| FMR LLC | US$6.5億 | 0.03% |
| BlackRock, Inc. | US$2.7億 | 0.00% |
| RA CAPITAL MANAGEMENT, L.P. | US$2.2億 | 2.32% |
| WELLINGTON MANAGEMENT GROUP LLP | US$2.2億 | 0.04% |
| Fairmount Funds Management LLC | US$2.1億 | 15.38% |
| Avidity Partners Management LP | US$1.8億 | 35.76% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$1.7億 | 0.00% |
| Octagon Capital Advisors LP | US$1.6億 | 18.08% |
| TCG Crossover Management, LLC | US$1.4億 | 4.03% |
| CITADEL ADVISORS LLC | US$1.4億 | 0.02% |
| STATE STREET CORP | US$1.2億 | 0.00% |
| T. Rowe Price Investment Management, Inc. | US$1.1億 | 0.07% |
| Venrock Adviser, LLC | US$9902.6萬 | 3.70% |
| FRED ALGER MANAGEMENT, LLC | US$9750.9萬 | 0.43% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$9625.3萬 | 0.01% |
| Polar Capital Holdings Plc | US$9029.9萬 | 0.32% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | US$8558.3萬 | 1.01% |
| FRANKLIN RESOURCES INC | US$8125.0萬 | 0.02% |
| Cormorant Asset Management, LP | US$7972.4萬 | 4.00% |
| GEODE CAPITAL MANAGEMENT, LLC | US$7690.5萬 | 0.00% |
| BRAIDWELL LP | US$7547.5萬 | 2.52% |
| BAKER BROS. ADVISORS LP | US$7151.4萬 | 0.41% |
| FARALLON CAPITAL MANAGEMENT LLC | US$7015.7萬 | 0.40% |
| UBS Group AG | US$6556.5萬 | 0.01% |
| SILVERARC CAPITAL MANAGEMENT, LLC | US$5494.6萬 | 5.61% |
| Point72 Asset Management, L.P. | US$5401.1萬 | 0.07% |
| Catalio Capital Management, LP | US$4702.1萬 | 9.82% |
| GOLDMAN SACHS GROUP INC | US$4598.9萬 | 0.01% |
| JENNISON ASSOCIATES LLC | US$4071.3萬 | 0.03% |
| Balyasny Asset Management L.P. | US$3978.5萬 | 0.05% |
| ALLIANCEBERNSTEIN L.P. | US$3816.3萬 | 0.01% |
| Woodline Partners LP | US$3637.6萬 | 0.14% |
| SAMLYN CAPITAL, LLC | US$3617.9萬 | 0.62% |
| MPM BIOIMPACT LLC | US$3558.1萬 | 2.75% |
| Affinity Asset Advisors, LLC | US$3356.8萬 | 1.73% |
| Logos Global Management LP | US$3356.8萬 | 1.68% |
| Artisan Partners Limited Partnership | US$3206.8萬 | 0.05% |
| BARCLAYS PLC | US$3185.7萬 | 0.01% |
| Spruce Street Capital LP | US$3132.5萬 | 7.53% |
| Sio Capital Management, LLC | US$3105.4萬 | 4.45% |
| Bain Capital Life Sciences Investors, LLC | US$3041.8萬 | 2.74% |
| AMERIPRISE FINANCIAL INC | US$3008.3萬 | 0.01% |
| Vivo Capital, LLC | US$2970.8萬 | 2.47% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$2932.0萬 | 0.00% |
| MARSHALL WACE, LLP | US$2869.5萬 | 0.03% |
| DIMENSIONAL FUND ADVISORS LP | US$2729.6萬 | 0.01% |
| Driehaus Capital Management LLC | US$2662.9萬 | 0.20% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$2563.3萬 | 0.00% |
| NORTHERN TRUST CORP | US$2549.1萬 | 0.00% |
| LORD, ABBETT & CO. LLC | US$2511.0萬 | 0.08% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$2410.2萬 | 0.00% |
| TANG CAPITAL MANAGEMENT LLC | US$2221.3萬 | 1.13% |
| MILLENNIUM MANAGEMENT LLC | US$2198.4萬 | 0.01% |
| VANGUARD FIDUCIARY TRUST CO | US$2095.3萬 | 0.01% |
| RTW INVESTMENTS, LP | US$2081.7萬 | 0.21% |
| Freestone Grove Partners LP | US$2013.6萬 | 0.14% |
| EVENTIDE ASSET MANAGEMENT, LLC | US$1890.4萬 | 0.31% |
| First Turn Management, LLC | US$1854.0萬 | 2.07% |
| Nuveen, LLC | US$1825.1萬 | 0.00% |
| Candriam S.C.A. | US$1791.9萬 | 0.09% |
| Ensign Peak Advisors, Inc | US$1714.8萬 | 0.03% |
| Jefferies Financial Group Inc. | US$1698.6萬 | 0.12% |
| BANK OF AMERICA CORP /DE/ | US$1584.2萬 | 0.00% |
| Bank of New York Mellon Corp | US$1581.2萬 | 0.00% |
| PFM Health Sciences, LP | US$1444.6萬 | 1.32% |
| Artia Global Partners LP | US$1367.8萬 | 2.74% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$1342.7萬 | 0.02% |
| Caption Management, LLC | US$1291.5萬 | 0.08% |
| Walleye Capital LLC | US$1288.9萬 | 0.05% |
| Integral Health Asset Management, LLC | US$1258.8萬 | 0.60% |
| D. E. Shaw & Co., Inc. | US$1255.5萬 | 0.01% |
| Tri Locum Partners LP | US$1221.4萬 | 1.71% |
| Invesco Ltd. | US$1097.2萬 | 0.00% |
| Russell Investments Group, Ltd. | US$1083.1萬 | 0.01% |
| Atika Capital Management LLC | US$1080.9萬 | 1.70% |
| TD Asset Management Inc | US$978.3萬 | 0.01% |
| LMR Partners LLP | US$977.2萬 | 0.02% |
| Hudson Bay Capital Management LP | US$916.7萬 | 0.03% |
| Atom Investors LP | US$904.3萬 | 0.65% |
| SummitTX Capital, L.P. | US$839.6萬 | 0.26% |
| SEVEN GRAND MANAGERS, LLC | US$839.2萬 | 0.56% |
| MORGAN STANLEY | US$817.8萬 | 0.00% |
| Cinctive Capital Management LP | US$792.3萬 | 0.52% |
| Patient Square Capital LP | US$787.9萬 | 1.40% |
| SEI INVESTMENTS CO | US$774.1萬 | 0.01% |
| ExodusPoint Capital Management, LP | US$717.8萬 | 0.06% |
| STEMPOINT CAPITAL LP | US$717.5萬 | 1.37% |
| MOODY ALDRICH PARTNERS LLC | US$689.2萬 | 1.24% |
| Rhenman & Partners Asset Management AB | US$685.0萬 | 0.85% |
| AMERICAN CENTURY COMPANIES INC | US$663.8萬 | 0.00% |
| Informed Momentum Co LLC | US$643.2萬 | 0.74% |
| Schonfeld Strategic Advisors LLC | US$616.5萬 | 0.04% |
| Swiss National Bank | US$579.0萬 | 0.00% |
| Nantahala Capital Management, LLC | US$564.6萬 | 0.21% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$547.5萬 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$507.2萬 | 0.00% |
| Trexquant Investment LP | US$495.8萬 | 0.04% |
| NEUBERGER BERMAN GROUP LLC | US$495.8萬 | 0.00% |
| ADAR1 Capital Management, LLC | US$461.6萬 | 0.27% |
| Seven Fleet Capital Management LP | US$455.3萬 | 1.45% |
| Alyeska Investment Group, L.P. | US$438.5萬 | 0.01% |
| Nicholas Investment Partners, LP | US$430.1萬 | 0.31% |
| Burkehill Global Management, LP | US$419.6萬 | 0.21% |
| Evergreen Quality Fund GP, Ltd. | US$419.6萬 | 0.10% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$402.6萬 | 0.01% |
| RHUMBLINE ADVISERS | US$379.2萬 | 0.00% |
| ALGERT GLOBAL LLC | US$372.6萬 | 0.06% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$344.8萬 | 0.01% |
| LPL Financial LLC | US$342.6萬 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$340.6萬 | 0.00% |
| Squarepoint Ops LLC | US$325.1萬 | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | US$313.5萬 | 0.00% |
| ALPS ADVISORS INC | US$303.8萬 | 0.01% |
| HighVista Strategies LLC | US$298.6萬 | 0.82% |
| Blackstone Inc. | US$294.1萬 | 0.01% |
| DEUTSCHE BANK AG\ | US$264.0萬 | 0.00% |
| Rafferty Asset Management, LLC | US$262.0萬 | 0.01% |
| ENVESTNET ASSET MANAGEMENT INC | US$261.7萬 | 0.00% |
| Qube Research & Technologies Ltd | US$254.7萬 | 0.00% |
| JPMORGAN CHASE & CO | US$253.8萬 | 0.00% |
| Rock Springs Capital Management LP | US$224.5萬 | 0.13% |
| DV Trading LLC | US$222.8萬 | 0.05% |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | US$217.1萬 | 0.02% |
| JANE STREET GROUP, LLC | US$195.5萬 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$192.0萬 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$187.2萬 | 0.00% |
| Engineers Gate Manager LP | US$183.9萬 | 0.02% |
| Legal & General Group Plc | US$181.5萬 | 0.00% |
| ArrowMark Colorado Holdings LLC | US$174.5萬 | 0.05% |
| SIG BROKERAGE, LP | US$170.3萬 | 0.04% |
| MetLife Investment Management, LLC | US$163.9萬 | 0.01% |
| Brevan Howard Capital Management LP | US$163.1萬 | 0.01% |
| ROYAL BANK OF CANADA | US$160.1萬 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$158.7萬 | 0.00% |
| BLAIR WILLIAM & CO/IL | US$153.4萬 | 0.00% |
| PRUDENTIAL FINANCIAL INC | US$152.1萬 | 0.00% |
| PEAK6 LLC | US$150.4萬 | 0.00% |
| Vanguard Global Advisers, LLC | US$148.8萬 | 0.00% |
| Darwin Global Management, Ltd. | US$145.7萬 | 0.04% |
| JANUS HENDERSON GROUP PLC | US$138.4萬 | 0.00% |
| BESSEMER GROUP INC | US$135.4萬 | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | US$131.4萬 | 0.00% |
| RAYMOND JAMES FINANCIAL INC | US$126.6萬 | 0.00% |
| PROFUND ADVISORS LLC | US$119.6萬 | 0.04% |
| WELLS FARGO & COMPANY/MN | US$115.7萬 | 0.00% |
| XTX Topco Ltd | US$109.5萬 | 0.02% |
| Fisher Asset Management, LLC | US$105.9萬 | 0.00% |
| Legato Capital Management LLC | US$105.2萬 | 0.10% |
| GLENMEDE TRUST CO NA | US$104.6萬 | 0.01% |
| Lisanti Capital Growth, LLC | US$104.1萬 | 0.26% |