |
| Informed Momentum Co LLC | US$259.9萬 | 0.30% |
| Balyasny Asset Management L.P. | US$257.9萬 | 0.00% |
| ALGERT GLOBAL LLC | US$250.3萬 | 0.04% |
| Susquehanna Portfolio Strategies, LLC | US$248.4萬 | 0.04% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$244.8萬 | 0.00% |
| BARCLAYS PLC | US$232.8萬 | 0.00% |
| IRIDIAN ASSET MANAGEMENT LLC/CT | US$225.3萬 | 0.91% |
| Birchview Capital, LP | US$223.0萬 | 1.27% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | US$216.9萬 | 0.01% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$206.4萬 | 0.00% |
| Headlands Technologies LLC | US$203.2萬 | 0.23% |
| KVP Capital Advisors, LP | US$193.5萬 | 1.45% |
| Y-Intercept (Hong Kong) Ltd | US$191.0萬 | 0.04% |
| Erste Asset Management GmbH | US$182.7萬 | 0.02% |
| CITIGROUP INC | US$180.2萬 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | US$178.3萬 | 0.00% |
| GSA CAPITAL PARTNERS LLP | US$153.5萬 | 0.10% |
| BIT Capital GmbH | US$151.8萬 | 0.07% |
| ExodusPoint Capital Management, LP | US$147.2萬 | 0.01% |
| AWM Investment Company, Inc. | US$143.9萬 | 0.16% |
| Man Group plc | US$139.9萬 | 0.00% |
| Deuterium Capital Management, LLC | US$129.5萬 | 1.51% |
| WINTON GROUP Ltd | US$121.7萬 | 0.04% |
| Legal & General Group Plc | US$119.9萬 | 0.00% |
| IMC-Chicago, LLC | US$117.7萬 | 0.00% |
| ROYAL BANK OF CANADA | US$116.4萬 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$114.5萬 | 0.00% |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | US$113.8萬 | 0.00% |
| Steward Partners Investment Advisory, LLC | US$111.7萬 | 0.01% |
| HighVista Strategies LLC | US$104.7萬 | 0.29% |
| GLENMEDE TRUST CO NA | US$99.8萬 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$98.4萬 | 0.00% |
| Point72 Asset Management, L.P. | US$96.2萬 | 0.00% |
| Walleye Capital LLC | US$92.7萬 | 0.00% |
| Engineers Gate Manager LP | US$88.5萬 | 0.01% |
| FIFTH LANE CAPITAL, LP | US$86.3萬 | 1.05% |
| SECTORAL ASSET MANAGEMENT INC | US$82.1萬 | 0.68% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$81.2萬 | 0.00% |
| Vanguard Global Advisers, LLC | US$81.0萬 | 0.00% |
| Scientech Research LLC | US$79.4萬 | 0.66% |
| ENVESTNET ASSET MANAGEMENT INC | US$78.3萬 | 0.00% |
| JANUS HENDERSON GROUP PLC | US$77.1萬 | 0.00% |
| OCCUDO QUANTITATIVE STRATEGIES LP | US$76.1萬 | 0.04% |
| Hudson Bay Capital Management LP | US$74.3萬 | 0.00% |
| Palumbo Wealth Management LLC | US$73.2萬 | 0.18% |
| ALLSTATE CORP | US$70.8萬 | 0.01% |
| State of New Jersey Common Pension Fund D | US$59.6萬 | 0.00% |
| Schonfeld Strategic Advisors LLC | US$58.0萬 | 0.00% |
| Diametric Capital, LP | US$53.3萬 | 0.14% |
| CenterBook Partners LP | US$53.3萬 | 0.03% |
| PEAK6 LLC | US$50.4萬 | 0.00% |
| Catalyst Funds Management Pty Ltd | US$48.2萬 | 0.08% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$48.2萬 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | US$47.9萬 | 0.00% |
| Bank of New York Mellon Corp | US$47.5萬 | 0.00% |
| Neo Ivy Capital Management | US$46.3萬 | 0.12% |
| Vanguard Investments Australia, Ltd. | US$45.7萬 | 0.00% |
| FOX RUN MANAGEMENT, L.L.C. | US$44.8萬 | 0.08% |
| GROUP ONE TRADING LLC | US$42.8萬 | 0.00% |
| Persistent Asset Partners Ltd | US$41.9萬 | 0.16% |
| SIMPLEX TRADING, LLC | US$41.2萬 | 0.00% |
| KLP KAPITALFORVALTNING AS | US$37.4萬 | 0.00% |
| Gainplan LLC | US$36.0萬 | 0.27% |
| Virtus Investment Advisers, LLC | US$35.9萬 | 0.10% |
| FNY Investment Advisers, LLC | US$34.1萬 | 0.15% |
| Entropy Technologies, LP | US$33.0萬 | 0.02% |
| LPL Financial LLC | US$32.7萬 | 0.00% |
| SEI INVESTMENTS CO | US$32.2萬 | 0.00% |
| OSAIC HOLDINGS, INC. | US$31.6萬 | 0.00% |
| Seven Fleet Capital Management LP | US$30.9萬 | 0.10% |
| XTX Topco Ltd | US$29.5萬 | 0.01% |
| FARALLON CAPITAL MANAGEMENT LLC | US$28.8萬 | 0.00% |