| TCG Crossover Management, LLC | US$9649.9万 | 2.76% |
| RA CAPITAL MANAGEMENT, L.P. | US$9642.5万 | 1.02% |
| FCPM III SERVICES B.V. | US$7345.4万 | 10.17% |
| Venrock Adviser, LLC | US$5426.4万 | 2.03% |
| Frazier Life Sciences Management, L.P. | US$4538.4万 | 1.17% |
| Caligan Partners LP | US$3434.3万 | 2.29% |
| GREAT POINT PARTNERS LLC | US$3122.0万 | 7.18% |
| Paradigm Biocapital Advisors LP | US$3122.0万 | 0.64% |
| FMR LLC | US$2746.8万 | 0.00% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$2557.0万 | 0.00% |
| MARSHALL WACE, LLP | US$2057.4万 | 0.02% |
| STATE STREET CORP | US$1995.3万 | 0.00% |
| NEXTBio Capital Management LP | US$1783.9万 | 8.28% |
| BlackRock, Inc. | US$1417.9万 | 0.00% |
| Logos Global Management LP | US$1338.0万 | 0.67% |
| Rosalind Advisors, Inc. | US$1248.8万 | 5.02% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$991.4万 | 0.13% |
| UBS Group AG | US$871.2万 | 0.00% |
| BRAIDWELL LP | US$832.7万 | 0.28% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$729.3万 | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | US$611.5万 | 0.00% |
| Clearline Capital LP | US$581.9万 | 0.30% |
| SPHERA FUNDS MANAGEMENT LTD. | US$574.3万 | 0.91% |
| Laurion Capital Management LP | US$568.5万 | 0.25% |
| Propel Bio Management, LLC | US$558.7万 | 3.52% |
| GOLDMAN SACHS GROUP INC | US$467.2万 | 0.00% |
| MILLENNIUM MANAGEMENT LLC | US$461.3万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$331.0万 | 0.00% |
| Jump Financial, LLC | US$308.7万 | 0.04% |
| TUDOR INVESTMENT CORP ET AL | US$272.2万 | 0.01% |
| CITADEL ADVISORS LLC | US$265.4万 | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | US$229.8万 | 0.00% |
| MORGAN STANLEY | US$208.2万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$201.4万 | 0.00% |
| AXIOM INVESTORS LLC /DE | US$170.8万 | 0.02% |
| Quadrature Capital Ltd | US$136.7万 | 0.02% |
| JANE STREET GROUP, LLC | US$135.4万 | 0.00% |
| NORTHERN TRUST CORP | US$115.2万 | 0.00% |
| JOHNSON & JOHNSON | US$95.9万 | 0.15% |
| Simplify Asset Management Inc. | US$95.5万 | 0.01% |
| Rafferty Asset Management, LLC | US$90.1万 | 0.00% |
| Brevan Howard Capital Management LP | US$75.3万 | 0.01% |
| Irenic Capital Management LP | US$58.3万 | 0.04% |
| Engineers Gate Manager LP | US$48.0万 | 0.01% |
| Squarepoint Ops LLC | US$45.5万 | 0.00% |
| Sarissa Capital Management LP | US$45.3万 | 0.29% |
| Bollard Group LLC | US$42.8万 | 0.01% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$39.6万 | 0.00% |
| PROFUND ADVISORS LLC | US$39.3万 | 0.01% |
| Scientech Research LLC | US$26.8万 | 0.22% |
| AXQ CAPITAL, LP | US$26.8万 | 0.03% |
| INDEPENDENT FINANCIAL GROUP, LLC | US$24.9万 | 0.01% |
| SEI INVESTMENTS CO | US$24.5万 | 0.00% |
| Vanguard Global Advisers, LLC | US$23.0万 | 0.00% |
| WINTON GROUP Ltd | US$21.2万 | 0.01% |
| Cannon Global Investment Management, LLC | US$20.9万 | 0.41% |
| Invesco Ltd. | US$20.7万 | 0.00% |
| Diametric Capital, LP | US$18.0万 | 0.05% |
| GROUP ONE TRADING LLC | US$16.2万 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$13.1万 | 0.01% |
| CITIGROUP INC | US$9.6万 | 0.00% |
| JPMORGAN CHASE & CO | US$6.4万 | 0.00% |
| Tower Research Capital LLC (TRC) | US$6.2万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$5.2万 | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | US$3.9万 | 0.00% |
| GF FUND MANAGEMENT CO. LTD. | US$6636.0 | 0.00% |
| Quantbot Technologies LP | US$5477.0 | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | US$4389.0 | 0.00% |
| ROYAL BANK OF CANADA | US$4000.0 | 0.00% |
| BARCLAYS PLC | US$2426.0 | 0.00% |
| Allworth Financial LP | US$1303.0 | 0.00% |
| Parallel Advisors, LLC | US$856.0 | 0.00% |
| MAI Capital Management | US$714.0 | 0.00% |
| SIGNATUREFD, LLC | US$696.0 | 0.00% |
| Ameritas Advisory Services, LLC | US$660.0 | 0.00% |
| Fortitude Family Office, LLC | US$553.0 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | US$507.4 | 0.00% |
| WPG Advisers, LLC | US$375.0 | 0.00% |
| SBI Securities Co., Ltd. | US$54.0 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$18.0 | 0.00% |