| T. Rowe Price Investment Management, Inc. | US$11.5億 | 0.80% |
| BlackRock, Inc. | US$10.9億 | 0.02% |
| FMR LLC | US$7.1億 | 0.04% |
| WELLINGTON MANAGEMENT GROUP LLP | US$5.3億 | 0.10% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$3.9億 | 0.02% |
| STATE STREET CORP | US$3.8億 | 0.01% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$3.6億 | 0.01% |
| Avoro Capital Advisors LLC | US$2.2億 | 2.16% |
| GEODE CAPITAL MANAGEMENT, LLC | US$2.1億 | 0.01% |
| BANK OF AMERICA CORP /DE/ | US$2.1億 | 0.02% |
| RTW INVESTMENTS, LP | US$1.8億 | 1.78% |
| ARMISTICE CAPITAL, LLC | US$1.8億 | 3.12% |
| Integral Health Asset Management, LLC | US$1.7億 | 8.20% |
| GOLDMAN SACHS GROUP INC | US$1.6億 | 0.02% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$1.5億 | 0.02% |
| UBS Group AG | US$1.4億 | 0.02% |
| Caption Management, LLC | US$1.2億 | 0.71% |
| Polar Capital Holdings Plc | US$1.1億 | 0.39% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$1.0億 | 0.01% |
| CITADEL ADVISORS LLC | US$1.0億 | 0.02% |
| MORGAN STANLEY | US$9920.0萬 | 0.01% |
| Paradigm Biocapital Advisors LP | US$9760.3萬 | 1.99% |
| NORTHERN TRUST CORP | US$9501.8萬 | 0.01% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$9207.9萬 | 0.01% |
| Deep Track Capital, LP | US$9058.1萬 | 1.48% |
| Capital International Investors | US$8824.1萬 | 0.02% |
| Ikarian Capital, LLC | US$8189.1萬 | 6.65% |
| Frazier Life Sciences Management, L.P. | US$7644.8萬 | 1.97% |
| Balyasny Asset Management L.P. | US$7237.9萬 | 0.09% |
| PRINCIPAL FINANCIAL GROUP INC | US$7207.2萬 | 0.04% |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | US$7168.3萬 | 0.24% |
| Bank of New York Mellon Corp | US$6631.8萬 | 0.01% |
| Woodline Partners LP | US$6593.8萬 | 0.25% |
| Royalty Pharma Sub-Manager, LLC | US$6461.8萬 | 37.40% |
| Logos Global Management LP | US$5767.1萬 | 2.88% |
| JPMORGAN CHASE & CO | US$5691.3萬 | 0.00% |
| Melqart Asset Management (UK) Ltd | US$5562.5萬 | 5.48% |
| VANGUARD FIDUCIARY TRUST CO | US$5270.3萬 | 0.01% |
| Qube Research & Technologies Ltd | US$5137.3萬 | 0.06% |
| Capital Research Global Investors | US$5081.7萬 | 0.01% |
| Fisher Asset Management, LLC | US$5063.6萬 | 0.02% |
| Pictet Asset Management Holding SA | US$4929.7萬 | 0.05% |
| D. E. Shaw & Co., Inc. | US$4925.7萬 | 0.03% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$4708.2萬 | 0.05% |
| Affinity Asset Advisors, LLC | US$4616.9萬 | 2.38% |
| FEDERATED HERMES, INC. | US$4610.1萬 | 0.07% |
| Point72 Asset Management, L.P. | US$4356.7萬 | 0.06% |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | US$4352.1萬 | 3.69% |
| MARSHALL WACE, LLP | US$4327.7萬 | 0.04% |
| ADAR1 Capital Management, LLC | US$4169.2萬 | 2.45% |
| BROWN ADVISORY INC | US$4051.2萬 | 0.07% |
| Siren, L.L.C. | US$4046.6萬 | 1.12% |
| Foresite Capital Management IV, LLC | US$3317.2萬 | 13.99% |
| MPM BIOIMPACT LLC | US$3295.5萬 | 2.54% |
| GW&K Investment Management, LLC | US$3260.0萬 | 0.29% |
| Invesco Ltd. | US$3196.5萬 | 0.00% |
| AMERIPRISE FINANCIAL INC | US$3193.4萬 | 0.01% |
| Aberdeen Group plc | US$3185.3萬 | 0.05% |
| EVENTIDE ASSET MANAGEMENT, LLC | US$3157.7萬 | 0.52% |
| AMERICAN CENTURY COMPANIES INC | US$2926.1萬 | 0.02% |
| ALLIANCEBERNSTEIN L.P. | US$2917.0萬 | 0.01% |
| TD Asset Management Inc | US$2773.8萬 | 0.02% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$2744.1萬 | 0.36% |
| FRANKLIN RESOURCES INC | US$2700.9萬 | 0.01% |
| RHUMBLINE ADVISERS | US$2435.9萬 | 0.02% |
| GROUP ONE TRADING LLC | US$2399.1萬 | 0.05% |
| Nuveen, LLC | US$2318.8萬 | 0.01% |
| GSK plc | US$2243.8萬 | 3.74% |
| Candriam S.C.A. | US$2209.4萬 | 0.11% |
| GILDER GAGNON HOWE & CO LLC | US$2181.5萬 | 0.26% |
| MILLENNIUM MANAGEMENT LLC | US$2154.3萬 | 0.01% |
| JANE STREET GROUP, LLC | US$2121.0萬 | 0.00% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | US$2054.1萬 | 0.01% |
| CITIGROUP INC | US$2011.9萬 | 0.01% |
| E. Ohman J:or Asset Management AB | US$1982.3萬 | 0.52% |
| Vestal Point Capital, LP | US$1977.3萬 | 0.55% |
| Trails Edge Capital Partners, LP | US$1977.3萬 | 4.53% |
| SPHERA FUNDS MANAGEMENT LTD. | US$1971.5萬 | 3.13% |
| NOMURA HOLDINGS INC | US$1932.0萬 | 0.05% |
| TWO SIGMA INVESTMENTS, LP | US$1878.5萬 | 0.02% |
| First Turn Management, LLC | US$1869.9萬 | 2.09% |
| JANUS HENDERSON GROUP PLC | US$1859.3萬 | 0.01% |
| Susquehanna Portfolio Strategies, LLC | US$1835.1萬 | 0.27% |
| BARCLAYS PLC | US$1764.1萬 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | US$1710.1萬 | 0.02% |
| DIADEMA PARTNERS LP | US$1647.8萬 | 2.80% |
| Handelsbanken Fonder AB | US$1630.0萬 | 0.05% |
| Capital World Investors | US$1595.3萬 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$1586.0萬 | 0.00% |
| Swiss National Bank | US$1514.6萬 | 0.01% |
| Sarissa Capital Management LP | US$1506.9萬 | 9.56% |
| HSBC HOLDINGS PLC | US$1463.2萬 | 0.01% |
| DAFNA Capital Management LLC | US$1433.5萬 | 3.26% |
| Freestone Grove Partners LP | US$1428.7萬 | 0.10% |
| Catalio Capital Management, LP | US$1420.4萬 | 2.97% |
| Mirador Capital Partners LP | US$1335.8萬 | 1.89% |
| Hudson Bay Capital Management LP | US$1321.3萬 | 0.05% |
| EMERALD ADVISERS, LLC | US$1310.4萬 | 0.41% |
| California Public Employees Retirement System | US$1308.5萬 | 0.01% |
| DEUTSCHE BANK AG\ | US$1233.4萬 | 0.00% |
| SEGALL BRYANT & HAMILL, LLC | US$1187.7萬 | 0.17% |
| Checkpoint Capital L.P. | US$1186.4萬 | 4.26% |
| PINNACLE ASSOCIATES LTD | US$1167.0萬 | 0.15% |
| Russell Investments Group, Ltd. | US$1147.0萬 | 0.01% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$1101.5萬 | 0.01% |
| AQR CAPITAL MANAGEMENT LLC | US$1031.8萬 | 0.00% |
| Legal & General Group Plc | US$995.4萬 | 0.00% |
| Alyeska Investment Group, L.P. | US$988.7萬 | 0.03% |
| Retirement Systems of Alabama | US$987.9萬 | 0.03% |
| FIRST TRUST ADVISORS LP | US$961.6萬 | 0.01% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$900.3萬 | 0.01% |
| EMERALD MUTUAL FUND ADVISERS TRUST | US$892.8萬 | 0.43% |
| STEMPOINT CAPITAL LP | US$854.0萬 | 1.64% |
| Impax Asset Management Group plc | US$823.9萬 | 0.06% |
| ROYCE & ASSOCIATES LP | US$819.2萬 | 0.08% |
| MetLife Investment Management, LLC | US$812.9萬 | 0.04% |
| ALGERT GLOBAL LLC | US$771.9萬 | 0.12% |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | US$728.3萬 | 0.01% |
| LMR Partners LLP | US$710.5萬 | 0.02% |
| Creative Planning | US$710.2萬 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$705.2萬 | 0.01% |
| Exome Asset Management LLC | US$683.6萬 | 3.54% |
| PEREGRINE CAPITAL MANAGEMENT LLC | US$683.0萬 | 0.25% |
| Lombard Odier Asset Management (Europe) Ltd | US$674.9萬 | 0.37% |
| Schonfeld Strategic Advisors LLC | US$669.4萬 | 0.05% |
| Boxer Capital Management, LLC | US$659.1萬 | 0.87% |
| Monashee Investment Management LLC | US$659.1萬 | 3.59% |
| DIMENSIONAL FUND ADVISORS LP | US$622.9萬 | 0.00% |
| Sofinnova Investments, Inc. | US$605.0萬 | 0.23% |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | US$599.0萬 | 0.07% |
| THORNBURG INVESTMENT MANAGEMENT INC | US$548.3萬 | 0.06% |
| Walleye Trading LLC | US$533.9萬 | 0.01% |
| J. Goldman & Co LP | US$524.0萬 | 0.15% |
| NEUBERGER BERMAN GROUP LLC | US$508.1萬 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$490.0萬 | 0.00% |
| Erste Asset Management GmbH | US$484.6萬 | 0.04% |
| Rafferty Asset Management, LLC | US$478.6萬 | 0.02% |
| Aquatic Capital Management LLC | US$477.7萬 | 0.14% |
| Granahan Investment Management, LLC | US$477.6萬 | 0.23% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$475.0萬 | 0.01% |
| SILVERARC CAPITAL MANAGEMENT, LLC | US$469.3萬 | 0.48% |
| Nicholas Investment Partners, LP | US$460.3萬 | 0.33% |
| SEI INVESTMENTS CO | US$460.1萬 | 0.00% |
| Pier Capital, LLC | US$458.6萬 | 0.76% |
| CANADA LIFE ASSURANCE Co | US$451.9萬 | 0.01% |
| RAYMOND JAMES FINANCIAL INC | US$451.5萬 | 0.00% |
| Tyro Capital Management LLC | US$426.2萬 | 0.46% |
| ACT CAPITAL MANAGEMENT, LLC | US$425.1萬 | 3.34% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | US$413.8萬 | 0.03% |
| Seven Fleet Capital Management LP | US$403.8萬 | 1.28% |