| TCG Crossover Management, LLC | US$7.2億 | 20.65% |
| UBS Group AG | US$5.1億 | 0.08% |
| Darwin Global Management, Ltd. | US$3.5億 | 9.34% |
| MORGAN STANLEY | US$1.9億 | 0.01% |
| Vestal Point Capital, LP | US$1.7億 | 4.67% |
| Caligan Partners LP | US$1.6億 | 10.83% |
| ADAR1 Capital Management, LLC | US$1.6億 | 9.43% |
| CITADEL ADVISORS LLC | US$1.5億 | 0.02% |
| WESTFIELD CAPITAL MANAGEMENT CO LP | US$1.5億 | 0.62% |
| FMR LLC | US$1.4億 | 0.01% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$1.4億 | 0.02% |
| Helikon Investments Ltd | US$1.1億 | 4.26% |
| Eversept Partners, LP | US$1.0億 | 5.49% |
| JANUS HENDERSON GROUP PLC | US$9800.7萬 | 0.05% |
| BAKER BROS. ADVISORS LP | US$9752.0萬 | 0.56% |
| LORD, ABBETT & CO. LLC | US$9519.5萬 | 0.31% |
| Paradigm Biocapital Advisors LP | US$8601.5萬 | 1.76% |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | US$8528.5萬 | 7.23% |
| Cormorant Asset Management, LP | US$8462.6萬 | 4.25% |
| BANK OF AMERICA CORP /DE/ | US$8192.3萬 | 0.01% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$7701.8萬 | 0.01% |
| Octagon Capital Advisors LP | US$7538.4萬 | 8.34% |
| Logos Global Management LP | US$7516.1萬 | 3.75% |
| Point72 Asset Management, L.P. | US$7207.0萬 | 0.09% |
| Ensign Peak Advisors, Inc | US$7035.5萬 | 0.13% |
| MILLENNIUM MANAGEMENT LLC | US$6915.9萬 | 0.03% |
| Artia Global Partners LP | US$6689.3萬 | 13.39% |
| JPMORGAN CHASE & CO | US$6445.9萬 | 0.00% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$6227.4萬 | 0.81% |
| Saturn V Capital Management LP | US$6042.9萬 | 10.94% |
| First Turn Management, LLC | US$5187.5萬 | 5.80% |
| ORBIMED ADVISORS LLC | US$5185.6萬 | 1.06% |
| Aberdeen Group plc | US$4801.9萬 | 0.08% |
| BlackRock, Inc. | US$4758.4萬 | 0.00% |
| Affinity Asset Advisors, LLC | US$4509.7萬 | 2.33% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$4460.0萬 | 0.07% |
| FRANKLIN RESOURCES INC | US$4262.8萬 | 0.01% |
| Ikarian Capital, LLC | US$3889.2萬 | 3.16% |
| GOLDMAN SACHS GROUP INC | US$3883.9萬 | 0.00% |
| PERCEPTIVE ADVISORS LLC | US$3662.1萬 | 0.72% |
| EVENTIDE ASSET MANAGEMENT, LLC | US$3569.4萬 | 0.59% |
| STEMPOINT CAPITAL LP | US$3494.1萬 | 6.69% |
| PRINCIPAL FINANCIAL GROUP INC | US$3477.2萬 | 0.02% |
| SILVERARC CAPITAL MANAGEMENT, LLC | US$3368.7萬 | 3.44% |
| DIADEMA PARTNERS LP | US$3048.7萬 | 5.19% |
| Holocene Advisors, LP | US$2880.1萬 | 0.07% |
| Vivo Capital, LLC | US$2667.3萬 | 2.22% |
| LMR Partners LLP | US$2536.0萬 | 0.06% |
| Woodline Partners LP | US$2515.3萬 | 0.10% |
| JANE STREET GROUP, LLC | US$2400.0萬 | 0.00% |
| Balyasny Asset Management L.P. | US$2379.4萬 | 0.03% |
| JENNISON ASSOCIATES LLC | US$2344.3萬 | 0.02% |
| READYSTATE ASSET MANAGEMENT LP | US$2249.5萬 | 1.01% |
| Boxer Capital Management, LLC | US$2227.0萬 | 2.92% |
| ExodusPoint Capital Management, LP | US$2148.8萬 | 0.17% |
| Centiva Capital, LP | US$1998.2萬 | 0.15% |
| Creek Drive Management Group LLC | US$1725.9萬 | 3.93% |
| Evergreen Quality Fund GP, Ltd. | US$1606.8萬 | 0.37% |
| Hudson Bay Capital Management LP | US$1552.0萬 | 0.05% |
| Nantahala Capital Management, LLC | US$1528.1萬 | 0.56% |
| Sio Capital Management, LLC | US$1512.1萬 | 2.17% |
| Squadron Capital Management LLC | US$1447.6萬 | 5.30% |
| Kite Lake Capital Management (UK) LLP | US$1444.2萬 | 11.58% |
| NAN FUNG TRINITY (HK) LTD | US$1435.7萬 | 1.58% |
| Apis Capital Advisors, LLC | US$1434.2萬 | 2.21% |
| Invesco Ltd. | US$1407.7萬 | 0.00% |
| Patient Square Capital LP | US$1350.1萬 | 2.40% |
| TUDOR INVESTMENT CORP ET AL | US$1295.1萬 | 0.02% |
| HighVista Strategies LLC | US$1261.1萬 | 3.48% |
| TimesSquare Capital Management, LLC | US$1215.8萬 | 0.21% |
| FEDERATED HERMES, INC. | US$1204.8萬 | 0.02% |
| MPM BIOIMPACT LLC | US$1194.4萬 | 0.92% |
| IMC-Chicago, LLC | US$1181.9萬 | 0.00% |
| FINDELL CAPITAL MANAGEMENT LLC | US$1169.2萬 | 3.42% |
| Prosight Management, LP | US$1169.2萬 | 1.92% |
| Pictet Asset Management Holding SA | US$1120.2萬 | 0.01% |
| SEI INVESTMENTS CO | US$1049.4萬 | 0.01% |
| BARCLAYS PLC | US$1010.8萬 | 0.00% |
| Nicholas Investment Partners, LP | US$1004.4萬 | 0.72% |
| AMERIPRISE FINANCIAL INC | US$924.6萬 | 0.00% |
| ODDO BHF ASSET MANAGEMENT SAS | US$907.5萬 | 0.36% |
| Davern Capital Partners, LP | US$869.9萬 | 2.39% |
| ANDERA PARTNERS | US$869.9萬 | 4.92% |
| Velan Capital Investment Management LP | US$857.4萬 | 5.37% |
| LPL Financial LLC | US$839.2萬 | 0.00% |
| Voleon Capital Management LP | US$820.9萬 | 0.18% |
| ACT CAPITAL MANAGEMENT, LLC | US$789.5萬 | 6.20% |
| TD Asset Management Inc | US$729.9萬 | 0.01% |
| Russell Investments Group, Ltd. | US$726.8萬 | 0.01% |
| K2 PRINCIPAL FUND, L.P. | US$709.8萬 | 0.50% |
| ENVESTNET ASSET MANAGEMENT INC | US$659.3萬 | 0.00% |
| SAMSARA BIOCAPITAL, LLC | US$630.0萬 | 0.61% |
| D. E. Shaw & Co., Inc. | US$614.1萬 | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | US$571.4萬 | 0.00% |
| SEVEN GRAND MANAGERS, LLC | US$556.8萬 | 0.37% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$551.4萬 | 0.01% |
| Trexquant Investment LP | US$542.8萬 | 0.04% |
| Catalio Capital Management, LP | US$525.5萬 | 1.10% |
| Walleye Trading LLC | US$521.9萬 | 0.01% |
| Erste Asset Management GmbH | US$507.5萬 | 0.05% |
| HRT FINANCIAL LP | US$505.2萬 | 0.01% |
| Alberta Investment Management Corp | US$501.1萬 | 0.03% |
| Seven Fleet Capital Management LP | US$479.4萬 | 1.52% |
| Atle Fund Management AB | US$478.4萬 | 1.54% |
| SYQUANT CAPITAL SAS | US$473.2萬 | 0.74% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$429.8萬 | 0.00% |
| Candriam S.C.A. | US$401.5萬 | 0.02% |
| GROUP ONE TRADING LLC | US$398.3萬 | 0.01% |
| Ally Bridge Group (NY) LLC | US$375.4萬 | 3.03% |
| Walleye Capital LLC | US$350.7萬 | 0.01% |
| Verition Fund Management LLC | US$346.8萬 | 0.02% |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | US$338.0萬 | 0.21% |
| Atika Capital Management LLC | US$320.7萬 | 0.50% |
| Hunting Hill Global Capital, LLC | US$298.1萬 | 2.31% |
| PFM Health Sciences, LP | US$296.9萬 | 0.27% |
| Persistent Asset Partners Ltd | US$289.7萬 | 1.08% |
| GUGGENHEIM CAPITAL LLC | US$279.2萬 | 0.02% |
| CAXTON ASSOCIATES LLP | US$275.6萬 | 0.06% |
| Dorsey Wright & Associates | US$261.1萬 | 0.32% |
| Brummer Multi-Strategy AB | US$249.7萬 | 10.40% |
| Cinctive Capital Management LP | US$223.3萬 | 0.15% |
| VOYA INVESTMENT MANAGEMENT LLC | US$206.0萬 | 0.00% |
| Militia Capital Management LLC | US$189.3萬 | 0.43% |
| DIVERSIFY WEALTH MANAGEMENT, LLC | US$188.4萬 | 0.03% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$182.0萬 | 0.00% |
| PSquared Asset Management AG | US$180.4萬 | 0.63% |
| Quinn Opportunity Partners LLC | US$178.2萬 | 0.09% |
| FIFTH LANE CAPITAL, LP | US$176.6萬 | 2.14% |
| HSBC HOLDINGS PLC | US$171.2萬 | 0.00% |
| ROYAL BANK OF CANADA | US$168.4萬 | 0.00% |
| BANQUE PICTET & CIE SA | US$167.5萬 | 0.01% |
| Schonfeld Strategic Advisors LLC | US$159.4萬 | 0.01% |
| E Fund Management Co., Ltd. | US$152.9萬 | 0.05% |
| FORA Capital, LLC | US$146.9萬 | 0.11% |
| China Universal Asset Management Co., Ltd. | US$143.7萬 | 0.11% |
| J. Goldman & Co LP | US$142.0萬 | 0.04% |
| Progeny 3, Inc. | US$136.3萬 | 0.07% |
| AdvisorShares Investments LLC | US$131.4萬 | 0.24% |
| Mariner, LLC | US$122.4萬 | 0.00% |
| STIFEL FINANCIAL CORP | US$120.0萬 | 0.00% |
| Jefferies Financial Group Inc. | US$113.1萬 | 0.01% |
| Diametric Capital, LP | US$111.4萬 | 0.29% |
| Avidity Partners Management LP | US$111.4萬 | 0.23% |
| HIMENSION CAPITAL (SINGAPORE) PTE. LTD. | US$107.6萬 | 0.08% |
| Virtu Financial LLC | US$106.3萬 | 0.04% |
| Brevan Howard Capital Management LP | US$105.8萬 | 0.01% |
| KENNEDY CAPITAL MANAGEMENT LLC | US$97.5萬 | 0.02% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$96.6萬 | 0.00% |
| CenterBook Partners LP | US$93.9萬 | 0.05% |
| NINE MASTS CAPITAL Ltd | US$83.5萬 | 0.12% |