| BAKER BROS. ADVISORS LP | $7.6億 | 4.36% |
| BlackRock, Inc. | $1.5億 | 0.00% |
| STATE STREET CORP | $8580.5万 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $7774.1万 | 0.01% |
| BRAIDWELL LP | $6932.8万 | 2.31% |
| GOLDMAN SACHS GROUP INC | $6629.1万 | 0.01% |
| VANGUARD CAPITAL MANAGEMENT LLC | $6545.5万 | 0.00% |
| RTW INVESTMENTS, LP | $5672.0万 | 0.56% |
| TCG Crossover Management, LLC | $5510.4万 | 1.58% |
| Ikarian Capital, LLC | $5206.4万 | 4.23% |
| Boxer Capital Management, LLC | $5188.1万 | 6.81% |
| JANUS HENDERSON GROUP PLC | $5054.0万 | 0.02% |
| ICONIQ Capital, LLC | $4828.1万 | 1.08% |
| CITADEL ADVISORS LLC | $3973.6万 | 0.01% |
| GEODE CAPITAL MANAGEMENT, LLC | $3814.3万 | 0.00% |
| SILVERARC CAPITAL MANAGEMENT, LLC | $3781.2万 | 3.86% |
| T. Rowe Price Investment Management, Inc. | $3190.5万 | 0.02% |
| Balyasny Asset Management L.P. | $2769.6万 | 0.04% |
| Board of Trustees of The Leland Stanford Junior University | $2637.0万 | 3.11% |
| Artisan Partners Limited Partnership | $2631.5万 | 0.04% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $2191.9万 | 0.03% |
| MORGAN STANLEY | $1966.5万 | 0.00% |
| Point72 Asset Management, L.P. | $1752.5万 | 0.02% |
| DIADEMA PARTNERS LP | $1677.5万 | 2.85% |
| WELLINGTON MANAGEMENT GROUP LLP | $1663.3万 | 0.00% |
| NORTHERN TRUST CORP | $1491.8万 | 0.00% |
| Squadron Capital Management LLC | $1448.6万 | 5.31% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $1391.6万 | 0.00% |
| BOOTHBAY FUND MANAGEMENT, LLC | $1358.1万 | 0.18% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $1333.4万 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | $1200.8万 | 0.00% |
| Invesco Ltd. | $1162.9万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | $1145.0万 | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | $1121.9万 | 0.02% |
| BOONE CAPITAL MANAGEMENT LLC | $1072.4万 | 3.29% |
| VANGUARD FIDUCIARY TRUST CO | $984.0万 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $925.7万 | 0.00% |
| D. E. Shaw & Co., Inc. | $876.6万 | 0.01% |
| FEDERATED HERMES, INC. | $801.3万 | 0.01% |
| Atom Investors LP | $727.2万 | 0.52% |
| FMR LLC | $701.1万 | 0.00% |
| TD Asset Management Inc | $618.7万 | 0.01% |
| UBS Group AG | $583.9万 | 0.00% |
| ALGERT GLOBAL LLC | $563.9万 | 0.08% |
| Bruce & Co., Inc. | $552.7万 | 1.58% |
| Trexquant Investment LP | $470.4万 | 0.03% |
| JANE STREET GROUP, LLC | $467.7万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $459.8万 | 0.00% |
| SPHERA FUNDS MANAGEMENT LTD. | $437.6万 | 0.69% |
| PFM Health Sciences, LP | $437.3万 | 0.40% |
| Bank of New York Mellon Corp | $424.4万 | 0.00% |
| Resolute Capital Asset Partners LLC | $381.2万 | 2.01% |
| TWO SIGMA INVESTMENTS, LP | $379.2万 | 0.00% |
| Nuveen, LLC | $363.3万 | 0.00% |
| Informed Momentum Co LLC | $336.9万 | 0.39% |
| AQR CAPITAL MANAGEMENT LLC | $327.1万 | 0.00% |
| RIA Advisory Group LLC | $322.8万 | 0.77% |
| PRUDENTIAL FINANCIAL INC | $305.8万 | 0.00% |
| WELLS FARGO & COMPANY/MN | $294.0万 | 0.00% |
| Rafferty Asset Management, LLC | $272.6万 | 0.01% |
| Harvest Investment Services, LLC | $272.0万 | 0.50% |
| Squarepoint Ops LLC | $270.9万 | 0.00% |
| JPMORGAN CHASE & CO | $268.3万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | $266.3万 | 0.00% |
| National Philanthropic Trust | $253.1万 | 0.03% |
| Jefferies Financial Group Inc. | $252.6万 | 0.02% |
| AMERIPRISE FINANCIAL INC | $249.7万 | 0.00% |
| Persistent Asset Partners Ltd | $236.9万 | 0.88% |
| Maven Securities LTD | $224.7万 | 0.04% |
| Swiss National Bank | $218.8万 | 0.00% |
| Jain Global LLC | $200.4万 | 0.01% |
| STATE OF WISCONSIN INVESTMENT BOARD | $187.8万 | 0.00% |
| FRED ALGER MANAGEMENT, LLC | $184.4万 | 0.01% |
| RHUMBLINE ADVISERS | $182.8万 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $166.8万 | 0.00% |
| HighVista Strategies LLC | $166.1万 | 0.46% |
| POLEN CAPITAL MANAGEMENT LLC | $157.6万 | 0.01% |
| DEUTSCHE BANK AG\ | $157.3万 | 0.00% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $156.1万 | 0.01% |
| VICTORY CAPITAL MANAGEMENT INC | $143.5万 | 0.00% |
| PROFUND ADVISORS LLC | $121.4万 | 0.04% |
| Vanguard Global Advisers, LLC | $116.6万 | 0.00% |
| PANAGORA ASSET MANAGEMENT INC | $113.3万 | 0.00% |
| Walleye Capital LLC | $112.3万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $112.1万 | 0.00% |
| FRANKLIN RESOURCES INC | $111.9万 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | $107.6万 | 0.00% |
| Aries Wealth Management | $95.3万 | 0.21% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $84.8万 | 0.00% |
| Schonfeld Strategic Advisors LLC | $84.4万 | 0.01% |
| Headlands Technologies LLC | $78.5万 | 0.09% |
| MetLife Investment Management, LLC | $77.6万 | 0.00% |
| Legal & General Group Plc | $76.9万 | 0.00% |
| SIMPLEX TRADING, LLC | $75.3万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | $73.1万 | 0.00% |
| Russell Investments Group, Ltd. | $71.0万 | 0.00% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | $69.4万 | 0.01% |
| XTX Topco Ltd | $68.5万 | 0.01% |
| Optimize Financial Inc | $68.0万 | 0.33% |
| SG Americas Securities, LLC | $65.3万 | 0.00% |
| Artia Global Partners LP | $64.9万 | 0.13% |
| Palumbo Wealth Management LLC | $58.3万 | 0.14% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $57.6万 | 0.00% |
| Vanguard Personalized Indexing Management, LLC | $57.1万 | 0.01% |
| Cerity Partners LLC | $56.7万 | 0.00% |
| Continuum Advisory, LLC | $56.6万 | 0.05% |
| MILLENNIUM MANAGEMENT LLC | $54.4万 | 0.00% |
| SIG BROKERAGE, LP | $51.1万 | 0.01% |
| Campbell & CO Investment Adviser LLC | $50.4万 | 0.03% |
| Engineers Gate Manager LP | $45.8万 | 0.01% |
| LPL Financial LLC | $45.6万 | 0.00% |
| Caption Management, LLC | $43.8万 | 0.00% |
| Virtus Investment Advisers, LLC | $43.7万 | 0.12% |
| Quantinno Capital Management LP | $43.4万 | 0.00% |
| BARCLAYS PLC | $43.1万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | $41.8万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | $41.4万 | 0.00% |
| China Universal Asset Management Co., Ltd. | $41.3万 | 0.03% |
| CITIGROUP INC | $40.7万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | $40.6万 | 0.00% |
| AMERICAN CENTURY COMPANIES INC | $39.5万 | 0.00% |
| SEI INVESTMENTS CO | $39.2万 | 0.00% |
| Y-Intercept (Hong Kong) Ltd | $38.1万 | 0.01% |
| PSP Research LLC | $38.1万 | 0.27% |
| State of New Jersey Common Pension Fund D | $37.8万 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | $36.8万 | 0.00% |
| Virtu Financial LLC | $35.5万 | 0.01% |
| Verdad Advisers, LP | $34.7万 | 0.39% |
| Brooklyn Investment Group | $34.6万 | 0.01% |
| E Fund Management Co., Ltd. | $34.3万 | 0.01% |
| Creative Planning | $32.1万 | 0.00% |
| ALLSTATE CORP | $32.1万 | 0.00% |
| ProShare Advisors LLC | $31.3万 | 0.00% |
| Vanguard Investments Australia, Ltd. | $31.3万 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | $30.4万 | 0.00% |
| Quadrature Capital Ltd | $30.0万 | 0.00% |
| J. Goldman & Co LP | $29.0万 | 0.01% |
| Brevan Howard Capital Management LP | $26.3万 | 0.00% |
| KLP KAPITALFORVALTNING AS | $24.4万 | 0.00% |
| Cetera Investment Advisers | $22.8万 | 0.00% |
| Cambridge Investment Research Advisors, Inc. | $21.4万 | 0.00% |
| MANGROVE PARTNERS IM, LLC | $21.2万 | 0.02% |
| Tower Research Capital LLC (TRC) | $21.0万 | 0.01% |
| CANADA LIFE ASSURANCE Co | $18.9万 | 0.00% |
| CWM, LLC | $13.1万 | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | $12.1万 | 0.00% |
| STRS OHIO | $11.8万 | 0.00% |
| Ameritas Investment Partners, Inc. | $11.8万 | 0.00% |
| NISA INVESTMENT ADVISORS, LLC | $11.7万 | 0.00% |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | $10.9万 | 0.00% |